Host-microbiota maladaptation in colorectal cancer.

abstract：:Microtubules have a central role in eukaryotic cell polarity, in part through interactions between microtubule end-binding proteins and the cell cortex. In the fission yeast Schizosaccharomyces pombe, microtubules and the polarity modulator tea1p maintain cylindrical cell shape and strictly antipodal cell growth. The ...

journal_title：Nature

authors： Snaith HA,Sawin KE

更新日期：2003-06-05 00:00:00

abstract：:Fermi-liquid theory (the standard model of metals) has been challenged by the discovery of anomalous properties in an increasingly large number of metals. The anomalies often occur near a quantum critical point--a continuous phase transition in the limit of absolute zero, typically between magnetically ordered and par...

journal_title：Nature

authors： Doiron-Leyraud N,Walker IR,Taillefer L,Steiner MJ,Julian SR,Lonzarich GG

更新日期：2003-10-09 00:00:00

abstract：:Bacterial toxins represent a vast reservoir of biochemical diversity that can be repurposed for biomedical applications. Such proteins include a group of predicted interbacterial toxins of the deaminase superfamily, members of which have found application in gene-editing techniques1,2. Because previously described cyt...

journal_title：Nature

authors： Mok BY,de Moraes MH,Zeng J,Bosch DE,Kotrys AV,Raguram A,Hsu F,Radey MC,Peterson SB,Mootha VK,Mougous JD,Liu DR

更新日期：2020-07-01 00:00:00

abstract：:After observation of detailed structural evidence for the origin of birds from dinosaurs, and in light of evidence that dinosaur bone tissue resembles the histology in mammals, the histology of bone has become one of the focal points in discussions of the physiology of dinosaurs and Mesozoic birds. Most of this micros...

journal_title：Nature

authors： Rensberger JM,Watabe M

更新日期：2000-08-10 00:00:00

abstract：:Mineral nitrogen in nature is often found in the form of nitrate (NO3(-)). Numerous microorganisms evolved to assimilate nitrate and use it as a major source of mineral nitrogen uptake. Nitrate, which is central in nitrogen metabolism, is first reduced to nitrite (NO2(-)) through a two-electron reduction reaction. The...

journal_title：Nature

authors： Zheng H,Wisedchaisri G,Gonen T

更新日期：2013-05-30 00:00:00

abstract：:THE cause of extinction of the woolly mammoth, Mammuthus primigenius (Blumenbach), is still debated. A major environmental change at the Pleistocene-Holocene boundary, hunting by early man, or both together are among the main explanations that have been suggested. But hardly anyone has doubted that mammoths had become...

journal_title：Nature

authors： Vartanyan SL,Garutt VE,Sher AV

更新日期：1993-03-25 00:00:00

abstract：:Melanocytes are phenotypically prominent but histologically inconspicuous skin cells. They are responsible for the pigmentation of skin and hair, and thereby contribute to the appearance of skin and provide protection from damage by ultraviolet radiation. Pigmentation mutants in various species are highly informative ...

journal_title：Nature

authors： Lin JY,Fisher DE

更新日期：2007-02-22 00:00:00

abstract：:Multiplicative operations are important in sensory processing, but their biophysical implementation remains largely unknown. We investigated an identified neuron (the lobula giant movement detector, LGMD, of locusts) whose output firing rate in response to looming visual stimuli has been described by two models, one o...

journal_title：Nature

authors： Gabbiani F,Krapp HG,Koch C,Laurent G

更新日期：2002-11-21 00:00:00

abstract：:Activation of a visual pigment molecule to initiate phototransduction requires a minimum energy, Ea, that need not be wholly derived from a photon, but may be supplemented by heat. Theory predicts that absorbance at very long wavelengths declines with the fraction of molecules that have a sufficient complement of ther...

journal_title：Nature

authors： Koskelainen A,Ala-Laurila P,Fyhrquist N,Donner K

更新日期：2000-01-13 00:00:00

abstract：:The solar wind blows outward from the Sun and forms a bubble of solar material in the interstellar medium. The termination shock occurs where the solar wind changes from being supersonic (with respect to the surrounding interstellar medium) to being subsonic. The shock was crossed by Voyager 1 at a heliocentric radius...

journal_title：Nature

authors： Richardson JD,Kasper JC,Wang C,Belcher JW,Lazarus AJ

更新日期：2008-07-03 00:00:00

abstract：:Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the excessive production of mature myeloid cells and arise from the acquisition of somatic driver mutations in haematopoietic stem cells (HSCs). Epidemiological studies indicate a substantial heritable component of MPNs that is among the h...

