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NATURE文献大全abstract::The bacterial CRISPR/Cas9 system allows sequence-specific gene editing in many organisms and holds promise as a tool to generate models of human diseases, for example, in human pluripotent stem cells. CRISPR/Cas9 introduces targeted double-stranded breaks (DSBs) with high efficiency, which are typically repaired by no...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature17664
更新日期:2016-05-05 00:00:00
abstract::Mr Clinton appears ready to compromise on health care reform despite previous denials. ...
journal_title:Nature
pub_type: 社论
doi:10.1038/371002c0
更新日期:1994-09-01 00:00:00
abstract::Common genetic contributions to autism spectrum disorder (ASD) reside in risk gene variants that individually have minimal effect sizes. As environmental factors that perturb neurodevelopment also underlie idiopathic ASD, it is crucial to identify altered regulators that can orchestrate multiple ASD risk genes during ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0423-5
更新日期:2018-08-01 00:00:00
abstract::The overexpression of defined transcription factors in somatic cells results in their reprogramming into induced pluripotent stem (iPS) cells. The extremely low efficiency and slow kinetics of in vitro reprogramming suggest that further rare events are required to generate iPS cells. The nature and identity of these e...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08285
更新日期:2009-08-27 00:00:00
abstract::The collagens represent an interesting example of a structurally related but genetically distinct family of proteins. Type I, the most abundant of the vertebrate collagens, comprises two pro alpha 1(I) chains and one pro alpha 2(I) chain, each containing terminal propeptides and a central domain of 338 (Gly, X, Y) rep...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/310337a0
更新日期:1984-07-26 00:00:00
abstract::A parliamentary and union delegation has expressed to the British government its concern over the possible demise of the Genetic Manipulation Advisory Group (GMAG). The delegation proposed that GMAG continue to ensure the safe development of recombinant DNA technology and extend its role to cover the ethics of human ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/299387a0
更新日期:1982-09-30 00:00:00
abstract::Coordinated cell migration is essential in many fundamental biological processes including embryonic development, organogenesis, wound healing and the immune response. During organogenesis, groups of cells are directed to specific locations within the embryo. Here we show that the zebrafish miles apart (mil) mutation ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35018092
更新日期:2000-07-13 00:00:00
abstract::Fresnel lenses allow almost perfect imaging in widely different circumstances, but their focus is perfect only for a single wavelength. Wang et al. have shown how the effective bandpass may be widened for X-ray microscopy by using a compound diffractive/refractive lens near to an absorption edge. A compound lens has a...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/426245b
更新日期:2003-11-20 00:00:00
abstract::Non-small-cell lung cancer is the leading cause of cancer-related death worldwide. Chemotherapies such as the topoisomerase II (TopoII) inhibitor etoposide effectively reduce disease in a minority of patients with this cancer; therefore, alternative drug targets, including epigenetic enzymes, are under consideration f...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14122
更新日期:2015-04-09 00:00:00
abstract::Relative to the present day, meridional temperature gradients in the Early Eocene age ( approximately 56-53 Myr ago) were unusually low, with slightly warmer equatorial regions but with much warmer subtropical Arctic and mid-latitude climates. By the end of the Eocene epoch ( approximately 34 Myr ago), the first major...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature08399
更新日期:2009-10-08 00:00:00
abstract::The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 A resolution. TFIIA is composed of a beta-barrel and a four-helix bundle motif that together have a boot-like appearance. The beta-barrel extends the TBP beta-...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/381127a0
更新日期:1996-05-09 00:00:00
abstract::Muscle force is generated by myosin crossbridges interacting with actin. As estimated from stiffness and equatorial X-ray diffraction of muscle and muscle fibres, most myosin crossbridges are attached to actin during isometric contraction, but a much smaller fraction is bound stereospecifically. To determine the fract...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/40651
更新日期:1997-07-10 00:00:00
abstract::Genome instability is central to ageing, cancer and other diseases. It is not only proteins involved in DNA replication or the DNA damage response (DDR) that are important for maintaining genome integrity: from yeast to higher eukaryotes, mutations in genes involved in pre-mRNA splicing and in the biogenesis and expor...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13374
更新日期:2014-07-17 00:00:00
abstract::One approach to the controlled release of drugs involves incorporation of the drug molecules into the matrix of microscopic polymer spheres or capsules. Existing methods for preparing such microparticles do not, however, always guarantee a constant release rate, for example because drug molecules may be trapped prefer...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/367258a0
更新日期:1994-01-20 00:00:00
abstract::Human-mediated translocation of species to areas beyond their natural distribution (which results in 'alien' populations1) is a key signature of the Anthropocene2, and is a primary global driver of biodiversity loss and environmental change3. Stemming the tide of invasions requires understanding why some species fail ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1292-2
更新日期:2019-07-01 00:00:00
