Fission yeast mod5p regulates polarized growth through anchoring of tea1p at cell tips.


:Microtubules have a central role in eukaryotic cell polarity, in part through interactions between microtubule end-binding proteins and the cell cortex. In the fission yeast Schizosaccharomyces pombe, microtubules and the polarity modulator tea1p maintain cylindrical cell shape and strictly antipodal cell growth. The tea1p protein is transported to cell tips by association with growing microtubule plus ends; once at cell tips, tea1p releases from microtubule ends and associates with the cell cortex, where it coordinates polarized growth. Here we describe a cortical protein, mod5p, that regulates the dynamic behaviour of tea1p. In mod5Delta cells, tea1p is efficiently transported on microtubules to cell tips but fails to anchor properly at the cortex and thus fails to accumulate to normal levels. mod5p contains a signal for carboxy-terminal prenylation and in wild-type cells is associated with the plasma membrane at cell tips. However, in tea1Delta cells, although mod5p remains localized to the plasma membrane, mod5p is no longer restricted to the cell tips. We propose that tea1p and mod5p act in a positive-feedback loop in the microtubule-mediated regulation of cell polarity.






Snaith HA,Sawin KE





Has Abstract


2003-06-05 00:00:00
















  • Formation of proinsulin by immobilized Bacillus subtilis.

    abstract::There has been an increasing interest in the use of immobilized cells for the production of pharmaceuticals as well as for products such as high fructose syrup or ethanol. Some of these compounds are now produced on an industrial scale whereby the cells are used in a resting or growing state or in a nonviable form as ...


    pub_type: 杂志文章


    authors: Mosbach K,Birnbaum S,Hardy K,Davies J,Bülow L

    更新日期:1983-04-07 00:00:00

  • Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups.

    abstract::The rates and routes of lethal systemic spread in breast cancer are poorly understood owing to a lack of molecularly characterized patient cohorts with long-term, detailed follow-up data. Long-term follow-up is especially important for those with oestrogen-receptor (ER)-positive breast cancers, which can recur up to t...


    pub_type: 杂志文章


    authors: Rueda OM,Sammut SJ,Seoane JA,Chin SF,Caswell-Jin JL,Callari M,Batra R,Pereira B,Bruna A,Ali HR,Provenzano E,Liu B,Parisien M,Gillett C,McKinney S,Green AR,Murphy L,Purushotham A,Ellis IO,Pharoah PD,Rueda C,Apari

    更新日期:2019-03-01 00:00:00

  • GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas.

    abstract::Growth of basal cell carcinomas (BCCs) requires high levels of hedgehog (HH) signalling through the transcription factor GLI. Although inhibitors of membrane protein smoothened (SMO) effectively suppress HH signalling, early tumour resistance illustrates the need for additional downstream targets for therapy. Here we ...


    pub_type: 杂志文章


    authors: Atwood SX,Li M,Lee A,Tang JY,Oro AE

    更新日期:2013-02-28 00:00:00

  • X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis.

    abstract::Non-ribosomal peptide synthetase (NRPS) mega-enzyme complexes are modular assembly lines that are involved in the biosynthesis of numerous peptide metabolites independently of the ribosome. The multiple interactions between catalytic domains within the NRPS machinery are further complemented by additional interactions...


    pub_type: 杂志文章


    authors: Haslinger K,Peschke M,Brieke C,Maximowitsch E,Cryle MJ

    更新日期:2015-05-07 00:00:00

  • T cells can present antigens such as HIV gp120 targeted to their own surface molecules.

    abstract::To trigger class II-restricted T cells, antigen presenting cells have to capture antigens, process them and display their fragments in association with class II molecules. In most species, activated T cells express class II molecules; however, no evidence has been found that these cells can present soluble antigens. T...


    pub_type: 杂志文章


    authors: Lanzavecchia A,Roosnek E,Gregory T,Berman P,Abrignani S

    更新日期:1988-08-11 00:00:00

  • Glycine binding primes NMDA receptor internalization.

    abstract::NMDA (N-methyl-d-aspartate) receptors (NMDARs) are a principal subtype of excitatory ligand-gated ion channel with prominent roles in physiological and disease processes in the central nervous system. Recognition that glycine potentiates NMDAR-mediated currents as well as being a requisite co-agonist of the NMDAR subt...


    pub_type: 杂志文章


    authors: Nong Y,Huang YQ,Ju W,Kalia LV,Ahmadian G,Wang YT,Salter MW

    更新日期:2003-03-20 00:00:00

  • Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR.

