Functional dissection of TFIIB domains required for TFIIB-TFIID-promoter complex formation and basal transcription activity.

abstract：:B cells are important in the pathogenesis of many, and perhaps all, immune-mediated diseases. Each B cell expresses a single B cell receptor (BCR)1, and the diverse range of BCRs expressed by the total B cell population of an individual is termed the 'BCR repertoire'. Our understanding of the BCR repertoire in the con...

journal_title：Nature

authors： Bashford-Rogers RJM,Bergamaschi L,McKinney EF,Pombal DC,Mescia F,Lee JC,Thomas DC,Flint SM,Kellam P,Jayne DRW,Lyons PA,Smith KGC

更新日期：2019-10-01 00:00:00

abstract：:The murine cardioviruses, such as the Mengo and encephalomyocarditis viruses, and the bovine aphthoviruses, such as foot-and-mouth disease virus, are distinguished among positive-strand RNA viruses by the presence of long homopolymeric poly(C) tracts within their 5' noncoding sequences. Although the specific lengths (...

journal_title：Nature

authors： Duke GM,Osorio JE,Palmenberg AC

更新日期：1990-02-01 00:00:00

abstract：:Particle physicists see neutrons as tiny massive particles with a confinement radius of about 0.7 fm and a distinct internal quark gluon structure. In quantum mechanics, neutrons are described by wave packets whose spatial extent may become ten orders of magnitude larger than the confinement radius, and can even reach...

journal_title：Nature

authors： Rauch H,Lemmel H,Baron M,Loidl R

更新日期：2002-06-06 00:00:00

abstract：:Observations from Earth-orbiting satellites have been a key component in monitoring climate change for the past two decades. This has become possible with the availability of air temperatures from the Microwave Sounding Unit (MSU) since 1979, sea surface temperatures from the Advanced Very High Resolution Radiometer (...

journal_title：Nature

authors： Wentz FJ,Schabel M

更新日期：2000-01-27 00:00:00

abstract：:Our understanding of Alzheimer's disease pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic form of the disease. It may be possible to overcome these challenges by reprogramming primary cells from patients into induced pluripotent stem cell...

journal_title：Nature

authors： Israel MA,Yuan SH,Bardy C,Reyna SM,Mu Y,Herrera C,Hefferan MP,Van Gorp S,Nazor KL,Boscolo FS,Carson CT,Laurent LC,Marsala M,Gage FH,Remes AM,Koo EH,Goldstein LS

更新日期：2012-01-25 00:00:00

abstract：:Indirect-benefit models of sexual selection assert that females gain heritable offspring advantages through a mating bias for males of superior genetic quality. This has generally been tested by associating a simple morphological quality indicator (for example, bird tail length) with offspring viability. However, sele...

journal_title：Nature

authors： Fedorka KM,Mousseau TA

更新日期：2004-05-06 00:00:00

abstract：:Transposable elements from prokaryotic and eukaryotic organisms are discrete DNA segments bounded by inverted or directly repeated sequences that insert into non-homologous DNA in a reaction that is independent of the general recombination functions of the host. The mechanisms proposed generally involve a staggered do...

journal_title：Nature

authors： Murphy E,Löfdahl S

更新日期：1984-01-19 00:00:00

abstract：:The spectral purity of an oscillator is central to many applications, such as detecting gravity waves, defining the second, ground-state cooling and quantum manipulation of nanomechanical objects, and quantum computation. Recent proposals suggest that laser oscillators which use very narrow optical transitions in atom...

journal_title：Nature

authors： Bohnet JG,Chen Z,Weiner JM,Meiser D,Holland MJ,Thompson JK

更新日期：2012-04-04 00:00:00

abstract：:Using numerical simulation, Holmström et al. proposed a plausible alternative explanation of the observed Lyman-alpha absorption that was seen during the transit of HD 209458b (ref. 2). They conclude that radiation pressure alone cannot explain the observations and that a peculiar stellar wind is needed. Here we show ...

journal_title：Nature

authors： Lecavelier des Etangs A,Vidal-Madjar A,Désert JM

更新日期：2008-11-13 00:00:00

abstract：:The canonical Wnt/β-catenin signalling pathway governs diverse developmental, homeostatic and pathological processes. Palmitoylated Wnt ligands engage cell-surface frizzled (FZD) receptors and LRP5 and LRP6 co-receptors, enabling β-catenin nuclear translocation and TCF/LEF-dependent gene transactivation. Mutations in ...