abstract::There has been much interest in the biochemical and biophysical processes that couple extracellular signals to alterations in gene expression. While many early events associated with the treatment of cells with growth factors have been described (for example, ion flux and protein phosphorylation), it has proved diffic...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/322552a0
更新日期:1986-08-07 00:00:00
abstract::Relative motion is one of the most salient cues for segmentation of a visual scene into separate objects. This is illustrated by the vivid contours that are perceived when random dot patterns move in different directions. Once motion is halted in such displays the segmentation contours disappear. This makes random dot...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/363541a0
更新日期:1993-06-10 00:00:00
abstract::The outcomes of evolution are determined by a stochastic dynamical process that governs how mutations arise and spread through a population. However, it is difficult to observe these dynamics directly over long periods and across entire genomes. Here we analyse the dynamics of molecular evolution in twelve experimenta...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature24287
更新日期:2017-11-02 00:00:00
abstract::The germ-cell lineage ensures the continuity of life through the generation of male and female gametes, which unite to form a totipotent zygote. We have previously demonstrated that, by using cytokines, embryonic stem cells and induced pluripotent stem cells can be induced into epiblast-like cells (EpiLCs) and then in...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12417
更新日期:2013-09-12 00:00:00
abstract::Natural composite materials are renowned for their mechanical strength and toughness: despite being highly mineralized, with the organic component constituting not more than a few per cent of the composite material, the fracture toughness exceeds that of single crystals of the pure mineral by two to three orders of ma...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35016535
更新日期:2000-06-29 00:00:00
abstract::Locomotion relies on neural networks called central pattern generators (CPGs) that generate periodic motor commands for rhythmic movements. In vertebrates, the excitatory synaptic drive for inducing the spinal CPG can originate from either supraspinal glutamatergic inputs or from within the spinal cord. Here we identi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08323
更新日期:2009-09-17 00:00:00
abstract::Yeasts, which have been a component of the human diet for at least 7,000 years, possess an elaborate cell wall α-mannan. The influence of yeast mannan on the ecology of the human microbiota is unknown. Here we show that yeast α-mannan is a viable food source for the Gram-negative bacterium Bacteroides thetaiotaomicron...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13995
更新日期:2015-01-08 00:00:00
abstract::Ligand-gated ion channels, a major class of cell-surface proteins, have a pseudosymmetric structure with five highly homologous subunits arranged around a central ion pore. The correct assembly of each channel, whose subunit composition varies with cell type and stage of development, requires specific recognition betw...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/352064a0
更新日期:1991-07-04 00:00:00
abstract::Most of the 470-million-year history of plants on land belongs to bryophytes, pteridophytes and gymnosperms, which eventually yielded to the ecological dominance by angiosperms 90 Myr ago. Our knowledge of angiosperm phylogeny, particularly the branching order of the earliest lineages, has recently been increased by t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35054555
更新日期:2001-02-01 00:00:00
abstract::Megakaryocytopoiesis is the cellular developmental process that leads to platelet production. At least two humoral growth factors may be necessary for megakaryocyte proliferation and maturation. One is a megakaryocyte-colony stimulating factor (MK-CSF) which induces the proliferation and differentiation of megakaryocy...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/369571a0
更新日期:1994-06-16 00:00:00
abstract::RNAs that contain specific high-affinity binding sites for small molecule ligands immobilized on a solid support are present at a frequency of roughly one in 10(10)-10(11) in pools of random sequence RNA molecules. Here we describe a new in vitro selection procedure designed to ensure the isolation of RNAs that bind t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/364550a0
更新日期:1993-08-05 00:00:00
abstract::The ice-rich surface of the jovian satellite Europa is sparsely cratered, suggesting that this moon might be geologically active today. Moreover, models of the satellite's interior indicate that tidal interactions with Jupiter might produce enough heat to maintain a subsurface liquid water layer. But the mechanisms of...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/34862
更新日期:1998-01-22 00:00:00
abstract::A fundamental challenge to our understanding of biodiversity is to explain why some groups of species undergo adaptive radiations, diversifying extensively into many and varied species, whereas others do not. Both extrinsic environmental factors (for example, resource availability, climate) and intrinsic lineage-speci...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11144
更新日期:2012-07-19 00:00:00
abstract::Recurrent chromosomal translocations involving the mixed lineage leukaemia (MLL) gene initiate aggressive forms of leukaemia, which are often refractory to conventional therapies. Many MLL-fusion partners are members of the super elongation complex (SEC), a critical regulator of transcriptional elongation, suggesting ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10509
更新日期:2011-10-02 00:00:00
abstract::The hippocampus is an important part of the limbic system in the human brain that has essential roles in spatial navigation and the consolidation of information from short-term memory to long-term memory1,2. Here we use single-cell RNA sequencing and assay for transposase-accessible chromatin using sequencing (ATAC-se...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1917-5
更新日期:2020-01-01 00:00:00