Membrane association of Rab5 mediated by GDP-dissociation inhibitor and accompanied by GDP/GTP exchange.

abstract：:The average air temperature at the Earth's surface has increased by 0.06 degrees C per decade during the 20th century, and by 0.19 degrees C per decade from 1979 to 1998. Climate models generally predict amplified warming in polar regions, as observed in Antarctica's peninsula region over the second half of the 20th c...

journal_title：Nature

authors： Doran PT,Priscu JC,Lyons WB,Walsh JE,Fountain AG,McKnight DM,Moorhead DL,Virginia RA,Wall DH,Clow GD,Fritsen CH,McKay CP,Parsons AN

更新日期：2002-01-31 00:00:00

abstract：:Synaptic plasticity dependent on N-methyl-D-aspartate (NMDA) receptors is thought to underlie certain types of learning and memory. In support of this, both hippocampal long-term potentiation and spatial learning in a watermaze are impaired by blocking NMDA receptors with a selective antagonist D(-)-2-amino-5-phosphon...

journal_title：Nature

authors： Bannerman DM,Good MA,Butcher SP,Ramsay M,Morris RG

更新日期：1995-11-09 00:00:00

abstract：:Eukaryotic transfer RNA genes have two internal discontinuous control regions, the A and B blocks, which correspond approximately to the D-stem and the pseudo-U arm of tRNA. In reconstituted transcription systems at least two components are required to direct accurate initiation by RNA polymerase (refs 4,5). However, ...

journal_title：Nature

authors： Smagowicz W,Ruet A,Camier S,Sentenac A,Fromageot P,Sternbach H

更新日期：1983-08-25 00:00:00

abstract：:One of the outstanding challenges in the field of porous materials is the design and synthesis of chemical structures with exceptionally high surface areas. Such materials are of critical importance to many applications involving catalysis, separation and gas storage. The claim for the highest surface area of a disord...

journal_title：Nature

authors： Chae HK,Siberio-Pérez DY,Kim J,Go Y,Eddaoudi M,Matzger AJ,O'Keeffe M,Yaghi OM

更新日期：2004-02-05 00:00:00

abstract：:Nitrogen enrichment is widely thought to be responsible for the loss of plant species from temperate terrestrial ecosystems. This view is based on field surveys and controlled experiments showing that species richness correlates negatively with high productivity and nitrogen enrichment. However, as the type of nutrien...

journal_title：Nature

authors： Wassen MJ,Venterink HO,Lapshina ED,Tanneberger F

更新日期：2005-09-22 00:00:00

abstract：:The coupling of ATP hydrolysis to electron transfer by the enzyme nitrogenase during biological nitrogen fixation is an important example of a nucleotide-dependent transduction mechanism. The crystal structure has been determined for the complex between the Fe-protein and MoFe-protein components of nitrogenase stabili...

journal_title：Nature

authors： Schindelin H,Kisker C,Schlessman JL,Howard JB,Rees DC

更新日期：1997-05-22 00:00:00

abstract：:Ground- and aircraft-based measurements show that the seasonal amplitude of Northern Hemisphere atmospheric carbon dioxide (CO2) concentrations has increased by as much as 50 per cent over the past 50 years. This increase has been linked to changes in temperate, boreal and arctic ecosystem properties and processes suc...

journal_title：Nature

authors： Gray JM,Frolking S,Kort EA,Ray DK,Kucharik CJ,Ramankutty N,Friedl MA

更新日期：2014-11-20 00:00:00

abstract：:For more than 140 years, pollen tube guidance in flowering plants has been thought to be mediated by chemoattractants derived from target ovules. However, there has been no convincing evidence of any particular molecule being the true attractant that actually controls the navigation of pollen tubes towards ovules. Eme...

journal_title：Nature

authors： Okuda S,Tsutsui H,Shiina K,Sprunck S,Takeuchi H,Yui R,Kasahara RD,Hamamura Y,Mizukami A,Susaki D,Kawano N,Sakakibara T,Namiki S,Itoh K,Otsuka K,Matsuzaki M,Nozaki H,Kuroiwa T,Nakano A,Kanaoka MM,Dresselhaus T,Sa

更新日期：2009-03-19 00:00:00

abstract：:Activation of Janus kinase 2 (JAK2) by chromosomal translocations or point mutations is a frequent event in haematological malignancies. JAK2 is a non-receptor tyrosine kinase that regulates several cellular processes by inducing cytoplasmic signalling cascades. Here we show that human JAK2 is present in the nucleus o...

journal_title：Nature

authors： Dawson MA,Bannister AJ,Göttgens B,Foster SD,Bartke T,Green AR,Kouzarides T

更新日期：2009-10-08 00:00:00

abstract：:The evolutionary theory of ageing explains why ageing occurs, giving valuable insight into the mechanisms underlying the complex cellular and molecular changes that contribute to senescence. Such understanding also helps to clarify how the genome shapes the ageing process, thereby aiding the study of the genetic facto...

