Change of carrier density at the pseudogap critical point of a cuprate superconductor.

abstract：:53BP1 governs a specialized, context-specific branch of the classical non-homologous end joining DNA double-strand break repair pathway. Mice lacking 53bp1 (also known as Trp53bp1) are immunodeficient owing to a complete loss of immunoglobulin class-switch recombination1,2, and reduced fidelity of long-range V(D)J rec...

journal_title：Nature

authors： Ghezraoui H,Oliveira C,Becker JR,Bilham K,Moralli D,Anzilotti C,Fischer R,Deobagkar-Lele M,Sanchiz-Calvo M,Fueyo-Marcos E,Bonham S,Kessler BM,Rottenberg S,Cornall RJ,Green CM,Chapman JR

更新日期：2018-08-01 00:00:00

abstract：:Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium that is characterized by the accumulation of mutations and a dysregulated immune response. Up to 90% of disease risk is thought to be due to environmental factors such as diet, which is consistent with a growing body of literature that des...

journal_title：Nature

authors： Janney A,Powrie F,Mann EH

更新日期：2020-09-01 00:00:00

abstract：:Protein G is a cell-surface protein from Streptococcus which binds to IgG molecules from a wide range of species with an affinity comparable to that of antigen. The high affinity of protein G for the Fab portion of IgG poses a particular challenge in molecular recognition, given the variability of heavy chain subclass...

journal_title：Nature

authors： Derrick JP,Wigley DB

更新日期：1992-10-22 00:00:00

abstract：:High-harmonic generation is a well-known method of producing coherent extreme-ultraviolet (EUV) light, with photon energies up to about 0.5 keV (refs 1, 2). This is achieved by focusing a femtosecond laser into a gas, and high harmonics of the fundamental laser frequency are radiated in the forward direction. However,...

journal_title：Nature

authors： Paul A,Bartels RA,Tobey R,Green H,Weiman S,Christov IP,Murnane MM,Kapteyn HC,Backus S

更新日期：2003-01-02 00:00:00

abstract：:Networks of interacting proteins orchestrate the responses of living cells to a variety of external stimuli, but how sensitive is the functioning of these protein networks to variations in their biochemical parameters? One possibility is that to achieve appropriate function, the reaction rate constants and enzyme conc...

journal_title：Nature

authors： Alon U,Surette MG,Barkai N,Leibler S

更新日期：1999-01-14 00:00:00

abstract：:The horizontal separation of the eyes means that objects nearer or farther than the fixation point project to different locations on the two retinae, differing principally in their horizontal coordinates (horizontal binocular disparity). Disparity-selective neurons have generally been studied with disparities applied ...

journal_title：Nature

authors： Cumming BG

更新日期：2002-08-08 00:00:00

abstract：:Highly efficient neutron detectors are critical in many sectors, including national security1,2, medicine3, crystallography4 and astronomy5. The main neutron detection technologies currently used involve 3He-gas-filled proportional counters6 and light scintillators7 for thermalized neutrons. Semiconductors could provi...

journal_title：Nature

authors： Chica DG,He Y,McCall KM,Chung DY,Pak RO,Trimarchi G,Liu Z,De Lurgio PM,Wessels BW,Kanatzidis MG

更新日期：2020-01-01 00:00:00

abstract：:Oscillations in cyclin-dependent kinase (CDK) activity drive the somatic cell cycle. After entry into mitosis, CDKs activate the anaphase-promoting complex (APC), which then promotes cyclin degradation and mitotic exit. The re-accumulation of cyclin A causes the inactivation of APC and entry into S phase, but how cycl...

journal_title：Nature

authors： Rape M,Kirschner MW

更新日期：2004-12-02 00:00:00

abstract：:The recognition of foreign antigens by T lymphocytes is essential to most adaptive immune responses. It is driven by specific T-cell antigen receptors (TCRs) binding to antigenic peptide-major histocompatibility complex (pMHC) molecules on other cells. If productive, these interactions promote the formation of an immu...

journal_title：Nature

authors： Huppa JB,Axmann M,Mörtelmaier MA,Lillemeier BF,Newell EW,Brameshuber M,Klein LO,Schütz GJ,Davis MM

更新日期：2010-02-18 00:00:00

abstract：:The DNA polymerase V (pol V) and RecA proteins are essential components of a mutagenic translesion synthesis pathway in Escherichia coli designed to cope with DNA damage. Previously, it has been assumed that RecA binds to the DNA template strand being copied. Here we show, however, that pol-V-catalysed translesion syn...

journal_title：Nature

authors： Schlacher K,Cox MM,Woodgate R,Goodman MF

更新日期：2006-08-24 00:00:00

abstract：:All living organisms use ion channels to regulate the transport of ions across cellular membranes. Certain ion channels are classed as voltage-dependent because they have a voltage-sensing structure that induces their pores to open in response to changes in the cell membrane voltage. Until recently, the voltage-depend...

