alpha-Chain contacts in the polymerisation of sickle haemogloblin.

abstract：:The development and maintenance of an epithelium requires finely balanced rates of growth and cell death. However, the mechanical and biochemical mechanisms that ensure proper feedback control of tissue growth, which when deregulated contribute to tumorigenesis, are poorly understood. Here we use the fly notum as a mo...

journal_title：Nature

authors： Marinari E,Mehonic A,Curran S,Gale J,Duke T,Baum B

更新日期：2012-04-15 00:00:00

abstract：:Individuals with congenital or acquired prolongation of the QT interval, or long QT syndrome (LQTS), are at risk of life-threatening ventricular arrhythmia. LQTS is commonly genetic in origin but can also be caused or exacerbated by environmental factors. A missense mutation in the L-type calcium channel Ca(V)1.2 lead...

journal_title：Nature

authors： Yazawa M,Hsueh B,Jia X,Pasca AM,Bernstein JA,Hallmayer J,Dolmetsch RE

更新日期：2011-03-10 00:00:00

abstract：:A biologically active complementary DNA clone of a transforming gene present in a human colon carcinoma contains gene sequences of both tropomyosin and a previously unknown protein tyrosine kinase. The predicted protein (641 amino acids) encoded by this oncogene seems to have been formed by a somatic rearrangement tha...

journal_title：Nature

authors： Martin-Zanca D,Hughes SH,Barbacid M

更新日期：1986-02-27 00:00:00

abstract：:Cyclosporin A, a cyclic undecapeptide, is a potent immunosuppressant that binds to a peptidyl-prolyl cis-trans isomerase of 165 amino acids, cyclophilin. The cyclosporin A/cyclophilin complex inhibits the calcium- and calmodulin-dependent phosphatase, calcineurin, resulting in a failure to activate genes encoding inte...

journal_title：Nature

authors： Thériault Y,Logan TM,Meadows R,Yu L,Olejniczak ET,Holzman TF,Simmer RL,Fesik SW

更新日期：1993-01-07 00:00:00

abstract：:The growth and differentiation of cytolytic T lymphocytes (CTL) is regulated by soluble growth hormones, of which interleukin-2 (IL-2) is considered to be of prime importance. Here we report that the lymphokine B-cell stimulatory factor (BSF-1 or interleukin-4) also has profound effects on the generation of these func...

journal_title：Nature

authors： Widmer MB,Grabstein KH

更新日期：1987-04-23 00:00:00

abstract：:The best spectrographs are limited in stability by their calibration light source. Laser frequency combs are the ideal calibrators for astronomical spectrographs. They emit a spectrum of lines that are equally spaced in frequency and that are as accurate and stable as the atomic clock relative to which the comb is sta...

journal_title：Nature

authors： Wilken T,Curto GL,Probst RA,Steinmetz T,Manescau A,Pasquini L,González Hernández JI,Rebolo R,Hänsch TW,Udem T,Holzwarth R

更新日期：2012-05-30 00:00:00

abstract：:The masses of the supermassive black holes found in galaxy bulges are correlated with a multitude of galaxy properties, leading to suggestions that galaxies and black holes may evolve together. The number of reliably measured black-hole masses is small, and the number of methods for measuring them is limited, holding ...

journal_title：Nature

authors： Davis TA,Bureau M,Cappellari M,Sarzi M,Blitz L

更新日期：2013-02-21 00:00:00

abstract：:Homeostatic mechanisms in mammals respond to hormones and nutrients to maintain blood glucose levels within a narrow range. Caloric restriction causes many changes in glucose metabolism and extends lifespan; however, how this metabolism is connected to the ageing process is largely unknown. We show here that the Sir2 ...

journal_title：Nature

authors： Rodgers JT,Lerin C,Haas W,Gygi SP,Spiegelman BM,Puigserver P

更新日期：2005-03-03 00:00:00

abstract：:Cryo-electron microscopy (cryo-EM) has the capacity to capture molecular machines in action1-3. ATP-binding cassette (ABC) exporters are highly dynamic membrane proteins that extrude a wide range of substances from the cytosol4-6 and thereby contribute to essential cellular processes, adaptive immunity and multidrug r...

journal_title：Nature

authors： Hofmann S,Januliene D,Mehdipour AR,Thomas C,Stefan E,Brüchert S,Kuhn BT,Geertsma ER,Hummer G,Tampé R,Moeller A

