Abstract：
:During development, neuronal survival is regulated by the limited availability of neurotrophins, which are proteins of the nerve growth factor (NGF) family. Activation of specific trk tyrosine kinase receptors by the neurotrophins blocks programmed cell death. The trkA-specific ligand NGF has also been shown to activate the non-tyrosine kinase receptor p75, a member of the tumour necrosis factor (TNF) receptor and Fas (APO-1/CD95) family. Here we report that, early in development, endogenous NGF causes the death of retinal neurons that express p75 but not trkA. These results indicate that, as with cells of the immune system, the death of neurons in the central nervous system can also be induced by ligands, and that the effect of NGF on cell fate depends on the type of receptor expressed by developing neurons.
journal_name
Naturejournal_title
Natureauthors
Frade JM,Rodríguez-Tébar A,Barde YAdoi
10.1038/383166a0subject
Has Abstractpub_date
1996-09-12 00:00:00pages
166-8issue
6596eissn
0028-0836issn
1476-4687journal_volume
383pub_type
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