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NATURE文献大全abstract::The majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, HIV, Ebola and SARS). Understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals f...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature22975
更新日期:2017-06-29 00:00:00
abstract::Gut commensal microbes shape the mucosal immune system by regulating the differentiation and expansion of several types of T cell. Clostridia, a dominant class of commensal microbe, can induce colonic regulatory T (Treg) cells, which have a central role in the suppression of inflammatory and allergic responses. Howeve...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12721
更新日期:2013-12-19 00:00:00
abstract::Landscapes modified by glacial erosion show a distinct distribution of surface area with elevation (hypsometry). In particular, the height of these regions is influenced by climatic gradients controlling the altitude where glacial and periglacial processes are the most active, and as a result, surface area is focused ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11786
更新日期:2013-01-10 00:00:00
abstract::Many animals rely on an internal heading representation when navigating in varied environments1-10. How this representation is linked to the sensory cues that define different surroundings is unclear. In the fly brain, heading is represented by 'compass' neurons that innervate a ring-shaped structure known as the elli...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1767-1
更新日期:2019-12-01 00:00:00
abstract::Sea ice and dust flux increased greatly in the Southern Ocean during the last glacial period. Palaeorecords provide contradictory evidence about marine productivity in this region, but beyond one glacial cycle, data were sparse. Here we present continuous chemical proxy data spanning the last eight glacial cycles (740...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04614
更新日期:2006-03-23 00:00:00
abstract::The molecular machinery responsible for the generation of transport carriers moving from the Golgi complex to the plasma membrane relies on a tight interplay between proteins and lipids. Among the lipid-binding proteins of this machinery, we previously identified the four-phosphate adaptor protein FAPP2, the pleckstri...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06097
更新日期:2007-09-06 00:00:00
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journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-07552-1
更新日期:2018-11-01 00:00:00
abstract::Activation of oncogenes by mechanisms other than genetic aberrations such as mutations, translocations, or amplifications is largely undefined. Here we report a novel isoform of the anaplastic lymphoma kinase (ALK) that is expressed in ∼11% of melanomas and sporadically in other human cancer types, but not in normal t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature15258
更新日期:2015-10-15 00:00:00
abstract::At early stages of the mammalian visual cortex, neurons with similar stimulus selectivities are vertically arrayed through the thickness of the cortical sheet and clustered in patches or bands across the surface. This organization, referred to as a 'column', has been found with respect to one-dimensional stimulus para...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/360343a0
更新日期:1992-11-26 00:00:00
abstract::Pheromone-based behaviours are crucial in animals from insects to mammals, and reproductive isolation is often based on pheromone differences. However, the genetic mechanisms by which pheromone signals change during the evolution of new species are largely unknown. In the sexual communication system of moths (Insecta:...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09058
更新日期:2010-07-22 00:00:00
abstract::The alternative non-homologous end-joining (NHEJ) machinery facilitates several genomic rearrangements, some of which can lead to cellular transformation. This error-prone repair pathway is triggered upon telomere de-protection to promote the formation of deleterious chromosome end-to-end fusions. Using next-generatio...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14157
更新日期:2015-02-12 00:00:00
abstract::In eukaryotes, accurate chromosome segregation in mitosis and meiosis maintains genome stability and prevents aneuploidy. Kinetochores are large protein complexes that, by assembling onto specialized Cenp-A nucleosomes1,2, function to connect centromeric chromatin to microtubules of the mitotic spindle3,4. Whereas the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1609-1
更新日期:2019-10-01 00:00:00
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journal_title:Nature
pub_type: 面试
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更新日期:2018-11-01 00:00:00
abstract::Four-residue beta-turns and larger loop structures represent a significant fraction of globular protein surfaces and play an important role in determining the conformation and specificity of enzyme active sites and antibody-combining sites. Turns are an attractive starting point to develop protein design methods, as t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/339073a0
更新日期:1989-05-04 00:00:00
abstract::Geochemical and sedimentological evidence suggest that the rapid climate warming oscillations of the last ice age, the Dansgaard-Oeschger cycles, were coupled to fluctuations in North Atlantic meridional overturning circulation through its regulation of poleward heat flux. The balance between cold meltwater from the n...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05121
更新日期:2006-10-05 00:00:00
