Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracle.

abstract：:The molecular and cellular basis of T-lymphocyte activation remains a central question in immunology. The growth of already proliferating T cells is known to depend on T-cell growth factor (TCGF), a physiological mitogen. Noncycling T lymphocytes, however, are not sensitive to TCGF. They require a short contact with m...

journal_title：Nature

authors： Larsson EL,Iscove NN,Coutinho A

更新日期：1980-02-14 00:00:00

abstract：:The McDonough strain of the feline sarcoma virus contains a transforming gene (v-fms) which contains partial nucleotide homology with proto-oncogenes encoding tyrosine kinases. One of the v-fms-encoded products, gp140fms, is a cell surface transmembrane glycoprotein that may function as a growth factor receptor. Altho...

journal_title：Nature

authors： Sariban E,Mitchell T,Kufe D

更新日期：1985-07-04 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), a much milder form of the disease where the age of onset can sometimes be as late as the third or fourth decade of life, are caused by mutations in the same X-linked gene, a 14 kilobase (kb) transcript which is spread over more than 2 megabases of ...

journal_title：Nature

authors： England SB,Nicholson LV,Johnson MA,Forrest SM,Love DR,Zubrzycka-Gaarn EE,Bulman DE,Harris JB,Davies KE

更新日期：1990-01-11 00:00:00

abstract：:Embryonal tumours with multilayered rosettes (ETMRs) are aggressive paediatric embryonal brain tumours with a universally poor prognosis1. Here we collected 193 primary ETMRs and 23 matched relapse samples to investigate the genomic landscape of this distinct tumour type. We found that patients with tumours in which t...

journal_title：Nature

authors： Lambo S,Gröbner SN,Rausch T,Waszak SM,Schmidt C,Gorthi A,Romero JC,Mauermann M,Brabetz S,Krausert S,Buchhalter I,Koster J,Zwijnenburg DA,Sill M,Hübner JM,Mack N,Schwalm B,Ryzhova M,Hovestadt V,Papillon-Cavanagh S,

更新日期：2019-12-01 00:00:00

abstract：:A main limitation of therapies that selectively target kinase signalling pathways is the emergence of secondary drug resistance. Cetuximab, a monoclonal antibody that binds the extracellular domain of epidermal growth factor receptor (EGFR), is effective in a subset of KRAS wild-type metastatic colorectal cancers. Aft...

journal_title：Nature

authors： Misale S,Yaeger R,Hobor S,Scala E,Janakiraman M,Liska D,Valtorta E,Schiavo R,Buscarino M,Siravegna G,Bencardino K,Cercek A,Chen CT,Veronese S,Zanon C,Sartore-Bianchi A,Gambacorta M,Gallicchio M,Vakiani E,Boscaro V,

更新日期：2012-06-28 00:00:00

abstract：:In obesity and type 2 diabetes, expression of the GLUT4 glucose transporter is decreased selectively in adipocytes. Adipose-specific Glut4 (also known as Slc2a4) knockout (adipose-Glut4(-/-)) mice show insulin resistance secondarily in muscle and liver. Here we show, using DNA arrays, that expression of retinol bindin...

journal_title：Nature

authors： Yang Q,Graham TE,Mody N,Preitner F,Peroni OD,Zabolotny JM,Kotani K,Quadro L,Kahn BB

更新日期：2005-07-21 00:00:00

abstract：:The 30S ribosomal subunit binds messenger RNA and the anticodon stem-loop of transfer RNA during protein synthesis. A crystallographic analysis of the structure of the subunit from the bacterium Thermus thermophilus is presented. At a resolution of 5.5 A, the phosphate backbone of the ribosomal RNA is visible, as are ...

journal_title：Nature

authors： Clemons WM Jr,May JL,Wimberly BT,McCutcheon JP,Capel MS,Ramakrishnan V

更新日期：1999-08-26 00:00:00

abstract：:Haemophilia B, or Christmas disease, is an inherited X-chromosome-linked bleeding disorder caused by a defect in clotting factor IX and occurs in about 1 in 30,000 males in the United Kingdom. Injection of factor IX concentrate obtained from blood donors allows most patients to be successfully managed. However, becaus...

journal_title：Nature

authors： Anson DS,Austen DE,Brownlee GG

更新日期：1985-06-20 00:00:00

abstract：:Protein engineering is being developed for mapping the energetics and pathway of protein folding. From kinetic studies on wild-type and mutant proteins, the sequence and energetics of formation of tertiary interactions of side chains can be mapped and the formation of secondary structure inferred. Here we cross-check ...

