Abstract:
:Certain mast cell products, including the tetrapeptides Ala-Gly-Ser-Glu (Ala4) and Val-Gly-Ser-Glu (Val4) of the eosinophil chemotactic factor of anaphylaxis (ECF-A) and histamine, are preferentially chemotactic for eosinophils in vitro. Amino acid substitutions or modifications of the ECF-A tetrapeptides may substantially alter the chemotactic activity of human eosinophils. The cellular mechanism whereby ECF-A tetrapeptides enhance IgG-dependent killing of schistosomula by rat eosinophils is, however, unclear. We now report that the parent tetrapeptides and the substituted analogue Val-Pro-Ser-Glu (Pro3), but not histamine, increase the number of rat and human eosinophils that form rosettes with erythrocytes bearing IgG antibodies. Moreover, we find a correlation between the effect of these substances on the expression of rat eosinophil IgG Fc receptors and their capacity to increase the IgG-dependent cytotoxicity of rat eosinophils for Schistosoma mansoni schistosomula.
journal_name
Naturejournal_title
Natureauthors
Capron M,Capron A,Goetzl EJ,Austen KFdoi
10.1038/289071a0subject
Has Abstractpub_date
1981-01-01 00:00:00pages
71-3issue
5793eissn
0028-0836issn
1476-4687journal_volume
289pub_type
杂志文章相关文献
NATURE文献大全abstract::Autism spectrum disorder (ASD) is an early-onset developmental disorder characterized by deficits in communication and social interaction and restrictive or repetitive behaviours1,2. Family studies demonstrate that ASD has a substantial genetic basis with contributions both from inherited and de novo variants3,4. It h...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-03078-7
更新日期:2021-01-01 00:00:00
abstract::Sex differences in behaviour extend to cognitive-like processes such as learning, but the underlying dimorphisms in neural circuit development and organization that generate these behavioural differences are largely unknown. Here we define at the single-cell level-from development, through neural circuit connectivity,...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature15700
更新日期:2015-10-15 00:00:00
abstract::The limited ranges of the wild progenitors of many of the primary European domestic species point to their origins further east in Anatolia or the fertile crescent. The wild ox (Bos primigenius), however, ranged widely and it is unknown whether it was domesticated within Europe as one feature of a local contribution t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35074088
更新日期:2001-04-26 00:00:00
abstract::How to image objects that are hidden from a camera's view is a problem of fundamental importance to many fields of research, with applications in robotic vision, defence, remote sensing, medical imaging and autonomous vehicles. Non-line-of-sight (NLOS) imaging at macroscopic scales has been demonstrated by scanning a ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature25489
更新日期:2018-03-15 00:00:00
abstract::In the nematode Caenorhabditis elegans six hypodermal cells, the vulval precursor cells, are each competent to generate vulval cells. Normally only the three nearest precursor cells to the uterine anchor cell generate the vulva (22 nuclei), while the three others fuse with the non-specialized hypodermal syncytium (hyp...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/348169a0
更新日期:1990-11-08 00:00:00
abstract::Critical issues in the cognitive neuroscience of language are whether there are multiple systems for the representation of meaning, perhaps organized by processing system (such as vision or language), and whether further subsystems are distinguishable within these larger ones. We describe here a patient (K.R.) with ce...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/359060a0
更新日期:1992-09-03 00:00:00
abstract::Transcriptional activator proteins (activators) function, at least in part, by increasing preinitiation complex assembly (for reviews see refs 1-4). Previous studies have shown that an acidic activator forms a contact with the general transcription factor TFIIB (refs 5-7) and recruits it into the preinitiation complex...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/371717a0
更新日期:1994-10-20 00:00:00
abstract::The dopa analogue 6-fluorodopa (6-FD) used with positron emission tomography (PET) allows in vivo visualization of dopamine and its metabolites in nigrostriatal nerve endings. We have now found abnormal 6-FD scans in four subjects exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). None had parkinsonism. T...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/317246a0
更新日期:1985-09-19 00:00:00
abstract::The dispute among federal agencies over regulation of commercial biotechnology has been addressed in the Federal Register by the Office of Science and Technology Policy (OSTP), which says the Recombinant DNA Advisory Committee of the National Institutes of Health should continue to oversee biomedical research in this ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/313085b0
更新日期:1985-01-10 00:00:00
abstract::Human epithelia are permanently challenged by bacteria and fungi, including commensal and pathogenic microbiota. In the gut, the fraction of strict anaerobes increases from proximal to distal, reaching 99% of bacterial species in the colon. At colonic mucosa, oxygen partial pressure is below 25% of airborne oxygen con...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09674
更新日期:2011-01-20 00:00:00
abstract::Highly efficient neutron detectors are critical in many sectors, including national security1,2, medicine3, crystallography4 and astronomy5. The main neutron detection technologies currently used involve 3He-gas-filled proportional counters6 and light scintillators7 for thermalized neutrons. Semiconductors could provi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1886-8
更新日期:2020-01-01 00:00:00
abstract::Cancer cells hijack and remodel existing metabolic pathways for their benefit. Argininosuccinate synthase (ASS1) is a urea cycle enzyme that is essential in the conversion of nitrogen from ammonia and aspartate to urea. A decrease in nitrogen flux through ASS1 in the liver causes the urea cycle disorder citrullinaemia...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature15529
更新日期:2015-11-19 00:00:00
abstract::Whereas short-term memory lasts from minutes to hours, long-term memory (LTM) can last for days or even an entire lifetime. LTM generally forms after spaced repeated training sessions and involves the regulation of gene expression, thereby implicating transcription factors in the initial steps of LTM establishment. Ho...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02726