    abstract::Exchange dynamics between molecules free in solution and bound to the surface of a large supramolecular structure, a polymer, a membrane or solid support are important in many phenomena in biology and materials science. Here we present a novel and generally applicable solution NMR technique, known as dark-state exchan...


    pub_type: 杂志文章


    authors: Fawzi NL,Ying J,Ghirlando R,Torchia DA,Clore GM

    更新日期:2011-10-30 00:00:00

  • Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring.

    abstract::Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis largely owing to inefficient diagnosis and tenacious drug resistance. Activation of pancreatic stellate cells (PSCs) and consequent development of dense stroma are prominent features accounting for this aggressive biology1,2. The reciprocal interplay betwe...


    pub_type: 杂志文章


    authors: Shi Y,Gao W,Lytle NK,Huang P,Yuan X,Dann AM,Ridinger-Saison M,DelGiorno KE,Antal CE,Liang G,Atkins AR,Erikson G,Sun H,Meisenhelder J,Terenziani E,Woo G,Fang L,Santisakultarm TP,Manor U,Xu R,Becerra CR,Borazanci

    更新日期:2019-05-01 00:00:00

  • The structural basis of the activation of Ras by Sos.

    abstract::The crystal structure of human H-Ras complexed with the Ras guanine-nucleotide-exchange-factor region of the Son of sevenless (Sos) protein has been determined at 2.8 A resolution. The normally tight interaction of nucleotides with Ras is disrupted by Sos in two ways. First, the insertion into Ras of an alpha-helix fr...


    pub_type: 杂志文章


    authors: Boriack-Sjodin PA,Margarit SM,Bar-Sagi D,Kuriyan J

    更新日期:1998-07-23 00:00:00

  • Piezoelectricity of single-atomic-layer MoS2 for energy conversion and piezotronics.

    abstract::The piezoelectric characteristics of nanowires, thin films and bulk crystals have been closely studied for potential applications in sensors, transducers, energy conversion and electronics. With their high crystallinity and ability to withstand enormous strain, two-dimensional materials are of great interest as high-p...


    pub_type: 杂志文章


    authors: Wu W,Wang L,Li Y,Zhang F,Lin L,Niu S,Chenet D,Zhang X,Hao Y,Heinz TF,Hone J,Wang ZL

    更新日期:2014-10-23 00:00:00

  • Mfsd2a is critical for the formation and function of the blood-brain barrier.

    abstract::The central nervous system (CNS) requires a tightly controlled environment free of toxins and pathogens to provide the proper chemical composition for neural function. This environment is maintained by the 'blood-brain barrier' (BBB), which is composed of blood vessels whose endothelial cells display specialized tight...


    pub_type: 杂志文章


    authors: Ben-Zvi A,Lacoste B,Kur E,Andreone BJ,Mayshar Y,Yan H,Gu C

    更新日期:2014-05-22 00:00:00

  • Duplication and remoulding of tRNA genes during the evolutionary rearrangement of mitochondrial genomes.

    abstract::During the evolution of sea urchins, a transfer RNA gene lost its tRNA function and became part of a protein-coding gene. This functional loss of a tRNA with specificity for one group of leucine codons (CUN, where N is any base) was accompanied by the gain of a new tRNA with that specificity. The new tRNA gene for CUN...


    pub_type: 杂志文章


    authors: Cantatore P,Gadaleta MN,Roberti M,Saccone C,Wilson AC

    更新日期:1987-10-29 00:00:00

  • Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells.

    abstract::Gut commensal microbes shape the mucosal immune system by regulating the differentiation and expansion of several types of T cell. Clostridia, a dominant class of commensal microbe, can induce colonic regulatory T (Treg) cells, which have a central role in the suppression of inflammatory and allergic responses. Howeve...


    pub_type: 杂志文章


    authors: Furusawa Y,Obata Y,Fukuda S,Endo TA,Nakato G,Takahashi D,Nakanishi Y,Uetake C,Kato K,Kato T,Takahashi M,Fukuda NN,Murakami S,Miyauchi E,Hino S,Atarashi K,Onawa S,Fujimura Y,Lockett T,Clarke JM,Topping DL,Tomita

    更新日期:2013-12-19 00:00:00

  • Endogenous human microRNAs that suppress breast cancer metastasis.

    abstract::A search for general regulators of cancer metastasis has yielded a set of microRNAs for which expression is specifically lost as human breast cancer cells develop metastatic potential. Here we show that restoring the expression of these microRNAs in malignant cells suppresses lung and bone metastasis by human cancer c...


    pub_type: 杂志文章


    authors: Tavazoie SF,Alarcón C,Oskarsson T,Padua D,Wang Q,Bos PD,Gerald WL,Massagué J

