On-line, voluntary control of human temporal lobe neurons.

abstract：:Citrullination is the post-translational conversion of an arginine residue within a protein to the non-coded amino acid citrulline. This modification leads to the loss of a positive charge and reduction in hydrogen-bonding ability. It is carried out by a small family of tissue-specific vertebrate enzymes called peptid...

journal_title：Nature

authors： Christophorou MA,Castelo-Branco G,Halley-Stott RP,Oliveira CS,Loos R,Radzisheuskaya A,Mowen KA,Bertone P,Silva JC,Zernicka-Goetz M,Nielsen ML,Gurdon JB,Kouzarides T

更新日期：2014-03-06 00:00:00

abstract：:Subduction zones produce the largest earthquakes. Over the past two decades, space geodesy has revolutionized our view of crustal deformation between consecutive earthquakes. The short time span of modern measurements necessitates comparative studies of subduction zones that are at different stages of the deformation ...

journal_title：Nature

authors： Wang K,Hu Y,He J

更新日期：2012-04-18 00:00:00

abstract：:The dopamine-containing projection from the ventral tegmental area of the midbrain to the nucleus accumbens is critically involved in mediating the reinforcing properties of cocaine. Although neurons in this area respond to rewards on a subsecond timescale, neurochemical studies have only addressed the role of dopamin...

journal_title：Nature

authors： Phillips PE,Stuber GD,Heien ML,Wightman RM,Carelli RM

更新日期：2003-04-10 00:00:00

abstract：:The preparation of synthetic molecules showing the remarkable efficiencies characteristic of natural biopolymer catalysts remains a formidable challenge for chemical biology. Although significant advances have been made in the understanding of protein structure and function, the de novo construction of such systems re...

journal_title：Nature

authors： Severin K,Lee DH,Kennan AJ,Ghadiri MR

更新日期：1997-10-16 00:00:00

abstract：:Devices that convert information from one form into another according to a definite procedure are known as automata. One such hypothetical device is the universal Turing machine, which stimulated work leading to the development of modern computers. The Turing machine and its special cases, including finite automata, o...

journal_title：Nature

authors： Benenson Y,Paz-Elizur T,Adar R,Keinan E,Livneh Z,Shapiro E

更新日期：2001-11-22 00:00:00

abstract：:It has been speculated that brain activities might directly control adaptive immune responses in lymphoid organs, although there is little evidence for this. Here we show that splenic denervation in mice specifically compromises the formation of plasma cells during a T cell-dependent but not T cell-independent immune ...

journal_title：Nature

authors： Zhang X,Lei B,Yuan Y,Zhang L,Hu L,Jin S,Kang B,Liao X,Sun W,Xu F,Zhong Y,Hu J,Qi H

更新日期：2020-05-01 00:00:00

abstract：:The sequencing of ancient DNA has enabled the reconstruction of speciation, migration and admixture events for extinct taxa1. However, the irreversible post-mortem degradation2 of ancient DNA has so far limited its recovery-outside permafrost areas-to specimens that are not older than approximately 0.5 million years (...

journal_title：Nature

authors： Cappellini E,Welker F,Pandolfi L,Ramos-Madrigal J,Samodova D,Rüther PL,Fotakis AK,Lyon D,Moreno-Mayar JV,Bukhsianidze M,Rakownikow Jersie-Christensen R,Mackie M,Ginolhac A,Ferring R,Tappen M,Palkopoulou E,Dickinson MR,S

更新日期：2019-10-01 00:00:00

abstract：:We have sequenced and annotated the genome of fission yeast (Schizosaccharomyces pombe), which contains the smallest number of protein-coding genes yet recorded for a eukaryote: 4,824. The centromeres are between 35 and 110 kilobases (kb) and contain related repeats including a highly conserved 1.8-kb element. Regions...

journal_title：Nature

authors： Wood V,Gwilliam R,Rajandream MA,Lyne M,Lyne R,Stewart A,Sgouros J,Peat N,Hayles J,Baker S,Basham D,Bowman S,Brooks K,Brown D,Brown S,Chillingworth T,Churcher C,Collins M,Connor R,Cronin A,Davis P,Feltwell T,Fr

更新日期：2002-02-21 00:00:00

abstract：:During the subduction of oceanic lithosphere, water is liberated from minerals by progressive dehydration reactions and is thought to be critical to several geologically important processes such as island-arc volcanism, intermediate-depth seismicity and chemical exchange between the subducting lithosphere and mantle. ...

