Abstract:
:Inositol trisphosphate is a second messenger that controls many cellular processes by generating internal calcium signals. It operates through receptors whose molecular and physiological properties closely resemble the calcium-mobilizing ryanodine receptors of muscle. This family of intracellular calcium channels displays the regenerative process of calcium-induced calcium release responsible for the complex spatiotemporal patterns of calcium waves and oscillations. Such a dynamic signalling pathway controls many cellular processes, including fertilization, cell growth, transformation, secretion, smooth muscle contraction, sensory perception and neuronal signalling.
journal_name
Naturejournal_title
Natureauthors
Berridge MJdoi
10.1038/361315a0subject
Has Abstractpub_date
1993-01-28 00:00:00pages
315-25issue
6410eissn
0028-0836issn
1476-4687journal_volume
361pub_type
杂志文章,评审相关文献
NATURE文献大全abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-020-2958-5
更新日期:2020-12-01 00:00:00
abstract::The site of action of the antispastic drug baclofen has long been considered to reside in the spinal cord although supraspinal effects have also been reported. This beta-chlorophenyl derivative of the neurotransmitter gamma-aminobutyric acid (GABA) depresses both monosynaptic and polysynaptic transmission in the cord ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/307071a0
更新日期:1984-01-05 00:00:00
abstract::Although a few cancer genes are mutated in a high proportion of tumours of a given type (>20%), most are mutated at intermediate frequencies (2-20%). To explore the feasibility of creating a comprehensive catalogue of cancer genes, we analysed somatic point mutations in exome sequences from 4,742 human cancers and the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12912
更新日期:2014-01-23 00:00:00
abstract::The unusual helium-rich (type Ib) supernova SN 2005E is distinguished from all supernovae hitherto observed by its faint and rapidly fading light curve, prominent calcium lines in late-phase spectra and lack of any mark of recent star formation near the supernova location. These properties are claimed to be explained ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09055
更新日期:2010-05-20 00:00:00
abstract::Through their functional diversification, distinct lineages of CD4(+) T cells can act to either drive or constrain immune-mediated pathology. Transcription factors are critical in the generation of cellular diversity, and negative regulators antagonistic to alternate fates often act in conjunction with positive regula...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12199
更新日期:2013-06-27 00:00:00
abstract::A type Ia supernova is thought to be a thermonuclear explosion of either a single carbon-oxygen white dwarf or a pair of merging white dwarfs. The explosion fuses a large amount of radioactive (56)Ni (refs 1-3). After the explosion, the decay chain from (56)Ni to (56)Co to (56)Fe generates γ-ray photons, which are rep...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13672
更新日期:2014-08-28 00:00:00
abstract::Galactose oxidase is an extracellular enzyme secreted by the fungus Dactylium dendroides. It is monomeric, with a relative molecular mass of 68,000, catalyses the stereospecific oxidation of a broad range of primary alcohol substrates and possesses a unique mononuclear copper site essential for catalysing a two-electr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/350087a0
更新日期:1991-03-07 00:00:00
abstract::A parliamentary and union delegation has expressed to the British government its concern over the possible demise of the Genetic Manipulation Advisory Group (GMAG). The delegation proposed that GMAG continue to ensure the safe development of recombinant DNA technology and extend its role to cover the ethics of human ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/299387a0
更新日期:1982-09-30 00:00:00
abstract::Current human immunodeficiency virus-1 (HIV-1) vaccines elicit strain-specific neutralizing antibodies. However, cross-reactive neutralizing antibodies arise in approximately 20% of HIV-1-infected individuals, and details of their generation could provide a blueprint for effective vaccination. Here we report the isola...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12053
更新日期:2013-04-25 00:00:00
abstract::Mountain glaciers and ice caps are contributing significantly to present rates of sea level rise and will continue to do so over the next century and beyond. The Canadian Arctic Archipelago, located off the northwestern shore of Greenland, contains one-third of the global volume of land ice outside the ice sheets, but...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10089
更新日期:2011-05-19 00:00:00
abstract::The heterotrimeric G proteins mediate a variety of cellular processes by coupling transmembrane receptors to different effector molecules, including adenylyl cyclases and inositol-phospholipid-specific phospholipase C (PLC)1-3. Activation of adenylyl cyclases results in the production of cyclic AMP and activation of c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/382083a0
更新日期:1996-07-04 00:00:00
abstract::As the extracellular matrix at the original site of a neuromuscular junction seems to play a major part in the specificity of synaptic regeneration, considerable attention has been paid to unique molecules localized to this region. Here we describe an extracellular matrix glycoprotein of the elasmobranch electric orga...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/314441a0
更新日期:1985-04-04 00:00:00
abstract::A short exposure of primary cultures of mouse mammary tumour cells to glucocorticoids results in at least a three-fold stimulation of mammary tumour virus (MTV) production. Specific interaction of glucocorticoids with the cytoplasmic and nuclear receptors can also be demonstrated. The biological potency of various ste...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/262107a0
更新日期:1976-07-08 00:00:00
abstract::For unknown reasons, autoimmune diseases such as type 1 diabetes develop after prolonged periods of inflammation of mononuclear cells in target tissues. Here we show that progression of pancreatic islet inflammation to overt diabetes in nonobese diabetic (NOD) mice is driven by the 'avidity maturation' of a prevailing...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35021081
更新日期:2000-08-17 00:00:00
