Abstract:
:Despite considerable global investment, only 60% of people who live with HIV currently receive antiretroviral therapy. The sustainability of current programmes remains unknown and key incidence rates are declining only modestly. Given the complexities and expenses associated with lifelong medication, developing an effective curative intervention is now a global priority. Here we review why and where a cure is needed, and how it might be achieved. We argue for expanding these efforts from resource-rich regions to sub-Saharan Africa and elsewhere: for any intervention to have an effect, region-specific biological, therapeutic and implementation issues must be addressed.
journal_name
Naturejournal_title
Natureauthors
Ndung'u T,McCune JM,Deeks SGdoi
10.1038/s41586-019-1841-8subject
Has Abstractpub_date
2019-12-01 00:00:00pages
397-405issue
7787eissn
0028-0836issn
1476-4687pii
10.1038/s41586-019-1841-8journal_volume
576pub_type
杂志文章,评审相关文献
NATURE文献大全abstract::Multiple endocrine neoplasia type 1 (MEN-1) is a predisposition to hyperplasia of the parathyroid glands, and to hyperplasia or tumours of the anterior pituitary and the endocrine pancreas, and is inherited as an autosomal dominant trait. Here we map the MEN-1 locus to chromosome 11 by family studies, and demonstrate ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/332085a0
更新日期:1988-03-03 00:00:00
abstract::Quantum computers are expected to outperform conventional computers in several important applications, from molecular simulation to search algorithms, once they can be scaled up to large numbers-typically millions-of quantum bits (qubits)1-3. For most solid-state qubit technologies-for example, those using superconduc...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2171-6
更新日期:2020-04-01 00:00:00
abstract::Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous insight into gene function and congenital disorders. As part of the International Mouse Phenotyping Consortium effort to generate and phenotypically characterize 5,...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature19356
更新日期:2016-09-22 00:00:00
abstract::The interplay between magnetic fields and interacting particles can lead to exotic phases of matter that exhibit topological order and high degrees of spatial entanglement. Although these phases were discovered in a solid-state setting, recent innovations in systems of ultracold neutral atoms-uncharged atoms that do n...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature22811
更新日期:2017-06-21 00:00:00
abstract::Clonal deletion in the thymus plays a major part in T-cell tolerance to self antigens. But the mechanism of negative selection, its fine specificity and the threshold of affinity and avidity remains unknown. We have now examined these aspects of negative selection with mice expressing a transgenic T-cell receptor with...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/351482a0
更新日期:1991-06-06 00:00:00
abstract::DNA mismatch repair is critical for increasing replication fidelity in organisms ranging from bacteria to humans. MutS protein, a member of the ABC ATPase superfamily, recognizes mispaired and unpaired bases in duplex DNA and initiates mismatch repair. Mutations in human MutS genes cause a predisposition to hereditary...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35037509
更新日期:2000-10-12 00:00:00
abstract::Continental rifts are important sources of mantle carbon dioxide (CO2) emission into Earth's atmosphere1-3. Because deep carbon is stored for long periods in the lithospheric mantle4-6, rift CO2 flux depends on lithospheric processes that control melt and volatile transport1,3,7. The influence of compositional and thi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2328-3
更新日期:2020-06-01 00:00:00
abstract::The mutation brachypodism (bp) alters the length and number of bones in the limbs of mice but spares the axial skeleton. It illustrates the importance of specific genes in controlling the morphogenesis of individual skeletal elements in the tetrapod limb. We now report the isolation of three new members of the transfo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/368639a0
更新日期:1994-04-14 00:00:00
abstract::Climate models with increased levels of carbon dioxide predict that global warming causes heating in the tropics, but investigations of ancient climates based on palaeodata have generally indicated cool tropical temperatures during supposed greenhouse episodes. For example, in the Late Cretaceous and Eocene epochs the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35097000
更新日期:2001-10-04 00:00:00
abstract::Mass spectrometry is a powerful technology for the analysis of large numbers of endogenous proteins. However, the analytical challenges associated with comprehensive identification and relative quantification of cellular proteomes have so far appeared to be insurmountable. Here, using advances in computational proteom...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07341
更新日期:2008-10-30 00:00:00
abstract::Methane-oxidizing bacteria (methanotrophs) require large quantities of copper for the membrane-bound (particulate) methane monooxygenase. Certain methanotrophs are also able to switch to using the iron-containing soluble methane monooxygenase to catalyse methane oxidation, with this switchover regulated by copper. Met...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14854
更新日期:2015-09-03 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 评论,社论
doi:10.1038/d41586-019-00483-5
更新日期:2019-02-01 00:00:00
abstract::Recognition and removal of apoptotic cells by professional phagocytes, including dendritic cells and macrophages, preserves immune self-tolerance and prevents chronic inflammation and autoimmune pathologies. The diverse array of phagocytes that reside within different tissues, combined with the necessarily prompt natu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature20138
更新日期:2016-11-24 00:00:00
abstract::Asteroids are primitive Solar System bodies that evolve both collisionally and through disruptions arising from rapid rotation. These processes can lead to the formation of binary asteroids and to the release of dust, both directly and, in some cases, through uncovering frozen volatiles. In a subset of the asteroids c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature23892
更新日期:2017-09-20 00:00:00
abstract::The ras-related low-molecular-mass GTPases participate in signal transduction involving a variety of cellular functions, including cell-cycle progression, cellular differentiation, cytoskeletal organization, protein transport and secretion. The cycling of these proteins between GTP-bound and GDP-bound states is partia...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/359153a0
更新日期:1992-09-10 00:00:00
abstract::Specific chromosomal deletions sometimes associated with tumours such as retinoblastoma (chromosome 13q14) and Wilm's tumour (chromosome 11p13) have led to the hypothesis that recessive genes may be involved in tumorigenesis. This hypothesis is supported by demonstration of allele loss specific for these regions using...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/329451a0
更新日期:1987-10-01 00:00:00
abstract::There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study (using the Affymetrix GeneChip 500K Mapping Array Set) undertaken in the British population, which has examined approxima...
