Abstract：
:Microtubules have a central role in eukaryotic cell polarity, in part through interactions between microtubule end-binding proteins and the cell cortex. In the fission yeast Schizosaccharomyces pombe, microtubules and the polarity modulator tea1p maintain cylindrical cell shape and strictly antipodal cell growth. The tea1p protein is transported to cell tips by association with growing microtubule plus ends; once at cell tips, tea1p releases from microtubule ends and associates with the cell cortex, where it coordinates polarized growth. Here we describe a cortical protein, mod5p, that regulates the dynamic behaviour of tea1p. In mod5Delta cells, tea1p is efficiently transported on microtubules to cell tips but fails to anchor properly at the cortex and thus fails to accumulate to normal levels. mod5p contains a signal for carboxy-terminal prenylation and in wild-type cells is associated with the plasma membrane at cell tips. However, in tea1Delta cells, although mod5p remains localized to the plasma membrane, mod5p is no longer restricted to the cell tips. We propose that tea1p and mod5p act in a positive-feedback loop in the microtubule-mediated regulation of cell polarity.
journal_name
Naturejournal_title
Natureauthors
Snaith HA,Sawin KEdoi
10.1038/nature01672keywords:
subject
Has Abstractpub_date
2003-06-05 00:00:00pages
647-51issue
6940eissn
0028-0836issn
1476-4687pii
nature01672journal_volume
423pub_type
杂志文章相关文献
NATURE文献大全abstract：:During animal development, cells have to respond appropriately to localized secreted signals. Proper responses to Hedgehog, transforming growth factor-beta, epidermal growth factor and fibroblast growth factor/Ras signals require cognate inducible antagonists such as Patched, Dad, Argos and Sprouty. Wnt signals are cr...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35001615
更新日期：2000-02-17 00:00:00
abstract：:On being heated, ice melts into liquid water. Although in practice this process tends to be heterogeneous, it can occur homogeneously inside bulk ice. The thermally induced homogeneous melting of solids is fairly well understood, and involves the formation and growth of melting nuclei. But in the case of water, resili...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature12190
更新日期：2013-06-20 00:00:00
abstract：:It has been established that many eukaryotic mRNAs contain poly(adenylic acid) tracts at their 3'-termini. The polyadenylation of mRNA occurs post-transcriptionally in the nucleus as a rapid, initial addition of 100-200 adenylate residues to the pre-mRNA (ref. 1). Subsequently, a slower chain extension (6-8 bases) of ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/267178a0
更新日期：1977-05-12 00:00:00
abstract：:In Drosophila, Decapentaplegic (Dpp) and Wingless (Wg) are two secreted signalling proteins of the transforming growth factor (TGF)-beta and Wnt families, respectively. Although both are often required during development, only a few downstream components of these signalling pathways have been described. Here we presen...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/383630a0
更新日期：1996-10-17 00:00:00
abstract：:Developing neurons transiently express somatostatin and its receptors, but little is known about their function at these early stages. As we thought that endogenous somatostatin might control the migratory behaviour of immature neurons, we have examined the effects of somatostatin in cerebellar granule cells of early ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/415077a
更新日期：2002-01-03 00:00:00
abstract：:Organocatalysis-catalysis mediated by small chiral organic molecules-is a powerful technology for enantioselective synthesis, and has extensive applications in traditional ionic, two-electron-pair reactivity domains. Recently, organocatalysis has been successfully combined with photochemical reactivity to unlock previ...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/nature25175
更新日期：2018-01-31 00:00:00
abstract：:Cocaine is believed to work by blocking the dopamine transporter (DAT) and thereby increasing the availability of free dopamine within the brain. Although this concept is central to current cocaine research and to treatment development, a direct relationship between DAT blockade and the subjective effects of cocaine h...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/386827a0
更新日期：1997-04-24 00:00:00
abstract：:Deaf children whose access to usable conventional linguistic input, signed or spoken, is severely limited nevertheless use gesture to communicate. These gestures resemble natural language in that they are structured at the level both of sentence and of word. Although the inclination to use gesture may be traceable to ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/34646
更新日期：1998-01-15 00:00:00
abstract：:The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mev...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/343425a0
更新日期：1990-02-01 00:00:00
abstract：:Specific genes can be inactivated or mutated in the mouse germ line. The phenotypic consequences of the mutation can provide pivotal information on the function of the gene in development and maintenance of the mammalian organism. The procedure entails homologous recombination in embryonic stem cells, which, on fusion...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/348649a0
更新日期：1990-12-13 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 评论,信件
doi：10.1038/d41586-019-00232-8
更新日期：2019-01-01 00:00:00
abstract：:Cancer somatic mutations can generate neoantigens that distinguish malignant from normal cells. However, the personalized identification and validation of neoantigens remains a major challenge. Here we discover neoantigens in human mantle-cell lymphomas by using an integrated genomic and proteomic strategy that interr...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature21433
更新日期：2017-03-30 00:00:00
abstract：:Measles virus is an aerosol-transmitted virus that affects more than 10 million children each year and accounts for approximately 120,000 deaths. Although it was long believed to replicate in the respiratory epithelium before disseminating, it was recently shown to infect initially macrophages and dendritic cells of t...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature10639
更新日期：2011-11-02 00:00:00
