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NATURE文献大全abstract::Deoxygenated sickle haemoglobin polymerizes into long 210-A diameter fibres that distort and decrease the deformability of red blood cells, and cause sickle cell disease. The fibres consist of seven intertwined double strands. They can form birefringent nematic liquid crystals (tactoids) and spherulites. Rheologically...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/345833a0
更新日期:1990-06-28 00:00:00
abstract::The Hubbard model, formulated by physicist John Hubbard in the 1960s1, is a simple theoretical model of interacting quantum particles in a lattice. The model is thought to capture the essential physics of high-temperature superconductors, magnetic insulators and other complex quantum many-body ground states2,3. Althou...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2085-3
更新日期:2020-03-01 00:00:00
abstract::Indirect-benefit models of sexual selection assert that females gain heritable offspring advantages through a mating bias for males of superior genetic quality. This has generally been tested by associating a simple morphological quality indicator (for example, bird tail length) with offspring viability. However, sele...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02492
更新日期:2004-05-06 00:00:00
abstract::In multinucleated heterokaryons formed from the fusion of differentiated muscle cells to either hepatocytes or fibroblasts, muscle-specific gene expression is activated, liver-specific gene expression is repressed, and there are changes in the location of the Golgi apparatus. An understanding of the regulatory mechani...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/344454a0
更新日期:1990-03-29 00:00:00
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journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-07674-6
更新日期:2018-12-01 00:00:00
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journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-07109-2
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abstract::Thyroid hormones and retinoic acid function through nuclear receptors that belong to the steroid/thyroid-hormone receptor superfamily. Thyroid hormone receptors (TRs) and retinoic acid receptors (RARs) require auxiliary nuclear proteins for efficient DNA binding. Here we report that retinoid X receptors RXR alpha is o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/355441a0
更新日期:1992-01-30 00:00:00
abstract::Disruption of the normal regulation of cell-cycle progression and division lies at the heart of the events leading to cancer. Complex networks of regulatory factors, the tumour microenvironment and stress signals, such as those resulting from damaged DNA, dictate whether cancer cells proliferate or die. Recent progres...
journal_title:Nature
pub_type: 杂志文章,评审
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abstract::Light absorption by the visual pigment rhodopsin triggers, through G-protein coupling, a cascade of events in the outer segment of the rod cell of the vertebrate retina that results in membrane hyperpolarization and nerve excitation. Rhodopsin, which contains 348 amino acids, has seven helices that cross the disk memb...
journal_title:Nature
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abstract::Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemented through the development, integration and application of single-cell...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/s41586-020-2715-9
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abstract::Combined analyses of gene networks and DNA sequence variation can provide new insights into the aetiology of common diseases that may not be apparent from genome-wide association studies alone. Recent advances in rat genomics are facilitating systems-genetics approaches. Here we report the use of integrated genome-wid...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09386
更新日期:2010-09-23 00:00:00
abstract::Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a form of terminal cell-cycle arrest associated with pro-inflammatory...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature24050
更新日期:2017-10-19 00:00:00
abstract::In Drosophila, the establishment of regional commitments along most of the anterior/posterior axis of the developing embryo depends on two clusters of homeotic genes: the Antennapedia complex (ANT-C) and the bithorax complex (BX-C). The red flour beetle has a single complex (HOM-C) representing the homologues of the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/350072a0
更新日期:1991-03-07 00:00:00
abstract::AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-subtype ionotropic glutamate receptors mediate fast excitatory neurotransmission throughout the central nervous system. Gated by the neurotransmitter glutamate, AMPA receptors are critical for synaptic strength, and dysregulation of AMPA receptor-mediated si...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature23479
更新日期:2017-09-07 00:00:00
abstract::Synapsin I is a neuron-specific phosphoprotein localized to the cytoplasmic surface of synaptic vesicles. This phosphoprotein is a major substrate for cyclic AMP-dependent and calcium/calmodulin-dependent protein kinases. Its state of phosphorylation can be altered both in vivo and in vitro by a variety of physiologic...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326704a0
更新日期:1987-04-16 00:00:00
abstract::Type II topoisomerases help regulate DNA topology during transcription, replication and recombination by catalysing DNA strand transfer through transient double-stranded breaks. All type II topoisomerases described so far are members of a single protein family. We have cloned and sequenced the genes encoding the A and...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/386414a0
