Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.

abstract：:The largest products of magmatic activity on Earth, the great bodies of granite and their corresponding large eruptions, have a dual nature: homogeneity at the large scale and spatial and temporal heterogeneity at the small scale. This duality calls for a mechanism that selectively removes the large-scale heterogeneit...

journal_title：Nature

authors： Burgisser A,Bergantz GW

更新日期：2011-03-10 00:00:00

abstract：:Learning through trial-and-error interactions allows animals to adapt innate behavioural ‘rules of thumb’ to the local environment, improving their prospects for survival and reproduction. Naive Drosophila melanogaster males, for example, court both virgin and mated females, but learn through experience to selectively...

journal_title：Nature

authors： Keleman K,Vrontou E,Krüttner S,Yu JY,Kurtovic-Kozaric A,Dickson BJ

更新日期：2012-09-06 00:00:00

abstract：:Alternative splicing of eukaryotic messenger RNA precursors is now known to be of widespread importance in generating multiple transcripts from a single gene. This phenomenon has emphasized the problem of the way in which splice sites are selected; recent studies have discussed the role of secondary structure or affin...

journal_title：Nature

authors： Eperon LP,Estibeiro JP,Eperon IC

更新日期：1986-11-20 00:00:00

abstract：:Ten eleven translocation (TET) enzymes, including TET1, TET2 and TET3, convert 5-methylcytosine to 5-hydroxymethylcytosine and regulate gene transcription. However, the molecular mechanism by which TET family enzymes regulate gene transcription remains elusive. Using protein affinity purification, here we search for f...

journal_title：Nature

authors： Chen Q,Chen Y,Bian C,Fujiki R,Yu X

更新日期：2013-01-24 00:00:00

abstract：:The products of the classical human major histocompatibility complex (MHC) class I genes (HLA-A, -B, -C) are highly polymorphic molecules that bind peptides and present them to T lymphocytes. The non-polymorphic, non-classical MHC class I gene products (HLA-E, -F, -G) are not restricting elements for the majority of T...

journal_title：Nature

authors： Watkins DI,Chen ZW,Hughes AL,Evans MG,Tedder TF,Letvin NL

更新日期：1990-07-05 00:00:00

abstract：:The clinical benefit for patients with diverse types of metastatic cancers that has been observed upon blockade of the interaction between PD-1 and PD-L1 has highlighted the importance of this inhibitory axis in the suppression of tumour-specific T-cell responses. Notwithstanding the key role of PD-L1 expression by ce...

journal_title：Nature

authors： Mezzadra R,Sun C,Jae LT,Gomez-Eerland R,de Vries E,Wu W,Logtenberg MEW,Slagter M,Rozeman EA,Hofland I,Broeks A,Horlings HM,Wessels LFA,Blank CU,Xiao Y,Heck AJR,Borst J,Brummelkamp TR,Schumacher TNM

更新日期：2017-09-07 00:00:00

abstract：:Amyloid beta-protein (AP) is a peptide of relative molecular mass (Mr) 42,000 found in the senile plaques, cerebrovascular amyloid deposits, and neurofibrillary tangles of patients with Alzheimer's disease and Down's syndrome (trisomy 21). Recent molecular genetic evidence has indicated that AP is encoded as part of a...

journal_title：Nature

authors： Tanzi RE,St George-Hyslop PH,Haines JL,Polinsky RJ,Nee L,Foncin JF,Neve RL,McClatchey AI,Conneally PM,Gusella JF

更新日期：1987-09-10 00:00:00

abstract：:The actions of many peptide growth factors include both stimulation and inhibition of cell proliferation, as well as effects unrelated to the control of cell growth. One peptide can have both stimulatory and inhibitory activity in a single cell, depending on the context of the other signal molecules present. ...

journal_title：Nature

authors： Sporn MB,Roberts AB

更新日期：1988-03-17 00:00:00

abstract：:The importance of the dopaminergic system in brain function has been emphasized by its association with neurological and psychiatric disorders such as Parkinson's disease and schizophrenia. On the basis of their biochemical and pharmacological characteristics, dopamine receptors are classified into D1 and D2 subtypes....

journal_title：Nature

authors： Zhou QY,Grandy DK,Thambi L,Kushner JA,Van Tol HH,Cone R,Pribnow D,Salon J,Bunzow JR,Civelli O

更新日期：1990-09-06 00:00:00

abstract：:Age-related macular degeneration (AMD), a leading cause of blindness worldwide, is as prevalent as cancer in industrialized nations. Most blindness in AMD results from invasion of the retina by choroidal neovascularisation (CNV). Here we show that the eosinophil/mast cell chemokine receptor CCR3 is specifically expres...

