The murine T-cell receptor uses a limited repertoire of expressed V beta gene segments.

abstract：:Neurotransmitters modulate the activity of ion channels through a variety of second messengers, including cyclic AMP, cyclic GMP and the products of phosphatidylinositol breakdown. Little is known about how different transmitters acting through different second-messenger systems interact within a cell to regulate sing...

journal_title：Nature

authors： Belardetti F,Kandel ER,Siegelbaum SA

更新日期：1987-01-08 00:00:00

abstract：:Alzheimer's disease is the world's most common dementing illness. Deposition of amyloid-β peptide drives cerebral neuroinflammation by activating microglia. Indeed, amyloid-β activation of the NLRP3 inflammasome in microglia is fundamental for interleukin-1β maturation and subsequent inflammatory events. However, it r...

journal_title：Nature

authors： Heneka MT,Kummer MP,Stutz A,Delekate A,Schwartz S,Vieira-Saecker A,Griep A,Axt D,Remus A,Tzeng TC,Gelpi E,Halle A,Korte M,Latz E,Golenbock DT

更新日期：2013-01-31 00:00:00

abstract：:The central nervous system (CNS) requires a tightly controlled environment free of toxins and pathogens to provide the proper chemical composition for neural function. This environment is maintained by the 'blood-brain barrier' (BBB), which is composed of blood vessels whose endothelial cells display specialized tight...

journal_title：Nature

authors： Ben-Zvi A,Lacoste B,Kur E,Andreone BJ,Mayshar Y,Yan H,Gu C

更新日期：2014-05-22 00:00:00

abstract：:Quantum information science involves the storage, manipulation and communication of information encoded in quantum systems, where the phenomena of superposition and entanglement can provide enhancements over what is possible classically. Large-scale quantum information processors require stable and addressable quantum...

journal_title：Nature

authors： Moehring DL,Maunz P,Olmschenk S,Younge KC,Matsukevich DN,Duan LM,Monroe C

更新日期：2007-09-06 00:00:00

abstract：:Chemokines are chemotactic cytokines that activate and direct the migration of leukocytes. There are two subfamilies, the CXC and the CC chemokines. We recently found that the CXC-chemokine stromal cell-derived factor-1 (SDF-1) is a highly efficacious lymphocyte chemoattractant. Chemokines act on responsive leukocyte ...

journal_title：Nature

authors： Bleul CC,Farzan M,Choe H,Parolin C,Clark-Lewis I,Sodroski J,Springer TA

更新日期：1996-08-29 00:00:00

abstract：:Recent observations have revealed streams of gas and stars in the halo of the Milky Way that are the debris from interactions between our Galaxy and some of its dwarf companion galaxies; the Sagittarius dwarf galaxy and the Magellanic clouds. Analysis of the material has shown that much of the halo is made up of canni...

journal_title：Nature

authors： Ibata R,Irwin M,Lewis G,Ferguson AM,Tanvir N

更新日期：2001-07-05 00:00:00

abstract：:Nitrogen is an essential nutrient for all organisms that must have been available since the origin of life. Abiotic processes including hydrothermal reduction, photochemical reactions, or lightning discharge could have converted atmospheric N2 into assimilable NH4(+), HCN, or NOx species, collectively termed fixed nit...

journal_title：Nature

authors： Stüeken EE,Buick R,Guy BM,Koehler MC

更新日期：2015-04-30 00:00:00

abstract：:In magnetic memory devices, logical bits are recorded by selectively setting the magnetization vector of individual magnetic domains either 'up' or 'down'. In such devices, the fastest and most efficient recording method involves precessional switching: when a magnetic field B(p) is applied as a write pulse over a per...

journal_title：Nature

authors： Tudosa I,Stamm C,Kashuba AB,King F,Siegmann HC,Stöhr J,Ju G,Lu B,Weller D

更新日期：2004-04-22 00:00:00

abstract：:Recent studies have shown that normal cellular sequences on chromosome 13 are lost during the development of retinoblastomas and that sequences on chromosome 11 are similarly lost during the development of Wilms' kidney tumours and embryonal tumours. Cells from these tumors have been found to contain either the patern...

journal_title：Nature

authors： Fearon ER,Feinberg AP,Hamilton SH,Vogelstein B

更新日期：1985-11-28 00:00:00

abstract：:Peptidoglycan is the major structural constituent of the bacterial cell wall, forming a meshwork outside the cytoplasmic membrane that maintains cell shape and prevents lysis. In Gram-negative bacteria, peptidoglycan is located in the periplasm, where it is protected from exogenous lytic enzymes by the outer membrane....

