相关文献
NATURE文献大全abstract::The interrelationships between major living vertebrate, and even chordate, groups are now reasonably well resolved thanks to a large amount of generally congruent data derived from molecular sequences, anatomy and physiology. But fossils provide unexpected combinations of characters that help us to understand how the ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature14437
更新日期:2015-04-23 00:00:00
abstract::Because their molecular signatures are often prominent in extracts of sediments, bacteria are thought to be important contributors to petroleum source beds. It has been shown recently, however, that abundances of biomarkers do not always reflect relative contributions to sedimentary organic carbon (Corg). The contrib...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/369224a0
更新日期:1994-05-19 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/d41586-019-00737-2
更新日期:2019-03-01 00:00:00
abstract::There is ample evidence that the secretion of follicle stimulating hormone (FSH) by the pituitary gland is regulated by a nonsteroidal hormone of gonadal origin, termed inhibin. In several species, testicular extracts, gonadal lymph and seminal plasma have been shown to contain proteins which inhibit FSH release; lack...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/285246a0
更新日期:1980-05-22 00:00:00
abstract::Most of the progress in human culture has required the exploitation of energy resources. About 100 years ago, the major source of energy shifted from recent solar to fossil hydrocarbons, including liquid and gaseous petroleum. Technology has generally led to a greater use of hydrocarbon fuels for most human activities...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02130
更新日期:2003-11-20 00:00:00
abstract::The normal cellular form of prion protein (PrPC) is a precursor to the pathogenic protease-resistant forms (PrPSc) believed to cause scrapie, bovine spongiform encephalopathy (BSE) and Creutzfeldt-Jakob disease. Its amino terminus contains the octapeptide PHGGGWGQ, which is repeated four times and is among the best-pr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/37783
更新日期:1997-12-18 00:00:00
abstract::Quantum simulation--the use of one quantum system to simulate a less controllable one--may provide an understanding of the many quantum systems which cannot be modelled using classical computers. Considerable progress in control and manipulation has been achieved for various quantum systems, but one of the remaining c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13565
更新日期:2014-08-07 00:00:00
abstract::The DNA synthetic (S) phase of cell division is about twice as long in human basal cell carcinoma (BCC) as the normal epidermis and several non-malignant skin diseases. A similar increase in S phase duration seems to occur in tumours of the human oesophagus, larynx and recto-colon. At the molecular level, the overall ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/285265a0
更新日期:1980-05-22 00:00:00
abstract::Close inbreeding is known for a variety of small mammal species for which a high probability of mortality during dispersal makes helping and delayed maturation a relatively secure fitness option. Prolonged inbreeding, however, is usually associated with lowered fitness, and it has been shown that most highly inbred sm...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/380619a0
更新日期:1996-04-18 00:00:00
abstract::On the basis of their primary structure, the lysine-rich histones are a unified family of proteins. Each has an amino acid chain which falls into three distinct domains. Only the central domain (approximately 80 residues) is in a folded conformation. It is protected from trypsin digestion in chromatin and corresponds ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/288675a0
更新日期:1980-12-25 00:00:00
abstract::When present in single-stranded DNA, palindromic or quasi-palindromic sequences have the potential to form complex secondary structures, including hairpins, which may facilitate interstrand misalignment of direct repeats and be responsible for diverse types of replication-based mutations, including deletions, addition...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/352544a0
更新日期:1991-08-08 00:00:00
abstract::Sudden cardiac death is the leading cause of death in the industrialized world, with the majority of such tragedies being due to ventricular fibrillation. Ventricular fibrillation is a frenzied and irregular disturbance of the heart rhythm that quickly renders the heart incapable of sustaining life. Rotors, electrophy...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/32170
更新日期:1998-03-05 00:00:00
abstract::It is not yet clear whether humans are able to learn while they are sleeping. Here we show that full-term human newborns can be taught to discriminate between similar vowel sounds when they are fast asleep. It is possible that such sleep training soon after birth could find application in clinical or educational situa...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/415599b
更新日期:2002-02-07 00:00:00
abstract::Biological dinitrogen fixation provides the largest input of nitrogen to the oceans, therefore exerting important control on the ocean's nitrogen inventory and primary productivity. Nitrogen-isotope data from ocean sediments suggest that the marine-nitrogen inventory has been balanced for the past 3,000 years (ref. 4)...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11338
更新日期:2012-08-16 00:00:00
abstract::An ongoing challenge in chemical research is to design catalysts that select the outcomes of the reactions of complex molecules. Chemists rely on organocatalysts or transition metal catalysts to control stereoselectivity, regioselectivity and periselectivity (selectivity among possible pericyclic reactions). Nature ac...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2743-5
更新日期:2020-10-01 00:00:00
