Effect of cell history on response to helix-loop-helix family of myogenic regulators.

abstract：:Most patients with cancer either do not respond to immune checkpoint blockade or develop resistance to it, often because of acquired mutations that impair antigen presentation. Here we show that loss of function of the RNA-editing enzyme ADAR1 in tumour cells profoundly sensitizes tumours to immunotherapy and overcome...

journal_title：Nature

authors： Ishizuka JJ,Manguso RT,Cheruiyot CK,Bi K,Panda A,Iracheta-Vellve A,Miller BC,Du PP,Yates KB,Dubrot J,Buchumenski I,Comstock DE,Brown FD,Ayer A,Kohnle IC,Pope HW,Zimmer MD,Sen DR,Lane-Reticker SK,Robitschek EJ,Grif

更新日期：2019-01-01 00:00:00

abstract：:Quantum information science involves the storage, manipulation and communication of information encoded in quantum systems, where the phenomena of superposition and entanglement can provide enhancements over what is possible classically. Large-scale quantum information processors require stable and addressable quantum...

journal_title：Nature

authors： Moehring DL,Maunz P,Olmschenk S,Younge KC,Matsukevich DN,Duan LM,Monroe C

更新日期：2007-09-06 00:00:00

abstract：:Owing to their scientific and technological importance, inorganic single crystals with highly reactive surfaces have long been studied. Unfortunately, surfaces with high reactivity usually diminish rapidly during the crystal growth process as a result of the minimization of surface energy. A typical example is titaniu...

journal_title：Nature

authors： Yang HG,Sun CH,Qiao SZ,Zou J,Liu G,Smith SC,Cheng HM,Lu GQ

更新日期：2008-05-29 00:00:00

abstract：:Cell and lipid membranes are able to bend, as manifested during membrane fusion and the formation of non-lamellar lyotropic mesophases in water. But there is an energy cost to bending of lipid layers, called the curvature elastic energy. Although the functional form of this energy is known, a complete quantitative kno...

journal_title：Nature

authors： Chung H,Caffrey M

更新日期：1994-03-17 00:00:00

abstract：:Assembly of multi-component supramolecular machines is fundamental to biology, yet in most cases, assembly pathways and their control are poorly understood. An example is the type III secretion machine, which mediates the transfer of bacterial virulence proteins into host cells. A central component of this nanomachine...

journal_title：Nature

authors： Marlovits TC,Kubori T,Lara-Tejero M,Thomas D,Unger VM,Galán JE

更新日期：2006-06-01 00:00:00

abstract：:The amino-terminal region of the common corticotropin/beta-lipotrophin (beta-LPH) precursor has been identified in the AtT-20 mouse tumor cells as a glycopeptide with an apparent molecular weight of 16,000 (the '16K fragment'). A third melanotropin core sequence or gamma-MSH similar to that found in ACTH and beta-LPH ...

journal_title：Nature

authors： Al-Dujaili EA,Hope J,Estivariz FE,Lowry PJ,Edwards CR

更新日期：1981-05-14 00:00:00

abstract：:Life implies movement. Most forms of movement in the living world are powered by tiny protein machines known as molecular motors. Among the best known are motors that use sophisticated intramolecular amplification mechanisms to take nanometre steps along protein tracks in the cytoplasm. These motors transport a wide v...

journal_title：Nature

authors： Schliwa M,Woehlke G

更新日期：2003-04-17 00:00:00

abstract：:Acute stress suppresses pain by activating brain pathways that engage opioid or non-opioid mechanisms. Here we show that an opioid-independent form of this phenomenon, termed stress-induced analgesia, is mediated by the release of endogenous marijuana-like (cannabinoid) compounds in the brain. Blockade of cannabinoid ...

journal_title：Nature

authors： Hohmann AG,Suplita RL,Bolton NM,Neely MH,Fegley D,Mangieri R,Krey JF,Walker JM,Holmes PV,Crystal JD,Duranti A,Tontini A,Mor M,Tarzia G,Piomelli D

更新日期：2005-06-23 00:00:00

abstract：:The existence of prostate stem cells (PSCs) was first postulated from the observation that normal prostate regeneration can occur after repeated cycles of androgen deprivation and replacement in rodents. Given the critical role of PSCs in maintaining prostate tissue integrity and their potential involvement in prostat...

journal_title：Nature

authors： Leong KG,Wang BE,Johnson L,Gao WQ

更新日期：2008-12-11 00:00:00

abstract：:One of us has previously reported that treatment of the Keilin and Hartree heart-muscle preparation with 2,3-dimercaptopropanol (BAL), in the presence of air, leads to the complete inactivation of the succinate oxidase system with little if any effect on the activities of succinate dehydrogenase (until more than half ...