更新日期：2019-07-01 00:00:00

abstract：:Werner's syndrome (WS) is a rare autosomal recessive disease in which the affected individuals display symptoms of premature ageing. The substantial phenotypic overlap between WS and normal ageing indicates that these two conditions may have pathogenetic mechanisms in common. The WS mutation has pleiotropic effects, a...

journal_title：Nature

authors： Goto M,Rubenstein M,Weber J,Woods K,Drayna D

更新日期：1992-02-20 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) and other neurotrophins have a vital role in the development of the rat and mouse nervous system by influencing the expression of many specific genes that promote differentiation, cell survival, synapse formation and, later, synaptic plasticity. Although nitric oxide (NO) is kn...

journal_title：Nature

authors： Nott A,Watson PM,Robinson JD,Crepaldi L,Riccio A

更新日期：2008-09-18 00:00:00

abstract：:Histone post-translational modifications (PTMs) are associated with epigenetic states that form the basis for cell-type-specific gene expression1,2. Once established, histone PTMs can be maintained by positive feedback involving enzymes that recognize a pre-existing histone modification and catalyse the same modificat...

journal_title：Nature

authors： Yu R,Wang X,Moazed D

更新日期：2018-06-01 00:00:00

abstract：:Co-evolution between plants and their natural enemies is generally believed to have generated much of the Earth's biological diversity. A process analogous to co-evolution occurs in agricultural systems, in which natural enemies adapt to crop resistance introduced by breeding or genetic engineering. Because of this si...

journal_title：Nature

authors： Rausher MD

更新日期：2001-06-14 00:00:00

abstract：:NMDA (N-methyl-d-aspartate) receptors (NMDARs) are a principal subtype of excitatory ligand-gated ion channel with prominent roles in physiological and disease processes in the central nervous system. Recognition that glycine potentiates NMDAR-mediated currents as well as being a requisite co-agonist of the NMDAR subt...

journal_title：Nature

authors： Nong Y,Huang YQ,Ju W,Kalia LV,Ahmadian G,Wang YT,Salter MW

更新日期：2003-03-20 00:00:00

abstract：:Metabolic phenotypes are the products of interactions among a variety of factors-dietary, other lifestyle/environmental, gut microbial and genetic. We use a large-scale exploratory analytical approach to investigate metabolic phenotype variation across and within four human populations, based on 1H NMR spectroscopy. M...

journal_title：Nature

authors： Holmes E,Loo RL,Stamler J,Bictash M,Yap IK,Chan Q,Ebbels T,De Iorio M,Brown IJ,Veselkov KA,Daviglus ML,Kesteloot H,Ueshima H,Zhao L,Nicholson JK,Elliott P

更新日期：2008-05-15 00:00:00

abstract：:Ribosomes are translational machineries that catalyse protein synthesis. Ribosome structures from various species are known at the atomic level, but obtaining the structure of the human ribosome has remained a challenge; efforts to address this would be highly relevant with regard to human diseases. Here we report the...

journal_title：Nature

authors： Khatter H,Myasnikov AG,Natchiar SK,Klaholz BP

更新日期：2015-04-30 00:00:00

abstract：:Recent studies have shown that normal cellular sequences on chromosome 13 are lost during the development of retinoblastomas and that sequences on chromosome 11 are similarly lost during the development of Wilms' kidney tumours and embryonal tumours. Cells from these tumors have been found to contain either the patern...

journal_title：Nature

authors： Fearon ER,Feinberg AP,Hamilton SH,Vogelstein B

更新日期：1985-11-28 00:00:00

abstract：:In vertebrates the developing hindbrain is organized in segmental units. These units provide the primary grid for differentiation and axonal outgrowth. In the more anterior regions of the brain, however, the subdivisions remain more controversial. Cellular and molecular studies of the embryonic brain in lower vertebra...

journal_title：Nature

authors： Krauss S,Johansen T,Korzh V,Fjose A

更新日期：1991-09-19 00:00:00

abstract：:The importance of the dopaminergic system in brain function has been emphasized by its association with neurological and psychiatric disorders such as Parkinson's disease and schizophrenia. On the basis of their biochemical and pharmacological characteristics, dopamine receptors are classified into D1 and D2 subtypes....

journal_title：Nature

authors： Zhou QY,Grandy DK,Thambi L,Kushner JA,Van Tol HH,Cone R,Pribnow D,Salon J,Bunzow JR,Civelli O

更新日期：1990-09-06 00:00:00

abstract：:Time-of-flight mass spectrometry-most notably matrix-assisted laser-desorption-ionization time-of-flight (MALDI-TOF) spectrometry-is an important class of techniques for the study of proteins and other biomolecules. Although these techniques provide excellent performance for masses up to about 20,000 daltons, there ha...