journal_title:Nature
pub_type: 杂志文章,多中心研究
doi:10.1038/nature05911
更新日期:2007-06-07 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 历史文章,新闻
doi:10.1038/d41586-018-07518-3
更新日期:2018-11-01 00:00:00
abstract::Since the discovery of insulin nearly 70 years ago, there has been no problem more fundamental to diabetes research than understanding how insulin works at the cellular level. Insulin binds to the alpha subunit of the insulin receptor which activates the tyrosine kinase in the beta subunit, but the molecular events li...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/352073a0
更新日期:1991-07-04 00:00:00
abstract::Materials showing simultaneous ferroelectric and magnetic ordering are attracting a great deal of interest because of their unusual physics and potential applications. Hemberger et al. have reported relaxor-like dielectric properties and colossal magnetocapacitance (in excess of 500%) for the cubic spinel compound CdC...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/nature06156
更新日期:2007-08-23 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-019-00588-x
更新日期:2019-02-01 00:00:00
abstract::Guided by brain-like 'spiking' computational frameworks, neuromorphic computing-brain-inspired computing for machine intelligence-promises to realize artificial intelligence while reducing the energy requirements of computing platforms. This interdisciplinary field began with the implementation of silicon circuits for...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/s41586-019-1677-2
更新日期:2019-11-01 00:00:00
abstract::Globular star clusters are compact and massive stellar systems old enough to have witnessed the entire history of our Galaxy, the Milky Way. Although recent results suggest that their formation may have been more complex than previously thought, they still are the best approximation to a stellar population formed over...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08581
更新日期:2009-11-26 00:00:00
abstract::The importance of the dopaminergic system in brain function has been emphasized by its association with neurological and psychiatric disorders such as Parkinson's disease and schizophrenia. On the basis of their biochemical and pharmacological characteristics, dopamine receptors are classified into D1 and D2 subtypes....
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/347076a0
更新日期:1990-09-06 00:00:00
abstract::In Drosophila melanogaster, the rRNA genes (rDNA) are clustered at single sites on two non-homologous chromosomes, the X and Y. Examination of the structure of X and Y rDNAs with restriction endonucleases reveals that the X rDNA contains repeating units not present in the Y. Such observations, as well as genetic evide...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/263027a0
更新日期:1976-09-02 00:00:00
abstract::Water availability limits plant growth and production in almost all terrestrial ecosystems. However, biomes differ substantially in sensitivity of aboveground net primary production (ANPP) to between-year variation in precipitation. Average rain-use efficiency (RUE; ANPP/precipitation) also varies between biomes, supp...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02561
更新日期:2004-06-10 00:00:00
abstract::Daily life continually confronts us with an exuberance of external, sensory stimuli competing with a rich stream of internal deliberations, plans and ruminations. The brain must select one or more of these for further processing. How this competition is resolved across multiple sensory and cognitive regions is not kno...
journal_title:Nature
pub_type: 临床试验,杂志文章
doi:10.1038/nature09510
更新日期:2010-10-28 00:00:00
abstract::Quantum simulation--the use of one quantum system to simulate a less controllable one--may provide an understanding of the many quantum systems which cannot be modelled using classical computers. Considerable progress in control and manipulation has been achieved for various quantum systems, but one of the remaining c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13565
更新日期:2014-08-07 00:00:00
abstract::This corrects the article DOI: 10.1038/nature18614. ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
doi:10.1038/nature25991
更新日期:2018-03-21 00:00:00
abstract::Type Ia supernovae have been used empirically as 'standard candles' to demonstrate the acceleration of the expansion of the Universe even though fundamental details, such as the nature of their progenitor systems and how the stars explode, remain a mystery. There is consensus that a white dwarf star explodes after acc...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10644
更新日期:2011-12-14 00:00:00