Isolation of genetic elements that increase frequencies of plasmid recombinants.

abstract：:Butterflies rely extensively on colour vision to adapt to the natural world. Most species express a broad range of colour-sensitive Rhodopsin proteins in three types of ommatidia (unit eyes), which are distributed stochastically across the retina. The retinas of Drosophila melanogaster use just two main types, in whic...

journal_title：Nature

authors： Perry M,Kinoshita M,Saldi G,Huo L,Arikawa K,Desplan C

更新日期：2016-07-14 00:00:00

abstract：:Establishing the age at death of individuals is an important step in their identification and can be done with high precision up to adolescence by analysis of dentition, but it is more difficult in adults. Here we show that the amount of radiocarbon present in tooth enamel as a result of nuclear bomb testing during 19...

journal_title：Nature

authors： Spalding KL,Buchholz BA,Bergman LE,Druid H,Frisén J

更新日期：2005-09-15 00:00:00

abstract：:In developing mammalian muscle, axon branches of several motor neurons co-innervate the same muscle fibre. Competition among them results in the strengthening of one and the withdrawal of the rest. It is not known why one particular axon branch survives or why some competitions resolve sooner than others. Here we show...

journal_title：Nature

authors： Kasthuri N,Lichtman JW

更新日期：2003-07-24 00:00:00

abstract：:Five new double-mutant haemoglobins composed of betaS chains and alpha chains with different substitutions, which are located at the surface of the tetramer, have been prepared. Although all the hybrids are more soluble than deoxyhaemoglobin S, the individual differences between these molecules make it possible to eva...

journal_title：Nature

authors： Benesch RE,Yung S,Benesch R,Mack J,Schneider RG

更新日期：1976-03-18 00:00:00

abstract：:The formation of a primordial crust is a critical step in the evolution of terrestrial planets but the timing of this process is poorly understood. The mineral zircon is a powerful tool for constraining crust formation because it can be accurately dated with the uranium-to-lead (U-Pb) isotopic decay system and is resi...

journal_title：Nature

authors： Bouvier LC,Costa MM,Connelly JN,Jensen NK,Wielandt D,Storey M,Nemchin AA,Whitehouse MJ,Snape JF,Bellucci JJ,Moynier F,Agranier A,Gueguen B,Schönbächler M,Bizzarro M

更新日期：2018-06-01 00:00:00

abstract：: ...

journal_title：Nature

authors： Segal M

更新日期：2018-11-01 00:00:00

abstract：:Recent studies have shown that developing nerve fibres grow directly to their targets and are guided by specific cues, but the nature of these cues and the mechanism of guidance remain unknown. The growth of sympathetic axons towards an artificial source of nerve growth factor (NGF) in vivo and of sensory neurites up ...

journal_title：Nature

authors： Lumsden AG,Davies AM

更新日期：1983-12-22 00:00:00

abstract：:Local galaxies are broadly divided into two main classes, star-forming (gas-rich) and quiescent (passive and gas-poor). The primary mechanism responsible for quenching star formation in galaxies and transforming them into quiescent and passive systems is still unclear. Sudden removal of gas through outflows or strippi...

journal_title：Nature

authors： Peng Y,Maiolino R,Cochrane R

更新日期：2015-05-14 00:00:00

abstract：:Ultrathin ferroelectric materials could potentially enable low-power perovskite ferroelectric tetragonality logic and nonvolatile memories1,2. As ferroelectric materials are made thinner, however, the ferroelectricity is usually suppressed. Size effects in ferroelectrics have been thoroughly investigated in perovskite...

journal_title：Nature

authors： Cheema SS,Kwon D,Shanker N,Dos Reis R,Hsu SL,Xiao J,Zhang H,Wagner R,Datar A,McCarter MR,Serrao CR,Yadav AK,Karbasian G,Hsu CH,Tan AJ,Wang LC,Thakare V,Zhang X,Mehta A,Karapetrova E,Chopdekar RV,Shafer P,Arenh

更新日期：2020-04-01 00:00:00

abstract：:The guinea-pig (Cavia porcellus), traditionally classified as a New World hystricomorph rodent, often shows anomalous morphological and molecular features in comparison with other eutherian mammals. For example, its insulin differs from that of other mammals in anabolic and growth-promoting activities and in its capab...