journal_title：Nature

authors： Russell AB,Hood RD,Bui NK,LeRoux M,Vollmer W,Mougous JD

更新日期：2011-07-20 00:00:00

abstract：:The Wnt family of secreted glycoproteins mediate cell cell interactions during cell growth and differentiation in both embryos and adults. Canonical Wnt signalling by way of the beta-catenin pathway is transduced by two receptor families. Frizzled proteins and lipoprotein-receptor-related proteins 5 and 6 (LRP5/6) bin...

journal_title：Nature

authors： Mao B,Wu W,Davidson G,Marhold J,Li M,Mechler BM,Delius H,Hoppe D,Stannek P,Walter C,Glinka A,Niehrs C

更新日期：2002-06-06 00:00:00

abstract：:Species that depend on membership in social groups for survival exhibit changes in neuronal gene expression and behaviour when they face restricted social interactions or isolation1-3. Here we show that, across the lifespan of zebrafish (Danio rerio), social isolation specifically decreased the level of transcription ...

journal_title：Nature

authors： Anneser L,Alcantara IC,Gemmer A,Mirkes K,Ryu S,Schuman EM

更新日期：2020-12-01 00:00:00

abstract：:Although the nuclear properties of the late actinides (plutonium, americium and curium) are fully understood and widely applied to energy generation, their solid-state properties do not fit within standard models and are the subject of active research. Plutonium displays phases with enormous volume differences, and bo...

journal_title：Nature

authors： Shim JH,Haule K,Kotliar G

更新日期：2007-03-29 00:00:00

abstract：:Metabotropic γ-aminobutyric acid receptors (GABAB) are involved in the modulation of synaptic responses in the central nervous system and have been implicated in neuropsychological conditions that range from addiction to psychosis1. GABAB belongs to class C of the G-protein-coupled receptors, and its functional entity...

journal_title：Nature

authors： Shaye H,Ishchenko A,Lam JH,Han GW,Xue L,Rondard P,Pin JP,Katritch V,Gati C,Cherezov V

更新日期：2020-08-01 00:00:00

abstract：:Non-impulsive seismic radiation or 'tremor' has long been observed at volcanoes and more recently around subduction zones. Although the number of observations of non-volcanic tremor is steadily increasing, the causative mechanism remains unclear. Some have attributed non-volcanic tremor to the movement of fluids, whil...

journal_title：Nature

authors： Rubinstein JL,Vidale JE,Gomberg J,Bodin P,Creager KC,Malone SD

更新日期：2007-08-02 00:00:00

abstract：:Naive lymphocytes continually enter and exit lymphoid organs in a recirculation process that is essential for immune surveillance. During immune responses, the egress process can be shut down transiently. When this occurs locally it increases lymphocyte numbers in the responding lymphoid organ; when it occurs systemic...

journal_title：Nature

authors： Shiow LR,Rosen DB,Brdicková N,Xu Y,An J,Lanier LL,Cyster JG,Matloubian M

更新日期：2006-03-23 00:00:00

abstract：:Do biological motors move with regular steps? To address this question, we constructed instrumentation with the spatial and temporal sensitivity to resolve movement on a molecular scale. We deposited silica beads carrying single molecules of the motor protein kinesin on microtubules using optical tweezers and analysed...

journal_title：Nature

authors： Svoboda K,Schmidt CF,Schnapp BJ,Block SM

更新日期：1993-10-21 00:00:00

abstract：:Although a few cancer genes are mutated in a high proportion of tumours of a given type (>20%), most are mutated at intermediate frequencies (2-20%). To explore the feasibility of creating a comprehensive catalogue of cancer genes, we analysed somatic point mutations in exome sequences from 4,742 human cancers and the...

journal_title：Nature

authors： Lawrence MS,Stojanov P,Mermel CH,Robinson JT,Garraway LA,Golub TR,Meyerson M,Gabriel SB,Lander ES,Getz G

更新日期：2014-01-23 00:00:00

abstract：:Diatoms are one of the most ecologically successful classes of photosynthetic marine eukaryotes in the contemporary oceans. Over the past 30 million years, they have helped to moderate Earth's climate by absorbing carbon dioxide from the atmosphere, sequestering it via the biological carbon pump and ultimately burying...

journal_title：Nature

authors： Bailleul B,Berne N,Murik O,Petroutsos D,Prihoda J,Tanaka A,Villanova V,Bligny R,Flori S,Falconet D,Krieger-Liszkay A,Santabarbara S,Rappaport F,Joliot P,Tirichine L,Falkowski PG,Cardol P,Bowler C,Finazzi G