abstract::Mesenchymal cells contribute to the 'stroma' of most normal and malignant tissues, with specific mesenchymal cells participating in the regulatory niches of stem cells. By examining how mesenchymal osteolineage cells modulate haematopoiesis, here we show that deletion of Dicer1 specifically in mouse osteoprogenitors, ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08851
更新日期:2010-04-08 00:00:00
abstract::Protein synthesis takes place on the ribosome, where genetic information carried by messenger RNA is translated into a sequence of amino acids. This process is terminated when a stop codon moves into the ribosomal decoding centre (DC) and is recognized by a class-1 release factor (RF). RFs have a conserved GGQ amino-a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01224
更新日期:2003-01-02 00:00:00
abstract::Interstellar dust plays a crucial role in the evolution of the Universe by assisting the formation of molecules, by triggering the formation of the first low-mass stars, and by absorbing stellar ultraviolet-optical light and subsequently re-emitting it at infrared/millimetre wavelengths. Dust is thought to be produced...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02930
更新日期:2004-09-30 00:00:00
abstract::A key step in the elimination of pathogens from the body is the covalent binding of complement proteins C3 and C4 to their surfaces. Proteolytic activation of these proteins results in a conformational change, and an internal thioester is exposed which reacts with amino or hydroxyl groups on the target surface to form...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/379177a0
更新日期:1996-01-11 00:00:00
abstract::Males and females share many traits that have a common genetic basis; however, selection on these traits often differs between the sexes, leading to sexual conflict. Under such sexual antagonism, theory predicts the evolution of genetic architectures that resolve this sexual conflict. Yet, despite intense theoretical ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature16062
更新日期:2015-12-17 00:00:00
abstract::The formation of a primordial crust is a critical step in the evolution of terrestrial planets but the timing of this process is poorly understood. The mineral zircon is a powerful tool for constraining crust formation because it can be accurately dated with the uranium-to-lead (U-Pb) isotopic decay system and is resi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0222-z
更新日期:2018-06-01 00:00:00
abstract::Formation of electron pairs is essential to superconductivity. For conventional superconductors, tunnelling spectroscopy has established that pairing is mediated by bosonic modes (phonons); a peak in the second derivative of tunnel current d2I/dV2 corresponds to each phonon mode. For high-transition-temperature (high-...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04973
更新日期:2006-08-03 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 评论,新闻
doi:10.1038/d41586-019-00450-0
更新日期:2019-02-01 00:00:00
abstract::The discovery of the basis of genetic variation has opened inroads to understanding our history as a species. It has revealed the remarkable genetic similarity we share with other individuals as well as with our closest primate relatives. To understand what make us unique, both as individuals and as a species, we need...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature01400
更新日期:2003-01-23 00:00:00
abstract::Various mechanisms have been proposed for beta-adrenergically mediated relaxation of smooth muscle. All theories suggest the involvement of cyclic AMP as a second messenger: beta-agonists stimulate adenylate cyclase which converts ATP to cyclic AMP and protein kinase, activated by cyclic AMP, is then thought to cataly...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/281682a0
更新日期:1979-10-25 00:00:00
abstract::The factors driving glacial changes in ocean overturning circulation are not well understood. On the basis of a comparison of 20 climate variables over the past four glacial cycles, the SPECMAP project proposed that summer insolation at high northern latitudes (that is, Milankovitch forcing) drives the same sequence o...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature07425
更新日期:2008-11-06 00:00:00
abstract::We have previously identified a structurally abnormal insulin in the serum and pancreas of a middle-aged man with diabetes mellitus which arose from a leucine for phenylalanine substitution at position 24 or 25 of the insulin B chain; further analysis of the patient's leukocyte DNA showed that one of the patient's ins...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/302540a0
更新日期:1983-04-07 00:00:00
abstract::The female germ line undergoes a unique sequence of differentiation processes that confers totipotency to the egg. The reconstitution of these events in vitro using pluripotent stem cells is a key achievement in reproductive biology and regenerative medicine. Here we report successful reconstitution in vitro of the en...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature20104
更新日期:2016-11-10 00:00:00
abstract::Transcriptional activator proteins (activators) function, at least in part, by increasing preinitiation complex assembly (for reviews see refs 1-4). Previous studies have shown that an acidic activator forms a contact with the general transcription factor TFIIB (refs 5-7) and recruits it into the preinitiation complex...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/371717a0
更新日期:1994-10-20 00:00:00
abstract::The formation of precise connections between retina and lateral geniculate nucleus (LGN) involves the activity-dependent elimination of some synapses, with strengthening and retention of others. Here we show that the major histocompatibility complex (MHC) class I molecule H2-D(b) is necessary and sufficient for synaps...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13154
更新日期:2014-05-08 00:00:00