Abstract:
:Microtubules have a central role in eukaryotic cell polarity, in part through interactions between microtubule end-binding proteins and the cell cortex. In the fission yeast Schizosaccharomyces pombe, microtubules and the polarity modulator tea1p maintain cylindrical cell shape and strictly antipodal cell growth. The tea1p protein is transported to cell tips by association with growing microtubule plus ends; once at cell tips, tea1p releases from microtubule ends and associates with the cell cortex, where it coordinates polarized growth. Here we describe a cortical protein, mod5p, that regulates the dynamic behaviour of tea1p. In mod5Delta cells, tea1p is efficiently transported on microtubules to cell tips but fails to anchor properly at the cortex and thus fails to accumulate to normal levels. mod5p contains a signal for carboxy-terminal prenylation and in wild-type cells is associated with the plasma membrane at cell tips. However, in tea1Delta cells, although mod5p remains localized to the plasma membrane, mod5p is no longer restricted to the cell tips. We propose that tea1p and mod5p act in a positive-feedback loop in the microtubule-mediated regulation of cell polarity.
journal_name
Naturejournal_title
Natureauthors
Snaith HA,Sawin KEdoi
10.1038/nature01672keywords:
subject
Has Abstractpub_date
2003-06-05 00:00:00pages
647-51issue
6940eissn
0028-0836issn
1476-4687pii
nature01672journal_volume
423pub_type
杂志文章相关文献
NATURE文献大全abstract::Psoriasis is a chronic inflammatory skin disorder that affects approximately 2-3% of the population worldwide and has severe effects on patients' physical and psychological well-being. The discovery that psoriasis is an immune-mediated disease has led to more targeted, effective therapies; recent advances have focused...
journal_title:Nature
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/nature14175
更新日期:2015-05-14 00:00:00
abstract::Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determine both disease suscep...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/329599a0
更新日期:1987-10-15 00:00:00
abstract::Humans are able to classify novel items correctly by category; some other animals have also been shown to do this. During category learning, humans group perceptual stimuli by abstracting qualities from similarity relationships of their physical properties. Forming categories is fundamental to cognition and can be ind...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35089076
更新日期:2001-08-16 00:00:00
abstract::Homopyrimidine oligonucleotides bind to homopurine-homopyrimidine sequences of duplex DNA forming a local triple helix. This binding can be demonstrated either directly by a footprinting technique, gel assays, or indirectly by inducing irreversible reactions in the target sequence, such as photocrosslinking or cleavag...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/344358a0
更新日期:1990-03-22 00:00:00
abstract::A main limitation of therapies that selectively target kinase signalling pathways is the emergence of secondary drug resistance. Cetuximab, a monoclonal antibody that binds the extracellular domain of epidermal growth factor receptor (EGFR), is effective in a subset of KRAS wild-type metastatic colorectal cancers. Aft...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11156
更新日期:2012-06-28 00:00:00
abstract::Pro-inflammatory cytokines activate the transcription factor NF-kappaB by stimulating the activity of a protein kinase that phosphorylates IkappaB, an inhibitor of NF-kappaB, at sites that trigger its ubiquitination and degradation. This results in the nuclear translocation of freed NF-kappaB dimers and the activation...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/26261
更新日期:1998-09-17 00:00:00
abstract::Crossover recombination events between homologous chromosomes are required to form chiasmata, temporary connections between homologues that ensure their proper segregation at meiosis I. Despite this requirement for crossovers and an excess of the double-strand DNA breaks that are the initiating events for meiotic reco...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12577
更新日期:2013-10-31 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 面试
doi:10.1038/d41586-018-07198-z
更新日期:2018-11-01 00:00:00
abstract::Local galaxies are broadly divided into two main classes, star-forming (gas-rich) and quiescent (passive and gas-poor). The primary mechanism responsible for quenching star formation in galaxies and transforming them into quiescent and passive systems is still unclear. Sudden removal of gas through outflows or strippi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14439
更新日期:2015-05-14 00:00:00
abstract::Non-insulin-dependent diabetes mellitus (NIDDM) is a major health problem, affecting 5% of the world population. Genetic factors are important in NIDDM, but the mechanisms leading to glucose intolerance are unknown. Genetic linkage has been investigated in multigeneration families to localize, and ultimately identify,...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/356162a0
更新日期:1992-03-12 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 评论,新闻
doi:10.1038/d41586-019-00260-4
更新日期:2019-02-01 00:00:00
abstract::The search to understand the mechanisms regulating brain wiring has relied on biochemical purification approaches in vertebrates and genetic approaches in invertebrates to identify molecular cues and receptors for axon guidance. Here we describe a phenotype-based gene-trap screen in mice designed for the large-scale i...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35065539
更新日期:2001-03-08 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/d41586-019-00676-y
更新日期:2019-02-01 00:00:00
abstract::In multinucleated heterokaryons formed from the fusion of differentiated muscle cells to either hepatocytes or fibroblasts, muscle-specific gene expression is activated, liver-specific gene expression is repressed, and there are changes in the location of the Golgi apparatus. An understanding of the regulatory mechani...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/344454a0
更新日期:1990-03-29 00:00:00
abstract::Cocaine is a powerfully addictive substance and new strategies are needed to treat its abuse. Generating an active immunization to cocaine offers a means of blocking the actions of the drug by preventing it from entering the central nervous system, and should have fewer side effects than treatments based on manipulati...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/378727a0