journal_title：Nature

authors： Slater EC,de Vries S

更新日期：1980-12-25 00:00:00

abstract：:In Drosophila, a large group of structural genes exhibit coordinate regulation, not because they function in a common developmental pathway but because they happen to reside on the X chromosome. These genes are subjected to the regulatory mechanism of dosage compensation which insures that their phenotypic products ar...

journal_title：Nature

authors： Belote JM,Lucchesi JC

更新日期：1980-06-19 00:00:00

abstract：:Malignancy is a common and dreaded complication following organ transplantation. The high incidence of neoplasm and its aggressive progression, which are associated with immunosuppressive therapy, are thought to be due to the resulting impairment of the organ recipient's immune-surveillance system. Here we report a me...

journal_title：Nature

authors： Hojo M,Morimoto T,Maluccio M,Asano T,Morimoto K,Lagman M,Shimbo T,Suthanthiran M

更新日期：1999-02-11 00:00:00

abstract：:Methyl chloride is the largest natural source of ozone-depleting chlorine compounds, and accounts for about 15 per cent of the present atmospheric chlorine content. This contribution was likely to have been relatively greater in pre-industrial times, when additional anthropogenic sources-such as chlorofluorocarbons-we...

journal_title：Nature

authors： Yokouchi Y,Ikeda M,Inuzuka Y,Yukawa T

更新日期：2002-03-14 00:00:00

abstract：:ELLIPTICAL galaxies acting as gravitational lenses occasionally produce spectacular images-Einstein rings-of distant objects. Giant arcs(1) and radio rings(2) have been observed. A wide variety of image morphologies is possible, the generation of which is qualitatively understood in terms of large magnifications at ca...

journal_title：Nature

authors： Langston GI,Conner SR,Lehar J,Burke BF,Weiler KW

更新日期：1990-03-01 00:00:00

abstract：:Comparative mapping, which compares the location of homologous genes in different species, is a powerful tool for studying genome evolution. Comparative maps suggest that rates of chromosomal change in mammals can vary from one to ten rearrangements per million years. On the basis of these rates we would expect 84 to ...

journal_title：Nature

authors： Burt DW,Bruley C,Dunn IC,Jones CT,Ramage A,Law AS,Morrice DR,Paton IR,Smith J,Windsor D,Sazanov A,Fries R,Waddington D

更新日期：1999-11-25 00:00:00

abstract：:Galactic cosmic rays (CRs) are widely believed to be accelerated by shock waves associated with the expansion of supernova ejecta into the interstellar medium. A key issue in this long-standing conjecture is a theoretical prediction that the interstellar magnetic field can be substantially amplified at the shock of a ...

journal_title：Nature

authors： Uchiyama Y,Aharonian FA,Tanaka T,Takahashi T,Maeda Y

更新日期：2007-10-04 00:00:00

abstract：:The evolution of self-fertilization in hermaphrodites is opposed by costs that decrease the value of self progeny relative to that of outcross progeny. However, self-fertilization is common in plants; 20% are highly selfing and 33% are intermediate between selfing and outcrossing. Darwin proposed an adaptive benefit o...

journal_title：Nature

authors： Kalisz S,Vogler DW,Hanley KM

更新日期：2004-08-19 00:00:00

abstract：:Polycomb group proteins have an essential role in the epigenetic maintenance of repressive chromatin states. The gene-silencing activity of the Polycomb repressive complex 2 (PRC2) depends on its ability to trimethylate lysine 27 of histone H3 (H3K27) by the catalytic SET domain of the EZH2 subunit, and at least two o...

journal_title：Nature

authors： Margueron R,Justin N,Ohno K,Sharpe ML,Son J,Drury WJ 3rd,Voigt P,Martin SR,Taylor WR,De Marco V,Pirrotta V,Reinberg D,Gamblin SJ

更新日期：2009-10-08 00:00:00

abstract：:Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. Progression to CRPC after androgen ablation therapy is predominantly driven by deregulated androgen receptor (AR) signalling. Despite the success of recently approved therapies targeting AR signalling, such as abi...

journal_title：Nature

authors： Asangani IA,Dommeti VL,Wang X,Malik R,Cieslik M,Yang R,Escara-Wilke J,Wilder-Romans K,Dhanireddy S,Engelke C,Iyer MK,Jing X,Wu YM,Cao X,Qin ZS,Wang S,Feng FY,Chinnaiyan AM

更新日期：2014-06-12 00:00:00

abstract：:Arid ecosystems, which occupy about 20% of the earth's terrestrial surface area, have been predicted to be one of the most responsive ecosystem types to elevated atmospheric CO2 and associated global climate change. Here we show, using free-air CO2 enrichment (FACE) technology in an intact Mojave Desert ecosystem, tha...

journal_title：Nature

authors： Smith SD,Huxman TE,Zitzer SF,Charlet TN,Housman DC,Coleman JS,Fenstermaker LK,Seemann JR,Nowak RS

