Naloxone-reversible effect of opioids on pinocytosis in Amoeba proteus.

abstract：:Monocular lid suture during the sensitive period early in the life of a kitten disrupts normal development of inputs from the two eyes to the visual cortex, causing a decrease in the fraction of cortical cells responding to the deprived eye. Such an ocular dominance shift has been assumed to depend on patterned visual...

journal_title：Nature

authors： Chapman B,Jacobson MD,Reiter HO,Stryker MP

更新日期：1986-11-13 00:00:00

abstract：:Remodelling its shape, or morphogenesis, is a fundamental property of living tissue. It underlies much of embryonic development and numerous pathologies. Convergent extension (CE) of the axial mesoderm of vertebrates is an intensively studied model for morphogenetic processes that rely on cell rearrangement. It involv...

journal_title：Nature

authors： Ninomiya H,Elinson RP,Winklbauer R

更新日期：2004-07-15 00:00:00

abstract：:Long before infants reach, crawl or walk, they explore the world by looking: they look to learn and to engage, giving preferential attention to social stimuli, including faces, face-like stimuli and biological motion. This capacity-social visual engagement-shapes typical infant development from birth and is pathognomo...

journal_title：Nature

authors： Constantino JN,Kennon-McGill S,Weichselbaum C,Marrus N,Haider A,Glowinski AL,Gillespie S,Klaiman C,Klin A,Jones W

更新日期：2017-07-20 00:00:00

abstract：:Gram-negative bacteria possess a complex cell envelope that consists of a plasma membrane, a peptidoglycan cell wall and an outer membrane. The envelope is a selective chemical barrier1 that defines cell shape2 and allows the cell to sustain large mechanical loads such as turgor pressure3. It is widely believed that t...

journal_title：Nature

authors： Rojas ER,Billings G,Odermatt PD,Auer GK,Zhu L,Miguel A,Chang F,Weibel DB,Theriot JA,Huang KC

更新日期：2018-07-01 00:00:00

abstract：:The discovery of Higgs-boson decays in a background of standard-model processes was assisted by machine learning methods. The classifiers used to separate signals such as these from background are trained using highly unerring but not completely perfect simulations of the physical processes involved, often resulting i...

journal_title：Nature

authors： Mott A,Job J,Vlimant JR,Lidar D,Spiropulu M

更新日期：2017-10-18 00:00:00

abstract：:The hydrosulphide ion (HS(-)) and its undissociated form, hydrogen sulphide (H(2)S), which are believed to have been critical to the origin of life on Earth, remain important in physiology and cellular signalling. As a major metabolite in anaerobic bacterial growth, hydrogen sulphide is a product of both assimilatory ...

journal_title：Nature

authors： Czyzewski BK,Wang DN

更新日期：2012-03-11 00:00:00

abstract：:The annual cycle in the Earth's surface temperature is extremely large-comparable in magnitude to the glacial-interglacial cycles over most of the planet. Trends in the phase and the amplitude of the annual cycle have been observed, but the causes and significance of these changes remain poorly understood-in part beca...

journal_title：Nature

authors： Stine AR,Huybers P,Fung IY

更新日期：2009-01-22 00:00:00

abstract：:Specific genes can be inactivated or mutated in the mouse germ line. The phenotypic consequences of the mutation can provide pivotal information on the function of the gene in development and maintenance of the mammalian organism. The procedure entails homologous recombination in embryonic stem cells, which, on fusion...

journal_title：Nature

authors： te Riele H,Maandag ER,Clarke A,Hooper M,Berns A

更新日期：1990-12-13 00:00:00

abstract：:The architecture of trabecular bone, the porous bone found in the spine and at articulating joints, provides the requirements for optimal load transfer, by pairing suitable strength and stiffness to minimal weight according to rules of mathematical design. But, as it is unlikely that the architecture is fully pre-prog...

journal_title：Nature

authors： Huiskes R,Ruimerman R,van Lenthe GH,Janssen JD

更新日期：2000-06-08 00:00:00

abstract：:The origin of cooperation is a central challenge to our understanding of evolution. The fact that microbial interactions can be manipulated in ways that animal interactions cannot has led to a growing interest in microbial models of cooperation and competition. For the budding yeast Saccharomyces cerevisiae to grow on...