abstract：:The 3-A structure of DNA-binding protein II, which exhibits histone-like properties in bacteria, has been determined. The molecule is dimeric and appears to bind to the phosphate backbone of DNA through two symmetry-related arms. A mechanism by which the protein induces DNA supercoiling is proposed. ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/310376a0
更新日期：1984-08-02 00:00:00
abstract：:Positron emission tomography (PET) measurements of brain blood flow were used to monitor changes in the human primary and secondary somatosensory cortices during the period when somatosensory stimuli were expected. In anticipation of either focal or innocuous touching, or localized, painful shocks, blood flow decrease...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/373249a0
更新日期：1995-01-19 00:00:00
abstract：:Recognition of an avirulent pathogen triggers the rapid production of the reactive oxygen intermediates superoxide (O2-) and hydrogen peroxide (H2O2). This oxidative burst drives crosslinking of the cell wall, induces several plant genes involved in cellular protection and defence, and is necessary for the initiation ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/29087
更新日期：1998-08-06 00:00:00
abstract：:G-protein-coupled receptors comprise the largest family of mammalian transmembrane receptors. They mediate numerous cellular pathways by coupling with downstream signalling transducers, including the hetrotrimeric G proteins Gs (stimulatory) and Gi (inhibitory) and several arrestin proteins. The structural mechanisms ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-018-0215-y
更新日期：2018-06-01 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 新闻
doi：10.1038/d41586-019-00012-4
更新日期：2019-01-01 00:00:00
abstract：:Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder which affects approximately 1 in 3,300 males, making it the most common of the neuromuscular dystrophies. The biochemical basis of the disease is unknown and as yet no effective treatment is available. A small number of females are also affected with ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/318672a0
更新日期：1985-12-19 00:00:00
abstract：:The rapid turnover of the mammalian intestinal epithelium is supported by stem cells located around the base of the crypt. In addition to the Lgr5 marker, intestinal stem cells have been associated with other markers that are expressed heterogeneously within the crypt base region. Previous quantitative clonal fate ana...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature12972
更新日期：2014-03-20 00:00:00
abstract：:Nuclear pore complexes reside in the nuclear envelope of eukaryotic cells and mediate the nucleocytoplasmic exchange of macromolecules. Traffic is regulated by mobile transport receptors that target their cargo to the central translocation channel, where phenylalanine-glycine-rich repeats serve as binding sites. The s...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature06170
更新日期：2007-10-04 00:00:00
abstract：:It has long been thought that mature oligodendrocytes in the adult mammalian central nervous system (CNS) are post-mitotic and are unable to proliferate in response to injury. The implications of this have been profound, because it has been suggested that this failure of oligodendrocytes to undergo mitosis is perhaps ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/308274a0
更新日期：1984-03-15 00:00:00
abstract：:The RNA polymerase II large subunit contains an essential carboxy-terminal domain (CTD) believed to be involved in the response to regulators during transcription initiation. The CTD is phosphorylated on a portion of RNA polymerase II molecules in vivo and it can be phosphorylated by the general transcription factor T...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/374280a0
更新日期：1995-03-16 00:00:00
abstract：:Kinetoplastid RNA editing alters mitochondrial RNA transcripts by addition and deletion of uridine residues, producing open reading frames that may be twice as long as the original RNA. Although the COIII gene encoding cytochrome c oxidase subunit III in Trypanosoma brucei is edited along its entire length, the presum...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/363179a0
更新日期：1993-05-13 00:00:00
abstract：:An outstanding question is how cells control the number and size of membrane organelles. The small GTPase Rab5 has been proposed to be a master regulator of endosome biogenesis. Here, to test this hypothesis, we developed a mathematical model of endosome dependency on Rab5 and validated it by titrating down all three ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature11133
更新日期：2012-05-23 00:00:00
abstract：:The Fanconi anaemia (FA) pathway repairs DNA damage caused by endogenous and chemotherapy-induced DNA crosslinks, and responds to replication stress1,2. Genetic inactivation of this pathway by mutation of genes encoding FA complementation group (FANC) proteins impairs development, prevents blood production and promote...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-019-1703-4
更新日期：2019-11-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41586-020-2691-0
更新日期：2020-09-01 00:00:00
abstract：:Although stars form from clouds of gas and dust, there are insignificant amounts of gas around ordinary (Sun-like) stars. This suggests that hydrogen and helium, the primary constituents of planets such as Jupiter and Saturn, are not easily retained in orbit as a star matures. The gas-giant planets in the Solar System...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/373494a0
更新日期：1995-02-09 00:00:00
abstract：:The crystal structure of the human p27Kip1 kinase inhibitory domain bound to the phosphorylated cyclin A-cyclin-dependent kinase 2 (Cdk2) complex has been determined at 2.3 angstrom. p27Kip1 binds the complex as an extended structure interacting with both cyclin A and Cdk2. On cyclin A, it binds in a groove formed by ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/382325a0
更新日期：1996-07-25 00:00:00
abstract：:Cancer genomics has revealed many genes and core molecular processes that contribute to human malignancies, but the genetic and molecular bases of many rare cancers remains unclear. Genetic predisposition accounts for 5 to 10% of cancer diagnoses in children1,2, and genetic events that cooperate with known somatic dri...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2164-5
更新日期：2020-04-01 00:00:00
