S-Nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons.

abstract：:The development of immunologic interventions that can target the viral reservoir in HIV-1-infected individuals is a major goal of HIV-1 research. However, little evidence exists that the viral reservoir can be sufficiently targeted to improve virologic control following discontinuation of antiretroviral therapy. Here ...

journal_title：Nature

authors： Borducchi EN,Cabral C,Stephenson KE,Liu J,Abbink P,Ng'ang'a D,Nkolola JP,Brinkman AL,Peter L,Lee BC,Jimenez J,Jetton D,Mondesir J,Mojta S,Chandrashekar A,Molloy K,Alter G,Gerold JM,Hill AL,Lewis MG,Pau MG,Schuit

更新日期：2016-12-08 00:00:00

abstract：:High-coverage whole-genome sequence studies have so far focused on a limited number of geographically restricted populations, or been targeted at specific diseases, such as cancer. Nevertheless, the availability of high-resolution genomic data has led to the development of new methodologies for inferring population hi...

journal_title：Nature

authors： Pagani L,Lawson DJ,Jagoda E,Mörseburg A,Eriksson A,Mitt M,Clemente F,Hudjashov G,DeGiorgio M,Saag L,Wall JD,Cardona A,Mägi R,Wilson Sayres MA,Kaewert S,Inchley C,Scheib CL,Järve M,Karmin M,Jacobs GS,Antao T,Ilie

更新日期：2016-10-13 00:00:00

abstract：:Aquifex aeolicus was one of the earliest diverging, and is one of the most thermophilic, bacteria known. It can grow on hydrogen, oxygen, carbon dioxide, and mineral salts. The complex metabolic machinery needed for A. aeolicus to function as a chemolithoautotroph (an organism which uses an inorganic carbon source for...

journal_title：Nature

authors： Deckert G,Warren PV,Gaasterland T,Young WG,Lenox AL,Graham DE,Overbeek R,Snead MA,Keller M,Aujay M,Huber R,Feldman RA,Short JM,Olsen GJ,Swanson RV

更新日期：1998-03-26 00:00:00

abstract：:In contrast to double-stranded DNA, there has so far been little evidence that double-stranded RNA can undergo major conformational transitions. We have investigated the conformation in different conditions of the double-stranded RNA molecule poly(G-C).poly(G-C), by NMR, circular dichroism and absorbance spectroscopy....

journal_title：Nature

authors： Hall K,Cruz P,Tinoco I Jr,Jovin TM,van de Sande JH

更新日期：1984-10-11 00:00:00

abstract：:Chick embryo fibroblasts (CEF) infected with avian sarcoma virus become rapidly transformed as a result of expression of the viral src gene in the form of a single polypeptide of molecular weight 60,000 (pp60src) with protein kinase activity and suggested preferential association with the plasma membrane. Studies with...

journal_title：Nature

authors： Witt DP,Gordon JA

更新日期：1980-09-18 00:00:00

abstract：:Histoplasma capsulatum, like many other fungal pathogens, is dimorphic: it exists as mycelia in the soil and yeast in animal hosts. Because only the yeast phase is parasitic, factors which affect morphogenesis have been of interest for understanding and controlling pathogenicity. In culture, the mycelial to yeast tran...

journal_title：Nature

authors： Lambowitz AM,Kobayashi GS,Painter A,Medoff G

更新日期：1983-06-30 00:00:00

abstract：:Visual stimuli can acquire positive or negative value through their association with rewards and punishments, a process called reinforcement learning. Although we now know a great deal about how the brain analyses visual information, we know little about how visual representations become linked with values. To study t...

journal_title：Nature

authors： Paton JJ,Belova MA,Morrison SE,Salzman CD

更新日期：2006-02-16 00:00:00

abstract：:Null mutations of glass specifically remove photoreceptor cells, leaving other cell types intact. We have isolated the glass gene and have shown that its transcript encodes a putative protein of 604 amino acids with five zinc-fingers. The glass product may be a transcription factor required for the development of a si...

journal_title：Nature

authors： Moses K,Ellis MC,Rubin GM

更新日期：1989-08-17 00:00:00

abstract：:The way in which proteins attain and maintain their final form is of fundamental importance. Recent work has focused on the role of a set of ubiquitous proteins, termed chaperonins, in the assembly of phage and multisubunit proteins. The range of chaperonin action is unknown; they could interact with most cellular pol...

