Abstract：
:Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determine both disease susceptibility and resistance, and that the structure of the DQ molecule, in particular residue 57 of the beta-chain, specifies the autoimmune response against the insulin-producing islet cells.
journal_name
Naturejournal_title
Natureauthors
Todd JA,Bell JI,McDevitt HOdoi
10.1038/329599a0subject
Has Abstractpub_date
1987-10-15 00:00:00pages
599-604issue
6140eissn
0028-0836issn
1476-4687journal_volume
329pub_type
杂志文章相关文献
NATURE文献大全abstract：:Calnexin, an endoplasmic reticulum transmembrane protein, represents a new type of molecular chaperone that selectively associates in a transient fashion with newly synthesized monomeric glycoproteins in HepG2 cells. Calnexin only recognizes glycoproteins when they are incompletely folded. Dissociation of glycoprotein...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/364771a0
更新日期：1993-08-26 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 评论,新闻
doi：10.1038/d41586-018-07008-6
更新日期：2018-11-01 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 新闻
doi：10.1038/d41586-018-07342-9
更新日期：2018-11-01 00:00:00
abstract：:In Dictyostelium discoideum, carbohydrate binding proteins (CBPs) or lectins have been implicated in the molecular basis of cellular cohesion. To determine the role of these CBPs, we have attempted to isolate structural gene mutants in which the CBPs have a defective affinity for carbohydrate ligands. We now report th...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/279215a0
更新日期：1979-05-17 00:00:00
abstract：:The enzyme isopenicillin N synthetase (IPS) catalyses the oxidative condensation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine (LLD-ACV) to isopenicillin N, which is a central reaction in the pathway to clinically important penicillins and cephalosporins. Here we report the cloning, characterization and expressi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/318191a0
更新日期：1985-11-14 00:00:00
abstract：:Four incorrect figure citations in this Letter have been corrected online. ...
journal_title：Nature
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41586-018-0560-x
更新日期：2018-11-01 00:00:00
abstract：:Nanofabrication strategies are becoming increasingly expensive and equipment-intensive, and consequently less accessible to researchers. As an alternative, scanning probe lithography has become a popular means of preparing nanoscale structures, in part owing to its relatively low cost and high resolution, and a regist...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09697
更新日期：2011-01-27 00:00:00
abstract：:A significant portion of prebiotic organic matter on the early Earth may have been introduced by carbonaceous asteroids and comets. The distribution and stable-isotope composition of individual organic compounds in carbonaceous meteorites, which are thought to be derived from asteroidal parent bodies, may therefore pr...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/348047a0
更新日期：1990-11-01 00:00:00
abstract：:In this Article, in Fig. 1a, the 5' and 3' labels were reversed in the DNA sequence, and Fig. 4 was missing panel labels a-e. These errors have been corrected online. ...
journal_title：Nature
pub_type： 已发布勘误
doi：10.1038/s41586-019-1343-8
更新日期：2019-07-01 00:00:00
abstract：:Shiga toxin and some other protein toxins that act on targets in the cytosol have previously been shown to enter the trans-Golgi network. Transport by this route may be necessary for translocation of the toxin to the cytosol and for intoxication, but it is not known whether the enzymatically active part of the toxins ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/358510a0
更新日期：1992-08-06 00:00:00
abstract：:The search to understand the mechanisms regulating brain wiring has relied on biochemical purification approaches in vertebrates and genetic approaches in invertebrates to identify molecular cues and receptors for axon guidance. Here we describe a phenotype-based gene-trap screen in mice designed for the large-scale i...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35065539
更新日期：2001-03-08 00:00:00
abstract：:When mountains form through the collision of lithospheric plates, uplift of the Earth's surface is accompanied by thickening of the crust, and the buoyancy of these deep crustal roots (relative to the surrounding mantle) is thought to contribute to the support of mountain topography. Once active tectonism ceases, cont...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature00855
更新日期：2002-06-27 00:00:00
abstract：:Globular star clusters that formed at the same cosmic time may have evolved rather differently from the dynamical point of view (because that evolution depends on the internal environment) through a variety of processes that tend progressively to segregate stars more massive than the average towards the cluster centre...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature11686
更新日期：2012-12-20 00:00:00
abstract：:Curare has long been regarded as a typical competitive antagonist of acetylcholine (ACh) at the vertebrate neuromuscular junction. Recently, however, it has been shown that curare can also block the channels opened by ACh at the frog neuromuscular junction as well as on rat and Aplysia neurones; moreover, curare is ab...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/298272a0
更新日期：1982-07-15 00:00:00
abstract：:When chemical reactions whose rate increases with the concentration of a product species are carried out in imperfectly mixed systems, a variety of complex behaviours can occur. These phenomena, which have relevance for biological processes as well, include chaotic and stochastic behaviour and selection of one final s...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/374321a0
更新日期：1995-03-23 00:00:00
abstract：:CD4(+) T helper 2 (T(H)2) cells secrete interleukin (IL)4, IL5 and IL13, and are required for immunity to gastrointestinal helminth infections. However, T(H)2 cells also promote chronic inflammation associated with asthma and allergic disorders. The non-haematopoietic-cell-derived cytokines thymic stromal lymphopoieti...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature08901
