A binding site on mast cells and basophils for the anti-allergic drug cromolyn.

abstract：:The P2Y12 receptor (P2Y12R), one of eight members of the P2YR family expressed in humans, is one of the most prominent clinical drug targets for inhibition of platelet aggregation. Although mutagenesis and modelling studies of the P2Y12R provided useful insights into ligand binding, the agonist and antagonist recognit...

journal_title：Nature

authors： Zhang J,Zhang K,Gao ZG,Paoletta S,Zhang D,Han GW,Li T,Ma L,Zhang W,Müller CE,Yang H,Jiang H,Cherezov V,Katritch V,Jacobson KA,Stevens RC,Wu B,Zhao Q

更新日期：2014-05-01 00:00:00

abstract：:Spin dynamics in antiferromagnets has much shorter timescales than in ferromagnets, offering attractive properties for potential applications in ultrafast devices1-3. However, spin-current generation via antiferromagnetic resonance and simultaneous electrical detection by the inverse spin Hall effect in heavy metals h...

journal_title：Nature

authors： Li J,Wilson CB,Cheng R,Lohmann M,Kavand M,Yuan W,Aldosary M,Agladze N,Wei P,Sherwin MS,Shi J

更新日期：2020-02-01 00:00:00

abstract：:The biochemical and morphological differentiation of actinomycetes makes them academically and economically interesting. Their secondary metabolites provide the majority of medically and agriculturally important antibiotics (streptomycete genes may also be the primary source of clinically important antibiotic resistan...

journal_title：Nature

authors： Thompson CJ,Ward JM,Hopwood DA

更新日期：1980-07-31 00:00:00

abstract：:Systems of colour vision are normally identical in all members of a species, but a single design may not be adequate for species living in a diverse range of light environments. Here we show that in the mantis shrimp Haptosquilla trispinosa, which occupies a range of depths in the ocean, long-wavelength colour recepto...

journal_title：Nature

authors： Cronin TW,Caldwell RL,Marshall J

更新日期：2001-05-31 00:00:00

abstract：:After observation of detailed structural evidence for the origin of birds from dinosaurs, and in light of evidence that dinosaur bone tissue resembles the histology in mammals, the histology of bone has become one of the focal points in discussions of the physiology of dinosaurs and Mesozoic birds. Most of this micros...

journal_title：Nature

authors： Rensberger JM,Watabe M

更新日期：2000-08-10 00:00:00

abstract：:The molecular mechanisms of exon definition and back-splicing are fundamental unanswered questions in pre-mRNA splicing. Here we report cryo-electron microscopy structures of the yeast spliceosomal E complex assembled on introns, providing a view of the earliest event in the splicing cycle that commits pre-mRNAs to sp...

journal_title：Nature

authors： Li X,Liu S,Zhang L,Issaian A,Hill RC,Espinosa S,Shi S,Cui Y,Kappel K,Das R,Hansen KC,Zhou ZH,Zhao R

更新日期：2019-09-01 00:00:00

abstract：:The mobilization of aluminium from acidic forest soils is arguably the most ecologically important consequence of acid deposition in the environment because of its adverse effects on soils, forest vegetation and surface water. Here we show that there has been a significant decline in the concentrations of aluminium sp...

journal_title：Nature

authors： Palmer SM,Driscoll CT

更新日期：2002-05-16 00:00:00

abstract：:The hope that hybridoma antibodies would reveal unique cell surface antigens during embryogenesis, differentiation and oncogenesis has been replaced by the realization that such antigens are mainly carbohydrate structures of glycoproteins and glycolipids occurring in many cell types. These findings either may reflect ...

journal_title：Nature

authors： Feizi T

更新日期：1985-03-07 00:00:00

abstract：:The origin of cooperation is a central challenge to our understanding of evolution. The fact that microbial interactions can be manipulated in ways that animal interactions cannot has led to a growing interest in microbial models of cooperation and competition. For the budding yeast Saccharomyces cerevisiae to grow on...

journal_title：Nature

authors： Gore J,Youk H,van Oudenaarden A

更新日期：2009-05-14 00:00:00

abstract：:Homologous recombination is a molecular process that has multiple important roles in DNA metabolism, both for DNA repair and genetic variation in all forms of life. Generally, homologous recombination involves the exchange of genetic information between two identical or nearly identical DNA molecules; however, homolog...