journal_title：Nature

authors： Gore J,Youk H,van Oudenaarden A

更新日期：2009-05-14 00:00:00

abstract：:Every cancer originates from a single cell. During expansion of the neoplastic cell population, individual cells acquire genetic and phenotypic differences from each other. Here, to investigate the nature and extent of intra-tumour diversification, we characterized organoids derived from multiple single cells from thr...

journal_title：Nature

authors： Roerink SF,Sasaki N,Lee-Six H,Young MD,Alexandrov LB,Behjati S,Mitchell TJ,Grossmann S,Lightfoot H,Egan DA,Pronk A,Smakman N,van Gorp J,Anderson E,Gamble SJ,Alder C,van de Wetering M,Campbell PJ,Stratton MR,Clevers

更新日期：2018-04-01 00:00:00

abstract：:(Na+ + K+)ATPase contains two different subunits, a catalytic subunit (alpha) and a subunit with uncertain function (beta). The enzyme binds ATP, ouabain and vanadate, and can be phosphorylated by ATP as well as by inorganic phosphate. From the previously reported maximal binding and phosphorylation capacities of 3.5-...

journal_title：Nature

authors： Peters WH,Swarts HG,de Pont JJ,Schuurmans Stekhoven FM,Bonting SL

更新日期：1981-03-26 00:00:00

abstract：:Intracellular responses recorded in vitro from the cochleas of anaesthetized mammals have shown that the mechanoreceptive inner and outer hair cells are sharply tuned, accounting for many of the properties of the afferent fibres in the auditory nerve. However, in vivo it has not been possible to measure directly the e...

journal_title：Nature

authors： Russell IJ,Richardson GP,Cody AR

更新日期：1986-05-29 00:00:00

abstract：:Nicotine obtained from tobacco can improve learning and memory on various tasks and has been linked to arousal, attention, rapid information processing, working memory, and long-term memories that can cause craving years after someone has stopped smoking. One likely target for these effects is the hippocampus, a centr...

journal_title：Nature

authors： Gray R,Rajan AS,Radcliffe KA,Yakehiro M,Dani JA

更新日期：1996-10-24 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： DeRocher KA,Smeets PJM,Goodge BH,Zachman MJ,Balachandran PV,Stegbauer L,Cohen MJ,Gordon LM,Rondinelli JM,Kourkoutis LF,Joester D

更新日期：2020-08-01 00:00:00

abstract：:The recruitment model for gene activation stipulates that an activator works by bringing the transcriptional machinery to the DNA. Recent experiments in bacteria and yeast indicate that many genes can be activated by this mechanism. These findings have implications for our understanding of the nature of activating reg...

journal_title：Nature

authors： Ptashne M,Gann A

更新日期：1997-04-10 00:00:00

abstract：:In Drosophila, the establishment of regional commitments along most of the anterior/posterior axis of the developing embryo depends on two clusters of homeotic genes: the Antennapedia complex (ANT-C) and the bithorax complex (BX-C). The red flour beetle has a single complex (HOM-C) representing the homologues of the...

journal_title：Nature

authors： Stuart JJ,Brown SJ,Beeman RW,Denell RE

更新日期：1991-03-07 00:00:00

abstract：:The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a ligand-dependent transcription factor that is important in adipocyte differentiation and glucose homeostasis and which depends on interactions with co-activators, including steroid receptor co-activating factor-1 (SRC-1). Here we present the X-ray ...

journal_title：Nature

authors： Nolte RT,Wisely GB,Westin S,Cobb JE,Lambert MH,Kurokawa R,Rosenfeld MG,Willson TM,Glass CK,Milburn MV

更新日期：1998-09-10 00:00:00

abstract：:Sex roles are typically thought of as being fixed for a given species. In most animals males compete for females, whereas the females are more reluctant to mate. Therefore sexual selection usually acts most strongly on males. This is explained by males having a higher potential reproductive rate than females, leading ...

journal_title：Nature

authors： Forsgren E,Amundsen T,Borg AA,Bjelvenmark J

更新日期：2004-06-03 00:00:00

abstract：:Neurotransmitter/sodium symporters (NSSs) couple the uptake of neurotransmitter with one or more sodium ions, removing neurotransmitter from the synaptic cleft. NSSs are essential to the function of chemical synapses, are associated with multiple neurological diseases and disorders, and are the targets of therapeutic ...