journal_title：Nature

authors： Van Dyk TK,Gatenby AA,LaRossa RA

更新日期：1989-11-23 00:00:00

abstract：:A 12 amino-acid synthetic peptide (NANP)3 comprising the immunodominant epitope of Plasmodium falciparum circumsporozoite protein was conjugated to tetanus toxoid (TT), adjuvanted with aluminium hydroxide, and administered intramuscularly in three doses at monthly intervals to 35 healthy males as a malaria vaccine. No...

journal_title：Nature

authors： Herrington DA,Clyde DF,Losonsky G,Cortesia M,Murphy JR,Davis J,Baqar S,Felix AM,Heimer EP,Gillessen D

更新日期：1987-07-16 00:00:00

abstract：:Ice volume (and hence sea level) and deep-sea temperature are key measures of global climate change. Sea level has been documented using several independent methods over the past 0.5 million years (Myr). Older periods, however, lack such independent validation; all existing records are related to deep-sea oxygen isoto...

journal_title：Nature

authors： Rohling EJ,Foster GL,Grant KM,Marino G,Roberts AP,Tamisiea ME,Williams F

更新日期：2014-04-24 00:00:00

abstract：:The human nose is often considered something of a luxury, but in the rest of the animal world, from bacteria to mammals, detecting chemicals in the environment has been critical to the successful organism. An indication of the importance of olfactory systems is the significant proportion - as much as 4% - of the genom...

journal_title：Nature

authors： Firestein S

更新日期：2001-09-13 00:00:00

abstract：:Mitochondrial cytochrome oxidase is a functionally complex, membrane-bound respiratory enzyme which catalyses both the reduction of O2 to water and proton-pumping. During respiration, an exogenous donor, cytochrome c, donates four electrons to O2 bound at the bimetallic haem alpha 3 Fe-Cu centre within the enzyme. The...

journal_title：Nature

authors： Wikström M

更新日期：1989-04-27 00:00:00

abstract：:More than twenty types of retinal ganglion cells conduct visual information from the eye to the rest of the brain. Each retinal ganglion cell type tessellates the retina in a regular mosaic, so that every point in visual space is processed for visual primitives such as contrast and motion. This information flows to tw...

journal_title：Nature

authors： Feinberg EH,Meister M

更新日期：2015-03-12 00:00:00

abstract：:Some plasmid DNAs, when maintained in wild-type Escherichia coli strains, form high levels of oligomeric species while others remain primarily monomers. One explanation of this observation is that the plasmids that do not form circular oligomers lack a DNA sequence necessary for the formation or maintenance of circula...

journal_title：Nature

authors： James AA,Morrison PT,Kolodner R

更新日期：1983-05-19 00:00:00

abstract：:Temperature-dependent transition of conductance in ionic channels has been described in several membrane systems. We report here an abrupt change in the maximal rate of rise of the action potentials of the rat extensor digitorum longus (EDL) at 32 degrees C, indicating alteration in the functional characteristics of t...

journal_title：Nature

authors： Cheung DW,Daniel EE

更新日期：1980-01-31 00:00:00

abstract：:Human epithelia are permanently challenged by bacteria and fungi, including commensal and pathogenic microbiota. In the gut, the fraction of strict anaerobes increases from proximal to distal, reaching 99% of bacterial species in the colon. At colonic mucosa, oxygen partial pressure is below 25% of airborne oxygen con...

journal_title：Nature

authors： Schroeder BO,Wu Z,Nuding S,Groscurth S,Marcinowski M,Beisner J,Buchner J,Schaller M,Stange EF,Wehkamp J

更新日期：2011-01-20 00:00:00

abstract：:Multicellular organisms have co-evolved with complex consortia of viruses, bacteria, fungi and parasites, collectively referred to as the microbiota1. In mammals, changes in the composition of the microbiota can influence many physiologic processes (including development, metabolism and immune cell function) and are a...

journal_title：Nature

authors： Chu C,Murdock MH,Jing D,Won TH,Chung H,Kressel AM,Tsaava T,Addorisio ME,Putzel GG,Zhou L,Bessman NJ,Yang R,Moriyama S,Parkhurst CN,Li A,Meyer HC,Teng F,Chavan SS,Tracey KJ,Regev A,Schroeder FC,Lee FS,Liston C

更新日期：2019-10-01 00:00:00

abstract：:A congressional investigation alleges that some researchers have failed to report all the drug-company money that they have received--and that universities may have been too slow to police them. ...

journal_title：Nature

authors：

更新日期：2008-10-16 00:00:00

abstract：:The separation of cells into populations that do not intermix, termed compartments, is a fundamental organizing principle during development. Dorsal-ventral compartmentalization of the Drosophila wing is regulated downstream of the apterous (ap) gene, which encodes a transcription factor that specifies dorsal wing fat...