journal_title：Nature

authors： Bycroft M,Matouschek A,Kellis JT Jr,Serrano L,Fersht AR

更新日期：1990-08-02 00:00:00

abstract：:Quantum computers are expected to outperform conventional computers in several important applications, from molecular simulation to search algorithms, once they can be scaled up to large numbers-typically millions-of quantum bits (qubits)1-3. For most solid-state qubit technologies-for example, those using superconduc...

journal_title：Nature

authors： Yang CH,Leon RCC,Hwang JCC,Saraiva A,Tanttu T,Huang W,Camirand Lemyre J,Chan KW,Tan KY,Hudson FE,Itoh KM,Morello A,Pioro-Ladrière M,Laucht A,Dzurak AS

更新日期：2020-04-01 00:00:00

abstract：:The T-cell receptor (TCR) repertoire is selected in the thymus after rearrangement of genes encoding TCR alpha and beta chains. Selection is based on the recognition by newly emergent T cells of self-ligands associated with molecules of the major histocompatibility complex: some combinations result in positive selecti...

journal_title：Nature

authors： Dyson PJ,Knight AM,Fairchild S,Simpson E,Tomonari K

更新日期：1991-02-07 00:00:00

abstract：:Self-incompatibility in flowering plants is often controlled by a single nuclear gene (the S-gene) having several alleles. This gene prevents fertilization by self-pollen or by pollen bearing either of the two S-alleles expressed in the style. Sequence analysis shows that three alleles of the S gene of Nicotiana alata...

journal_title：Nature

authors： McClure BA,Haring V,Ebert PR,Anderson MA,Simpson RJ,Sakiyama F,Clarke AE

更新日期：1989-12-21 00:00:00

abstract：:Certain mast cell products, including the tetrapeptides Ala-Gly-Ser-Glu (Ala4) and Val-Gly-Ser-Glu (Val4) of the eosinophil chemotactic factor of anaphylaxis (ECF-A) and histamine, are preferentially chemotactic for eosinophils in vitro. Amino acid substitutions or modifications of the ECF-A tetrapeptides may substant...

journal_title：Nature

authors： Capron M,Capron A,Goetzl EJ,Austen KF

更新日期：1981-01-01 00:00:00

abstract：:Theory predicts that sexual behaviour in animals can evolve rapidly, accelerating the rate of species formation. Here we estimate the rate of speciation in Laupala, a group of forest-dwelling Hawaiian crickets that is characterized primarily through differences in male courtship song. We find that Laupala has the high...

journal_title：Nature

authors： Mendelson TC,Shaw KL

更新日期：2005-01-27 00:00:00

abstract：:The evolutionary history of extant hominoids (humans and apes) remains poorly understood. The African fossil record during the crucial time period, the Miocene epoch, largely comprises isolated jaws and teeth, and little is known about ape cranial evolution. Here we report on the, to our knowledge, most complete fossi...

journal_title：Nature

authors： Nengo I,Tafforeau P,Gilbert CC,Fleagle JG,Miller ER,Feibel C,Fox DL,Feinberg J,Pugh KD,Berruyer C,Mana S,Engle Z,Spoor F

更新日期：2017-08-09 00:00:00

abstract：:One approach to the controlled release of drugs involves incorporation of the drug molecules into the matrix of microscopic polymer spheres or capsules. Existing methods for preparing such microparticles do not, however, always guarantee a constant release rate, for example because drug molecules may be trapped prefer...

journal_title：Nature

authors： Pekarek KJ,Jacob JS,Mathiowitz E

更新日期：1994-01-20 00:00:00

abstract：:The mitotic recombination behaviour of a duplication of the his4 region on chromosome III in the yeast Saccharomyces cerevisiae was studied. The major recombination event between the duplicated segments is gene conversion unassociated with reciprocal recombination. The rad52-1 mutation preferentially decreases mitotic...

journal_title：Nature

authors： Jackson JA,Fink GR

更新日期：1981-07-23 00:00:00

abstract：:In a very short time the scanning tunnelling microscope has become an important tool in surface science, and physics in general. Its primary use has been to obtain atomic-resolution images of surfaces, but recently, efforts have been made to use it to manipulate materials as well as image them. One may now reasonably ...

journal_title：Nature

authors： Foster JS,Frommer JE,Arnett PC

更新日期：1988-01-28 00:00:00

abstract：:'Identifier' or ID sequences are present in 62% of the RNA polymerase II and III transcripts made in vitro from brain nuclei but in fewer than 4% of the transcripts made from the nuclei of other tissues. An homologous 160-nucleotide cytoplasmic poly(A)+ RNA species, BC1, and a smaller species, BC2, are located in vivo...

journal_title：Nature

authors： Sutcliffe JG,Milner RJ,Gottesfeld JM,Lerner RA

更新日期：1984-03-15 00:00:00

abstract：:Rates of atmospheric deposition of biologically active nitrogen (N) are two to seven times the pre-industrial rates in many developed nations because of combustion of fossil fuels and agricultural fertilization. They are expected to increase similarly over the next 50 years in industrializing nations of Asia and South...

