A dispersive morph in the naked mole-rat.

abstract：:c-Abl, a non-receptor tyrosine kinase, is activated by agents that damage DNA. This activation results in either arrest of the cell cycle in phase G1 or apoptotic cell death, both of which are dependent on the kinase activity of c-Abl. p73, a member of the p53 family of tumour-suppressor proteins, can also induce apop...

journal_title：Nature

authors： Agami R,Blandino G,Oren M,Shaul Y

更新日期：1999-06-24 00:00:00

abstract：:Juxtaposition between endoplasmic reticulum (ER) and mitochondria is a common structural feature, providing the physical basis for intercommunication during Ca(2+) signalling; yet, the molecular mechanisms controlling this interaction are unknown. Here we show that mitofusin 2, a mitochondrial dynamin-related protein ...

journal_title：Nature

authors： de Brito OM,Scorrano L

更新日期：2008-12-04 00:00:00

abstract：:Comprehensive identification of polymorphisms among individuals within a species is essential both for studying the genetic basis of phenotypic differences and for elucidating the evolutionary history of the species. Large-scale polymorphism surveys have recently been reported for human, mouse and Arabidopsis thaliana...

journal_title：Nature

authors： Schacherer J,Shapiro JA,Ruderfer DM,Kruglyak L

更新日期：2009-03-19 00:00:00

abstract：:The bmi-1 proto-oncogene can be activated by Moloney murine leukaemia proviral insertions in E mu-myc transgenic mice. It encodes a highly conserved nuclear protein of 324 amino acids which belongs to a family of proteins containing a putative new zinc-finger. Another closely related member of this family is the mouse...

journal_title：Nature

authors： van Lohuizen M,Frasch M,Wientjens E,Berns A

更新日期：1991-09-26 00:00:00

abstract：:Graphene oxide membranes-partially oxidized, stacked sheets of graphene-can provide ultrathin, high-flux and energy-efficient membranes for precise ionic and molecular sieving in aqueous solution. These materials have shown potential in a variety of applications, including water desalination and purification, gas and ...

journal_title：Nature

authors： Chen L,Shi G,Shen J,Peng B,Zhang B,Wang Y,Bian F,Wang J,Li D,Qian Z,Xu G,Liu G,Zeng J,Zhang L,Yang Y,Zhou G,Wu M,Jin W,Li J,Fang H

更新日期：2017-10-19 00:00:00

abstract：:Throughout the latter half of this century, the development and spread of resistance to most front-line antimalarial compounds used in the prevention and treatment of the most severe form of human malaria has given cause for grave clinical concern. Polymorphisms in pfmdr1, the gene encoding the P-glycoprotein homologu...

journal_title：Nature

authors： Reed MB,Saliba KJ,Caruana SR,Kirk K,Cowman AF

更新日期：2000-02-24 00:00:00

abstract：:Mesenchymal cells contribute to the 'stroma' of most normal and malignant tissues, with specific mesenchymal cells participating in the regulatory niches of stem cells. By examining how mesenchymal osteolineage cells modulate haematopoiesis, here we show that deletion of Dicer1 specifically in mouse osteoprogenitors, ...

journal_title：Nature

authors： Raaijmakers MH,Mukherjee S,Guo S,Zhang S,Kobayashi T,Schoonmaker JA,Ebert BL,Al-Shahrour F,Hasserjian RP,Scadden EO,Aung Z,Matza M,Merkenschlager M,Lin C,Rommens JM,Scadden DT

更新日期：2010-04-08 00:00:00

abstract：:The interplay of evolution and development has been at the heart of evolutionary theory for more than a century. Heterochrony—change in the timing or rate of developmental events—has been implicated in the evolution of major vertebrate lineages such as mammals, including humans. Birds are the most speciose land verteb...

journal_title：Nature

authors： Bhullar BA,Marugán-Lobón J,Racimo F,Bever GS,Rowe TB,Norell MA,Abzhanov A

更新日期：2012-07-12 00:00:00

abstract：:More than 50 copies of a phi X174 DNA template can be made in 60 min in an in vitro DNA replication system consisting of seven purfied replication proteins isolated from T4 bacteriophage-infected cells. By transfecting with the DNA products and assaying for the reversion of specific amber mutants, the high degree of b...

journal_title：Nature

authors： Hibner U,Alberts BM

更新日期：1980-05-29 00:00:00

abstract：:At one time the synthetic chemist's last resort, reactions catalysed by transition metals are now the preferred method for synthesizing many types of organic molecule. A recent success in this type of catalysis is the discovery of reactions that form bonds between carbon and heteroatoms (such as nitrogen, oxygen, sulp...

journal_title：Nature

authors： Hartwig JF

更新日期：2008-09-18 00:00:00

abstract：:Interstellar dust is responsible, through surface reactions, for the creation of molecular hydrogen, the main component of the interstellar clouds in which new stars form. Intermediate between small, gas-phase molecules and dust are the polycyclic aromatic hydrocarbons (PAHs). Such molecules could account for 2-30% of...