journal_title：Nature

authors： Rauskolb C,Correia T,Irvine KD

更新日期：1999-09-30 00:00:00

abstract：:T-cell clones that grow continuously in tissue culture have become a major tool for studying the properties of T lymphocytes. It is therefore important to know to what extent such clones resemble their normal counterparts. Several reports have appeared recently which demonstrate that long-term T-cell lines may lose th...

journal_title：Nature

authors： Simon MM,Weltzien HU,Bühring HJ,Eichmann K

更新日期：1984-03-22 00:00:00

abstract：:The detection of electron spins associated with single defects in solids is a critical operation for a range of quantum information and measurement applications under development. So far, it has been accomplished for only two defect centres in crystalline solids: phosphorus dopants in silicon, for which electrical rea...

journal_title：Nature

authors： Yin C,Rancic M,de Boo GG,Stavrias N,McCallum JC,Sellars MJ,Rogge S

更新日期：2013-05-02 00:00:00

abstract：:The yeast [PSI+] element represents a new type of genetic inheritance, in which changes in phenotype are transmitted by a 'protein only' mechanism reminiscent of the 'protein-only' transmission of mammalian prion diseases. The underlying molecular mechanisms for both are poorly understood and it is not clear how simil...

journal_title：Nature

authors： Liu JJ,Lindquist S

更新日期：1999-08-05 00:00:00

abstract：:Ice sheets are currently ignored in global methane budgets1,2. Although ice sheets have been proposed to contain large reserves of methane that may contribute to a rise in atmospheric methane concentration if released during periods of rapid ice retreat3,4, no data exist on the current methane footprint of ice sheets....

journal_title：Nature

authors： Lamarche-Gagnon G,Wadham JL,Sherwood Lollar B,Arndt S,Fietzek P,Beaton AD,Tedstone AJ,Telling J,Bagshaw EA,Hawkings JR,Kohler TJ,Zarsky JD,Mowlem MC,Anesio AM,Stibal M

更新日期：2019-01-01 00:00:00

abstract：:A brief account is provided of a meeting between federal officials and representatives of the Industrial Biotechnology Association (IBA), a consortium of companies concerned about the regulatory outlook for their industry. Current regulatory interest is focused on the Environmental Protection Agency, which has declar...

journal_title：Nature

authors： David P

更新日期：1983-10-27 00:00:00

abstract：:Microsomes prepared from rabbit or pig aortas transformed endoperoxides (PGG2 or PGH2) to an unstable substance (PGX) that inhibited human platelet aggregation. PGX was 30 times more potent in this respect than prostaglandin E1. PGX contracted some gastrointestinal smooth muscle and relaxed certain isolated blood vess...

journal_title：Nature

authors： Moncada S,Gryglewski R,Bunting S,Vane JR

更新日期：1976-10-21 00:00:00

abstract：:During intracellular Ca2+ signalling mitochondria accumulate significant amounts of Ca2+ from the cytosol. Mitochondrial Ca2+ uptake controls the rate of energy production, shapes the amplitude and spatio-temporal patterns of intracellular Ca2+ signals, and is instrumental to cell death. This Ca2+ uptake is undertaken...

journal_title：Nature

authors： Kirichok Y,Krapivinsky G,Clapham DE

更新日期：2004-01-22 00:00:00

abstract：:In contrast to protein-coding sequences, the significance of variation in non-coding DNA in human disease has been minimally explored. A great number of recent genome-wide association studies suggest that non-coding variation is a significant risk factor for common disorders, but the mechanisms by which this variation...

journal_title：Nature

authors： Visel A,Rubin EM,Pennacchio LA

更新日期：2009-09-10 00:00:00

abstract：:The classical theory of solids, based on the quantum mechanics of single electrons moving in periodic potentials, provides an excellent description of substances ranging from semiconducting silicon to superconducting aluminium. Over the last fifteen years, it has become increasingly clear that there are substances for...

journal_title：Nature

authors： Yeh A,Soh YA,Brooke J,Aeppli G,Rosenbaum TF,Hayden SM

更新日期：2002-10-03 00:00:00

abstract：:Excitatory synaptic transmission in the central nervous system is mediated primarily by the release of glutamate from presynaptic terminals onto postsynaptic channels gated by N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors. The myriad intracellular responses arisi...

journal_title：Nature

authors： Wang Y,Small DL,Stanimirovic DB,Morley P,Durkin JP

更新日期：1997-10-02 00:00:00