journal_title：Nature

authors： Keskin H,Shen Y,Huang F,Patel M,Yang T,Ashley K,Mazin AV,Storici F

更新日期：2014-11-20 00:00:00

abstract：: ...

journal_title：Nature

authors： Jia H

更新日期：2018-11-01 00:00:00

abstract：:Transfer RNA nucleotidyltransferases (CCA-adding enzymes) are responsible for the maturation or repair of the functional 3' end of tRNAs by means of the addition of the essential nucleotides CCA. However, it is unclear how tRNA nucleotidyltransferases polymerize CCA onto the 3' terminus of immature tRNAs without using...

journal_title：Nature

authors： Xiong Y,Steitz TA

更新日期：2004-08-05 00:00:00

abstract：:Indirect-benefit models of sexual selection assert that females gain heritable offspring advantages through a mating bias for males of superior genetic quality. This has generally been tested by associating a simple morphological quality indicator (for example, bird tail length) with offspring viability. However, sele...

journal_title：Nature

authors： Fedorka KM,Mousseau TA

更新日期：2004-05-06 00:00:00

abstract：:Small synthetic molecules called growth-hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from the pituitary. They act through GHS-R, a G-protein-coupled receptor for which the ligand is unknown. Recent cloning of GHS-R strongly suggests that an endogenous ligand for the receptor does exist and...

journal_title：Nature

authors： Kojima M,Hosoda H,Date Y,Nakazato M,Matsuo H,Kangawa K

更新日期：1999-12-09 00:00:00

abstract：:Sensory experiences exert a powerful influence on the function and future performance of neuronal circuits in the mammalian neocortex. Restructuring of synaptic connections is believed to be one mechanism by which cortical circuits store information about the sensory world. Excitatory synaptic structures, such as dend...

journal_title：Nature

authors： Hofer SB,Mrsic-Flogel TD,Bonhoeffer T,Hübener M

更新日期：2009-01-15 00:00:00

abstract：:Developing an optical amplifier on silicon is essential for the success of silicon-on-insulator (SOI) photonic integrated circuits. Recently, optical gain with a 1-nm bandwidth was demonstrated using the Raman effect, which led to the demonstration of a Raman oscillator, lossless optical modulation and optically tunab...

journal_title：Nature

authors： Foster MA,Turner AC,Sharping JE,Schmidt BS,Lipson M,Gaeta AL

更新日期：2006-06-22 00:00:00

abstract：:Continuous turnover of epithelia is ensured by the extensive self-renewal capacity of tissue-specific stem cells. Similarly, epithelial tumour maintenance relies on cancer stem cells (CSCs), which co-opt stem cell properties. For most tumours, the cellular origin of these CSCs and regulatory pathways essential for sus...

journal_title：Nature

authors： Malanchi I,Peinado H,Kassen D,Hussenet T,Metzger D,Chambon P,Huber M,Hohl D,Cano A,Birchmeier W,Huelsken J

更新日期：2008-04-03 00:00:00

abstract：:Excision of introns from nuclear precursors to messenger RNAs (pre-mRNAs) by the spliceosome requires two distinct phosphodiester transfer (transesterification) reactions: exchange of a 3'-5' for a 2'-5' bond in the first step (lariat formation) and exchange of one 3'-5' phosphodiester for another in the second step (...

journal_title：Nature

authors： Moore MJ,Sharp PA

更新日期：1993-09-23 00:00:00

abstract：:Caenorhabditis elegans senses environmental signals through ciliated sensory neurons located primarily in sensory organs in the head and tail. Cilia function as sensory receptors, and mutants with defective sensory cilia have impaired sensory perception. Cilia are membrane-bound microtubule-based structures and in C. ...

journal_title：Nature

authors： Apfeld J,Kenyon C

更新日期：1999-12-16 00:00:00

abstract：:Galactose oxidase is an extracellular enzyme secreted by the fungus Dactylium dendroides. It is monomeric, with a relative molecular mass of 68,000, catalyses the stereospecific oxidation of a broad range of primary alcohol substrates and possesses a unique mononuclear copper site essential for catalysing a two-electr...

journal_title：Nature

authors： Ito N,Phillips SE,Stevens C,Ogel ZB,McPherson MJ,Keen JN,Yadav KD,Knowles PF

