How automation is changing work.

abstract：:Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a form of terminal cell-cycle arrest associated with pro-inflammatory...

journal_title：Nature

authors： Dou Z,Ghosh K,Vizioli MG,Zhu J,Sen P,Wangensteen KJ,Simithy J,Lan Y,Lin Y,Zhou Z,Capell BC,Xu C,Xu M,Kieckhaefer JE,Jiang T,Shoshkes-Carmel M,Tanim KMAA,Barber GN,Seykora JT,Millar SE,Kaestner KH,Garcia BA,Ada

更新日期：2017-10-19 00:00:00

abstract：:The human gene for the hepatic enzyme phenylalanine hydroxylase has been cloned and used to analyse the phenylalanine hydroxylase locus in the human genome. The detection of polymorphisms in this locus by several restriction enzymes has allowed feasibility studies of prenatal diagnosis of classical phenylketonuria and...

journal_title：Nature

authors： Woo SL,Lidsky AS,Güttler F,Chandra T,Robson KJ

更新日期：1983-11-10 00:00:00

abstract：:Recombination is the exchange of information between two homologous chromosomes during meiosis. The rate of recombination per nucleotide, which profoundly affects the evolution of chromosomal segments, is calculated by comparing genetic and physical maps. Human physical maps have been constructed using cytogenetics, o...

journal_title：Nature

authors： Yu A,Zhao C,Fan Y,Jang W,Mungall AJ,Deloukas P,Olsen A,Doggett NA,Ghebranious N,Broman KW,Weber JL

更新日期：2001-02-15 00:00:00

abstract：:In associative learning, the activated neurones undergo a variety of concomitant functional alterations--increases or decreases of firing activity and modifications of membrane potential or resistance and of synaptic responsiveness. Synaptic transmission which can be strengthened only when there is paired activity in ...

journal_title：Nature

authors： Baranyi A,Fehér O

更新日期：1981-04-02 00:00:00

abstract：:Selective lowering of Abeta42 levels (the 42-residue isoform of the amyloid-beta peptide) with small-molecule gamma-secretase modulators (GSMs), such as some non-steroidal anti-inflammatory drugs, is a promising therapeutic approach for Alzheimer's disease. To identify the target of these agents we developed biotinyla...

journal_title：Nature

authors： Kukar TL,Ladd TB,Bann MA,Fraering PC,Narlawar R,Maharvi GM,Healy B,Chapman R,Welzel AT,Price RW,Moore B,Rangachari V,Cusack B,Eriksen J,Jansen-West K,Verbeeck C,Yager D,Eckman C,Ye W,Sagi S,Cottrell BA,Torpey J

更新日期：2008-06-12 00:00:00

abstract：:There seems a real prospect that one of the infectious scourges of the past half century will not persist much beyond the present century, but polio will be only the second infection of human beings to be eradicated. Many more remain. ...

journal_title：Nature

authors：

更新日期：1995-04-20 00:00:00

abstract：:The proto-oncogene c-myc is the cellular homologue of the transforming sequence carried by the avian myelocytomastosis virus MC29. A growing body of evidence implicates structural and functional alterations in and around proto-oncogenes such as c-myc in tumorogenesis. Here we report that comparison of the structure of...

journal_title：Nature

authors： Morse B,Rotherg PG,South VJ,Spandorfer JM,Astrin SM

更新日期：1988-05-05 00:00:00

abstract：:The four R-spondin secreted ligands (RSPO1-RSPO4) act via their cognate LGR4, LGR5 and LGR6 receptors to amplify WNT signalling1-3. Here we report an allelic series of recessive RSPO2 mutations in humans that cause tetra-amelia syndrome, which is characterized by lung aplasia and a total absence of the four limbs. Fun...

journal_title：Nature

authors： Szenker-Ravi E,Altunoglu U,Leushacke M,Bosso-Lefèvre C,Khatoo M,Thi Tran H,Naert T,Noelanders R,Hajamohideen A,Beneteau C,de Sousa SB,Karaman B,Latypova X,Başaran S,Yücel EB,Tan TT,Vlaminck L,Nayak SS,Shukla A,Giris

更新日期：2018-05-01 00:00:00

abstract：:Rho is the essential RNA helicase that sets the borders between transcription units and adjusts transcriptional yield to translational needs in bacteria. Although Rho was the first termination factor to be discovered, the actual mechanism by which it reaches and disrupts the elongation complex (EC) is unknown. Here we...

