Abstract:
:The promoter for a weakly expressed constitutive gene, the lactose repressor gene (lacI), has been sequenced, along with an 'up' promoter mutation Iq. The 10-fold enhancement in I expression found in Iq is the result of a single base change at position -35. To facilitate the sequencing, the lacI gene was cloned in a small plasmid.
journal_name
Naturejournal_title
Natureauthors
Calos MPdoi
10.1038/274762a0subject
Has Abstractpub_date
1978-08-24 00:00:00pages
762-5issue
5673eissn
0028-0836issn
1476-4687journal_volume
274pub_type
杂志文章相关文献
NATURE文献大全abstract::The insulins of New World hystricomorph rodents exhibit many novel amino acid changes in primary structure when compared with other mammalian insulins. These changes give rise to unusual properties (low potency, failure to self-associate) not shared by other naturally-occurring insulins. We report here on the primary ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/286822a0
更新日期:1980-08-21 00:00:00
abstract::Neurotransmitter release is initiated by influx of Ca2+ through voltage-gated Ca2+ channels, within 200 microseconds of the action potential arriving at the synaptic terminal, as the Ca2+ concentration increases from 100 nM to > 200 microM. Exocytosis requires high Ca2+ concentration, with a threshold of 20-50 microM ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/379451a0
更新日期:1996-02-01 00:00:00
abstract::Tumour-initiating cells capable of self-renewal and differentiation, which are responsible for tumour growth, have been identified in human haematological malignancies and solid cancers. If such minority populations are associated with tumour progression in human patients, specific targeting of tumour-initiating cells...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06489
更新日期:2008-01-17 00:00:00
abstract::Meristems are distinctive regions of plants that have capacity for continuous growth. Their developmental activity generates the majority of plant organs. It is currently unknown how cell division and cell differentiation are orchestrated in meristems, although genetic studies have demonstrated the relevance of a prop...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/36856
更新日期:1997-11-20 00:00:00
abstract::Quantum states of mechanical motion can be important resources for quantum information, metrology and studies of fundamental physics. Recent demonstrations of superconducting qubits coupled to acoustic resonators have opened up the possibility of performing quantum operations on macroscale motional modes1-3, which can...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0717-7
更新日期:2018-11-01 00:00:00
abstract::Cyclic ADP-ribose (cADPR) is a newly identified nucleotide which can release calcium from a variety of cells, suggesting it is a messenger for mobilizing internal Ca2+ stores. Its cyclic structure has now been confirmed by X-ray crystallography. Available results are consistent with it being a modulator of Ca(2+)-indu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/370307a0
更新日期:1994-07-28 00:00:00
abstract::The aspergilli comprise a diverse group of filamentous fungi spanning over 200 million years of evolution. Here we report the genome sequence of the model organism Aspergillus nidulans, and a comparative study with Aspergillus fumigatus, a serious human pathogen, and Aspergillus oryzae, used in the production of sake,...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04341
更新日期:2005-12-22 00:00:00
abstract::Sex and recombination are widespread, but explaining these phenomena has been one of the most difficult problems in evolutionary biology. Recombination is advantageous when different individuals in a population carry different advantageous alleles. By bringing together advantageous alleles onto the same chromosome, re...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05049
更新日期:2006-09-07 00:00:00
abstract::Sudden cardiac death is the leading cause of death in the industrialized world, with the majority of such tragedies being due to ventricular fibrillation. Ventricular fibrillation is a frenzied and irregular disturbance of the heart rhythm that quickly renders the heart incapable of sustaining life. Rotors, electrophy...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/32170
更新日期:1998-03-05 00:00:00
abstract::DNA replication in eukaryotes is strictly regulated by several mechanisms. A central step in this replication is the assembly of the heterohexameric minichromosome maintenance (MCM2-7) helicase complex at replication origins during G1 phase as an inactive double hexamer. Here, using cryo-electron microscopy, we report...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14685
更新日期:2015-08-13 00:00:00
abstract::Genetic manipulations of insect populations for pest control have been advocated for some time, but there are few cases where manipulated individuals have been released in the field and no cases where they have successfully invaded target populations. Population transformation using the intracellular bacterium Wolbach...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10356
更新日期:2011-08-24 00:00:00
abstract::Interest in attributing the risk of damaging weather-related events to anthropogenic climate change is increasing. Yet climate models used to study the attribution problem typically do not resolve the weather systems associated with damaging events such as the UK floods of October and November 2000. Occurring during t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09762
更新日期:2011-02-17 00:00:00
abstract::Japan's Ministry of Health will fund a major new heart transplantation project in an effort to resume heart transplants halted by a public outcry against the first such transplant 17 years ago. Opposition to organ donation, which has been attributed variously to Buddhist and Confucian views of the body and to Japanes...
