Abstract：
:Naturally occurring peptides with biological actions have in most cases been detected by observing their biological activities in crude extracts and their isolation has been followed using bioassays. As a complement to the classical biological detection systems, we have proposed a chemical detection system based on fragmentation of peptides in tissue extracts followed by identification of certain of these peptide fragments having distinct chemical features. One such chemical feature is the C-terminal amide structure which is characteristic of many biologically active peptides. We have devised a chemical assay method for peptides having such a structure and have found several previously unknown peptide amides in procine upper small intestinal tissues. We report here the isolation and characterization of two of them, designated PHI and PYY. PHI is related to secretin, vasoactive intestinal polypeptide (VIP, glucagon and gastric inhibitory polypeptide (GIP); PYY is related to the pancreatic polypeptide and to neurotensin. Both peptides exhibit biological activities and appear to be present not only in the intestine but also in brain.
journal_name
Naturejournal_title
Natureauthors
Tatemoto K,Mutt Vdoi
10.1038/285417a0subject
Has Abstractpub_date
1980-06-05 00:00:00pages
417-8issue
5764eissn
0028-0836issn
1476-4687journal_volume
285pub_type
杂志文章相关文献
NATURE文献大全abstract：:In vitro studies of muscle mitochondrial metabolism in patients with mitochondrial myopathy have identified a variety of functional defects of the mitochondrial respiratory chain, predominantly affecting complex I (NADH-CoQ reductase) or complex III (ubiquinol-cytochrome c reductase) in adult cases. These two enzymes ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/331717a0
更新日期：1988-02-25 00:00:00
abstract：:Embryonic development is driven by tightly regulated patterns of gene expression, despite extensive genetic variation among individuals. Studies of expression quantitative trait loci (eQTL) indicate that genetic variation frequently alters gene expression in cell-culture models and differentiated tissues. However, the...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature20802
更新日期：2017-01-19 00:00:00
abstract：:Understanding the pathogenesis of neuropsychiatric disorders is a substantial challenge for neurobiologists. It has long been hoped that identifying alleles that confer increased risk of such disorders would provide clues for neurobiological investigation. But this quest has been stymied by a lack of validated biologi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature07454
更新日期：2008-10-16 00:00:00
abstract：:The commitment of non-dividing cells (in G0) to enter division can be studied using primary cultures of lymphocytes. The cells are stable in G0 unless stimulated by mitogen such as concanavalin A (Con A). Commitment to enter the division cycle depends on the expression of gene(s) induced by Con A and the synthesis of ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/310143a0
更新日期：1984-07-12 00:00:00
abstract：:Information from the human genome sequence will eventually alter many aspects of clinical practice. It will increase through our understanding of disease mechanisms, and guide the development of new drugs and therapeutic procedures. In the short term, however, knowledge of the genome will have a profound clinical impa...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/nature02624
更新日期：2004-05-27 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 新闻
doi：10.1038/d41586-018-07372-3
更新日期：2018-12-01 00:00:00
abstract：:Q beta replicase, in the absence of added template, will synthesize RNA autocatalytically. A variety of small RNa species, termed '6S RNAs' are generated. As this reaction purportedly occurs in the absence of template, it has been termed 'de novo' RNA synthesis. The question of whether Q beta replicase can polymerize ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/301350a0
更新日期：1983-01-27 00:00:00
abstract：:Lymphocyte function-associated antigen-1 (LFA-1) is a heterodimer composed of an alpha and beta chain that is expressed on the surface of most leukocytes and is an essential molecule for adhesion reactions between cells participating in the immune response. A putative ligand for LFA-1 is the intercellular adhesion mol...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/333850a0
更新日期：1988-06-30 00:00:00
abstract：:Nitrogen is an essential nutrient for all organisms that must have been available since the origin of life. Abiotic processes including hydrothermal reduction, photochemical reactions, or lightning discharge could have converted atmospheric N2 into assimilable NH4(+), HCN, or NOx species, collectively termed fixed nit...
journal_title：Nature
pub_type： 历史文章,杂志文章
doi：10.1038/nature14180
更新日期：2015-04-30 00:00:00
abstract：:Therizinosauroids are an enigmatic group of dinosaurs known mostly from the Cretaceous period of Asia, whose derived members are characterized by elongate necks, laterally expanded pelves, small, leaf-shaped teeth, edentulous rostra and mandibular symphyses that probably bore keratinized beaks. Although more than a do...
journal_title：Nature
pub_type： 历史文章,杂志文章
doi：10.1038/nature03468
更新日期：2005-05-05 00:00:00
abstract：:The Kondo effect--a many-body phenomenon in condensed-matter physics involving the interaction between a localized spin and free electrons--was discovered in metals containing small amounts of magnetic impurities, although it is now recognized to be of fundamental importance in a wide class of correlated electron syst...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35015509
更新日期：2000-06-15 00:00:00
abstract：:Long interspersed nuclear elements-1 (LINE-1 or L1s) are abundant retrotransposons that comprise approximately 20% of mammalian genomes. Active L1 retrotransposons can impact the genome in a variety of ways, creating insertions, deletions, new splice sites or gene expression fine-tuning. We have shown previously that ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09544
更新日期：2010-11-18 00:00:00
abstract：:Magnetic surveys of the martian surface have revealed significantly lower magnetic field intensities over the gigantic impact craters Hellas and Argyre than over surrounding regions. The reduced fields are commonly attributed to pressure demagnetization caused by shock waves generated during meteorite impact, in the a...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature03560
更新日期：2005-05-12 00:00:00
abstract：:Called the "mystery of mysteries" by Darwin, speciation is still a little-understood area of evolution. Genetic analysis, however, has yielded new generalizations about speciation and suggests promising avenues of research. ...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/355511a0
更新日期：1992-02-06 00:00:00
abstract：:Exchange dynamics between molecules free in solution and bound to the surface of a large supramolecular structure, a polymer, a membrane or solid support are important in many phenomena in biology and materials science. Here we present a novel and generally applicable solution NMR technique, known as dark-state exchan...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature10577
更新日期：2011-10-30 00:00:00
abstract：:Miocene hominoid material is very scarce and has previously only been reported as cranial fragments in the Old World. Here we describe a new specimen of Ouranopithecus macedoniensis, which consists of the right part of the face of an adult male with a portion of the frontal bone, a portion of the left part of the face...
