Abstract：
:T-cell clones that grow continuously in tissue culture have become a major tool for studying the properties of T lymphocytes. It is therefore important to know to what extent such clones resemble their normal counterparts. Several reports have appeared recently which demonstrate that long-term T-cell lines may lose the specificity for which they were initially selected and acquire cytotoxic activity to a variety of targets, typical of the activity displayed by natural killer cells. We now report a number of instances in which murine cytotoxic T-cell clones have lost their original specific cytotoxic activity but have acquired strong specific cytotoxic activity for P815 mastocytoma target cells. Loss of the original specificity was usually observed after continuous in vitro cultivation for more than 6 months. We propose that this novel type of cytotoxicity should be called aged killer activity.
journal_name
Naturejournal_title
Natureauthors
Simon MM,Weltzien HU,Bühring HJ,Eichmann Kdoi
10.1038/308367a0subject
Has Abstractpub_date
1984-03-22 00:00:00pages
367-70issue
5957eissn
0028-0836issn
1476-4687journal_volume
308pub_type
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