abstract::The evolutionary biologist "studies the steps by which the miraculous adaptations so characteristic of every aspect of the organic world have evolved". But the general nature of such adaptive steps is still unclear. Evolution is often thought to be random and dependent on unpredictable events. In this light, one might...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35095046
更新日期:2001-09-20 00:00:00
abstract::Repetitive activation of excitatory synapses in the central nervous system results in a long-lasting increase in synaptic transmission called long-term potentiation (LTP). It is generally believed that this synaptic plasticity may underlie certain forms of learning and memory. LTP at most synapses involves the activat...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/41574
更新日期:1997-08-07 00:00:00
abstract::Deviations from the universal genetic code have been reported for several microorganisms. Termination codons are used for coding some amino acids in Paramecium, Mycoplasma or Tetrahymena, and in Escherichia coli, the UGA termination codon is used to code for selenocysteine. In mitochondria, the changes of sense codons...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/341164a0
更新日期:1989-09-14 00:00:00
abstract::AFTER exposure to secretagogues the small intestine changes from a tissue that absorbs fluid and electrolyte from lumen to blood into a tissue that secretes electrolyte and fluid into the lumen(1-4). It has been shown that this secretion results from an increase in the passive Cl(-) permeability of the mucosal border,...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/279446a0
更新日期:1979-05-31 00:00:00
abstract::This corrects the article DOI: 10.1038/nature24295. ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
doi:10.1038/nature25017
更新日期:2018-01-25 00:00:00
abstract::A set of restriction fragments cloned into phage lambda vectors has allowed us to locate a site necessary for full rpoBC expression. We find that these genes for the two large subunits of RNA polymerase and the genes, rplL and rplJ, for two ribosomal proteins, form a single operon. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/276033a0
更新日期:1978-11-02 00:00:00
abstract::gamma-Aminobutyric acid (GABA), a major inhibitory neurotransmitter in the mammalian nervous system, is known to operate bicuculline-sensitive Cl- channels through GABAA receptors and bicuculline-insensitive cation channels through GABAB receptors. Recent observations indicate that the retina may contain GABA receptor...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/361159a0
更新日期:1993-01-14 00:00:00
abstract::We have identified a cell type in 7-day-old rat optic nerve that differentiates into a fibrous astrocyte if cultured in the presence of fetal calf serum and into an oligodendrocyte if cultured in the absence of serum. In certain culture conditions some of these cells acquire a mixed phenotype, displaying properties of...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/303390a0
更新日期:1983-06-02 00:00:00
abstract::Leprosy is a spectral disease in which immune responses to Mycobacterium leprae correlate with the clinical, bacteriological and histopathological manifestations of disease, so study of its pathology provides insights into immunoregulatory mechanisms in man. At the tuberculoid pole, patients have few lesions in the sk...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/322459a0
更新日期:1986-07-31 00:00:00
abstract::Clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer, is characterized by elevated glycogen levels and fat deposition. These consistent metabolic alterations are associated with normoxic stabilization of hypoxia-inducible factors (HIFs) secondary to von Hippel-Lindau (VHL) mutations that occu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13557
更新日期:2014-09-11 00:00:00
abstract::Co-development of the cardiovascular and pulmonary systems is a recent evolutionary adaption to terrestrial life that couples cardiac output with the gas exchange function of the lung. Here we show that the murine pulmonary vasculature develops even in the absence of lung development. We have identified a population o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12358
更新日期:2013-08-29 00:00:00
abstract::Sex roles are typically thought of as being fixed for a given species. In most animals males compete for females, whereas the females are more reluctant to mate. Therefore sexual selection usually acts most strongly on males. This is explained by males having a higher potential reproductive rate than females, leading ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02562
更新日期:2004-06-03 00:00:00
abstract::One simple, widely accepted mechanism for generating an aberrant chromosome number, or aneuploidy, is through nondisjunction--a chromosome distribution error that occurs during mitosis when both copies of a duplicated chromosome are deposited into one daughter cell and none into the other. Shi and King challenge this ...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/nature05139
更新日期:2006-08-17 00:00:00
abstract::The polypeptide chains that make up proteins have thousands of atoms and hence millions of possible inter-atomic interactions. It might be supposed that the resulting complexity would make prediction of protein structure and protein-folding mechanisms nearly impossible. But the fundamental physics underlying folding m...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35011000
更新日期:2000-05-04 00:00:00
abstract::Osteoarthritis-the most common form of age-related degenerative whole-joint disease1-is primarily characterized by cartilage destruction, as well as by synovial inflammation, osteophyte formation and subchondral bone remodelling2,3. However, the molecular mechanisms that underlie the pathogenesis of osteoarthritis are...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-0920-1
更新日期:2019-02-01 00:00:00