journal_title：Nature

authors： Graur D,Hide WA,Li WH

更新日期：1991-06-20 00:00:00

abstract：:Design-specific control over excited-state dynamics is necessary for any application seeking to convert light into chemical potential. Such control is especially desirable in iron(II)-based chromophores, which are an Earth-abundant option for a wide range of photo-induced electron-transfer applications including solar...

journal_title：Nature

authors： Paulus BC,Adelman SL,Jamula LL,McCusker JK

更新日期：2020-06-01 00:00:00

abstract：:A major aim in immunology has been to understand how the immune system evokes characteristic responses to infection, foreign tissue grafts and tumours. The current view of immunoregulation is based mainly on studies of lymphocyte subsets, either in vitro or by adoptive transfer to irradiated recipients. Many reagents ...

journal_title：Nature

authors： Cobbold SP,Jayasuriya A,Nash A,Prospero TD,Waldmann H

更新日期：1984-12-06 00:00:00

abstract：:Nutrient signalling integrates and coordinates gene expression, metabolism and growth. However, its primary molecular mechanisms remain incompletely understood in plants and animals. Here we report unique Ca2+ signalling triggered by nitrate with live imaging of an ultrasensitive biosensor in Arabidopsis leaves and ro...

journal_title：Nature

authors： Liu KH,Niu Y,Konishi M,Wu Y,Du H,Sun Chung H,Li L,Boudsocq M,McCormack M,Maekawa S,Ishida T,Zhang C,Shokat K,Yanagisawa S,Sheen J

更新日期：2017-05-18 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2019-02-01 00:00:00

abstract：:The pseudogap is a partial gap in the electronic density of states that opens in the normal (non-superconducting) state of cuprate superconductors and whose origin is a long-standing puzzle. Its connection to the Mott insulator phase at low doping (hole concentration, p) remains ambiguous and its relation to the charg...

journal_title：Nature

authors： Badoux S,Tabis W,Laliberté F,Grissonnanche G,Vignolle B,Vignolles D,Béard J,Bonn DA,Hardy WN,Liang R,Doiron-Leyraud N,Taillefer L,Proust C

更新日期：2016-03-10 00:00:00

abstract：:Recent studies have demonstrated that monkeys and humans can use signals from the brain to guide computer cursors. Brain-computer interfaces (BCIs) may one day assist patients suffering from neurological injury or disease, but relatively low system performance remains a major obstacle. In fact, the speed and accuracy ...

journal_title：Nature

authors： Santhanam G,Ryu SI,Yu BM,Afshar A,Shenoy KV

更新日期：2006-07-13 00:00:00

abstract：:Type II DNA topoisomerases are ubiquitous ATP-dependent enzymes capable of transporting a DNA through a transient double-strand break in a second DNA segment. This enables them to untangle DNA and relax the interwound supercoils (plectonemes) that arise in twisted DNA. In vivo, they are responsible for untangling repl...

journal_title：Nature

authors： Strick TR,Croquette V,Bensimon D

更新日期：2000-04-20 00:00:00

abstract：:High-harmonic generation by focusing a femtosecond laser onto a gas is a well-known method of producing coherent extreme-ultraviolet (EUV) light. This nonlinear conversion process requires high pulse intensities, greater than 10(13) W cm(-2), which are not directly attainable using only the output power of a femtoseco...

journal_title：Nature

authors： Kim S,Jin J,Kim YJ,Park IY,Kim Y,Kim SW

更新日期：2008-06-05 00:00:00

abstract：:Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium that is characterized by the accumulation of mutations and a dysregulated immune response. Up to 90% of disease risk is thought to be due to environmental factors such as diet, which is consistent with a growing body of literature that des...

journal_title：Nature

authors： Janney A,Powrie F,Mann EH

更新日期：2020-09-01 00:00:00

abstract：:During anaphase identical sister chromatids separate and move towards opposite poles of the mitotic spindle. In the spindle, kinetochore microtubules have their plus ends embedded in the kinetochore and their minus ends at the spindle pole. Two models have been proposed to account for the movement of chromatids during...

journal_title：Nature

authors： Rogers GC,Rogers SL,Schwimmer TA,Ems-McClung SC,Walczak CE,Vale RD,Scholey JM,Sharp DJ