更新日期：2015-08-20 00:00:00

abstract：:Several hormones and neurotransmitters raise the cytosolic free Ca2+ concentration by stimulating the influx of Ca2+ and/or by mobilizing stored Ca2+. However, the link between the agonist receptor on the cell surface and the organelle(s) from which Ca2+ is mobilized is unknown. One feature of the agonists that increa...

journal_title：Nature

authors： Prentki M,Biden TJ,Janjic D,Irvine RF,Berridge MJ,Wollheim CB

更新日期：1984-06-07 00:00:00

abstract：:An increase in free calcium triggers catecholamine secretion from chromaffin cells and calmodulin is strongly implicated as the intracellular Ca2+ receptor. In our recent studies of calmodulin action in the chromaffin cell, micromolar Ca2+ concentrations resulted in calmodulin and cytosolic proteins becoming bound to ...

journal_title：Nature

authors： Geisow MJ,Burgoyne RD

更新日期：1983-02-03 00:00:00

abstract：:Inositol 1,4,5-trisphosphate (InsP3) can initiate calcium release into the cytoplasm in a variety of cells. From experiments using permeabilized cells, membrane vesicles, and patch-clamp techniques, it has been suggested that InsP3 acts by directly opening calcium channels. Here, we show that InsP3 induced openings of...

journal_title：Nature

authors： Ehrlich BE,Watras J

更新日期：1988-12-08 00:00:00

abstract：:Classical crystallography can determine structures as complicated as multi-component ribosomal assemblies with atomic resolution, but is inadequate for disordered systems--even those as simple as water ice--that occupy the complex middle ground between liquid-like randomness and crystalline periodic order. Correlated ...

journal_title：Nature

authors： Keen DA,Goodwin AL

更新日期：2015-05-21 00:00:00

abstract：: ...

journal_title：Nature

authors： Savage N

更新日期：2018-12-01 00:00:00

abstract：:Villin is an actin-binding protein of relative molecular mass (Mr) 95,000 found in the core bundle of microfilaments in brush border microvilli from intestine. In physiological calcium concentrations (less than 1 microM), villin crosslinks actin filaments into bundles. However, in free calcium concentrations (greater ...

journal_title：Nature

authors： Matsudaira P,Jakes R,Walker JE

更新日期：1985-05-16 00:00:00

abstract：:The primary function of the nerve cell is to process electrical signals. Over the past fifteen years there has been renewed interest in the detailed spatial analysis of signalling in individual neurons owing to experimental evidence that the regional electrical properties of neurons are complex. Thus the behaviour of ...

journal_title：Nature

authors： Zecević D

更新日期：1996-05-23 00:00:00

abstract：: ...

journal_title：Nature

authors： Clayton EW

更新日期：2018-12-01 00:00:00

abstract：:Materials showing simultaneous ferroelectric and magnetic ordering are attracting a great deal of interest because of their unusual physics and potential applications. Hemberger et al. have reported relaxor-like dielectric properties and colossal magnetocapacitance (in excess of 500%) for the cubic spinel compound CdC...

journal_title：Nature

authors： Catalan G,Scott JF

更新日期：2007-08-23 00:00:00

abstract：:Increasing population and consumption are placing unprecedented demands on agriculture and natural resources. Today, approximately a billion people are chronically malnourished while our agricultural systems are concurrently degrading land, water, biodiversity and climate on a global scale. To meet the world's future ...

journal_title：Nature

authors： Foley JA,Ramankutty N,Brauman KA,Cassidy ES,Gerber JS,Johnston M,Mueller ND,O'Connell C,Ray DK,West PC,Balzer C,Bennett EM,Carpenter SR,Hill J,Monfreda C,Polasky S,Rockström J,Sheehan J,Siebert S,Tilman D,Zaks DP

更新日期：2011-10-12 00:00:00

abstract：:Epigenetic pathways can regulate gene expression by controlling and interpreting chromatin modifications. Cancer cells are characterized by altered epigenetic landscapes, and commonly exploit the chromatin regulatory machinery to enforce oncogenic gene expression programs. Although chromatin alterations are, in princi...

journal_title：Nature

authors： Zuber J,Shi J,Wang E,Rappaport AR,Herrmann H,Sison EA,Magoon D,Qi J,Blatt K,Wunderlich M,Taylor MJ,Johns C,Chicas A,Mulloy JC,Kogan SC,Brown P,Valent P,Bradner JE,Lowe SW,Vakoc CR

更新日期：2011-08-03 00:00:00