journal_title：Nature

authors： Clark CM,Tilman D

更新日期：2008-02-07 00:00:00

abstract：:The 5'-->3' exoribonucleases (XRNs) comprise a large family of conserved enzymes in eukaryotes with crucial functions in RNA metabolism and RNA interference. XRN2, or Rat1 in yeast, functions primarily in the nucleus and also has an important role in transcription termination by RNA polymerase II (refs 7-14). Rat1 exo...

journal_title：Nature

authors： Xiang S,Cooper-Morgan A,Jiao X,Kiledjian M,Manley JL,Tong L

更新日期：2009-04-09 00:00:00

abstract：:Ants travelling to and fro between their nest and a foraging area may follow stereotyped foodward and homeward routes that are guided by different visual and directional memory sequences. Honeybees are known to fly a feeder-to-hive or hive-to-feeder vector according to whether or not they have recently fed--their feed...

journal_title：Nature

authors： Harris RA,Hempel de Ibarra N,Graham P,Collett TS

更新日期：2005-11-17 00:00:00

abstract：:Considerable evidence points to a role for G1 cyclin-dependent kinase (CDK) in allowing the accumulation of E2F transcription factor activity and induction of the S phase of the cell cycle. Numerous experiments have also demonstrated a critical role for both Myc and Ras activities in allowing cell-cycle progression. H...

journal_title：Nature

authors： Leone G,DeGregori J,Sears R,Jakoi L,Nevins JR

更新日期：1997-05-22 00:00:00

abstract：:The loose material--regolith--on the surfaces of asteroids is thought to represent ballistically emplaced ejecta from impacts but the identification of source craters and the detailed study of the regolith modification have been hampered by the limited spatial resolution and area coverage of the few asteroids imaged b...

journal_title：Nature

authors： Thomas PC,Veverka J,Robinson MS,Murchie S

更新日期：2001-09-27 00:00:00

abstract：:Recent studies have demonstrated that monkeys and humans can use signals from the brain to guide computer cursors. Brain-computer interfaces (BCIs) may one day assist patients suffering from neurological injury or disease, but relatively low system performance remains a major obstacle. In fact, the speed and accuracy ...

journal_title：Nature

authors： Santhanam G,Ryu SI,Yu BM,Afshar A,Shenoy KV

更新日期：2006-07-13 00:00:00

abstract：:Hepatocellularcarcinoma (HCC) that occur in woodchucks chronically infected with woodchuck hepatitis virus (WHV) were screened for activation of cellular oncogenes. Enhanced expression and allelic alterations of the c-myc oncogene were found in three HCC out of nine. Variations in the size of the c-myc transcripts, ra...

journal_title：Nature

authors： Möröy T,Marchio A,Etiemble J,Trépo C,Tiollais P,Buendia MA

更新日期：1986-11-20 00:00:00

abstract：:Water masers are found in dense molecular clouds closely associated with supermassive black holes at the centres of active galaxies. On the basis of the understanding of the local water-maser luminosity function, it was expected that masers at intermediate and high redshifts would be extremely rare. However, galaxies ...

journal_title：Nature

authors： Impellizzeri CM,McKean JP,Castangia P,Roy AL,Henkel C,Brunthaler A,Wucknitz O

更新日期：2008-12-18 00:00:00

abstract：:Networks have become a key approach to understanding systems of interacting objects, unifying the study of diverse phenomena including biological organisms and human society. One crucial step when studying the structure and dynamics of networks is to identify communities: groups of related nodes that correspond to fun...

journal_title：Nature

authors： Ahn YY,Bagrow JP,Lehmann S

更新日期：2010-08-05 00:00:00

abstract：:p97 is a 97,000 molecular weight cell-surface glycoprotein, which is present in human melanomas but in only trace amounts in normal adult tissues. Amino acid sequence and iron binding studies have shown that p97 is structurally and functionally related to transferrin. Reports that the genes for the transferrin recepto...

journal_title：Nature

authors： Plowman GD,Brown JP,Enns CA,Schröder J,Nikinmaa B,Sussman HH,Hellström KE,Hellström I

更新日期：1983-05-05 00:00:00

abstract：:The collagens represent an interesting example of a structurally related but genetically distinct family of proteins. Type I, the most abundant of the vertebrate collagens, comprises two pro alpha 1(I) chains and one pro alpha 2(I) chain, each containing terminal propeptides and a central domain of 338 (Gly, X, Y) rep...

journal_title：Nature

authors： Chu ML,de Wet W,Bernard M,Ding JF,Morabito M,Myers J,Williams C,Ramirez F

更新日期：1984-07-26 00:00:00