journal_title：Nature

authors： Bina CR,Navrotsky A

更新日期：2000-12-14 00:00:00

abstract：:The restriction of intermingling between specific cell populations is crucial for the maintenance of organized patterns during development. A striking example is the restriction of cell mixing between segments in the insect epidermis and the vertebrate hindbrain that may enable each segment to maintain a distinct iden...

journal_title：Nature

authors： Xu Q,Mellitzer G,Robinson V,Wilkinson DG

更新日期：1999-05-20 00:00:00

abstract：:Large panels of comprehensively characterized human cancer models, including the Cancer Cell Line Encyclopedia (CCLE), have provided a rigorous framework with which to study genetic variants, candidate targets, and small-molecule and biological therapeutics and to identify new marker-driven cancer dependencies. To imp...

journal_title：Nature

authors： Ghandi M,Huang FW,Jané-Valbuena J,Kryukov GV,Lo CC,McDonald ER 3rd,Barretina J,Gelfand ET,Bielski CM,Li H,Hu K,Andreev-Drakhlin AY,Kim J,Hess JM,Haas BJ,Aguet F,Weir BA,Rothberg MV,Paolella BR,Lawrence MS,Akbani R

更新日期：2019-05-01 00:00:00

abstract：:The additional author support information was erroneously omitted from the Supplementary Information. This has been corrected online. ...

journal_title：Nature

authors： Hilf N,Kuttruff-Coqui S,Frenzel K,Bukur V,Stevanović S,Gouttefangeas C,Platten M,Tabatabai G,Dutoit V,van der Burg SH,Straten PT,Martinez-Ricarte F,Ponsati B,Okada H,Lassen U,Admon A,Ottensmeier CH,Ulges A,Kreiter S,

更新日期：2019-02-01 00:00:00

abstract：:Haemoglobin is the prototype of an allosteric protein in which cooperative behaviour depends on interaction between unlike subunits. Here we present haematological and biochemical evidence that electrostatic interactions are an important determinant of haemoglobin assembly. Individuals heterozygous for positively char...

journal_title：Nature

authors： Bunn HF,McDonald MJ

更新日期：1983-12-01 00:00:00

abstract：:Efficient long-distance quantum teleportation is crucial for quantum communication and quantum networking schemes. Here we describe the high-fidelity teleportation of photons over a distance of 600 metres across the River Danube in Vienna, with the optimal efficiency that can be achieved using linear optics. Our resul...

journal_title：Nature

authors： Ursin R,Jennewein T,Aspelmeyer M,Kaltenbaek R,Lindenthal M,Walther P,Zeilinger A

更新日期：2004-08-19 00:00:00

abstract：:A fundamental tenet of cerebellar learning theories asserts that climbing fibre afferents from the inferior olive provide a teaching signal that promotes the gradual adaptation of movements. Data from several forms of motor learning provide support for this tenet. In pavlovian eyelid conditioning, for example, where a...

journal_title：Nature

authors： Medina JF,Nores WL,Mauk MD

更新日期：2002-03-21 00:00:00

abstract：:Medawar has suggested that the major histocompatibility gene complex (MHC) might be involved in the contact inhibition of movement shown by fibroblasts and epithelia. Contact inhibition of movement is that reaction of cells which stops the movement of one cell over another and thus leads to monolayering and other feat...

journal_title：Nature

authors： Curtis AS,Rooney P

更新日期：1979-09-20 00:00:00

abstract：:The travelling salesman problem is a classical problem in the field of combinatorial optimization, concerned with efficient methods for maximizing or minimizing a function of many independent variables. Given the positions of N cities, which in the simplest case lie in the plane, what is the shortest closed tour in wh...

journal_title：Nature

authors： Durbin R,Willshaw D

更新日期：1987-04-16 00:00:00

abstract：:The atmosphere and ionosphere of Venus have been studied in the past by spacecraft with remote sensing or in situ techniques. These early missions, however, have left us with questions about, for example, the atmospheric structure in the transition region from the upper troposphere to the lower mesosphere (50-90 km) a...

journal_title：Nature

authors： Pätzold M,Häusler B,Bird MK,Tellmann S,Mattei R,Asmar SW,Dehant V,Eidel W,Imamura T,Simpson RA,Tyler GL

