Chemical glycosylation in the synthesis of glycoconjugate antitumour vaccines.

abstract：:The ability to design proteins with high affinity and selectivity for any given small molecule is a rigorous test of our understanding of the physiochemical principles that govern molecular recognition. Attempts to rationally design ligand-binding proteins have met with little success, however, and the computational d...

journal_title：Nature

authors： Tinberg CE,Khare SD,Dou J,Doyle L,Nelson JW,Schena A,Jankowski W,Kalodimos CG,Johnsson K,Stoddard BL,Baker D

更新日期：2013-09-12 00:00:00

abstract：:Four-residue beta-turns and larger loop structures represent a significant fraction of globular protein surfaces and play an important role in determining the conformation and specificity of enzyme active sites and antibody-combining sites. Turns are an attractive starting point to develop protein design methods, as t...

journal_title：Nature

authors： Hynes TR,Kautz RA,Goodman MA,Gill JF,Fox RO

更新日期：1989-05-04 00:00:00

abstract：:To achieve stereoscopic vision, the brain must search for corresponding image features on the two retinas. As long as the eyes stay still, corresponding features are confined to narrow bands called epipolar lines. But when the eyes change position, the epipolar lines migrate on the retinas. To find the matching featur...

journal_title：Nature

authors： Schreiber K,Crawford JD,Fetter M,Tweed D

更新日期：2001-04-12 00:00:00

abstract：:Synapse assembly requires trans-synaptic signals between the pre- and postsynapse, but our understanding of the essential organizational molecules involved in this process remains incomplete. Teneurin proteins are conserved, epidermal growth factor (EGF)-repeat-containing transmembrane proteins with large extracellula...

journal_title：Nature

authors： Mosca TJ,Hong W,Dani VS,Favaloro V,Luo L

更新日期：2012-03-18 00:00:00

abstract：:An emerging concept in the field of cancer biology is that a rare population of 'tumour stem cells' exists among the heterogeneous group of cells that constitute a tumour. This concept, best described with human leukaemia, indicates that stem cell function (whether normal or neoplastic) might be defined by a common se...

journal_title：Nature

authors： Lessard J,Sauvageau G

更新日期：2003-05-15 00:00:00

abstract：:Ground- and aircraft-based measurements show that the seasonal amplitude of Northern Hemisphere atmospheric carbon dioxide (CO2) concentrations has increased by as much as 50 per cent over the past 50 years. This increase has been linked to changes in temperate, boreal and arctic ecosystem properties and processes suc...

journal_title：Nature

authors： Gray JM,Frolking S,Kort EA,Ray DK,Kucharik CJ,Ramankutty N,Friedl MA

更新日期：2014-11-20 00:00:00

abstract：:Cas9 is an RNA-guided DNA endonuclease that targets foreign DNA for destruction as part of a bacterial adaptive immune system mediated by clustered regularly interspaced short palindromic repeats (CRISPR). Together with single-guide RNAs, Cas9 also functions as a powerful genome engineering tool in plants and animals,...

journal_title：Nature

authors： Sternberg SH,LaFrance B,Kaplan M,Doudna JA

更新日期：2015-11-05 00:00:00

abstract：:Patchwork homology observed between divergent members of polymorphic multigene families is thought to reflect evolution by short-tract gene conversion (nonreciprocal recombination), although this mechanism cannot usually be confirmed in higher organisms. In contrast to meiotic conversions observed in laboratory yeast ...

journal_title：Nature

authors： Wheeler CJ,Maloney D,Fogel S,Goodenow RS

更新日期：1990-09-13 00:00:00

abstract：:OTULIN (OTU deubiquitinase with linear linkage specificity) removes linear polyubiquitin from proteins that have been modified by LUBAC (linear ubiquitin chain assembly complex) and is critical for preventing auto-inflammatory disease1,2 and embryonic lethality during mouse development3. Here we show that OTULIN promo...

journal_title：Nature

authors： Heger K,Wickliffe KE,Ndoja A,Zhang J,Murthy A,Dugger DL,Maltzman A,de Sousa E Melo F,Hung J,Zeng Y,Verschueren E,Kirkpatrick DS,Vucic D,Lee WP,Roose-Girma M,Newman RJ,Warming S,Hsiao YC,Kőműves LG,Webster JD,Newto

更新日期：2018-07-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) and other neurotrophins have a vital role in the development of the rat and mouse nervous system by influencing the expression of many specific genes that promote differentiation, cell survival, synapse formation and, later, synaptic plasticity. Although nitric oxide (NO) is kn...