abstract::To ensure cell survival, it is essential that the ubiquitous pro-apoptotic machinery is kept quiescent. As death is irreversible, cells must continually integrate developmental information with regulatory inputs to control the switch between repressing and activating apoptosis. Inappropriate activation or suppression ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01920
更新日期:2003-08-28 00:00:00
abstract::Disruption of the normal regulation of cell-cycle progression and division lies at the heart of the events leading to cancer. Complex networks of regulatory factors, the tumour microenvironment and stress signals, such as those resulting from damaged DNA, dictate whether cancer cells proliferate or die. Recent progres...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature03095
更新日期:2004-11-18 00:00:00
abstract::DNA fragments of chemically transformed and normal avian and murine cells induce transformation of NIH 3T3 mouse cells with low efficiencies. High molecular weight DNAs of cells transformed by DNA fragments induce transformation with high efficiencies in secondary transfection assays. It thus seems that endogenous tra...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/284418a0
更新日期:1980-04-03 00:00:00
abstract::The inhibitory activity associated with myelin is a major obstacle for successful axon regeneration in the adult mammalian central nervous system (CNS). In addition to myelin-associated glycoprotein (MAG) and Nogo-A, available evidence suggests the existence of additional inhibitors in CNS myelin. We show here that a ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature00867
更新日期:2002-06-27 00:00:00
abstract::The first nerve cells to appear in the limb buds of embryonic grasshoppers are a pair which lie at the distal tip and project axons along the length of the limb to the central nervous system (CNS). The stereotyped route navigated by these 'pioneer' axons is followed by other neurones and eventually becomes that of a m...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/304062a0
更新日期:1983-07-07 00:00:00
abstract::Systems of colour vision are normally identical in all members of a species, but a single design may not be adequate for species living in a diverse range of light environments. Here we show that in the mantis shrimp Haptosquilla trispinosa, which occupies a range of depths in the ocean, long-wavelength colour recepto...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35079184
更新日期:2001-05-31 00:00:00
abstract::The polypeptide chains that make up proteins have thousands of atoms and hence millions of possible inter-atomic interactions. It might be supposed that the resulting complexity would make prediction of protein structure and protein-folding mechanisms nearly impossible. But the fundamental physics underlying folding m...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35011000
更新日期:2000-05-04 00:00:00
abstract::Endothelial cells adopt tissue-specific characteristics to instruct organ development and regeneration1,2. This adaptability is lost in cultured adult endothelial cells, which do not vascularize tissues in an organotypic manner. Here, we show that transient reactivation of the embryonic-restricted ETS variant transcri...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2712-z
更新日期:2020-09-01 00:00:00
abstract::The neurotrophin receptor TrkB is essential for normal function of the mammalian brain. It is expressed in three splice variants. Full-length receptors (TrkB(FL)) possess an intracellular tyrosine kinase domain and are considered as those TrkB receptors that mediate the crucial effects of brain-derived neurotrophic fa...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01983
更新日期:2003-11-06 00:00:00
abstract::In the unactivated Limulus sperm, a 60- micro m-long bundle of actin filaments crosslinked by the protein scruin is bent and twisted into a coil around the base of the nucleus. At fertilization, the bundle uncoils and fully extends in five seconds to support a finger of membrane known as the acrosomal process. This bi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02881
更新日期:2004-09-02 00:00:00
abstract::Neurons expressing luteinizing hormone-releasing hormone (LHRH), found in the septal-preoptic nuclei and hypothalamus, control the release of gonadotropic hormones from the anterior pituitary gland and facilitate reproductive behaviour. LHRH-expressing neurons are also found in the nervus terminalis, a cranial nerve t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/338161a0
更新日期:1989-03-09 00:00:00
abstract::During an immune response, hypermutation of immunoglobulin genes in B cells proliferating within germinal centres (GCs) generates variant antibodies that react with higher affinity against either foreign or self antigens. Several experiments suggest that self-reactive B cells may be censored at this stage of the immun...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/375334a0
更新日期:1995-05-25 00:00:00
abstract::How does the human visual system 'bind' different fragments in the visual scene to create enduring representations of objects? A visual illusion known as 'metacontrast' or backward masking provides compelling evidence that perception is not instantaneous and that it occurs sequentially in distinct stages. If a solid w...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/373066a0
更新日期:1995-01-05 00:00:00
abstract::ELLIPTICAL galaxies acting as gravitational lenses occasionally produce spectacular images-Einstein rings-of distant objects. Giant arcs(1) and radio rings(2) have been observed. A wide variety of image morphologies is possible, the generation of which is qualitatively understood in terms of large magnifications at ca...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/344043a0
更新日期:1990-03-01 00:00:00
abstract::Miocene hominoid material is very scarce and has previously only been reported as cranial fragments in the Old World. Here we describe a new specimen of Ouranopithecus macedoniensis, which consists of the right part of the face of an adult male with a portion of the frontal bone, a portion of the left part of the face...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/345712a0
更新日期:1990-06-21 00:00:00
abstract::Only 10 different V beta gene segments were found when the sequences of 15 variable (V beta) genes of the mouse T-cell receptor were examined. From this analysis we calculate that the total number of expressed V beta gene segments may be 21 or fewer, which makes the expressed germline V beta repertoire much smaller th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/316517a0
更新日期:1985-08-08 00:00:00