journal_title：Nature

authors： Ruta V,Jiang Y,Lee A,Chen J,MacKinnon R

更新日期：2003-03-13 00:00:00

abstract：:The study of planarian regeneration may help us to understand how we can rebuild organs and tissues after injury, disease or ageing. The robust regenerative abilities of planarians are based upon a population of totipotent stem cells (neoblasts), and among the organs regenerated by these animals is a well-organized ce...

journal_title：Nature

authors： Cebrià F,Kobayashi C,Umesono Y,Nakazawa M,Mineta K,Ikeo K,Gojobori T,Itoh M,Taira M,Sánchez Alvarado A,Agata K

更新日期：2002-10-10 00:00:00

abstract：:White dwarfs represent the endpoint of stellar evolution for stars with initial masses between approximately 0.07 and 8-10, where is the mass of the Sun (more massive stars end their life as either black holes or neutron stars). The theory of stellar evolution predicts that the majority of white dwarfs have a core mad...

journal_title：Nature

authors： Dufour P,Liebert J,Fontaine G,Behara N

更新日期：2007-11-22 00:00:00

abstract：:Data from a rocket experiment show details which were not known from ground-based observations. ...

journal_title：Nature

authors： Sudbury GC,Ingham MF

更新日期：1970-05-09 00:00:00

abstract：:Immune-challenged vertebrate females transfer specific antibodies to their offspring, but this gratuitous immunity cannot operate in invertebrates. Here we show that constitutive immune defence is enhanced in sexual offspring of the bumble-bee Bombus terrestris L. when the parental colony is immune-challenged. Our fin...

journal_title：Nature

authors： Moret Y,Schmid-Hempel P

更新日期：2001-11-29 00:00:00

abstract：:Extinction from habitat loss is the signature conservation problem of the twenty-first century. Despite its importance, estimating extinction rates is still highly uncertain because no proven direct methods or reliable data exist for verifying extinctions. The most widely used indirect method is to estimate extinction...

journal_title：Nature

authors： He F,Hubbell SP

更新日期：2011-05-19 00:00:00

abstract：:The spontaneously hypertensive rat and the stroke-prone spontaneously hypertensive rat are useful models for human hypertension. In these strains hypertension is a polygenic trait, in which both autosomal and sex-linked genes can influence blood pressure. Linkage studies in crosses between the stroke-prone spontaneous...

journal_title：Nature

authors： Hilbert P,Lindpaintner K,Beckmann JS,Serikawa T,Soubrier F,Dubay C,Cartwright P,De Gouyon B,Julier C,Takahasi S

更新日期：1991-10-10 00:00:00

abstract：:The molecular machinery responsible for the generation of transport carriers moving from the Golgi complex to the plasma membrane relies on a tight interplay between proteins and lipids. Among the lipid-binding proteins of this machinery, we previously identified the four-phosphate adaptor protein FAPP2, the pleckstri...

journal_title：Nature

authors： D'Angelo G,Polishchuk E,Di Tullio G,Santoro M,Di Campli A,Godi A,West G,Bielawski J,Chuang CC,van der Spoel AC,Platt FM,Hannun YA,Polishchuk R,Mattjus P,De Matteis MA

更新日期：2007-09-06 00:00:00

abstract：:The primary structure of the poliovirus genome has been determined. The RNA molecule is 7,433 nucleotides long, polyadenylated at the 3' terminus, and covalently linked to a small protein (VPg) at the 5' terminus. An open reading frame of 2,207 consecutive triplets spans over 89% of the nucleotide sequence and codes f...

journal_title：Nature

authors： Kitamura N,Semler BL,Rothberg PG,Larsen GR,Adler CJ,Dorner AJ,Emini EA,Hanecak R,Lee JJ,van der Werf S,Anderson CW,Wimmer E

更新日期：1981-06-18 00:00:00

abstract：:Calcium permeability of basophil and mast cell membranes is stimulated on allergen binding to its specific membrane-bound IgE. This entry of Ca2+ ions into the cell triggers the degranulation and secretion process. Disodium cromoglycate (cromolyn DSCG), the disodium salt of 1,3-bis(-2-carboxychromon-5-yloxy)-2-hydroxy...

journal_title：Nature

authors： Mazurek N,Berger G,Pecht I

更新日期：1980-08-14 00:00:00

abstract：:Reactive oxygen species are involved in many cellular metabolic and signalling processes and are thought to have a role in disease, particularly in carcinogenesis and ageing. We have generated mice with targeted inactivation of Prdx1, a member of the peroxiredoxin family of antioxidant enzymes. Here we show that mice ...