    更新日期:2008-01-10 00:00:00

  • Quantum critical behaviour in a high-T(c) superconductor.

    abstract::Quantum criticality is associated with a system composed of a nearly infinite number of interacting quantum degrees of freedom at zero temperature, and it implies that the system looks on average the same regardless of the time- and length scale on which it is observed. Electrons on the atomic scale do not exhibit suc...


    pub_type: 杂志文章


    authors: van der Marel D,Molegraaf HJ,Zaanen J,Nussinov Z,Carbone F,Damascelli A,Eisaki H,Greven M,Kes PH,Li M

    更新日期:2003-09-18 00:00:00

  • Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo.

    abstract::In Parkinson's disease, brain dopamine neurons degenerate most prominently in the substantia nigra. Neurotrophic factors promote survival, differentiation and maintenance of neurons in developing and adult vertebrate nervous system. The most potent neurotrophic factor for dopamine neurons described so far is the glial...


    pub_type: 杂志文章


    authors: Lindholm P,Voutilainen MH,Laurén J,Peränen J,Leppänen VM,Andressoo JO,Lindahl M,Janhunen S,Kalkkinen N,Timmusk T,Tuominen RK,Saarma M

    更新日期:2007-07-05 00:00:00

  • Development of a preventive vaccine for Ebola virus infection in primates.

    abstract::Outbreaks of haemorrhagic fever caused by the Ebola virus are associated with high mortality rates that are a distinguishing feature of this human pathogen. The highest lethality is associated with the Zaire subtype, one of four strains identified to date. Its rapid progression allows little opportunity to develop nat...


    pub_type: 杂志文章


    authors: Sullivan NJ,Sanchez A,Rollin PE,Yang ZY,Nabel GJ

    更新日期:2000-11-30 00:00:00

  • Measurement of polarization with the Degree Angular Scale Interferometer.

    abstract::Measurements of the cosmic microwave background (CMB) radiation can reveal with remarkable precision the conditions of the Universe when it was approximately 400,000 years old. The three most fundamental properties of the CMB are its frequency spectrum (which determines the temperature), and the fluctuations in both t...


    pub_type: 杂志文章


    authors: Leitch EM,Kovac JM,Pryke C,Carlstrom JE,Halverson NW,Holzapfel WL,Dragovan M,Reddall B,Sandberg ES

    更新日期:2002-12-19 00:00:00

  • Pro-gamma-melanocyte-stimulating hormone cleavage in adrenal gland undergoing compensatory growth.

    abstract::Regulation of the rapid compensatory growth seen in the remaining adrenal gland of rats following unilateral adrenalectomy is poorly understood. The role of adrenocorticotropic hormone (ACTH) is obscure as immunoneutralization of circulating ACTH does not affect the observed compensatory growth or hyperplasia. This fi...


    pub_type: 杂志文章


    authors: Lowry PJ,Silas L,McLean C,Linton EA,Estivariz FE

    更新日期:1983-11-03 00:00:00

  • Evidence for grid cells in a human memory network.

    abstract::Grid cells in the entorhinal cortex of freely moving rats provide a strikingly periodic representation of self-location which is indicative of very specific computational mechanisms. However, the existence of grid cells in humans and their distribution throughout the brain are unknown. Here we show that the preferred ...


    pub_type: 杂志文章


    authors: Doeller CF,Barry C,Burgess N

    更新日期:2010-02-04 00:00:00

  • Direct observation of kinesin stepping by optical trapping interferometry.

    abstract::Do biological motors move with regular steps? To address this question, we constructed instrumentation with the spatial and temporal sensitivity to resolve movement on a molecular scale. We deposited silica beads carrying single molecules of the motor protein kinesin on microtubules using optical tweezers and analysed...


    pub_type: 杂志文章


    authors: Svoboda K,Schmidt CF,Schnapp BJ,Block SM

    更新日期:1993-10-21 00:00:00

  • Photoselective adaptive femtosecond quantum control in the liquid phase.

    abstract::Coherent light sources can be used to manipulate the outcome of light-matter interactions by exploiting interference phenomena in the time and frequency domain. A powerful tool in this emerging field of 'quantum control' is the adaptive shaping of femtosecond laser pulses, resulting, for instance, in selective molecul...


    pub_type: 杂志文章


    authors: Brixner T,Damrauer NH,Niklaus P,Gerber G

    更新日期:2001-11-01 00:00:00

  • Ecosystem resilience despite large-scale altered hydroclimatic conditions.

    abstract::Climate change is predicted to increase both drought frequency and duration, and when coupled with substantial warming, will establish a new hydroclimatological model for many regions. Large-scale, warm droughts have recently occurred in North America, Africa, Europe, Amazonia and Australia, resulting in major effects...


