Abstract:
:Interactions between animal viruses and antiviral antisera may exceptionally result in an apparent increase in viral infectivity. Halstead and coworkers demonstrated enhanced replication of dengue virus (a Flavivirus, family Togaviridae) in human or simian peripheral blood leucocytes carrying Fc receptors at subneutralising concentrations of antidengue antibody. We have used three continuous cell lines which express macrophage markers to explore the mechanism of this phenomenon. Dengue virus failed to replicate in these cells, but West Nile virus, another Flavivirus, replicated in all three, and we were able to demonstrate reproducibly 50--100-fold enhancement of virus yields in the presence of Flavivirus antisera, the effect also being directly demonstrable in P388D1 cells by increased numbers of virus-induced plaques. The phenomenon of antibody-dependent enhancement of viral replication is not unique to dengue virus, and may have far wider relevance in other viral infections.
journal_name
Naturejournal_title
Natureauthors
Peiris JS,Porterfield JSdoi
10.1038/282509a0subject
Has Abstractpub_date
1979-11-29 00:00:00pages
509-11issue
5738eissn
0028-0836issn
1476-4687journal_volume
282pub_type
杂志文章相关文献
NATURE文献大全abstract::Depleted uranium is a mildly radioactive waste product that is stockpiled worldwide. The chemical reactivity of uranium complexes is well documented, including the stoichiometric activation of small molecules of biological and industrial interest such as H2O, CO2, CO, or N2 (refs 1 - 11), but catalytic transformations...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature16530
更新日期:2016-02-18 00:00:00
abstract::Visible-light absorption and transport of the resultant electronic excitations to a reaction centre through Förster resonance energy transfer1-3 (FRET) are critical to the operation of biological light-harvesting systems4, and are used in various artificial systems made of synthetic dyes5, polymers6 or nanodots7,8. Th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-03081-y
更新日期:2021-01-01 00:00:00
abstract::The Environmental Protection Agency is preparing to regulate the biotechnology industry, claiming authority under the provisions of the Federal Toxic Substances Control Act (TOSCA) and the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA). In the agency's view, the products of recombinant DNA techniques can...
journal_title:Nature
pub_type: 新闻
doi:10.1038/306005a0
更新日期:1983-11-03 00:00:00
abstract::Two large-scale yeast two-hybrid screens were undertaken to identify protein-protein interactions between full-length open reading frames predicted from the Saccharomyces cerevisiae genome sequence. In one approach, we constructed a protein array of about 6,000 yeast transformants, with each transformant expressing on...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35001009
更新日期:2000-02-10 00:00:00
abstract::Although cell adhesion to substrate must ultimately depend on 'sticking' by physical forces at the outer surface, we suggest that control is exercised through the 'grip' of the cytoskeleton. Our experiments indicate that grip can be relaxed by agents which release surface glycoproteins from some form of side-to-side o...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/267124a0
更新日期:1977-05-12 00:00:00
abstract::Attempts to inhibit the recognition of soluble antigens by T lymphocytes using antibodies specific for the antigen in question have been uniformally unsuccessful, in contrast to the observed specific inhibition of antibody generation by B cells. One exception is the unique situation whereby anti-hapten antisera inhibi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/308547a0
更新日期:1984-04-05 00:00:00
abstract::The Notch genes encode single-pass transmembrane receptors that transduce the extracellular signals responsible for cell fate determination during several steps of metazoan development. The mechanism by which extracellular signals affect gene transcription and ultimately cell fate decisions is beginning to emerge for ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35016111
更新日期:2000-06-22 00:00:00
abstract::Vertebrate and invertebrate digestive systems show extensive similarities in their development, cellular makeup and genetic control. The Drosophila midgut is typical: enterocytes make up the majority of the intestinal epithelial monolayer, but are interspersed with hormone-producing enteroendocrine cells. Human (and m...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04333
更新日期:2006-01-26 00:00:00
abstract::Long-term potentiation of chemical synapses is closely related to memory and learning. Studies of this process have concentrated on chemically mediated excitatory synapses. By contrast, activity-dependent modification of gap junctions, which also widely exist in higher structures such as hippocampus and neocortex, has...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/348542a0
更新日期:1990-12-06 00:00:00
abstract::Acetaldehyde is a highly reactive, DNA-damaging metabolite that is produced upon alcohol consumption1. Impaired detoxification of acetaldehyde is common in the Asian population, and is associated with alcohol-related cancers1,2. Cells are protected against acetaldehyde-induced damage by DNA crosslink repair, which whe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2059-5
更新日期:2020-03-01 00:00:00
abstract::Global dust storms on Mars are rare1,2 but can affect the Martian atmosphere for several months. They can cause changes in atmospheric dynamics and inflation of the atmosphere3, primarily owing to solar heating of the dust3. In turn, changes in atmospheric dynamics can affect the distribution of atmospheric water vapo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1097-3
更新日期:2019-04-01 00:00:00
abstract::Since the early 1980s, most electronics have relied on the use of complementary metal-oxide-semiconductor (CMOS) transistors. However, the principles of CMOS operation, involving a switchable semiconductor conductance controlled by an insulating gate, have remained largely unchanged, even as transistors are miniaturiz...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0770-2
更新日期:2019-01-01 00:00:00
abstract::Microcrystals of the lipoprotein-phosphoprotein complex which are found in the oocytes of Xenopus laevis were examined using electron microscopy. Analysis of Fourier transforms of the images of the (010) and (001) projections showed the space group to be P2(1)22(1). Ten projections were combined to produce a map of th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/272028a0
更新日期:1978-03-02 00:00:00