更新日期：2000-11-02 00:00:00

abstract：:The perception of yellow has played a central role in distinguishing two main theories of colour vision. Hering proposed that yellow results from the activation of a distinct retinal-neural mechanism, whereas according to the Young-Helmholtz-Maxwell view, yellow results from the combined activation of red and green co...

journal_title：Nature

authors： Nijhawan R

更新日期：1997-03-06 00:00:00

abstract：:The protein TFIIB is a general transcription initiation factor that interacts with a promoter complex (D.DNA) containing the TATA-binding subunit (TFIID tau, or TBP) of TFIID to facilitate subsequent interaction with RNA polymerase II (ref. 2) through the associated TFIIF (ref. 3). The potential bridging function of T...

journal_title：Nature

authors： Hisatake K,Roeder RG,Horikoshi M

更新日期：1993-06-24 00:00:00

abstract：:Type Ia supernovae have been used empirically as 'standard candles' to demonstrate the acceleration of the expansion of the Universe even though fundamental details, such as the nature of their progenitor systems and how the stars explode, remain a mystery. There is consensus that a white dwarf star explodes after acc...

journal_title：Nature

authors： Nugent PE,Sullivan M,Cenko SB,Thomas RC,Kasen D,Howell DA,Bersier D,Bloom JS,Kulkarni SR,Kandrashoff MT,Filippenko AV,Silverman JM,Marcy GW,Howard AW,Isaacson HT,Maguire K,Suzuki N,Tarlton JE,Pan YC,Bildsten L,Ful

更新日期：2011-12-14 00:00:00

abstract：:Calcium-triggered fusion of synaptic vesicles and neurotransmitter release are fundamental signalling steps in the central nervous system. It is generally assumed that fast transmitter release is triggered by elevations in intracellular calcium concentration ([Ca2+]i) to at least 100 microM near the sites of vesicle f...

journal_title：Nature

authors： Schneggenburger R,Neher E

更新日期：2000-08-24 00:00:00

abstract：:Hydrophobic signal-sequences direct the transfer of secretory proteins across the inner membrane of prokaryotes and the endoplasmic reticulum membranes of eukaryotes. In mammalian cells, signal-sequences are recognized by the 54K protein (M(r) 54,000) of the signal recognition particle (SRP) which is believed to hold ...

journal_title：Nature

authors： Luirink J,High S,Wood H,Giner A,Tollervey D,Dobberstein B

更新日期：1992-10-22 00:00:00

abstract：:Pairs of asteroids sharing similar heliocentric orbits, but not bound together, were found recently. Backward integrations of their orbits indicated that they separated gently with low relative velocities, but did not provide additional insight into their formation mechanism. A previously hypothesized rotational fissi...

journal_title：Nature

authors： Pravec P,Vokrouhlický D,Polishook D,Scheeres DJ,Harris AW,Galád A,Vaduvescu O,Pozo F,Barr A,Longa P,Vachier F,Colas F,Pray DP,Pollock J,Reichart D,Ivarsen K,Haislip J,Lacluyze A,Kusnirák P,Henych T,Marchis F,Mac

更新日期：2010-08-26 00:00:00

abstract：:The NMDA (N-methyl-D-aspartate) receptor transduces the binding of glutamate and glycine, coupling it to the opening of a calcium-permeable ion channel 1 . Owing to the lack of high-resolution structural studies of the NMDA receptor, the mechanism by which ion-channel blockers occlude ion permeation is not well unders...

journal_title：Nature

authors： Song X,Jensen MØ,Jogini V,Stein RA,Lee CH,Mchaourab HS,Shaw DE,Gouaux E

更新日期：2018-04-01 00:00:00

abstract：:Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium that is characterized by the accumulation of mutations and a dysregulated immune response. Up to 90% of disease risk is thought to be due to environmental factors such as diet, which is consistent with a growing body of literature that des...

journal_title：Nature

authors： Janney A,Powrie F,Mann EH

更新日期：2020-09-01 00:00:00

abstract：:Intracellular signalling following mitogenic stimulation of quiescent cells involves the initiation of a phosphorylation cascade that leads to the rapid and reversible activation of the mitogen-activated protein (MAP) kinases ERK1 and ERK2. MAP kinase activation is mediated by dual phosphorylation within the motif Thr...

journal_title：Nature

authors： Ward Y,Gupta S,Jensen P,Wartmann M,Davis RJ,Kelly K

更新日期：1994-02-17 00:00:00

abstract：:The separation of cells into populations that do not intermix, termed compartments, is a fundamental organizing principle during development. Dorsal-ventral compartmentalization of the Drosophila wing is regulated downstream of the apterous (ap) gene, which encodes a transcription factor that specifies dorsal wing fat...

journal_title：Nature

authors： Rauskolb C,Correia T,Irvine KD

更新日期：1999-09-30 00:00:00