journal_title：Nature

authors： Takeda A,Baffi JZ,Kleinman ME,Cho WG,Nozaki M,Yamada K,Kaneko H,Albuquerque RJ,Dridi S,Saito K,Raisler BJ,Budd SJ,Geisen P,Munitz A,Ambati BK,Green MG,Ishibashi T,Wright JD,Humbles AA,Gerard CJ,Ogura Y,Pan Y,S

更新日期：2009-07-09 00:00:00

abstract：:The high-resolution seismic imaging of subducted oceanic slabs has become a powerful tool for reconstructing palaeogeography. The images can now be interpreted quantitatively by comparison with models of the general circulation of the Earth's mantle. Here we use a three-dimensional spherical computer model of mantle c...

journal_title：Nature

authors： Bunge HP,Grand SP

更新日期：2000-05-18 00:00:00

abstract：:Homogeneous nucleation and subsequent cluster growth leads to the formation of new aerosol particles in the atmosphere. The nucleation of sulfuric acid and organic vapours is thought to be responsible for the formation of new particles over continents, whereas iodine oxide vapours have been implicated in particle form...

journal_title：Nature

authors： Sipilä M,Sarnela N,Jokinen T,Henschel H,Junninen H,Kontkanen J,Richters S,Kangasluoma J,Franchin A,Peräkylä O,Rissanen MP,Ehn M,Vehkamäki H,Kurten T,Berndt T,Petäjä T,Worsnop D,Ceburnis D,Kerminen VM,Kulmala M,O'D

更新日期：2016-09-22 00:00:00

abstract：:Disruption of the normal regulation of cell-cycle progression and division lies at the heart of the events leading to cancer. Complex networks of regulatory factors, the tumour microenvironment and stress signals, such as those resulting from damaged DNA, dictate whether cancer cells proliferate or die. Recent progres...

journal_title：Nature

authors： Sawyers C

更新日期：2004-11-18 00:00:00

abstract：:Ecdysone in Drosophila has been a paradigm for steroid hormones since its ability to induce gene activity directly was demonstrated by its effects on moulting and polytene chromosome puffing. The ecdysone receptor (EcR) was recently confirmed as a member of the nuclear receptor superfamily by cloning and characterizat...

journal_title：Nature

authors： Thomas HE,Stunnenberg HG,Stewart AF

更新日期：1993-04-01 00:00:00

abstract：:The Hawaiian-Emperor volcanic island and seamount chain is usually attributed to a hot mantle plume, located beneath the Pacific lithosphere, that delivers material sourced from deep in the mantle to the surface. The shield volcanoes of the Hawaiian islands are distributed in two curvilinear, parallel trends (termed '...

journal_title：Nature

authors： Ren ZY,Ingle S,Takahashi E,Hirano N,Hirata T

更新日期：2005-08-11 00:00:00

abstract：:A non-discriminatory base analogue, or universal base, would be an invaluable component of oligonucleotide probes and primers for solving the design problems that arise as a result of the degeneracy of the genetic code, or when only fragmentary peptide sequence data are available. We have designed an alternative to pr...

journal_title：Nature

authors： Nichols R,Andrews PC,Zhang P,Bergstrom DE

更新日期：1994-06-09 00:00:00

abstract：:Sensory transduction in taste and olfaction, the principal chemical senses, seems to be mediated by membrane-associated proteins on the apical surfaces of the respective receptor cells. The recent isolation and characterization of soluble 'odorant-binding proteins' secreted from the nasal glands of rat, cow and frog, ...

journal_title：Nature

authors： Schmale H,Holtgreve-Grez H,Christiansen H

更新日期：1990-01-25 00:00:00

abstract：:The bacterial CRISPR/Cas9 system allows sequence-specific gene editing in many organisms and holds promise as a tool to generate models of human diseases, for example, in human pluripotent stem cells. CRISPR/Cas9 introduces targeted double-stranded breaks (DSBs) with high efficiency, which are typically repaired by no...

journal_title：Nature

authors： Paquet D,Kwart D,Chen A,Sproul A,Jacob S,Teo S,Olsen KM,Gregg A,Noggle S,Tessier-Lavigne M

更新日期：2016-05-05 00:00:00

abstract：:The visual system analyses information by decomposing complex objects into simple components (visual features) that are widely distributed across the cortex. When several objects are present simultaneously in the visual field, a mechanism is required to group (bind) together visual features that belong to each object ...

journal_title：Nature

authors： Usher M,Donnelly N

更新日期：1998-07-09 00:00:00

abstract：:Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determine both disease suscep...