journal_title：Nature

authors： Nott A,Watson PM,Robinson JD,Crepaldi L,Riccio A

更新日期：2008-09-18 00:00:00

abstract：:The ability to excise (repair) UV-induced pyrimidine dimers in Escherichia coli is not related to its ability to remove N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced O6-methylguanine (O6-MeG) from DNA. It was therefore surprising that certain xeroderma pigmentosum cell lines, deficient in dimer excision, were al...

journal_title：Nature

authors： Sklar R,Strauss B

更新日期：1981-01-29 00:00:00

abstract：:Haematopoiesis is an essential process that evolved in multicellular animals. At the heart of this process are haematopoietic stem cells (HSCs), which are multipotent and self-renewing, and generate the entire repertoire of blood and immune cells throughout an animal's life1. Although there have been comprehensive stu...

journal_title：Nature

authors： Rosental B,Kowarsky M,Seita J,Corey DM,Ishizuka KJ,Palmeri KJ,Chen SY,Sinha R,Okamoto J,Mantalas G,Manni L,Raveh T,Clarke DN,Tsai JM,Newman AM,Neff NF,Nolan GP,Quake SR,Weissman IL,Voskoboynik A

更新日期：2018-12-01 00:00:00

abstract：:Quantum mechanical experiments in ring geometries have long fascinated physicists. Open rings connected to leads, for example, allow the observation of the Aharonov-Bohm effect, one of the best examples of quantum mechanical phase coherence. The phase coherence of electrons travelling through a quantum dot embedded in...

journal_title：Nature

authors： Fuhrer A,Lüscher S,Ihn T,Heinzel T,Ensslin K,Wegscheider W,Bichler M

更新日期：2001-10-25 00:00:00

abstract：:Sex chromosomes in males of most eutherian mammals share only a small homologous segment, the pseudoautosomal region (PAR), in which the formation of double-strand breaks (DSBs), pairing and crossing over must occur for correct meiotic segregation1,2. How cells ensure that recombination occurs in the PAR is unknown. H...

journal_title：Nature

authors： Acquaviva L,Boekhout M,Karasu ME,Brick K,Pratto F,Li T,van Overbeek M,Kauppi L,Camerini-Otero RD,Jasin M,Keeney S

更新日期：2020-06-01 00:00:00

abstract：:Cells operate in dynamic environments using extraordinary communication capabilities that emerge from the interactions of genetic circuitry. The mammalian immune response is a striking example of the coordination of different cell types. Cell-to-cell communication is primarily mediated by signalling molecules that for...

journal_title：Nature

authors： Tay S,Hughey JJ,Lee TK,Lipniacki T,Quake SR,Covert MW

更新日期：2010-07-08 00:00:00

abstract：:The Gakkel ridge, which extends under the Arctic ice cap for approximately 1,800 km, is the slowest spreading ocean ridge on Earth. Its spreading created the Eurasian basin, which is isolated from the rest of the oceanic mantle by North America, Eurasia and the Lomonosov ridge. The Gakkel ridge thus provides unique op...

journal_title：Nature

authors： Goldstein SL,Soffer G,Langmuir CH,Lehnert KA,Graham DW,Michael PJ

更新日期：2008-05-01 00:00:00

abstract：:Recent studies have demonstrated that monkeys and humans can use signals from the brain to guide computer cursors. Brain-computer interfaces (BCIs) may one day assist patients suffering from neurological injury or disease, but relatively low system performance remains a major obstacle. In fact, the speed and accuracy ...

journal_title：Nature

authors： Santhanam G,Ryu SI,Yu BM,Afshar A,Shenoy KV

更新日期：2006-07-13 00:00:00

abstract：:Human T-cell receptors for antigen and major histocompatibility complex (MHC) determinants have now been defined on inducer, suppressor, and class 1 and class 2 MHC-specific cytotoxic T lymphocytes as T3-associated clonotypic molecules (Ti) of relative molecular mass 90,000 (90K) composed of one 49-54K alpha- and one ...

journal_title：Nature

authors： Fabbi M,Acuto O,Smart JE,Reinherz EL

更新日期：1984-11-15 00:00:00

abstract：:Paired-associate learning is often used to examine episodic memory in humans. Animal models include the recall of food-cache locations by scrub jays and sequential memory. Here we report a model in which rats encode, during successive sample trials, two paired associates (flavours of food and their spatial locations) ...