journal_title：Nature

authors： Kirkwood TB,Austad SN

更新日期：2000-11-09 00:00:00

abstract：:Since the discovery of the first exoplanets, it has been known that other planetary systems can look quite unlike our own. Until fairly recently, we have been able to probe only the upper range of the planet size distribution, and, since last year, to detect planets that are the size of Earth or somewhat smaller. Hith...

journal_title：Nature

authors： Barclay T,Rowe JF,Lissauer JJ,Huber D,Fressin F,Howell SB,Bryson ST,Chaplin WJ,Désert JM,Lopez ED,Marcy GW,Mullally F,Ragozzine D,Torres G,Adams ER,Agol E,Barrado D,Basu S,Bedding TR,Buchhave LA,Charbonneau D,Ch

更新日期：2013-02-28 00:00:00

abstract：:The Earth has distinctive convective behaviour, described by the plate tectonics model, in which lateral motion of the oceanic lithosphere of basaltic crust and peridotitic uppermost mantle is decoupled from the underlying mechanically weaker upper mantle (asthenosphere). The reason for differentiation at the lithosph...

journal_title：Nature

authors： Green DH,Hibberson WO,Kovács I,Rosenthal A

更新日期：2010-09-23 00:00:00

abstract：:Bivalve molluscs, the primary vectors of paralytic shellfish poisoning (PSP) in humans, show marked inter-species variation in their capacity to accumulate PSP toxins (PSTs) which has a neural basis. PSTs cause human fatalities by blocking sodium conductance in nerve fibres. Here we identify a molecular basis for inte...

journal_title：Nature

authors： Bricelj VM,Connell L,Konoki K,Macquarrie SP,Scheuer T,Catterall WA,Trainer VL

更新日期：2005-04-07 00:00:00

abstract：:Combined PD-1 and CTLA-4-targeted immunotherapy with nivolumab and ipilimumab is effective against melanoma, renal cell carcinoma and non-small-cell lung cancer1-3. However, this comes at the cost of frequent, serious immune-related adverse events, necessitating a reduction in the recommended dose of ipilimumab that i...

journal_title：Nature

authors： Perez-Ruiz E,Minute L,Otano I,Alvarez M,Ochoa MC,Belsue V,de Andrea C,Rodriguez-Ruiz ME,Perez-Gracia JL,Marquez-Rodas I,Llacer C,Alvarez M,de Luque V,Molina C,Teijeira A,Berraondo P,Melero I

更新日期：2019-05-01 00:00:00

abstract：:The extent of allelic variation has been estimated at 46 structural gene loci within three major colonies of Swiss mice and between inbred derivative strains. The colonies have retained nearly the same amount and type of variation found in natural murine or human populations despite laboratory propagation for more tha...

journal_title：Nature

authors： Rice MC,O'Brien SJ

更新日期：1980-01-10 00:00:00

abstract：:Electron transfer reactions are essential for life because they underpin oxidative phosphorylation and photosynthesis, processes leading to the generation of ATP, and are involved in many reactions of intermediary metabolism. Key to these roles is the formation of transient inter-protein electron transfer complexes. T...

journal_title：Nature

authors： Antonyuk SV,Han C,Eady RR,Hasnain SS

更新日期：2013-04-04 00:00:00

abstract：:Patterns in natural systems abound, from the stripes on a zebra to ripples in a riverbed. In many of these systems, the appearance of an ordered state is not unexpected as the outcome of an underlying ordered process. Thus crystal growth, honeycomb manufacture and floret evolution generate regular and predictable patt...

journal_title：Nature

authors： Shinbrot T,Muzzio FJ

更新日期：2001-03-08 00:00:00

abstract：:FokI is a member of an unusual class of bipartite restriction enzymes that recognize a specific DNA sequence and cleave DNA nonspecifically a short distance away from that sequence. Because of its unusual bipartite nature, FokI has been used to create artificial enzymes with new specificities. We have determined the c...

journal_title：Nature

authors： Wah DA,Hirsch JA,Dorner LF,Schildkraut I,Aggarwal AK

更新日期：1997-07-03 00:00:00

abstract：:It has been proposed that the hypothalamus helps to control ageing, but the mechanisms responsible remain unclear. Here we develop several mouse models in which hypothalamic stem/progenitor cells that co-express Sox2 and Bmi1 are ablated, as we observed that ageing in mice started with a substantial loss of these hypo...

journal_title：Nature

authors： Zhang Y,Kim MS,Jia B,Yan J,Zuniga-Hertz JP,Han C,Cai D

更新日期：2017-08-03 00:00:00

abstract：:In the chick embryo, left-right asymmetric patterns of gene expression in the lateral plate mesoderm are initiated by signals located in and around Hensen's node. Here we show that Caronte (Car), a secreted protein encoded by a member of the Cerberus/Dan gene family, mediates the Sonic hedgehog (Shh)-dependent inducti...