更新日期：2010-04-29 00:00:00
abstract：:Molecular noise is a natural phenomenon that is inherent to all biological systems1,2. How stochastic processes give rise to the robust outcomes that support tissue homeostasis remains unclear. Here we use single-molecule RNA fluorescent in situ hybridization (smFISH) on mouse stem cells derived from haematopoietic ti...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2432-4
更新日期：2020-07-01 00:00:00
abstract：:Transcription factors recognize specific genomic sequences to regulate complex gene-expression programs. Although it is well-established that transcription factors bind to specific DNA sequences using a combination of base readout and shape recognition, some fundamental aspects of protein-DNA binding remain poorly und...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2843-2
更新日期：2020-11-01 00:00:00
abstract：:Cells deficient in the Brca1 and Brca2 genes have reduced capacity to repair DNA double-strand breaks by homologous recombination and consequently are hypersensitive to DNA-damaging agents, including cisplatin and poly(ADP-ribose) polymerase (PARP) inhibitors. Here we show that loss of the MLL3/4 complex protein, PTIP...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature18325
更新日期：2016-07-21 00:00:00
abstract：:Epothilones A and B, two compounds that have been recently isolated from myxobacterium Sorangium cellulosum strain 90, have generated intense interest among chemists, biologists and clinicians owing to the structural complexity, unusual mechanism of interaction with microtubules and anticancer potential of these molec...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/387268a0
更新日期：1997-05-15 00:00:00
abstract：:In songbirds, the remarkable temporal precision of song is generated by a sparse sequence of bursts in the premotor nucleus HVC. To distinguish between two possible classes of models of neural sequence generation, we carried out intracellular recordings of HVC neurons in singing zebra finches (Taeniopygia guttata). We...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09514
更新日期：2010-11-18 00:00:00
abstract：:Global efforts to mitigate climate change are guided by projections of future temperatures. But the eventual equilibrium global mean temperature associated with a given stabilization level of atmospheric greenhouse gas concentrations remains uncertain, complicating the setting of stabilization targets to avoid potenti...
journal_title：Nature
pub_type： 历史文章,杂志文章
doi：10.1038/nature08019
更新日期：2009-04-30 00:00:00
abstract：:An attempt is made to understand the characteristics of pulsar slowdown in terms of various possible emission mechanisms. Though magnetic-dipole radiation seems to be dominant, the deviations from a pure dipolar decay are large compared with errors in measurement and indicate the presence of more complicated braking m...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/228445a0
更新日期：1970-10-31 00:00:00
abstract：:Systems governed by time reversible equations of motion often give rise to irreversible behaviour. The transition from reversible to irreversible behaviour is fundamental to statistical physics, but has not been observed experimentally in many-body systems. The flow of a newtonian fluid at low Reynolds number can be r...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature04380
更新日期：2005-12-15 00:00:00
abstract：:Susceptibility of rodent cells to infection by ecotropic murine leukaemia viruses (MuLV) is determined by binding of the virus envelope to a membrane receptor that has multiple membrane-spanning domains. Cells infected by ecotropic MuLV synthesize envelope protein, gp70, which binds to this receptor, thereby preventin...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/352725a0
更新日期：1991-08-22 00:00:00
abstract：:How to image objects that are hidden from a camera's view is a problem of fundamental importance to many fields of research, with applications in robotic vision, defence, remote sensing, medical imaging and autonomous vehicles. Non-line-of-sight (NLOS) imaging at macroscopic scales has been demonstrated by scanning a ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature25489
更新日期：2018-03-15 00:00:00
abstract：:The type I interferon (IFN) response protects cells from viral infection by inducing hundreds of interferon-stimulated genes (ISGs), some of which encode direct antiviral effectors. Recent screening studies have begun to catalogue ISGs with antiviral activity against several RNA and DNA viruses. However, antiviral ISG...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature12862
更新日期：2014-01-30 00:00:00
abstract：:Only three elements are ferromagnetic at room temperature: the transition metals iron, cobalt and nickel. The Stoner criterion explains why iron is ferromagnetic but manganese, for example, is not, even though both elements have an unfilled 3d shell and are adjacent in the periodic table: according to this criterion, ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature14621
更新日期：2015-08-06 00:00:00
abstract：:The class II region of the human major histocompatibility complex (MHC) encodes a polymorphic set of cell surface glycoproteins involved in the regulation of the immune response. Each glycoprotein is a heterodimer composed of a alpha-chain of relative molecular mass (Mr) 34,000 (34 K) and a beta-chain of Mr = 28K. The...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/323453a0
更新日期：1986-10-02 00:00:00
abstract：:A list of authors and their affiliations appears at the end of the paper New-particle formation is a major contributor to urban smog1,2, but how it occurs in cities is often puzzling3. If the growth rates of urban particles are similar to those found in cleaner environments (1-10 nanometres per hour), then existing un...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2270-4
更新日期：2020-05-01 00:00:00