journal_title：Nature

authors： Hilton GC,Martinis JM,Wollman DA,Irwin KD,Dulcie LL,Gerber D,Gillevet PM,Twerenbold D

更新日期：1998-02-12 00:00:00

abstract：:Electrophoretic studies suggest that bacterial populations consist of a number of independent clones and that genetic recombination is rare in nature. But DNA sequencing reveals that individual bacterial genes have a mosaic structure that could have arisen only by recombination. How can these observations be reconcile...

journal_title：Nature

authors： Smith JM,Dowson CG,Spratt BG

更新日期：1991-01-03 00:00:00

abstract：:Sensory experiences exert a powerful influence on the function and future performance of neuronal circuits in the mammalian neocortex. Restructuring of synaptic connections is believed to be one mechanism by which cortical circuits store information about the sensory world. Excitatory synaptic structures, such as dend...

journal_title：Nature

authors： Hofer SB,Mrsic-Flogel TD,Bonhoeffer T,Hübener M

更新日期：2009-01-15 00:00:00

abstract：:Neurotransmitters modulate the activity of ion channels through a variety of second messengers, including cyclic AMP, cyclic GMP and the products of phosphatidylinositol breakdown. Little is known about how different transmitters acting through different second-messenger systems interact within a cell to regulate sing...

journal_title：Nature

authors： Belardetti F,Kandel ER,Siegelbaum SA

更新日期：1987-01-08 00:00:00

abstract：:The ability to confine and store optical energy in small volumes has implications in fields ranging from cavity quantum electrodynamics to photonics. Of all cavity geometries, micrometre-sized dielectric spherical resonators are the best in terms of their ability to store energy for long periods of time within small v...

journal_title：Nature

authors： Spillane SM,Kippenberg TJ,Vahala KJ

更新日期：2002-02-07 00:00:00

abstract：:The structure of foot-and-mouth disease virus has been determined at close to atomic resolution by X-ray diffraction without experimental phase information. The virus shows similarities with other picornaviruses but also several unique features. The canyon or pit found in other picornaviruses is absent; this has impor...

journal_title：Nature

authors： Acharya R,Fry E,Stuart D,Fox G,Rowlands D,Brown F

更新日期：1989-02-23 00:00:00

abstract：:Current ideas about the dependence of neurons on target-derived growth factors were formulated on the basis of experiments involving neurons with projections to the periphery. Nerve growth factor (NGF) and recently identified members of the NGF family of neuronal growth factors, known as neurotrophins, are thought to ...

journal_title：Nature

authors： Yan Q,Elliott J,Snider WD

更新日期：1992-12-24 00:00:00

abstract：:Polycomb group proteins have an essential role in the epigenetic maintenance of repressive chromatin states. The gene-silencing activity of the Polycomb repressive complex 2 (PRC2) depends on its ability to trimethylate lysine 27 of histone H3 (H3K27) by the catalytic SET domain of the EZH2 subunit, and at least two o...

journal_title：Nature

authors： Margueron R,Justin N,Ohno K,Sharpe ML,Son J,Drury WJ 3rd,Voigt P,Martin SR,Taylor WR,De Marco V,Pirrotta V,Reinberg D,Gamblin SJ

更新日期：2009-10-08 00:00:00

abstract：:TPA (12-O-tetradecanoyl-phorbol-13-acetate) reversibly inhibits the binding of (125)I-labelled epidermal growth factor (EGF) to treated mouse and human cells, but does not affect the binding of various other ligands to their membrane receptors. It alters the affinity of the receptors for EGF without changing the total...

journal_title：Nature

authors： Shoyab M,De Larco JE,Todaro GJ

更新日期：1979-05-31 00:00:00

abstract：:The ethics of biological research, and its general impact, are hotly debated in the West. Japanese silence on the issues is counterproductive. Will the Human Genome Project provide the catalyst for change? ...

journal_title：Nature

authors： Macer D

更新日期：1992-10-29 00:00:00

abstract：:Spin dynamics in antiferromagnets has much shorter timescales than in ferromagnets, offering attractive properties for potential applications in ultrafast devices1-3. However, spin-current generation via antiferromagnetic resonance and simultaneous electrical detection by the inverse spin Hall effect in heavy metals h...

journal_title：Nature

authors： Li J,Wilson CB,Cheng R,Lohmann M,Kavand M,Yuan W,Aldosary M,Agladze N,Wei P,Sherwin MS,Shi J

更新日期：2020-02-01 00:00:00