更新日期：2007-11-29 00:00:00

abstract：:Ageing is a result of gradual and overall functional deteriorations across the body; however, it is unknown whether an individual tissue primarily works to mediate the ageing progress and control lifespan. Here we show that the hypothalamus is important for the development of whole-body ageing in mice, and that the un...

journal_title：Nature

authors： Zhang G,Li J,Purkayastha S,Tang Y,Zhang H,Yin Y,Li B,Liu G,Cai D

更新日期：2013-05-09 00:00:00

abstract：:The biological importance of DNA methylation for gene expression in eukaryotes is becoming increasingly evident, and a direct role of methylation in gene expression has been suggested by an analysis of the infectivity of integrated retroviral genomes in a transfection assay. These studies, however, did not address whe...

journal_title：Nature

authors： Simon D,Stuhlmann H,Jähner D,Wagner H,Werner E,Jaenisch R

更新日期：1983-07-21 00:00:00

abstract：:Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas (TCGA) pilot project aims to assess the value of large-scale multi-dimensional analysis of these molecular characteristics in human c...

journal_title：Nature

authors： Cancer Genome Atlas Research Network.

更新日期：2008-10-23 00:00:00

abstract：:Multiple sclerosis is thought to be an autoimmune disease of the central nervous system mediated by T cells specific for a myelin antigen. Myelin basic protein has been studied as a potential autoantigen in the disease because of its role as an encephalitogen in experimental autoimmune encephalomyelitis and post-viral...

journal_title：Nature

authors： Ota K,Matsui M,Milford EL,Mackin GA,Weiner HL,Hafler DA

更新日期：1990-07-12 00:00:00

abstract：:Many extensions of the Standard Model of particle physics explain the dominance of matter over antimatter in our Universe by neutrinos being their own antiparticles. This would imply the existence of neutrinoless double-β decay, which is an extremely rare lepton-number-violating radioactive decay process whose detecti...

journal_title：Nature

authors： GERDA Collaboration.

更新日期：2017-04-05 00:00:00

abstract：:General alarm about genetics continues, fanned by the expectation that what may one day be possible will be a reality tomorrow. Moderation is the most urgent need, but understanding would also help. ...

journal_title：Nature

authors：

更新日期：1994-01-13 00:00:00

abstract：: ...

journal_title：Nature

authors： Woolston C

更新日期：2019-01-01 00:00:00

abstract：:Serine proteases are present in virtually all organisms and function both inside and outside the cell; they exist as two families, the 'trypsin-like' and the 'subtilisin-like', that have independently evolved a similar catalytic device characterized by the Ser, His, Asp triad, an oxyanion binding site, and possibly ot...

journal_title：Nature

authors： Carter P,Wells JA

更新日期：1988-04-07 00:00:00

abstract：:A major problem in the elucidation of the molecular mechanisms governing development is the distinction between direct and indirect regulatory interactions among developmental control genes. In vivo studies have indicated that the Drosophila segmentation gene fushi tarazu (ftz) directly or indirectly autoregulates its...

journal_title：Nature

authors： Schier AF,Gehring WJ

更新日期：1992-04-30 00:00:00

abstract：:Naturally occurring peptides with biological actions have in most cases been detected by observing their biological activities in crude extracts and their isolation has been followed using bioassays. As a complement to the classical biological detection systems, we have proposed a chemical detection system based on fr...

journal_title：Nature

authors： Tatemoto K,Mutt V

更新日期：1980-06-05 00:00:00

abstract：:Understanding exotic forms of magnetism in quantum mechanical systems is a central goal of modern condensed matter physics, with implications for systems ranging from high-temperature superconductors to spintronic devices. Simulating magnetic materials in the vicinity of a quantum phase transition is computationally i...

journal_title：Nature

authors： Simon J,Bakr WS,Ma R,Tai ME,Preiss PM,Greiner M

更新日期：2011-04-21 00:00:00

abstract：:The evolutionary divergence of a single species into two has never been directly observed in nature, primarily because speciation can take a long time to occur. A ring species, in which a chain of intergrading populations encircles a barrier and the terminal forms coexist without interbreeding, provides a situation in...

journal_title：Nature

authors： Irwin DE,Bensch S,Price TD

更新日期：2001-01-18 00:00:00