journal_title：Nature

authors： Bao EL,Nandakumar SK,Liao X,Bick AG,Karjalainen J,Tabaka M,Gan OI,Havulinna AS,Kiiskinen TTJ,Lareau CA,de Lapuente Portilla AL,Li B,Emdin C,Codd V,Nelson CP,Walker CJ,Churchhouse C,de la Chapelle A,Klein DE,Nilsson

更新日期：2020-10-01 00:00:00

abstract：:Direct dating of ductile shear zones and calculation of uplift/exhumation rates can be done using various radiometric dating techniques. But radiometric dating of shallow crustal faulting, which occurs in the crust's brittle regime, has remained difficult because the low temperatures typical of shallow crusted faults ...

journal_title：Nature

authors： van der Pluijm BA,Hall CM,Vrolijk PJ,Pevear DR,Covey MC

更新日期：2001-07-12 00:00:00

abstract：:Modern high-power lasers can generate extreme states of matter that are relevant to astrophysics, equation-of-state studies and fusion energy research. Laser-driven implosions of spherical polymer shells have, for example, achieved an increase in density of 1,000 times relative to the solid state. These densities are ...

journal_title：Nature

authors： Kodama R,Norreys PA,Mima K,Dangor AE,Evans RG,Fujita H,Kitagawa Y,Krushelnick K,Miyakoshi T,Miyanaga N,Norimatsu T,Rose SJ,Shozaki T,Shigemori K,Sunahara A,Tampo M,Tanaka KA,Toyama Y,Yamanaka T,Zepf M

更新日期：2001-08-23 00:00:00

abstract：:Proviruses of avian leukosis virus (ALV) are located in the vicinity of a putative cellular oncogene (c-myc) in ALV-induced bursal lymphomas. Enhanced expression of c-myc occurs in association with proviruses found in any of three configurations: (I) on the 5' side ('upstream') of c-myc in the same transcriptional ori...

journal_title：Nature

authors： Payne GS,Bishop JM,Varmus HE

更新日期：1982-01-21 00:00:00

abstract：:A characteristic feature of induced pinocytosis in Amoeba proteus is the formation of broad channels by invagination of the cell membrane. This process, which requires Ca2+, occurs in response to depolarising cations. High Ca2+ levels reduce pinocytosis induced by cations such as Na+ and Tris+, whereas pinocytosis ind...

journal_title：Nature

authors： Josefsson JO,Johansson P

更新日期：1979-11-01 00:00:00

abstract：:The gene encoding the large-T protein of polyoma virus (plt), the E1A genes of adenoviruses, the viral myc gene (v-myc) or rearranged forms of the cellular c-myc gene confer on rat embryo fibroblast (REF) cells in primary culture a series of new properties ('immortality', reduced serum requirement and sensitivity to t...

journal_title：Nature

authors： Connan G,Rassoulzadegan M,Cuzin F

更新日期：1985-03-21 00:00:00

abstract：:Oscillations in cyclin-dependent kinase (CDK) activity drive the somatic cell cycle. After entry into mitosis, CDKs activate the anaphase-promoting complex (APC), which then promotes cyclin degradation and mitotic exit. The re-accumulation of cyclin A causes the inactivation of APC and entry into S phase, but how cycl...

journal_title：Nature

authors： Rape M,Kirschner MW

更新日期：2004-12-02 00:00:00

abstract：:Serine proteases are present in virtually all organisms and function both inside and outside the cell; they exist as two families, the 'trypsin-like' and the 'subtilisin-like', that have independently evolved a similar catalytic device characterized by the Ser, His, Asp triad, an oxyanion binding site, and possibly ot...

journal_title：Nature

authors： Carter P,Wells JA

更新日期：1988-04-07 00:00:00

abstract：:Genotypic variation among independent isolates of human immunodeficiency virus type-1 (HIV-1) is well known, but its molecular basis and biological consequences are poorly understood. We examined the genesis of molecular variation in HIV-1 by sequential virus isolations from two chronically infected individuals and an...

journal_title：Nature

authors： Saag MS,Hahn BH,Gibbons J,Li Y,Parks ES,Parks WP,Shaw GM

更新日期：1988-08-04 00:00:00

abstract：:Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determine both disease suscep...