journal_title：Nature

authors： Neumann CA,Krause DS,Carman CV,Das S,Dubey DP,Abraham JL,Bronson RT,Fujiwara Y,Orkin SH,Van Etten RA

更新日期：2003-07-31 00:00:00

abstract：:The ability to pattern surfaces on a microscopic length scale is of importance for technological applications such as the fabrication of microelectronic circuits and digital storage media. Devices fabricated entirely from polymers are now available, opening up the possibility of adapting polymer processing technologie...

journal_title：Nature

authors： Higgins AM,Jones RA

更新日期：2000-03-30 00:00:00

abstract：:The versatility of Ca2+ signals derives from their spatio-temporal organization. For Ca2+ signals initiated by inositol-1,4,5-trisphosphate (InsP3), this requires local interactions between InsP3 receptors (InsP3Rs) mediated by their rapid stimulation and slower inhibition\ by cytosolic Ca2+. This allows hierarchical ...

journal_title：Nature

authors： Taufiq-Ur-Rahman,Skupin A,Falcke M,Taylor CW

更新日期：2009-04-02 00:00:00

abstract：:Cells deficient in the Brca1 and Brca2 genes have reduced capacity to repair DNA double-strand breaks by homologous recombination and consequently are hypersensitive to DNA-damaging agents, including cisplatin and poly(ADP-ribose) polymerase (PARP) inhibitors. Here we show that loss of the MLL3/4 complex protein, PTIP...

journal_title：Nature

authors： Ray Chaudhuri A,Callen E,Ding X,Gogola E,Duarte AA,Lee JE,Wong N,Lafarga V,Calvo JA,Panzarino NJ,John S,Day A,Crespo AV,Shen B,Starnes LM,de Ruiter JR,Daniel JA,Konstantinopoulos PA,Cortez D,Cantor SB,Fernandez-Ca

更新日期：2016-07-21 00:00:00

abstract：:The instruction of the immune system to be tolerant of self, thereby preventing autoimmunity, is facilitated by the education of T cells in a specialized organ, the thymus, in which self-reactive cells are either eliminated or differentiated into tolerogenic Foxp3(+) regulatory T (T(reg)) cells. However, it is unknown...

journal_title：Nature

authors： Lathrop SK,Bloom SM,Rao SM,Nutsch K,Lio CW,Santacruz N,Peterson DA,Stappenbeck TS,Hsieh CS

更新日期：2011-09-21 00:00:00

abstract：:Warming surface temperatures have driven a substantial reduction in the extent and duration of Northern Hemisphere snow cover1-3. These changes in snow cover affect Earth's climate system via the surface energy budget, and influence freshwater resources across a large proportion of the Northern Hemisphere4-6. In contr...

journal_title：Nature

authors： Pulliainen J,Luojus K,Derksen C,Mudryk L,Lemmetyinen J,Salminen M,Ikonen J,Takala M,Cohen J,Smolander T,Norberg J

更新日期：2020-05-01 00:00:00

abstract：:Positron-emission tomography (PET) can localize functions of the human brain by imaging regional cerebral blood flow (CBF) during voluntary behaviour. Functional brain mapping with PET, however, has been hindered by PET's poor spatial resolution (typically greater than 1 cm). We have developed an image-analysis strate...

journal_title：Nature

authors： Fox PT,Mintun MA,Raichle ME,Miezin FM,Allman JM,Van Essen DC

更新日期：1986-10-30 00:00:00

abstract：:So far, two genes associated with familial melanoma have been identified, accounting for a minority of genetic risk in families. Mutations in CDKN2A account for approximately 40% of familial cases, and predisposing mutations in CDK4 have been reported in a very small number of melanoma kindreds. Here we report the who...

journal_title：Nature

authors： Yokoyama S,Woods SL,Boyle GM,Aoude LG,MacGregor S,Zismann V,Gartside M,Cust AE,Haq R,Harland M,Taylor JC,Duffy DL,Holohan K,Dutton-Regester K,Palmer JM,Bonazzi V,Stark MS,Symmons J,Law MH,Schmidt C,Lanagan C,O'C

更新日期：2011-11-13 00:00:00

abstract：:Subduction zones produce the largest earthquakes. Over the past two decades, space geodesy has revolutionized our view of crustal deformation between consecutive earthquakes. The short time span of modern measurements necessitates comparative studies of subduction zones that are at different stages of the deformation ...

journal_title：Nature

authors： Wang K,Hu Y,He J

更新日期：2012-04-18 00:00:00

abstract：:Formation of catalytically active RNA structures within the spliceosome requires the assistance of proteins. However, little is known about the number and nature of proteins needed to establish and maintain the spliceosome's active site. Here we affinity-purified human spliceosomal C complexes and show that they catal...

journal_title：Nature

authors： Bessonov S,Anokhina M,Will CL,Urlaub H,Lührmann R

更新日期：2008-04-17 00:00:00