journal_title：Nature

authors： Yan KS,Janda CY,Chang J,Zheng GXY,Larkin KA,Luca VC,Chia LA,Mah AT,Han A,Terry JM,Ootani A,Roelf K,Lee M,Yuan J,Li X,Bolen CR,Wilhelmy J,Davies PS,Ueno H,von Furstenberg RJ,Belgrader P,Ziraldo SB,Ordonez H,H

更新日期：2017-05-11 00:00:00

abstract：:Therapeutic vaccines derived from carbohydrate antigen-adjuvant combinations are a promising approach for cancer immunotherapy. One of the critical limitations in this area is access to sufficient quantities of tumour-associated carbohydrate antigens and glycoconjugate adjuvants. At present, availability of the comple...

journal_title：Nature

authors： Galonić DP,Gin DY

更新日期：2007-04-26 00:00:00

abstract：:Animal behaviour arises from computations in neuronal circuits, but our understanding of these computations has been frustrated by the lack of detailed synaptic connection maps, or connectomes. For example, despite intensive investigations over half a century, the neuronal implementation of local motion detection in t...

journal_title：Nature

authors： Takemura SY,Bharioke A,Lu Z,Nern A,Vitaladevuni S,Rivlin PK,Katz WT,Olbris DJ,Plaza SM,Winston P,Zhao T,Horne JA,Fetter RD,Takemura S,Blazek K,Chang LA,Ogundeyi O,Saunders MA,Shapiro V,Sigmund C,Rubin GM,Scheffe

更新日期：2013-08-08 00:00:00

abstract：:Conrad et al. have generated human adult germline stem cells (haGSCs) from human testicular tissue, which they claim have similar pluripotent properties to human embryonic stem cells (hESCs). Here we investigate the pluripotency of haGSCs by using global gene-expression analysis based on their gene array data and comp...

journal_title：Nature

authors： Ko K,Araúzo-Bravo MJ,Tapia N,Kim J,Lin Q,Bernemann C,Han DW,Gentile L,Reinhardt P,Greber B,Schneider RK,Kliesch S,Zenke M,Schöler HR

更新日期：2010-06-24 00:00:00

abstract：:Networks of interacting proteins orchestrate the responses of living cells to a variety of external stimuli, but how sensitive is the functioning of these protein networks to variations in their biochemical parameters? One possibility is that to achieve appropriate function, the reaction rate constants and enzyme conc...

journal_title：Nature

authors： Alon U,Surette MG,Barkai N,Leibler S

更新日期：1999-01-14 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-10-01 00:00:00

abstract：:The peptide-loading complex (PLC) is a transient, multisubunit membrane complex in the endoplasmic reticulum that is essential for establishing a hierarchical immune response. The PLC coordinates peptide translocation into the endoplasmic reticulum with loading and editing of major histocompatibility complex class I (...

journal_title：Nature

authors： Blees A,Januliene D,Hofmann T,Koller N,Schmidt C,Trowitzsch S,Moeller A,Tampé R

更新日期：2017-11-23 00:00:00

abstract：:The role of magnetic domains (and the walls between domains) in determining the electrical properties of ferromagnetic materials has been investigated in great detail for many years, not least because control over domains offers a means of manipulating electron spin to control charge transport in 'spintronic' devices....

journal_title：Nature

authors： Kummamuru RK,Soh YA

更新日期：2008-04-17 00:00:00

abstract：:Pluto's tenuous nitrogen atmosphere was first detected by the imprint left on the light curve of a star that was occulted by the planet in 1985 (ref. 1), and studied more extensively during a second occultation event in 1988 (refs 2-6). These events are, however, quite rare and Pluto's atmosphere remains poorly unders...

journal_title：Nature

authors： Sicardy B,Widemann T,Lellouch E,Veillet C,Cuillandre JC,Colas F,Roques F,Beisker W,Kretlow M,Lagrange AM,Gendron E,Lacombe F,Lecacheux J,Birnbaum C,Fienga A,Leyrat C,Maury A,Raynaud E,Renner S,Schultheis M,Brooks

更新日期：2003-07-10 00:00:00

abstract：:DNA sequences have been analysed using models, such as an n-step Markov chain, that incorporate the possibility of short-range nucleotide correlations. We propose here a method for studying the stochastic properties of nucleotide sequences by constructing a 1:1 map of the nucleotide sequence onto a walk, which we term...

journal_title：Nature

authors： Peng CK,Buldyrev SV,Goldberger AL,Havlin S,Sciortino F,Simons M,Stanley HE