journal_title：Nature

authors： Todd JA,Bell JI,McDevitt HO

更新日期：1987-10-15 00:00:00

abstract：:Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50-70% of malignant melanomas. Pre-clinical studies have demonstrated that the B-RAF(V600E) mutation predicts a dependency on the mitogen-activated protein kinase (MAPK) signalling cascade in melanoma-an observation that has bee...

journal_title：Nature

authors： Johannessen CM,Boehm JS,Kim SY,Thomas SR,Wardwell L,Johnson LA,Emery CM,Stransky N,Cogdill AP,Barretina J,Caponigro G,Hieronymus H,Murray RR,Salehi-Ashtiani K,Hill DE,Vidal M,Zhao JJ,Yang X,Alkan O,Kim S,Harris JL

更新日期：2010-12-16 00:00:00

abstract：:In 2001 the Intergovernmental Panel on Climate Change projected the contribution to sea level rise from the Greenland ice sheet to be between -0.02 and +0.09 m from 1990 to 2100 (ref. 1). However, recent work has suggested that the ice sheet responds more quickly to climate perturbations than previously thought, parti...

journal_title：Nature

authors： Velicogna I,Wahr J

更新日期：2006-09-21 00:00:00

abstract：:Brood parasitism, where a brood of the parasitic species is fostered by the parents of another species, is well known among birds. In most cases, such offspring show a complete reliance upon their host parents for food, protection and warmth until their independence. In other vertebrate groups, however, such total dep...

journal_title：Nature

authors： Sato T

更新日期：1986-09-04 00:00:00

abstract：:Multiple sulphatase deficiency disease is an unusual autosomal recessive disorder characterised biochemically by a deficiency of several sulphohydrolase activities. The laboratory diagnosis of this combined neurological connective tissue disorder is made on the basis of decreased activities of the lysosomal enzymes, a...

journal_title：Nature

authors： Fiddler MB,Vine D,Shapira E,Nadler HL

更新日期：1979-11-01 00:00:00

abstract：:Spatial patterning is a ubiquitous feature of biological systems. Meiotic crossovers provide an interesting example, defined by the classic phenomenon of crossover interference. Here we identify a molecular pathway for interference by analysing crossover patterns in budding yeast. Topoisomerase II plays a central role...

journal_title：Nature

authors： Zhang L,Wang S,Yin S,Hong S,Kim KP,Kleckner N

更新日期：2014-07-31 00:00:00

abstract：:Fossil dinosaur embryos are surprisingly rare, being almost entirely restricted to Upper Cretaceous strata that record the late stages of non-avian dinosaur evolution. Notable exceptions are the oldest known embryos from the Early Jurassic South African sauropodomorph Massospondylus and Late Jurassic embryos of a ther...

journal_title：Nature

authors： Reisz RR,Huang TD,Roberts EM,Peng S,Sullivan C,Stein K,LeBlanc AR,Shieh D,Chang R,Chiang C,Yang C,Zhong S

更新日期：2013-04-11 00:00:00

abstract：:The toxicity of misfolded proteins and mitochondrial dysfunction are pivotal factors that promote age-associated functional neuronal decline and neurodegenerative disease. Accordingly, neurons invest considerable cellular resources in chaperones, protein degradation, autophagy and mitophagy to maintain proteostasis an...

journal_title：Nature

authors： Melentijevic I,Toth ML,Arnold ML,Guasp RJ,Harinath G,Nguyen KC,Taub D,Parker JA,Neri C,Gabel CV,Hall DH,Driscoll M

更新日期：2017-02-16 00:00:00

abstract：:The biological importance of DNA methylation for gene expression in eukaryotes is becoming increasingly evident, and a direct role of methylation in gene expression has been suggested by an analysis of the infectivity of integrated retroviral genomes in a transfection assay. These studies, however, did not address whe...

journal_title：Nature

authors： Simon D,Stuhlmann H,Jähner D,Wagner H,Werner E,Jaenisch R

更新日期：1983-07-21 00:00:00

abstract：:To artists, the face is a mirror of the soul. To biologists, the face reflects remarkable structural diversity--think of bulldogs and wolfhounds or galapagos finches. How do such variations in skeletal form arise? Do the same mechanisms control skeletogenesis elsewhere in the body? The answers lie in the molecular mac...

journal_title：Nature

authors： Helms JA,Schneider RA

更新日期：2003-05-15 00:00:00

abstract：:The Rab GTPases function as specific regulators of membrane transport. The GTP/GDP cycle is believed to control shuttling of Rab proteins between the cytosol and organelle membranes. In vitro, Rab proteins are removed from membranes by a protein that inhibits GDP dissociation (rabGDI), which leads to formation of a cy...

journal_title：Nature

authors： Ullrich O,Horiuchi H,Bucci C,Zerial M

更新日期：1994-03-10 00:00:00