更新日期：2004-01-22 00:00:00

abstract：:Myeloid precursors can be grown in vitro in the presence of specific growth factors; however, their expansion is limited by a competing process of terminal differentiation. Proto-oncogenes seem to be involved in cellular proliferation and/or differentiation and may also play a role in the myelopoietic process. Murine ...

journal_title：Nature

authors： Blasi E,Mathieson BJ,Varesio L,Cleveland JL,Borchert PA,Rapp UR

更新日期：1985-12-19 00:00:00

abstract：:Subduction zones produce the largest earthquakes. Over the past two decades, space geodesy has revolutionized our view of crustal deformation between consecutive earthquakes. The short time span of modern measurements necessitates comparative studies of subduction zones that are at different stages of the deformation ...

journal_title：Nature

authors： Wang K,Hu Y,He J

更新日期：2012-04-18 00:00:00

abstract：:What limits the rate at which sensory information can be transmitted across synaptic connections in the brain? High-frequency signalling is restricted to brief bursts at many central excitatory synapses, whereas graded ribbon-type synapses can sustain release and transmit information at high rates. Here we investigate...

journal_title：Nature

authors： Saviane C,Silver RA

更新日期：2006-02-23 00:00:00

abstract：:The B cells of the immune system, which secrete antibodies against foreign antigens, are fully specific and effective only after maturation in lymph nodes and other lymphoid tissues. Immunocompetent T cells play a crucial part in this process, but the molecular details of the way in which the two cell types interact h...

journal_title：Nature

authors： Clark EA,Ledbetter JA

更新日期：1994-02-03 00:00:00

abstract：:Calcium permeability of basophil and mast cell membranes is stimulated on allergen binding to its specific membrane-bound IgE. This entry of Ca2+ ions into the cell triggers the degranulation and secretion process. Disodium cromoglycate (cromolyn DSCG), the disodium salt of 1,3-bis(-2-carboxychromon-5-yloxy)-2-hydroxy...

journal_title：Nature

authors： Mazurek N,Berger G,Pecht I

更新日期：1980-08-14 00:00:00

abstract：:Heterotrimeric G-proteins bind to cell-surface receptors and are integral in transmission of signals from outside the cell. Upon activation of the Galpha subunit by binding of GTP, the Galpha and Gbetagamma subunits dissociate and interact with effector proteins for signal transduction. Regulatory proteins with the 19...

journal_title：Nature

authors： Kimple RJ,Kimple ME,Betts L,Sondek J,Siderovski DP

更新日期：2002-04-25 00:00:00

abstract：:Complex I is the first enzyme of the respiratory chain and has a central role in cellular energy production, coupling electron transfer between NADH and quinone to proton translocation by an unknown mechanism. Dysfunction of complex I has been implicated in many human neurodegenerative diseases. We have determined the...

journal_title：Nature

authors： Efremov RG,Baradaran R,Sazanov LA

更新日期：2010-05-27 00:00:00

abstract：:Animals learn that a tone can predict the occurrence of an electric shock through classical conditioning. Mice or rats trained in this manner display fear responses, such as freezing behaviour, when they hear the conditioned tone. Studies using amygdalectomized rats have shown that the amygdala is required for both th...

journal_title：Nature

authors： Garcia R,Vouimba RM,Baudry M,Thompson RF

更新日期：1999-11-18 00:00:00

abstract：:Quantum mechanical experiments in ring geometries have long fascinated physicists. Open rings connected to leads, for example, allow the observation of the Aharonov-Bohm effect, one of the best examples of quantum mechanical phase coherence. The phase coherence of electrons travelling through a quantum dot embedded in...

journal_title：Nature

authors： Fuhrer A,Lüscher S,Ihn T,Heinzel T,Ensslin K,Wegscheider W,Bichler M

更新日期：2001-10-25 00:00:00

abstract：:Q beta replicase, in the absence of added template, will synthesize RNA autocatalytically. A variety of small RNa species, termed '6S RNAs' are generated. As this reaction purportedly occurs in the absence of template, it has been termed 'de novo' RNA synthesis. The question of whether Q beta replicase can polymerize ...

journal_title：Nature

authors： Hill D,Blumenthal T

更新日期：1983-01-27 00:00:00