更新日期:1997-03-27 00:00:00
abstract::The first nerve cells to appear in the limb buds of embryonic grasshoppers are a pair which lie at the distal tip and project axons along the length of the limb to the central nervous system (CNS). The stereotyped route navigated by these 'pioneer' axons is followed by other neurones and eventually becomes that of a m...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/304062a0
更新日期:1983-07-07 00:00:00
abstract::Common genetic contributions to autism spectrum disorder (ASD) reside in risk gene variants that individually have minimal effect sizes. As environmental factors that perturb neurodevelopment also underlie idiopathic ASD, it is crucial to identify altered regulators that can orchestrate multiple ASD risk genes during ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0423-5
更新日期:2018-08-01 00:00:00
abstract::Networks have become a key approach to understanding systems of interacting objects, unifying the study of diverse phenomena including biological organisms and human society. One crucial step when studying the structure and dynamics of networks is to identify communities: groups of related nodes that correspond to fun...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09182
更新日期:2010-08-05 00:00:00
abstract::Recent theory on sexual selection suggests that females in species without paternal care choose mates by their secondary sexual characters because these indicate genotypic quality which will be transmitted to the offspring. These ideas are not yet empirically supported as data quantifying the relationship between fema...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/337166a0
更新日期:1989-01-12 00:00:00
abstract::The terrestrial sediment record indicates that the Earth's climate varied drastically in the Precambrian era (before 550 million years ago), ranging from surface temperatures similar to or higher than today's to global glaciation events. The most continuous record of sea surface temperatures of that time has been deri...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature05239
更新日期:2006-10-26 00:00:00
abstract::Type 1 diabetes (T1D) is a debilitating autoimmune disease that results from T-cell-mediated destruction of insulin-producing beta-cells. Its incidence has increased during the past several decades in developed countries, suggesting that changes in the environment (including the human microbial environment) may influe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07336
更新日期:2008-10-23 00:00:00
abstract::There has been much interest in the biochemical and biophysical processes that couple extracellular signals to alterations in gene expression. While many early events associated with the treatment of cells with growth factors have been described (for example, ion flux and protein phosphorylation), it has proved diffic...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/322552a0
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abstract::The discovery that the primary transcripts of many genes are processed to produce more than one kind of messenger RNA focuses attention on the control of RNA processing as a developmental regulatory mechanism. In the fruit-fly Drosophila melanogaster, differential splicing of a hierarchy of regulatory genes determines...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/340521a0
更新日期:1989-08-17 00:00:00
abstract::Schizophrenia is a severe mental illness with a typically chronic course affecting nearly 1% of the human population. It is generally accepted that genetic factors have an important pathogenic role in a substantial portion of schizophrenia cases; however, despite decades of family studies, there is no agreed-upon mode...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/336167a0
更新日期:1988-11-10 00:00:00
abstract::Early-life dietary transitions reflect fundamental aspects of primate evolution and are important determinants of health in contemporary human populations. Weaning is critical to developmental and reproductive rates; early weaning can have detrimental health effects but enables shorter inter-birth intervals, which inf...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature12169
更新日期:2013-06-13 00:00:00
abstract::Scanning probe microscopy is a versatile and powerful method that uses sharp tips to image, measure and manipulate matter at surfaces with atomic resolution. At cryogenic temperatures, scanning probe microscopy can even provide electron tunnelling spectra that serve as fingerprints of the vibrational properties of ads...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05530
更新日期:2007-03-01 00:00:00
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journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-019-00087-z
更新日期:2019-01-01 00:00:00
abstract::From drug delivery to chemical and biological catalysis and cosmetics, the need for efficient fabrication pathways for particles over a wide range of sizes, from a variety of materials, and in many different structures has been well established. Here we harness the inherent scalability of fibre production and an in-fi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11215
更新日期:2012-07-26 00:00:00
abstract::The ventral tegmental area (VTA) and nucleus accumbens (NAc) are essential for learning about environmental stimuli associated with motivationally relevant outcomes. The task of signalling such events, both rewarding and aversive, from the VTA to the NAc has largely been ascribed to dopamine neurons. The VTA also cont...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11657
更新日期:2012-12-20 00:00:00