journal_title：Nature

authors： Epshtein V,Dutta D,Wade J,Nudler E

更新日期：2010-01-14 00:00:00

abstract：:XX female mammals undergo transcriptional silencing of most genes on one of their two X chromosomes to equalize X-linked gene dosage with XY males in a process referred to as X-chromosome inactivation (XCI). XCI is an example of epigenetic regulation. Once enacted in individual cells of the early female embryo, XCI is...

journal_title：Nature

authors： Kalantry S,Purushothaman S,Bowen RB,Starmer J,Magnuson T

更新日期：2009-07-30 00:00:00

abstract：:Bacterial pathogens trigger specialized virulence factor secretion systems on encountering host cells. The ESX-1 protein secretion system of Mycobacterium tuberculosis-the causative agent of the human disease tuberculosis-delivers bacterial proteins into host cells during infection and is critical for virulence, but h...

journal_title：Nature

authors： Raghavan S,Manzanillo P,Chan K,Dovey C,Cox JS

更新日期：2008-08-07 00:00:00

abstract：:In a very short time the scanning tunnelling microscope has become an important tool in surface science, and physics in general. Its primary use has been to obtain atomic-resolution images of surfaces, but recently, efforts have been made to use it to manipulate materials as well as image them. One may now reasonably ...

journal_title：Nature

authors： Foster JS,Frommer JE,Arnett PC

更新日期：1988-01-28 00:00:00

abstract：:Endothelial cells line the inner surface of blood vessels and act as the main barrier to the passage of cells and large molecules from the blood stream to the tissues. Recent interest in the part played by the endothelium in regulating vascular tone has focused on the synthesis and secretion of prostacyclin and an end...

journal_title：Nature

authors： Lansman JB,Hallam TJ,Rink TJ

更新日期：1987-02-26 00:00:00

abstract：:Regulatory aspects of the Warnock Committee's report on reproductive technologies are summarized. A licensing authority with "substantial lay representation" would license practitioners and approve experimentation. Artificial insemination by donor would become a regulated service, and resulting children would be leg...

journal_title：Nature

authors：

更新日期：1984-07-26 00:00:00

abstract：:Several species related to Drosophila melanogaster have two loci containing sequences which code for the major heat-shock protein of molecular weight 70,000 (hsp70). These sequences are arranged as two pairs of inverted repeats. The structure of the 87C locus in D. melanogaster seems to have arisen through DNA inserti...

journal_title：Nature

authors： Leigh Brown AJ,Ish-Horowicz D

更新日期：1981-04-23 00:00:00

abstract：:Macrophages and dendritic cells have key roles in viral infections, providing virus reservoirs that frequently resist antiviral therapies and linking innate virus detection to antiviral adaptive immune responses. Human immunodeficiency virus 1 (HIV-1) fails to transduce dendritic cells and has a reduced ability to tra...

journal_title：Nature

authors： Hrecka K,Hao C,Gierszewska M,Swanson SK,Kesik-Brodacka M,Srivastava S,Florens L,Washburn MP,Skowronski J

更新日期：2011-06-29 00:00:00

abstract：:The neutron superfluid in most neutron stars should be in a highly turbulent state. If so, this turbulence drastically alters its rotational properties. ...

journal_title：Nature

authors： Greenstein G

更新日期：1970-08-22 00:00:00

abstract：:Metabotropic γ-aminobutyric acid receptors (GABAB) are involved in the modulation of synaptic responses in the central nervous system and have been implicated in neuropsychological conditions that range from addiction to psychosis1. GABAB belongs to class C of the G-protein-coupled receptors, and its functional entity...

journal_title：Nature

authors： Shaye H,Ishchenko A,Lam JH,Han GW,Xue L,Rondard P,Pin JP,Katritch V,Gati C,Cherezov V

更新日期：2020-08-01 00:00:00

abstract：:Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas (TCGA) pilot project aims to assess the value of large-scale multi-dimensional analysis of these molecular characteristics in human c...

journal_title：Nature

authors： Cancer Genome Atlas Research Network.

更新日期：2008-10-23 00:00:00

abstract：:Measurement of the free calcium concentration within a photo-receptor outer segment has been considered an important aim since the proposal by Hagins and Yoshikami that the primary event in phototransduction is a release of Ca (2+) inside the cell. More recent evidence has cast doubt on the calcium hypothesis, and the...

journal_title：Nature

authors： McNaughton PA,Cervetto L,Nunn BJ

更新日期：1986-07-17 00:00:00

abstract：:Myeloid precursors can be grown in vitro in the presence of specific growth factors; however, their expansion is limited by a competing process of terminal differentiation. Proto-oncogenes seem to be involved in cellular proliferation and/or differentiation and may also play a role in the myelopoietic process. Murine ...