abstract::The RNA polymerase elongation complex (EC) is both highly stable and processive, rapidly extending RNA chains for thousands of nucleotides. Understanding the mechanisms of elongation and its regulation requires detailed information about the structural organization of the EC. Here we report the 2.5-A resolution struct...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05932
更新日期:2007-07-12 00:00:00
abstract::The enzyme cytochrome c nitrite reductase catalyses the six-electron reduction of nitrite to ammonia as one of the key steps in the biological nitrogen cycle, where it participates in the anaerobic energy metabolism of dissimilatory nitrate ammonification. Here we report on the crystal structure of this enzyme from th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/22802
更新日期:1999-07-29 00:00:00
abstract::Satellite observations have transformed our understanding of the Antarctic cryosphere. The continent holds the vast majority of Earth's fresh water, and blankets swathes of the Southern Hemisphere in ice. Reductions in the thickness and extent of floating ice shelves have disturbed inland ice, triggering retreat, acce...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/s41586-018-0171-6
更新日期:2018-06-01 00:00:00
abstract::Cyclin degradation is the key step governing exit from mitosis and progress into the next cell cycle. When a region in the N terminus of cyclin is fused to a foreign protein, it produces a hybrid protein susceptible to proteolysis at mitosis. During the course of degradation, both cyclin and the hybrid form conjugates...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/349132a0
更新日期:1991-01-10 00:00:00
abstract::The presence of papillomaviruses in epithelial-derived cancers from several animal species has led to the speculation that these viruses may also have a pathogenic role in the development of certain human carcinomas, particularly those associated with the anogenital tract. Recently, human papillomavirus (HPV) DNA has ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/300771a0
更新日期:1982-12-23 00:00:00
abstract::Topological states of matter are characterized by topological invariants, which are physical quantities whose values are quantized and do not depend on the details of the system (such as its shape, size and impurities). Of these quantities, the easiest to probe is the electrical Hall conductance, and fractional values...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0184-1
更新日期:2018-07-01 00:00:00
abstract::Chemical reactions inside single crystals are likely to be highly selective, but examples of single crystal to single crystal (SC-SC) transformations are uncommon, because crystallinity is difficult to retain following the rearrangement of atoms in the solid state. The most widely studied SC-SC transformations involve...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09085
更新日期:2010-06-03 00:00:00
abstract::The lysis of murine sarcoma virus-murine leukaemia virus (MSV-MuLV)-induced tumour cells by cytotoxic T lymphocytes (CTL) appears to require that an antigen specified by MSV-MuLV, or induced by the infection, be presented in association with class I major histocompatibility complex antigens. The viral proteins of the ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/305815a0
更新日期:1983-10-27 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/d41586-018-07511-w
更新日期:2018-11-01 00:00:00
abstract::The murine cardioviruses, such as the Mengo and encephalomyocarditis viruses, and the bovine aphthoviruses, such as foot-and-mouth disease virus, are distinguished among positive-strand RNA viruses by the presence of long homopolymeric poly(C) tracts within their 5' noncoding sequences. Although the specific lengths (...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/343474a0
更新日期:1990-02-01 00:00:00
abstract::The mechanistic Target of Rapamycin Complex 1 (mTORC1) is a major regulator of eukaryotic growth that coordinates anabolic and catabolic cellular processes with inputs such as growth factors and nutrients, including amino acids. In mammals arginine is particularly important, promoting diverse physiological effects suc...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature19079
更新日期:2016-08-11 00:00:00
abstract::The relationship between the semantic processing of words and of pictures is a matter of debate among cognitive scientists. We studied the functional anatomy of such processing by using positron-emission tomography (PET). We contrasted activity during two semantic tasks (probing knowledge of associations between conce...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/383254a0
更新日期:1996-09-19 00:00:00
abstract::Although drugs are intended to be selective, at least some bind to several physiological targets, explaining side effects and efficacy. Because many drug-target combinations exist, it would be useful to explore possible interactions computationally. Here we compared 3,665 US Food and Drug Administration (FDA)-approved...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08506
更新日期:2009-11-12 00:00:00
abstract::The interplay between magnetic fields and interacting particles can lead to exotic phases of matter that exhibit topological order and high degrees of spatial entanglement. Although these phases were discovered in a solid-state setting, recent innovations in systems of ultracold neutral atoms-uncharged atoms that do n...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature22811
更新日期:2017-06-21 00:00:00
abstract::The dispute among federal agencies over regulation of commercial biotechnology has been addressed in the Federal Register by the Office of Science and Technology Policy (OSTP), which says the Recombinant DNA Advisory Committee of the National Institutes of Health should continue to oversee biomedical research in this ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/313085b0
更新日期:1985-01-10 00:00:00
abstract::Eukaryotic cells seem to use GTP hydrolysis to regulate vesicular traffic in exocytosis and endocytosis. The best evidence for this comes from studies on the yeast Saccharomyces cerevisiae that have identified two small Ras-related GTP-binding proteins, Sec4p and Ypt1p, which control distinct stages of the secretory p...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/345553a0
更新日期:1990-06-07 00:00:00
abstract::Cells are organized on length scales ranging from ångström to micrometres. However, the mechanisms by which ångström-scale molecular properties are translated to micrometre-scale macroscopic properties are not well understood. Here we show that interactions between diverse synthetic, multivalent macromolecules (includ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10879
更新日期:2012-03-07 00:00:00