Abstract:
:Suppressor of cytokine signalling-2 (SOCS-2) is a member of the suppressor of cytokine signalling family, a group of related proteins implicated in the negative regulation of cytokine action through inhibition of the Janus kinase (JAK) signal transducers and activators of transcription (STAT) signal-transduction pathway. Here we use mice unable to express SOCS-2 to examine its function in vivo. SOCS-2(-/-) mice grew significantly larger than their wild-type littermates. Increased body weight became evident after weaning and was associated with significantly increased long bone lengths and the proportionate enlargement of most organs. Characteristics of deregulated growth hormone and insulin-like growth factor-I (IGF-I) signalling, including decreased production of major urinary protein, increased local IGF-I production, and collagen accumulation in the dermis, were observed in SOCS-2-deficient mice, indicating that SOCS-2 may have an essential negative regulatory role in the growth hormone/IGF-I pathway.
journal_name
Naturejournal_title
Natureauthors
Metcalf D,Greenhalgh CJ,Viney E,Willson TA,Starr R,Nicola NA,Hilton DJ,Alexander WSdoi
10.1038/35016611keywords:
subject
Has Abstractpub_date
2000-06-29 00:00:00pages
1069-73issue
6790eissn
0028-0836issn
1476-4687journal_volume
405pub_type
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