更新日期:2004-07-22 00:00:00
abstract::Protonic ceramic fuel cells, like their higher-temperature solid-oxide fuel cell counterparts, can directly use both hydrogen and hydrocarbon fuels to produce electricity at potentially more than 50 per cent efficiency1,2. Most previous direct-hydrocarbon fuel cell research has focused on solid-oxide fuel cells based ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0082-6
更新日期:2018-05-01 00:00:00
abstract::Locomotion relies on neural networks called central pattern generators (CPGs) that generate periodic motor commands for rhythmic movements. In vertebrates, the excitatory synaptic drive for inducing the spinal CPG can originate from either supraspinal glutamatergic inputs or from within the spinal cord. Here we identi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08323
更新日期:2009-09-17 00:00:00
abstract::Somatic sexual differentiation in Drosophila melanogaster is accomplished by a hierarchy of genes of which one, Sex-lethal (Sxl), is required for the functional female-specific splicing of the transcripts of the immediately downstream regulatory gene, transformer (tra). The first exon of the tra primary transcript is ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/344461a0
更新日期:1990-03-29 00:00:00
abstract::Peptidoglycan (PG), an essential structure in the cell walls of the vast majority of bacteria, is critical for division and maintaining cell shape and hydrostatic pressure. Bacteria comprising the Chlamydiales were thought to be one of the few exceptions. Chlamydia harbour genes for PG biosynthesis and exhibit suscept...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12892
更新日期:2014-02-27 00:00:00
abstract::Complement-mediated inflammation exacerbates the tissue injury of ischaemic necrosis in heart attacks and strokes, the most common causes of death in developed countries. Large infarct size increases immediate morbidity and mortality and, in survivors of the acute event, larger non-functional scars adversely affect lo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04672
更新日期:2006-04-27 00:00:00
abstract::Proteins are inherently plastic molecules, whose function often critically depends on excursions between different molecular conformations (conformers). However, a rigorous understanding of the relation between a protein's structure, dynamics and function remains elusive. This is because many of the conformers on its ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10349
更新日期:2011-08-21 00:00:00
abstract::Separation of eukaryotic sister chromatids during the cell cycle is timed by the spindle assembly checkpoint (SAC) and ultimately triggered when separase cleaves cohesion-mediating cohesin1-3. Silencing of the SAC during metaphase activates the ubiquitin ligase APC/C (anaphase-promoting complex, also known as the cycl...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2182-3
更新日期:2020-04-01 00:00:00
abstract::In 1994, two independent groups extracted DNA from several Pleistocene epoch mammoths and noted differences among individual specimens. Subsequently, DNA sequences have been published for a number of extinct species. However, such ancient DNA is often fragmented and damaged, and studies to date have typically focused ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07446
更新日期:2008-11-20 00:00:00
abstract::The proto-oncogene c-myc is the cellular homologue of the transforming sequence carried by the avian myelocytomastosis virus MC29. A growing body of evidence implicates structural and functional alterations in and around proto-oncogenes such as c-myc in tumorogenesis. Here we report that comparison of the structure of...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/333087a0
更新日期:1988-05-05 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 评论,新闻
doi:10.1038/d41586-019-00393-6
更新日期:2019-02-01 00:00:00
abstract::The age of dense interstellar cloud cores, where stars and planets form, is a crucial parameter in star formation and difficult to measure. Some models predict rapid collapse, whereas others predict timescales of more than one million years (ref. 3). One possible approach to determining the age is through chemical cha...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13924
更新日期:2014-12-11 00:00:00
abstract::Growing concern about how loss of biodiversity will affect ecosystems has stimulated numerous studies. Although most studies have assumed that species go extinct randomly, species often go extinct in order of their sensitivity to a stress that intensifies through time (such as climate change). Here we show that the co...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02515
更新日期:2004-05-13 00:00:00
abstract::The heat-shock protein Hsp90 supports diverse but specific signal transducers and lies at the interface of several developmental pathways. We report here that when Drosophila Hsp90 is mutant or pharmacologically impaired, phenotypic variation affecting nearly any adult structure is produced, with specific variants dep...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/24550
更新日期:1998-11-26 00:00:00
abstract::HIV-1 immunotherapy with a combination of first generation monoclonal antibodies was largely ineffective in pre-clinical and clinical settings and was therefore abandoned. However, recently developed single-cell-based antibody cloning methods have uncovered a new generation of far more potent broadly neutralizing anti...
journal_title:Nature
pub_type: 杂志文章,多中心研究
doi:10.1038/nature14411
更新日期:2015-06-25 00:00:00
abstract::Species that depend on membership in social groups for survival exhibit changes in neuronal gene expression and behaviour when they face restricted social interactions or isolation1-3. Here we show that, across the lifespan of zebrafish (Danio rerio), social isolation specifically decreased the level of transcription ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2988-z
更新日期:2020-12-01 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-07268-2
更新日期:2018-11-01 00:00:00
abstract::Supersolids are exotic materials combining the frictionless flow of a superfluid with the crystal-like periodic density modulation of a solid. The supersolid phase of matter was predicted 50 years ago1-3 for solid helium4-8. Ultracold quantum gases have recently been made to exhibit periodic order typical of a crystal...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1568-6
更新日期:2019-10-01 00:00:00