journal_title：Nature
pub_type： 历史文章,杂志文章
doi：10.1038/345712a0
更新日期：1990-06-21 00:00:00
abstract：:Calcium influx through voltage-sensitive Ca2+ channels is the normal physiological stimulus for the activity-dependent release of neurotransmitters at synaptic contacts. It has been postulated that presynaptic inhibition of transmitter release is due to a reduction in Ca2+ influx at the nerve terminal, which could res...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/364635a0
更新日期：1993-08-12 00:00:00
abstract：:Hypogonadism in the mutant hpg mouse is characterized by a deficiency of hypothalamic gonadotropin releasing hormone (GnRH). Affected male mice exhibit immature reproductive organs, small abdominal testes and low pituitary and plasma gonadotropin concentrations. Recent studies have demonstrated the potential of fetal ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/298468a0
更新日期：1982-07-29 00:00:00
abstract：:While progress in fusion research continues with magnetic and inertial confinement, alternative approaches--such as Coulomb explosions of deuterium clusters and ultrafast laser-plasma interactions--also provide insight into basic processes and technological applications. However, attempts to produce fusion in a room t...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature03575
更新日期：2005-04-28 00:00:00
abstract：:The application of human embryonic stem (ES) cells in medicine and biology has an inherent reliance on understanding the starting cell population. Human ES cells differ from mouse ES cells and the specific embryonic origin of both cell types is unclear. Previous work suggested that mouse ES cells could only be obtaine...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature05972
更新日期：2007-07-12 00:00:00
abstract：:Anomalies in temperature and precipitation in northern Russia over the past few years have been viewed as manifestations of anthropogenic climate change, prompting suggestions that this may also account for exceptional forest fires in the region. Here we examine the number of forest-fire events across the boreal Russi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/440436a
更新日期：2006-03-23 00:00:00
abstract：:The overexpression of defined transcription factors in somatic cells results in their reprogramming into induced pluripotent stem (iPS) cells. The extremely low efficiency and slow kinetics of in vitro reprogramming suggest that further rare events are required to generate iPS cells. The nature and identity of these e...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature08285
更新日期：2009-08-27 00:00:00
abstract：:The elevation history of the Tibetan plateau provides direct insight into the tectonic processes associated with continent-continent collisions. Here we present oxygen-isotope-based estimates of the palaeo-altimetry of late Eocene and younger deposits of the Lunpola basin in the centre of the plateau, which indicate t...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature04506
更新日期：2006-02-09 00:00:00
abstract：:Tuberculosis is the leading cause of death in the world resulting from a single bacterial infection. Despite its enormous burden on world health, little is known about the molecular mechanisms of pathogenesis of Mycobacterium tuberculosis. Bacterial multiplication and concomitant tissue damage within an infected host,...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/47042
更新日期：1999-11-04 00:00:00
abstract：:The nucleosome subunit of chromatin consists of DNA folded around a histone core as a 1.8-turn left-handed solenoid. The crystal structure of the nucleosome core particle revealed that it has a dyad symmetry axis and that the minor helix groove faces outwards from the protein core. Richmond et al. noticed that the pat...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/328554a0
更新日期：1987-08-06 00:00:00
abstract：:The largest products of magmatic activity on Earth, the great bodies of granite and their corresponding large eruptions, have a dual nature: homogeneity at the large scale and spatial and temporal heterogeneity at the small scale. This duality calls for a mechanism that selectively removes the large-scale heterogeneit...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09799
更新日期：2011-03-10 00:00:00
abstract：:Transmission of obligate bacterial symbionts between generations is vital for the survival of the host. Although the larvae of certain hydrothermal vent tubeworms (Vestimentifera, Siboglinidae) are symbiont-free and possess a transient digestive system, these structures are lost during development, resulting in adult ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature04793
更新日期：2006-05-18 00:00:00
abstract：:The yeast [PSI+] element represents a new type of genetic inheritance, in which changes in phenotype are transmitted by a 'protein only' mechanism reminiscent of the 'protein-only' transmission of mammalian prion diseases. The underlying molecular mechanisms for both are poorly understood and it is not clear how simil...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/23048
更新日期：1999-08-05 00:00:00
abstract：:The ability to excise (repair) UV-induced pyrimidine dimers in Escherichia coli is not related to its ability to remove N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced O6-methylguanine (O6-MeG) from DNA. It was therefore surprising that certain xeroderma pigmentosum cell lines, deficient in dimer excision, were al...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/289417a0
更新日期：1981-01-29 00:00:00
abstract：:Neurons in the visual cortex typically respond selectively to the orientation, and velocity and direction of movement, of moving-bar stimuli. These responses are generally thought to provide information about the orientation and position of lines and edges in the visual field. Some cells are also endstopped, that is s...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/329438a0
更新日期：1987-10-01 00:00:00