journal_title：Nature

authors： Day M,Langston R,Morris RG

更新日期：2003-07-10 00:00:00

abstract：:Type III collagen is often found in the same tissues as type I collagen, yet the function and nature of the fibrils formed by the two collagens differ markedly. To understand the evolutionary history of the collagen gene family in more detail, we isolated the gene for type III collagen and compared its structure with ...

journal_title：Nature

authors： Yamada Y,Liau G,Mudryj M,Obici S,de Crombrugghe B

更新日期：1984-07-26 00:00:00

abstract：:Cosmological models in which dark matter consists of cold elementary particles predict that the dark halo population should extend to masses many orders of magnitude below those at which galaxies can form1-3. Here we report a cosmological simulation of the formation of present-day haloes over the full range of observe...

journal_title：Nature

authors： Wang J,Bose S,Frenk CS,Gao L,Jenkins A,Springel V,White SDM

更新日期：2020-09-01 00:00:00

abstract：: ...

journal_title：Nature

authors： Witze A

更新日期：2019-03-01 00:00:00

abstract：:In plants, the small GTP-binding proteins called Rops work as signalling switches that control growth, development and plant responses to various environmental stimuli. Rop proteins (Rho of plants, Rac-like and AtRac in Arabidopsis thaliana) belong to the Rho family of Ras-related GTP-binding proteins that turn on sig...

journal_title：Nature

authors： Berken A,Thomas C,Wittinghofer A

更新日期：2005-08-25 00:00:00

abstract：:During the last glacial period, the Laurentide Ice Sheet sporadically discharged huge numbers of icebergs through the Hudson Strait into the North Atlantic Ocean, leaving behind distinct layers of ice-rafted debris in the ocean sediments. Perplexingly, these massive discharge events-Heinrich events-occurred during the...

journal_title：Nature

authors： Bassis JN,Petersen SV,Mac Cathles L

更新日期：2017-02-15 00:00:00

abstract：:The computations performed by local neural populations, such as a cortical layer, are typically inferred from anatomical connectivity and observations of neural activity. Here we describe a method-influence mapping-that uses single-neuron perturbations to directly measure how cortical neurons reshape sensory represent...

journal_title：Nature

authors： Chettih SN,Harvey CD

更新日期：2019-03-01 00:00:00

abstract：:The histocompatibility-Y (H-Y) antigen is a minor histocompatibility antigen which has been detected on cell surfaces from the heterogametic sexes of mammalian, bird, amphibian, teleost and invertebrate species. H-Y is thought to be a male-determining substance in mammals because of its almost perfect correlation with...

journal_title：Nature

authors： Shapiro M,Erickson RP

更新日期：1981-04-09 00:00:00

abstract：:The recurrent patterns in the commonness and rarity of species in ecological communities--the relative species abundance--have puzzled ecologists for more than half a century. Here we show that the framework of the current neutral theory in ecology can easily be generalized to incorporate symmetric density dependence....

journal_title：Nature

authors： Volkov I,Banavar JR,He F,Hubbell SP,Maritan A

更新日期：2005-12-01 00:00:00

abstract：:The developmental fate of immature thymocytes is determined by the specificity of their T-cell antigen receptors (TCRs). Immature CD4+8+ thymocytes are positively selected to differentiate into mature T cells by recognition of peptides associated with major histocompatibility complex (MHC) encoded molecules on thymic ...

journal_title：Nature

authors： Takahama Y,Suzuki H,Katz KS,Grusby MJ,Singer A

更新日期：1994-09-01 00:00:00

abstract：:The metabolic basis of the autosomal recessive disease cystic fibrosis (CF) remains unidentified. Elevated levels of a serum protein in CF homozygotes and obligate heterozygotes have been described. As heterozygotes are clinically unaffected, any consistently observed abnormality in these individuals is a likely point...

journal_title：Nature

authors： Dorin JR,Novak M,Hill RE,Brock DJ,Secher DS,van Heyningen V

更新日期：1987-04-09 00:00:00

abstract：:The src gene product, p60src, of Rous sarcoma virus (RSV) is a tyrosine-specific protein kinase which is associated with the plasma membrane of infected cells. Myristic acid is bound in an amide linkage to glycine 2 of p60src. Of the N-terminal 30 kilodaltons of p60src, only amino acids 1-14 are required for myristyla...

journal_title：Nature

authors： Pellman D,Garber EA,Cross FR,Hanafusa H

更新日期：1985-03-28 00:00:00