更新日期：1992-03-12 00:00:00

abstract：:The RNA polymerase II general transcription factor TFIIH is composed of several polypeptides. The observation that the largest subunit of TFIIH is the excision-repair protein XPB/ERCC3 (ref. 1), a helicase implicated in the human DNA-repair disorders xeroderma pigmentosum (XP) and Cockayne's syndrome, suggests a funct...

journal_title：Nature

authors： Drapkin R,Reardon JT,Ansari A,Huang JC,Zawel L,Ahn K,Sancar A,Reinberg D

更新日期：1994-04-21 00:00:00

abstract：:Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a compl...

journal_title：Nature

authors： Perry JR,Day F,Elks CE,Sulem P,Thompson DJ,Ferreira T,He C,Chasman DI,Esko T,Thorleifsson G,Albrecht E,Ang WQ,Corre T,Cousminer DL,Feenstra B,Franceschini N,Ganna A,Johnson AD,Kjellqvist S,Lunetta KL,McMahon G,N

更新日期：2014-10-02 00:00:00

abstract：:The Pax-6 transcription-factor gene, containing a paired domain and a paired-type homeodomain, is conserved in structure and ubiquitously present among Metazoa. It is required for development of the central nervous system, and is mutated in human aniridia, mouse and rat small eye and Drosophila eyeless. We identified ...

journal_title：Nature

authors： Zhang Y,Emmons SW

更新日期：1995-09-07 00:00:00

abstract：:The emergence and outgrowth of a population of tumour cells resistant to multiple drugs is a major problem in the chemotherapeutic treatment of cancer. We have used highly drug-resistant cell lines developed in vitro to study the molecular basis of multidrug resistance. In these cell lines high levels of resistance ar...

journal_title：Nature

authors： Gros P,Ben Neriah YB,Croop JM,Housman DE

更新日期：1986-10-23 00:00:00

abstract：:During cell division, chromosomes are segregated to nascent daughter cells by attaching to the microtubules of the mitotic spindle through the kinetochore. Kinetochores are assembled on a specialized chromatin domain called the centromere, which is characterized by the replacement of nucleosomal histone H3 with the hi...

journal_title：Nature

authors： Guse A,Carroll CW,Moree B,Fuller CJ,Straight AF

更新日期：2011-08-28 00:00:00

abstract：:Helium-neon lasers emitting at 632.8 nm can influence the phytochrome controlled growth and development of plants more than a quarter of a mile away. It may therefore be possible to control the growth of crops using lasers to activate the phytochrome system. ...

journal_title：Nature

authors： Paleg LG,Aspinall D

更新日期：1970-12-05 00:00:00

abstract：:General alarm about genetics continues, fanned by the expectation that what may one day be possible will be a reality tomorrow. Moderation is the most urgent need, but understanding would also help. ...

journal_title：Nature

authors：

更新日期：1994-01-13 00:00:00

abstract：:For more than three-quarters of a century it has been assumed that basal metabolic rate increases as body mass raised to some power p. However, there is no broad consensus regarding the value of p: whereas many studies have asserted that p is 3/4 (refs 1-4; 'Kleiber's law'), some have argued that it is 2/3 (refs 5-7),...

journal_title：Nature

authors： Kolokotrones T,Van Savage,Deeds EJ,Fontana W

更新日期：2010-04-01 00:00:00

abstract：:In double-stranded-RNA (dsRNA) viruses found in animals, bacteria and yeast, the genome is transcribed within the structurally intact core of the virion with extraordinary efficiency. The structural organization of the genome and the enzymes involved in the transcription inside any of these viruses, critical for under...

journal_title：Nature

authors： Prasad BV,Rothnagel R,Zeng CQ,Jakana J,Lawton JA,Chiu W,Estes MK

更新日期：1996-08-01 00:00:00

abstract：:The ability to trap an object-whether a single atom or a macroscopic entity-affects fields as diverse as quantum optics, soft condensed-matter physics, biophysics and clinical medicine. Many sophisticated methodologies have been developed to counter the randomizing effect of Brownian motion in solution, but stable tra...

journal_title：Nature

authors： Krishnan M,Mojarad N,Kukura P,Sandoghdar V

更新日期：2010-10-07 00:00:00

abstract：:Targeting of proteins to appropriate subcellular compartments is a crucial process in all living cells. Secretory and membrane proteins usually contain an amino-terminal signal peptide, which is recognized by the signal recognition particle (SRP) when nascent polypeptide chains emerge from the ribosome. The SRP-riboso...

journal_title：Nature

authors： Janda CY,Li J,Oubridge C,Hernández H,Robinson CV,Nagai K

更新日期：2010-05-27 00:00:00