journal_title：Nature

authors： Rodríguez Esteban C,Capdevila J,Economides AN,Pascual J,Ortiz A,Izpisúa Belmonte JC

更新日期：1999-09-16 00:00:00

abstract：:The structure of poly(dA).poly(dT) currently arouses great interest, mainly because dAn.dTn stretches are associated with considerable DNA bending. Until recently the heteronomous DNA described by Arnott et al., with the poly(dA) and poly(dT) chains in A and B conformations respectively, was the only detailed model of...

journal_title：Nature

authors： Alexeev DG,Lipanov AA,Skuratovskii IYa

更新日期：1987-02-26 00:00:00

abstract：:Braunwald, a professor at Harvard Medical School, responds to a paper by Walter W. Stewart and Ned Feder ("The integrity of the scientific literature," Nature 1987 Jan 15; 325(6101): 207-214) concerning their findings of errors, discrepancies, and other lapses in publications coauthored by John Darsee, a biomedical re...

journal_title：Nature

authors： Braunwald E

更新日期：1987-01-15 00:00:00

abstract：:Transmission of obligate bacterial symbionts between generations is vital for the survival of the host. Although the larvae of certain hydrothermal vent tubeworms (Vestimentifera, Siboglinidae) are symbiont-free and possess a transient digestive system, these structures are lost during development, resulting in adult ...

journal_title：Nature

authors： Nussbaumer AD,Fisher CR,Bright M

更新日期：2006-05-18 00:00:00

abstract：:CRISPR-Cas genome-editing nucleases hold substantial promise for developing human therapeutic applications1-6 but identifying unwanted off-target mutations is important for clinical translation7. A well-validated method that can reliably identify off-targets in vivo has not been described to date, which means it is cu...

journal_title：Nature

authors： Akcakaya P,Bobbin ML,Guo JA,Malagon-Lopez J,Clement K,Garcia SP,Fellows MD,Porritt MJ,Firth MA,Carreras A,Baccega T,Seeliger F,Bjursell M,Tsai SQ,Nguyen NT,Nitsch R,Mayr LM,Pinello L,Bohlooly-Y M,Aryee MJ,Maresca

更新日期：2018-09-01 00:00:00

abstract：:When a force deforms an elastic object, practical experience suggests that the resulting displacement will be in the same direction as the force. This property is known as positive stiffness. Less familiar is the concept of negative stiffness, where the deforming force and the resulting displacement are in opposite di...

journal_title：Nature

authors： Lakes RS,Lee T,Bersie A,Wang YC

更新日期：2001-03-29 00:00:00

abstract：:The promoter for a weakly expressed constitutive gene, the lactose repressor gene (lacI), has been sequenced, along with an 'up' promoter mutation Iq. The 10-fold enhancement in I expression found in Iq is the result of a single base change at position -35. To facilitate the sequencing, the lacI gene was cloned in a s...

journal_title：Nature

authors： Calos MP

更新日期：1978-08-24 00:00:00

abstract：:The study of bacterial ion channels has provided fundamental insights into the structural basis of neuronal signalling; however, the native role of ion channels in bacteria has remained elusive. Here we show that ion channels conduct long-range electrical signals within bacterial biofilm communities through spatially ...

journal_title：Nature

authors： Prindle A,Liu J,Asally M,Ly S,Garcia-Ojalvo J,Süel GM

更新日期：2015-11-05 00:00:00

abstract：:The bacterial CRISPR/Cas9 system allows sequence-specific gene editing in many organisms and holds promise as a tool to generate models of human diseases, for example, in human pluripotent stem cells. CRISPR/Cas9 introduces targeted double-stranded breaks (DSBs) with high efficiency, which are typically repaired by no...

journal_title：Nature

authors： Paquet D,Kwart D,Chen A,Sproul A,Jacob S,Teo S,Olsen KM,Gregg A,Noggle S,Tessier-Lavigne M

更新日期：2016-05-05 00:00:00

abstract：:Spermiogenesis is a complex process by which postmeiotic male germ cells differentiate into mature spermatozoa. This process involves remarkable structural and biochemical changes including nuclear DNA compaction and acrosome formation. Transcription activator CREM (cyclic AMP-responsive element modulator) is highly e...

journal_title：Nature

authors： Nantel F,Monaco L,Foulkes NS,Masquilier D,LeMeur M,Henriksén K,Dierich A,Parvinen M,Sassone-Corsi P

更新日期：1996-03-14 00:00:00

abstract：:An experiment by the Gates Foundation is food for thought for other research agencies. ...

journal_title：Nature

authors：

更新日期：2008-10-30 00:00:00