更新日期：1991-03-07 00:00:00

abstract：:The NMDA (N-methyl-D-aspartate) receptor transduces the binding of glutamate and glycine, coupling it to the opening of a calcium-permeable ion channel 1 . Owing to the lack of high-resolution structural studies of the NMDA receptor, the mechanism by which ion-channel blockers occlude ion permeation is not well unders...

journal_title：Nature

authors： Song X,Jensen MØ,Jogini V,Stein RA,Lee CH,Mchaourab HS,Shaw DE,Gouaux E

更新日期：2018-04-01 00:00:00

abstract：:Archaeal and eukaryotic translation elongation factor 2 contain a unique post-translationally modified histidine residue called diphthamide, which is the target of diphtheria toxin. The biosynthesis of diphthamide was proposed to involve three steps, with the first being the formation of a C-C bond between the histidi...

journal_title：Nature

authors： Zhang Y,Zhu X,Torelli AT,Lee M,Dzikovski B,Koralewski RM,Wang E,Freed J,Krebs C,Ealick SE,Lin H

更新日期：2010-06-17 00:00:00

abstract：:At most synapses in the brain, short-term plasticity dynamically modulates synaptic strength. Rapid frequency-dependent changes in synaptic strength have key roles in sensory adaptation, gain control and many other neural computations. However, some auditory, vestibular and cerebellar synapses maintain constant streng...

journal_title：Nature

authors： Turecek J,Jackman SL,Regehr WG

更新日期：2017-11-23 00:00:00

abstract：:Neuronal circuits across several systems display remarkable plasticity to sensory input during postnatal development. Experience-dependent refinements are often restricted to well-defined critical periods in early life, but how these are established remains mostly unknown. A representative example is the loss of respo...

journal_title：Nature

authors： Fagiolini M,Hensch TK

更新日期：2000-03-09 00:00:00

abstract：:The macronutrient phosphorus is thought to limit primary productivity in the oceans on geological timescales. Although there has been a sustained effort to reconstruct the dynamics of the phosphorus cycle over the past 3.5 billion years, it remains uncertain whether phosphorus limitation persisted throughout Earth's h...

journal_title：Nature

authors： Reinhard CT,Planavsky NJ,Gill BC,Ozaki K,Robbins LJ,Lyons TW,Fischer WW,Wang C,Cole DB,Konhauser KO

更新日期：2017-01-19 00:00:00

abstract：:The tumour necrosis factor (TNF) ligand TALL-1 and its cognate receptors, BCMA, TACI and BAFF-R, were recently identified as members of the TNF superfamily, which are essential factors contributing to B-cell maturation. The functional, soluble fragment of TALL-1 (sTALL-1) forms a virus-like assembly for its proper fun...

journal_title：Nature

authors： Liu Y,Hong X,Kappler J,Jiang L,Zhang R,Xu L,Pan CH,Martin WE,Murphy RC,Shu HB,Dai S,Zhang G

更新日期：2003-05-01 00:00:00

abstract：: ...

journal_title：Nature

authors： Segal M

更新日期：2018-11-01 00:00:00

abstract：:Despite considerable global investment, only 60% of people who live with HIV currently receive antiretroviral therapy. The sustainability of current programmes remains unknown and key incidence rates are declining only modestly. Given the complexities and expenses associated with lifelong medication, developing an eff...

journal_title：Nature

authors： Ndung'u T,McCune JM,Deeks SG

更新日期：2019-12-01 00:00:00

abstract：:Dopamine D2 receptors (D2Rs) are densely expressed in the striatum and have been linked to neuropsychiatric disorders such as schizophrenia1,2. High-affinity binding of dopamine suggests that D2Rs detect transient reductions in dopamine concentration (the dopamine dip) during punishment learning3-5. However, the natur...

journal_title：Nature

authors： Iino Y,Sawada T,Yamaguchi K,Tajiri M,Ishii S,Kasai H,Yagishita S

更新日期：2020-03-01 00:00:00

abstract：:Genome sequencing has uncovered a new mutational phenomenon in cancer and congenital disorders called chromothripsis. Chromothripsis is characterized by extensive genomic rearrangements and an oscillating pattern of DNA copy number levels, all curiously restricted to one or a few chromosomes. The mechanism for chromot...

journal_title：Nature

authors： Zhang CZ,Spektor A,Cornils H,Francis JM,Jackson EK,Liu S,Meyerson M,Pellman D

更新日期：2015-06-11 00:00:00