journal_title:Nature
pub_type: 新闻
doi:10.1038/313338a0
更新日期:1985-01-31 00:00:00
abstract::Little is known about metabolic regulation in stem cells and how this modulates tissue regeneration or tumour suppression. We studied the Lkb1 tumour suppressor and its substrate AMP-activated protein kinase (AMPK), kinases that coordinate metabolism with cell growth. Deletion of the Lkb1 (also called Stk11) gene in m...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09571
更新日期:2010-12-02 00:00:00
abstract::Despite considerable global investment, only 60% of people who live with HIV currently receive antiretroviral therapy. The sustainability of current programmes remains unknown and key incidence rates are declining only modestly. Given the complexities and expenses associated with lifelong medication, developing an eff...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/s41586-019-1841-8
更新日期:2019-12-01 00:00:00
abstract::The Gulf Stream transports approximately 31 Sv (1 Sv = 10(6) m(3) s(-1)) of water and 1.3 x 10(15) W of heat into the North Atlantic ocean. The possibility of abrupt changes in Gulf Stream heat transport is one of the key uncertainties in predictions of climate change for the coming centuries. Given the limited length...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05277
更新日期:2006-11-30 00:00:00
abstract::Midbrain dopamine neurons are activated by reward or sensory stimuli predicting reward. These excitatory responses increase as the reward value increases. This response property has led to a hypothesis that dopamine neurons encode value-related signals and are inhibited by aversive events. Here we show that this is tr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08028
更新日期:2009-06-11 00:00:00
abstract::Magnetic interactions and magnetic impurities are destructive to superconductivity in conventional superconductors. By contrast, in some unconventional macroscopic quantum systems (such as superfluid 3He and superconducting UGe2), the superconductivity (or superfluidity) is actually mediated by magnetic interactions. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35082019
更新日期:2001-06-21 00:00:00
abstract::The capacity of the rough endoplasmic reticulum (RER) membrane of eukaryotic cells in translocate nascent presecretory proteins from the cytosol to the intracisternal space is preserved on cell fractionation and can be assayed in vitro. Two attempts to characterize this translocation activity have been reported. Warre...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/286174a0
更新日期:1980-07-10 00:00:00
abstract::The factors shaping cometary nuclei are still largely unknown, but could be the result of concurrent effects of evolutionary and primordial processes. The peculiar bilobed shape of comet 67P/Churyumov-Gerasimenko may be the result of the fusion of two objects that were once separate or the result of a localized excava...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature15511
更新日期:2015-10-15 00:00:00
abstract::Local galaxies are broadly divided into two main classes, star-forming (gas-rich) and quiescent (passive and gas-poor). The primary mechanism responsible for quenching star formation in galaxies and transforming them into quiescent and passive systems is still unclear. Sudden removal of gas through outflows or strippi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14439
更新日期:2015-05-14 00:00:00
abstract::Originally described by Lugaresi et al. in 1986 (ref. 1), fatal familial insomnia (FFI) is a rare inherited neurological disease characterized by the subacute progression of intractable insomnia and other autonomic abnormalities, cerebellar and pyramidal signs, myoclonus and dementia; neuropathologically, the major fe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/376434a0
更新日期:1995-08-03 00:00:00
abstract::Hunter-Schreger bands (HSB) are seen in teeth that are composed of crossed sets of enamel prisms. They are present in the teeth of man and many other mammals, but absent in most insectivores and multituberculates. It has been suggested that the presence of HSB makes the tooth enamel less likely to split and is associa...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/328150a0
更新日期:1987-07-09 00:00:00
abstract::Galactic cosmic rays (CRs) are widely believed to be accelerated by shock waves associated with the expansion of supernova ejecta into the interstellar medium. A key issue in this long-standing conjecture is a theoretical prediction that the interstellar magnetic field can be substantially amplified at the shock of a ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06210
更新日期:2007-10-04 00:00:00
abstract::Transport of calcium ions across membranes and against a thermodynamic gradient is essential to many biological processes, including muscle contraction, the citric acid cycle, glycogen metabolism, release of neurotransmitters, vision, biological signal transduction and immune response. Synthetic systems that transport...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01209
更新日期:2002-11-28 00:00:00
abstract::The kinetics of the thrombin-catalysed release of fibrino-peptides A and B from human fibrinogen have been investigated and a mechanism correlating the release of fibrinopeptides to fibrin formation is presented. The sequential release of fibrinopeptides results in sequential activation of two sets of polymerisation s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/275501a0
更新日期:1978-10-12 00:00:00
abstract::Parkinson's disease is characterized by loss of dopamine neurons in the substantia nigra1. Similar to other major neurodegenerative disorders, there are no disease-modifying treatments for Parkinson's disease. While most treatment strategies aim to prevent neuronal loss or protect vulnerable neuronal circuits, a poten...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2388-4
更新日期:2020-06-01 00:00:00
abstract::Functioning and processing of membrane proteins critically depend on the way their transmembrane segments are embedded in the membrane. Sphingolipids are structural components of membranes and can also act as intracellular second messengers. Not much is known of sphingolipids binding to transmembrane domains (TMDs) of...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10742
更新日期:2012-01-09 00:00:00
abstract::The modern giant sperm whale Physeter macrocephalus, one of the largest known predators, preys upon cephalopods at great depths. Lacking a functional upper dentition, it relies on suction for catching its prey; in contrast, several smaller Miocene sperm whales (Physeteroidea) have been interpreted as raptorial (versus...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09067
更新日期:2010-07-01 00:00:00
abstract::The classical strength profile of continents is derived from a quasi-static view of their rheological response to stress--one that does not consider dynamic interactions between brittle and ductile layers. Such interactions result in complexities of failure in the brittle-ductile transition and the need to couple ener...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04868
更新日期:2006-07-06 00:00:00