Abstract：
:Hox genes are essential for growth and patterning of the tetrapod limb skeleton. Mice mutant for the Hoxd-13 gene have an important delay in morphogenesis owing to reduced proliferation. Based on the appearance of atavisms in such mice, we suggested that modifications of Hox gene regulation may have been a source of morphological variation during the evolution of tetrapod limbs. Pectoral and pelvic fins are homologous to fore- and hindlimbs, respectively. To compare the relative importance of Hox genes during fin versus limb morphogenesis, we cloned zebrafish (Danio rerio) HoxD and HoxA complex genes and analysed their expression during fin development. The results suggest a scheme for the fin-limb transition in which the distal autopods (digits) are neomorphic structures produced by unequal proliferation of the posterior part of an ancestral appendix.
journal_name
Naturejournal_title
Natureauthors
Sordino P,van der Hoeven F,Duboule Ddoi
10.1038/375678a0subject
Has Abstractpub_date
1995-06-22 00:00:00pages
678-81issue
6533eissn
0028-0836issn
1476-4687journal_volume
375pub_type
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