    pub_type: 历史文章,杂志文章


    authors: Ponce Campos GE,Moran MS,Huete A,Zhang Y,Bresloff C,Huxman TE,Eamus D,Bosch DD,Buda AR,Gunter SA,Scalley TH,Kitchen SG,McClaran MP,McNab WH,Montoya DS,Morgan JA,Peters DP,Sadler EJ,Seyfried MS,Starks PJ

    更新日期:2013-02-21 00:00:00

  • Biosignatures as revealed by spectropolarimetry of Earthshine.

    abstract::Low-resolution intensity spectra of Earth's atmosphere obtained from space reveal strong signatures of life ('biosignatures'), such as molecular oxygen and methane with abundances far from chemical equilibrium, as well as the presence of a 'red edge' (a sharp increase of albedo for wavelengths longer than 700 nm) caus...


    pub_type: 杂志文章


    authors: Sterzik MF,Bagnulo S,Palle E

    更新日期:2012-02-29 00:00:00

  • Sexual selection and the maintenance of sex.

    abstract::Sex is expensive. A population of females that reproduce asexually should prima facie have twice the growth rate of an otherwise equivalent anisogamous sexual population lacking paternal care, or a population with modes of paternal care that can be co-opted by parthenogenetic females. The two leading theories for the ...


    pub_type: 杂志文章


    authors: Siller S,Department of Zoology, University of Oxford, UK.

    更新日期:2001-06-07 00:00:00

  • A rapid mechanism to remobilize and homogenize highly crystalline magma bodies.

    abstract::The largest products of magmatic activity on Earth, the great bodies of granite and their corresponding large eruptions, have a dual nature: homogeneity at the large scale and spatial and temporal heterogeneity at the small scale. This duality calls for a mechanism that selectively removes the large-scale heterogeneit...


    pub_type: 杂志文章


    authors: Burgisser A,Bergantz GW

    更新日期:2011-03-10 00:00:00

  • Replication fork stability confers chemoresistance in BRCA-deficient cells.

    abstract::Cells deficient in the Brca1 and Brca2 genes have reduced capacity to repair DNA double-strand breaks by homologous recombination and consequently are hypersensitive to DNA-damaging agents, including cisplatin and poly(ADP-ribose) polymerase (PARP) inhibitors. Here we show that loss of the MLL3/4 complex protein, PTIP...


    pub_type: 杂志文章


    authors: Ray Chaudhuri A,Callen E,Ding X,Gogola E,Duarte AA,Lee JE,Wong N,Lafarga V,Calvo JA,Panzarino NJ,John S,Day A,Crespo AV,Shen B,Starnes LM,de Ruiter JR,Daniel JA,Konstantinopoulos PA,Cortez D,Cantor SB,Fernandez-Ca

    更新日期:2016-07-21 00:00:00

  • The structure of an oligo(dA).oligo(dT) tract and its biological implications.

    abstract::Poly(dA).poly(dT) has unusual properties in that it cannot associate into nucleosomes and short, phased runs of it cause DNA bending. The crystal structure of a B-type DNA dodecamer containing a homopolymeric run of six A.T base pairs shows that this region possesses special structural features, including a system of ...


    pub_type: 杂志文章


    authors: Nelson HC,Finch JT,Luisi BF,Klug A

    更新日期:1987-11-19 00:00:00

  • Impact energy measurement in time-of-flight mass spectrometry with cryogenic microcalorimeters.

    abstract::Time-of-flight mass spectrometry-most notably matrix-assisted laser-desorption-ionization time-of-flight (MALDI-TOF) spectrometry-is an important class of techniques for the study of proteins and other biomolecules. Although these techniques provide excellent performance for masses up to about 20,000 daltons, there ha...


    pub_type: 杂志文章


    authors: Hilton GC,Martinis JM,Wollman DA,Irwin KD,Dulcie LL,Gerber D,Gillevet PM,Twerenbold D

    更新日期:1998-02-12 00:00:00

  • Mechanism of magnesium activation of calcium-activated potassium channels.

    abstract::Large-conductance (BK type) Ca(2+)-dependent K(+) channels are essential for modulating muscle contraction and neuronal activities such as synaptic transmission and hearing. BK channels are activated by membrane depolarization and intracellular Ca(2+) and Mg(2+) (refs 6-10). The energy provided by voltage, Ca(2+) and ...


    pub_type: 杂志文章


    authors: Shi J,Krishnamoorthy G,Yang Y,Hu L,Chaturvedi N,Harilal D,Qin J,Cui J

    更新日期:2002-08-22 00:00:00