journal_title：Nature

authors： Piscitelli CL,Krishnamurthy H,Gouaux E

更新日期：2010-12-23 00:00:00

abstract：:The most striking feature of the Sun's magnetic field is its cyclic behaviour. The number of sunspots, which are dark regions of strong magnetic field on the Sun's surface, varies with a period of about 11 years. Superposed on this cycle are secular changes that occur on timescales of centuries and events like the Mau...

journal_title：Nature

authors： Solanki SK,Schüssler M,Fligge M

更新日期：2000-11-23 00:00:00

abstract：:During the last glacial period, the Laurentide Ice Sheet sporadically discharged huge numbers of icebergs through the Hudson Strait into the North Atlantic Ocean, leaving behind distinct layers of ice-rafted debris in the ocean sediments. Perplexingly, these massive discharge events-Heinrich events-occurred during the...

journal_title：Nature

authors： Bassis JN,Petersen SV,Mac Cathles L

更新日期：2017-02-15 00:00:00

abstract：:The retinotectal projection has long been studied experimentally and theoretically, as a model for the formation of topographic brain maps. Neighbouring retinal ganglion cells (RGCs) project their axons to neighbouring positions in the optic tectum, thus re-establishing a continuous neural representation of visual spa...

journal_title：Nature

authors： Gosse NJ,Nevin LM,Baier H

更新日期：2008-04-17 00:00:00

abstract：:The verification of nuclear warheads for arms control involves a paradox: international inspectors will have to gain high confidence in the authenticity of submitted items while learning nothing about them. Proposed inspection systems featuring 'information barriers', designed to hide measurements stored in electronic...

journal_title：Nature

authors： Glaser A,Barak B,Goldston RJ

更新日期：2014-06-26 00:00:00

abstract：:Defining the functional relationships between proteins is critical for understanding virtually all aspects of cell biology. Large-scale identification of protein complexes has provided one important step towards this goal; however, even knowledge of the stoichiometry, affinity and lifetime of every protein-protein int...

journal_title：Nature

authors： Collins SR,Miller KM,Maas NL,Roguev A,Fillingham J,Chu CS,Schuldiner M,Gebbia M,Recht J,Shales M,Ding H,Xu H,Han J,Ingvarsdottir K,Cheng B,Andrews B,Boone C,Berger SL,Hieter P,Zhang Z,Brown GW,Ingles CJ,Emili

更新日期：2007-04-12 00:00:00

abstract：:The delivery of therapeutic drugs to solid tumours may be impaired by structural and functional abnormalities in blood and lymphatic vessels. Here we provide evidence that proliferating cancer cells cause intratumour vessels to compress and collapse. By reducing this compressive mechanical force and opening vessels, c...

journal_title：Nature

authors： Padera TP,Stoll BR,Tooredman JB,Capen D,di Tomaso E,Jain RK

更新日期：2004-02-19 00:00:00

abstract：:Interleukin-2 (IL-2) is a regulatory peptide important for the growth and differentiation of antigen-specific T lymphocytes and large granular lymphocytes. Interaction of IL-2 with its specific receptor results in the promotion of S-phase progression as well as, in certain circumstances, the production and release of ...

journal_title：Nature

authors： Farrar WL,Anderson WB

更新日期：1985-05-16 00:00:00

abstract：:Phase and antigenic variation of pilin expression in Neisseria gonorrhoeae result from recombination events in which variant sequences from one of the silent loci (pilS) are transferred to the expression locus (pilE). Such rearrangements were originally thought to be gene conversions, but findings showing that phase v...

journal_title：Nature

authors： Gibbs CP,Reimann BY,Schultz E,Kaufmann A,Haas R,Meyer TF

更新日期：1989-04-20 00:00:00

abstract：:The TE1 family of transposable elements (TEs) of Drosophila consists of unusually large transposons, cytologically visible in larval polytene chromosomes as one or more bands. They are composite elements, as their termini consist of foldback (FB) sequences which are themselves transposable. The location of FB elements...

journal_title：Nature

authors： Chia W,McGill S,Karp R,Gubb D,Ashburner M

更新日期：1985-07-04 00:00:00

abstract：:The vasa gene product of Drosophila melanogaster is required only in the female germ line. Progeny of females homozygous for vasa mutations lack posterior structures and pole cells. Isolation and characterization of vasa genomic and complementary DNA clones show that the transcript is abundant in the female germ line ...

journal_title：Nature

authors： Lasko PF,Ashburner M

更新日期：1988-10-13 00:00:00