更新日期:1995-12-14 00:00:00
abstract::In Drosophila and mice, olfactory receptor neurons (ORNs) expressing the same receptors have convergent axonal projections to specific glomerular targets in the antennal lobe/olfactory bulb, creating an odour map in this first olfactory structure of the central nervous system. Projection neurons of the Drosophila ante...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35102574
更新日期:2001-11-08 00:00:00
abstract::Melanoma is a tumour of transformed melanocytes, which are originally derived from the embryonic neural crest. It is unknown to what extent the programs that regulate neural crest development interact with mutations in the BRAF oncogene, which is the most commonly mutated gene in human melanoma. We have used zebrafish...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09882
更新日期:2011-03-24 00:00:00
abstract::Obesity is now so common within the world's population that it is beginning to replace undernutrition and infectious diseases as the most significant contributor to ill health. In particular, obesity is associated with diabetes mellitus, coronary heart disease, certain forms of cancer, and sleep-breathing disorders. O...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/35007508
更新日期:2000-04-06 00:00:00
abstract::Understanding the nature and origin of the asteroid population in Earth's vicinity (near-Earth asteroids, and its subset of potentially hazardous asteroids) is a matter of both scientific interest and practical importance. It is generally expected that the compositions of the asteroids that are most likely to hit Eart...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07154
更新日期:2008-08-14 00:00:00
abstract::When a person walks through a rigid environment while holding eyes and head fixed, the pattern of retinal motion flows radially away from a point, the focus of expansion (Fig. 1a). Under such conditions of translation, heading corresponds to the focus of expansion and people identify it readily. But when making an eye...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/360583a0
更新日期:1992-12-10 00:00:00
abstract::Protein modification by the conjugation of ubiquitin moieties--ubiquitination--plays a major part in many biological processes, including cell cycle and apoptosis. The enzymes that mediate ubiquitin-conjugation have been well-studied, but much less is known about the ubiquitin-specific proteases that mediate de-ubiqui...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01811
更新日期:2003-08-14 00:00:00
abstract::Necroptosis has emerged as an important pathway of programmed cell death in embryonic development, tissue homeostasis, immunity and inflammation. RIPK1 is implicated in inflammatory and cell death signalling and its kinase activity is believed to drive RIPK3-mediated necroptosis. Here we show that kinase-independent s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13608
更新日期:2014-09-04 00:00:00
abstract::Haematopoiesis, the process of mature blood and immune cell production, is functionally organized as a hierarchy, with self-renewing haematopoietic stem cells and multipotent progenitor cells sitting at the very top. Multiple models have been proposed as to what the earliest lineage choices are in these primitive haem...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature25168
更新日期:2018-01-11 00:00:00
abstract::Time is divided by geologists according to marked shifts in Earth's state. Recent global environmental changes suggest that Earth may have entered a new human-dominated geological epoch, the Anthropocene. Here we review the historical genesis of the idea and assess anthropogenic signatures in the geological record aga...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature14258
更新日期:2015-03-12 00:00:00
abstract::The primary function of the nerve cell is to process electrical signals. Over the past fifteen years there has been renewed interest in the detailed spatial analysis of signalling in individual neurons owing to experimental evidence that the regional electrical properties of neurons are complex. Thus the behaviour of ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/381322a0
更新日期:1996-05-23 00:00:00
abstract::Regulatory aspects of the Warnock Committee's report on reproductive technologies are summarized. A licensing authority with "substantial lay representation" would license practitioners and approve experimentation. Artificial insemination by donor would become a regulated service, and resulting children would be leg...
journal_title:Nature
pub_type: 新闻
doi:10.1038/310266b0
更新日期:1984-07-26 00:00:00
abstract::Five new double-mutant haemoglobins composed of betaS chains and alpha chains with different substitutions, which are located at the surface of the tetramer, have been prepared. Although all the hybrids are more soluble than deoxyhaemoglobin S, the individual differences between these molecules make it possible to eva...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/260219a0
更新日期:1976-03-18 00:00:00
abstract::HIV-1 protease processes the Gag and Gag-Pol polyproteins into mature structural and functional proteins, including itself, and is therefore indispensable for viral maturation. The mature protease is active only as a dimer with each subunit contributing catalytic residues. The full-length transframe region protease pr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07342
更新日期:2008-10-02 00:00:00
abstract::Mitochondrial genomes (mitochondrial DNA, mtDNA) encode essential oxidative phosphorylation (OXPHOS) components. Because hundreds of mtDNAs exist per cell, a deletion in a single mtDNA has little impact. However, if the deletion genome is enriched, OXPHOS declines, resulting in cellular dysfunction. For example, Kearn...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature17989
更新日期:2016-05-19 00:00:00
abstract::Quantum cryptography exploits the fundamental laws of quantum mechanics to provide a secure way to exchange private information. Such an exchange requires a common random bit sequence, called a key, to be shared secretly between the sender and the receiver. The basic idea behind quantum key distribution (QKD) has wide...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13303
更新日期:2014-05-22 00:00:00