journal_title：Nature

authors： Todd JA,Bell JI,McDevitt HO

更新日期：1987-10-15 00:00:00

abstract：:Recognition and removal of apoptotic cells by professional phagocytes, including dendritic cells and macrophages, preserves immune self-tolerance and prevents chronic inflammation and autoimmune pathologies. The diverse array of phagocytes that reside within different tissues, combined with the necessarily prompt natu...

journal_title：Nature

authors： Cummings RJ,Barbet G,Bongers G,Hartmann BM,Gettler K,Muniz L,Furtado GC,Cho J,Lira SA,Blander JM

更新日期：2016-11-24 00:00:00

abstract：:Some people inherit an unfortunate combination of genetic sequences, such that exposure to an external trigger causes their immune response to turn on their own tissues. Although mutations in a single gene can cause autoimmunity, most autoimmune diseases are associated with several sequence variants. Marked advances i...

journal_title：Nature

authors： Rioux JD,Abbas AK

更新日期：2005-06-02 00:00:00

abstract：:Human behaviour is thought to spread through face-to-face social networks, but it is difficult to identify social influence effects in observational studies, and it is unknown whether online social networks operate in the same way. Here we report results from a randomized controlled trial of political mobilization mes...

journal_title：Nature

authors： Bond RM,Fariss CJ,Jones JJ,Kramer AD,Marlow C,Settle JE,Fowler JH

更新日期：2012-09-13 00:00:00

abstract：:The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 A resolution. TFIIA is composed of a beta-barrel and a four-helix bundle motif that together have a boot-like appearance. The beta-barrel extends the TBP beta-...

journal_title：Nature

authors： Tan S,Hunziker Y,Sargent DF,Richmond TJ

更新日期：1996-05-09 00:00:00

abstract：:Type 1 diabetes (T1D) is a debilitating autoimmune disease that results from T-cell-mediated destruction of insulin-producing beta-cells. Its incidence has increased during the past several decades in developed countries, suggesting that changes in the environment (including the human microbial environment) may influe...

journal_title：Nature

authors： Wen L,Ley RE,Volchkov PY,Stranges PB,Avanesyan L,Stonebraker AC,Hu C,Wong FS,Szot GL,Bluestone JA,Gordon JI,Chervonsky AV

更新日期：2008-10-23 00:00:00

abstract：:Mating and egg laying are tightly cooordinated events in the reproductive life of all oviparous females. Oviposition is typically rare in virgin females but is initiated after copulation. Here we identify the neural circuitry that links egg laying to mating status in Drosophila melanogaster. Activation of female-speci...

journal_title：Nature

authors： Wang F,Wang K,Forknall N,Patrick C,Yang T,Parekh R,Bock D,Dickson BJ

更新日期：2020-03-01 00:00:00

abstract：:Therapeutic vaccines derived from carbohydrate antigen-adjuvant combinations are a promising approach for cancer immunotherapy. One of the critical limitations in this area is access to sufficient quantities of tumour-associated carbohydrate antigens and glycoconjugate adjuvants. At present, availability of the comple...

journal_title：Nature

authors： Galonić DP,Gin DY

更新日期：2007-04-26 00:00:00

abstract：:Since the discovery of the first exoplanets, it has been known that other planetary systems can look quite unlike our own. Until fairly recently, we have been able to probe only the upper range of the planet size distribution, and, since last year, to detect planets that are the size of Earth or somewhat smaller. Hith...

journal_title：Nature

authors： Barclay T,Rowe JF,Lissauer JJ,Huber D,Fressin F,Howell SB,Bryson ST,Chaplin WJ,Désert JM,Lopez ED,Marcy GW,Mullally F,Ragozzine D,Torres G,Adams ER,Agol E,Barrado D,Basu S,Bedding TR,Buchhave LA,Charbonneau D,Ch

更新日期：2013-02-28 00:00:00

abstract：:Regulatory aspects of the Warnock Committee's report on reproductive technologies are summarized. A licensing authority with "substantial lay representation" would license practitioners and approve experimentation. Artificial insemination by donor would become a regulated service, and resulting children would be leg...

journal_title：Nature

authors：

更新日期：1984-07-26 00:00:00

abstract：:The Earth's mantle is isotopically heterogeneous on length scales ranging from centimetres to more than 10(4) kilometres. This heterogeneity originates from partial melt extraction and plate tectonic recycling, whereas stirring during mantle convection tends to reduce it. Here we show that mid-ocean ridge basalts from...

journal_title：Nature

authors： Graham DW,Blichert-Toft J,Russo CJ,Rubin KH,Albarède F

更新日期：2006-03-09 00:00:00