Insertional mutagenesis of the myc locus by a LINE-1 sequence in a human breast carcinoma.

Abstract:

:The proto-oncogene c-myc is the cellular homologue of the transforming sequence carried by the avian myelocytomastosis virus MC29. A growing body of evidence implicates structural and functional alterations in and around proto-oncogenes such as c-myc in tumorogenesis. Here we report that comparison of the structure of myc from a ductal adenocarcinoma of the breast and from normal breast tissue of the same patient (Sc) revealed a tumour-specific rearrangement of one myc locus and amplification of the other myc locus. (For myc reviews see refs 1-4; for myc involvement in breast neoplasia see refs 5-7.) Within the second intron of the rearranged locus was a non-myc sequence with nearly complete homology to a long interspersed repetitive element (a LINE-1 sequence or L1). In this case, the L1 sequence has functioned as a mobile genetic element to produce a somatic mutation.

journal_name

Nature

journal_title

Nature

authors

Morse B,Rotherg PG,South VJ,Spandorfer JM,Astrin SM

doi

10.1038/333087a0

subject

Has Abstract

pub_date

1988-05-05 00:00:00

pages

87-90

issue

6168

eissn

0028-0836

issn

1476-4687

journal_volume

333

pub_type

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