Multiple spike-initiation zones in single neurons revealed by voltage-sensitive dyes.

Abstract:

:The primary function of the nerve cell is to process electrical signals. Over the past fifteen years there has been renewed interest in the detailed spatial analysis of signalling in individual neurons owing to experimental evidence that the regional electrical properties of neurons are complex. Thus the behaviour of many nerve cells cannot be understood on the basis of microelectrode measurements from the soma. Regional electrical properties of neurons have been studied using sharp microelectrode and patch-electrode recordings from neuronal processes, high-resolution multisite optical recordings of Ca2+ concentration changes and by using models to predict the distribution of membrane potential in the entire neuronal arborization. Additional direct evidence about electrical signalling in neuronal processes in situ can now be obtained by recording membrane potential changes using voltage-sensitive dyes. Here I demonstrate the existence of multiple action potential trigger zones in separate regions of the neuronal arborization of an identified molluscan neuron.

journal_name

Nature

journal_title

Nature

authors

Zecević D

doi

10.1038/381322a0

subject

Has Abstract

pub_date

1996-05-23 00:00:00

pages

322-5

issue

6580

eissn

0028-0836

issn

1476-4687

journal_volume

381

pub_type

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