journal_title：Nature

authors： Blasi E,Mathieson BJ,Varesio L,Cleveland JL,Borchert PA,Rapp UR

更新日期：1985-12-19 00:00:00

abstract：:The circadian clock imposes daily rhythms in cell proliferation, metabolism, inflammation and DNA damage response. Perturbations of these processes are hallmarks of cancer and chronic circadian rhythm disruption predisposes individuals to tumour development. This raises the hypothesis that pharmacological modulation o...

journal_title：Nature

authors： Sulli G,Rommel A,Wang X,Kolar MJ,Puca F,Saghatelian A,Plikus MV,Verma IM,Panda S

更新日期：2018-01-18 00:00:00

abstract：:Saturn's moon Titan has a nitrogen atmosphere comparable to Earth's, with a surface pressure of 1.4 bar. Numerical models reproduce the tropospheric conditions very well but have trouble explaining the observed middle-atmosphere temperatures, composition and winds. The top of the middle-atmosphere circulation has been...

journal_title：Nature

authors： Teanby NA,Irwin PG,Nixon CA,de Kok R,Vinatier S,Coustenis A,Sefton-Nash E,Calcutt SB,Flasar FM

更新日期：2012-11-29 00:00:00

abstract：:Transmissible spongiform encephalopathies are associated with accumulation of PrP(Sc), a conformer of a cellular protein called PrP(C). PrP(Sc) is thought to replicate by imparting its conformation onto PrP(C) (ref. 1), yet conformational discrimination between PrP(C) and PrP(Sc) has remained elusive. Because depositi...

journal_title：Nature

authors： Fischer MB,Roeckl C,Parizek P,Schwarz HP,Aguzzi A

更新日期：2000-11-23 00:00:00

abstract：:Suppressor of cytokine signalling-2 (SOCS-2) is a member of the suppressor of cytokine signalling family, a group of related proteins implicated in the negative regulation of cytokine action through inhibition of the Janus kinase (JAK) signal transducers and activators of transcription (STAT) signal-transduction pathw...

journal_title：Nature

authors： Metcalf D,Greenhalgh CJ,Viney E,Willson TA,Starr R,Nicola NA,Hilton DJ,Alexander WS

更新日期：2000-06-29 00:00:00

abstract：:Joining dissimilar materials such as plastics and metals in engineered structures remains a challenge1. Mechanical fastening, conventional welding and adhesive bonding are examples of techniques currently used for this purpose, but each of these methods presents its own set of problems2 such as formation of stress con...

journal_title：Nature

authors： Rivera J,Hosseini MS,Restrepo D,Murata S,Vasile D,Parkinson DY,Barnard HS,Arakaki A,Zavattieri P,Kisailus D

更新日期：2020-10-01 00:00:00

abstract：:The ability to control the quantum state of a single electron spin in a quantum dot is at the heart of recent developments towards a scalable spin-based quantum computer. In combination with the recently demonstrated controlled exchange gate between two neighbouring spins, driven coherent single spin rotations would p...

journal_title：Nature

authors： Koppens FH,Buizert C,Tielrooij KJ,Vink IT,Nowack KC,Meunier T,Kouwenhoven LP,Vandersypen LM

更新日期：2006-08-17 00:00:00

abstract：:Cancer cells acquire distinct metabolic adaptations to survive stress associated with tumour growth and to satisfy the anabolic demands of proliferation. The tumour suppressor protein p53 (also known as TP53) influences a range of cellular metabolic processes, including glycolysis, oxidative phosphorylation, glutamino...

journal_title：Nature

authors： Maddocks OD,Berkers CR,Mason SM,Zheng L,Blyth K,Gottlieb E,Vousden KH

更新日期：2013-01-24 00:00:00

abstract：:Guided by brain-like 'spiking' computational frameworks, neuromorphic computing-brain-inspired computing for machine intelligence-promises to realize artificial intelligence while reducing the energy requirements of computing platforms. This interdisciplinary field began with the implementation of silicon circuits for...

journal_title：Nature

authors： Roy K,Jaiswal A,Panda P

更新日期：2019-11-01 00:00:00

abstract：:Continuous turnover of epithelia is ensured by the extensive self-renewal capacity of tissue-specific stem cells. Similarly, epithelial tumour maintenance relies on cancer stem cells (CSCs), which co-opt stem cell properties. For most tumours, the cellular origin of these CSCs and regulatory pathways essential for sus...

journal_title：Nature

authors： Malanchi I,Peinado H,Kassen D,Hussenet T,Metzger D,Chambon P,Huber M,Hohl D,Cano A,Birchmeier W,Huelsken J

更新日期：2008-04-03 00:00:00