journal_title：Nature

authors： Cook DJ,Schlemmer S,Balucani N,Wagner DR,Steiner B,Saykally RJ

更新日期：1996-03-21 00:00:00

abstract：:Although lunar crystalline rocks are essentially devoid of nitrogen, the same is not true of the lunar regolith. The nitrogen contents of individual regolith samples (which can be as high as 0.012% by mass) correlate strongly with abundances of noble gases known to be implanted in the lunar surface by solar radiation,...

journal_title：Nature

authors： Kim JS,Kim Y,Marti K,Kerridge JF

更新日期：1995-06-01 00:00:00

abstract：:Vertical movement of the hip during locomotion causes a loaded backpack to be accelerated with each step, which imposes large peak forces on the wearer. Here we show that using bungee cords to suspend the load from a backpack frame reduces not only its vertical movement, and hence its vertical force on the carrier, bu...

journal_title：Nature

authors： Rome LC,Flynn L,Yoo TD

更新日期：2006-12-21 00:00:00

abstract：:The factors shaping cometary nuclei are still largely unknown, but could be the result of concurrent effects of evolutionary and primordial processes. The peculiar bilobed shape of comet 67P/Churyumov-Gerasimenko may be the result of the fusion of two objects that were once separate or the result of a localized excava...

journal_title：Nature

authors： Massironi M,Simioni E,Marzari F,Cremonese G,Giacomini L,Pajola M,Jorda L,Naletto G,Lowry S,El-Maarry MR,Preusker F,Scholten F,Sierks H,Barbieri C,Lamy P,Rodrigo R,Koschny D,Rickman H,Keller HU,A'Hearn MF,Agarwal J

更新日期：2015-10-15 00:00:00

abstract：:Peroxisomes are among the intracellular organelles of eukaryotic cells that contain specialized sets of enzymes with specific functions. Little is known of membranous components involved in assembly of the intracellular compartments. We isolated two peroxisome-deficient and mutually complementary, Chinese hamster ovar...

journal_title：Nature

authors： Tsukamoto T,Miura S,Fujiki Y

更新日期：1991-03-07 00:00:00

abstract：:In this Letter, Supplementary Fig. 1 was missing. This error has been corrected online. ...

journal_title：Nature

authors： Eaglesham JB,Pan Y,Kupper TS,Kranzusch PJ

更新日期：2019-05-01 00:00:00

abstract：:Interleukin-2 (IL-2) is a regulatory peptide important for the growth and differentiation of antigen-specific T lymphocytes and large granular lymphocytes. Interaction of IL-2 with its specific receptor results in the promotion of S-phase progression as well as, in certain circumstances, the production and release of ...

journal_title：Nature

authors： Farrar WL,Anderson WB

更新日期：1985-05-16 00:00:00

abstract：:The repressor of phage 434 binds to six operator sites on the phage chromosome. A comparison of the sequences of these 14-base-pair (bp) operator sites reveals a striking pattern: at five of the six sites, the symmetrically arrayed outer eight base pairs (four in each half-site) are identical and the remaining site di...

journal_title：Nature

authors： Koudelka GB,Harrison SC,Ptashne M

更新日期：1987-04-30 00:00:00

abstract：:Zika virus (ZIKV) remained obscure until the recent explosive outbreaks in French Polynesia (2013-2014) and South America (2015-2016). Phylogenetic studies have shown that ZIKV has evolved into African and Asian lineages. The Asian lineage of ZIKV was responsible for the recent epidemics in the Americas. However, the ...

journal_title：Nature

authors： Liu Y,Liu J,Du S,Shan C,Nie K,Zhang R,Li XF,Zhang R,Wang T,Qin CF,Wang P,Shi PY,Cheng G

更新日期：2017-05-25 00:00:00

abstract：:Pairs of asteroids sharing similar heliocentric orbits, but not bound together, were found recently. Backward integrations of their orbits indicated that they separated gently with low relative velocities, but did not provide additional insight into their formation mechanism. A previously hypothesized rotational fissi...

journal_title：Nature

authors： Pravec P,Vokrouhlický D,Polishook D,Scheeres DJ,Harris AW,Galád A,Vaduvescu O,Pozo F,Barr A,Longa P,Vachier F,Colas F,Pray DP,Pollock J,Reichart D,Ivarsen K,Haislip J,Lacluyze A,Kusnirák P,Henych T,Marchis F,Mac

更新日期：2010-08-26 00:00:00

abstract：:Tumour necrosis factor (TNF) elicits multiple biological effects through two distinct cell surface receptors, TNF-R1 (p55) and TNF-R2 (p75). Most TNF-mediated biological responses, such as cell death, gene induction, antiviral activity and cytokine production, have been attributed to TNF-R1 (refs 1-5). Gene targeting ...

journal_title：Nature

authors： Erickson SL,de Sauvage FJ,Kikly K,Carver-Moore K,Pitts-Meek S,Gillett N,Sheehan KC,Schreiber RD,Goeddel DV,Moore MW

更新日期：1994-12-08 00:00:00

abstract：:Nerve growth factor (NGF) is involved in a variety of processes involving signalling, such as cell differentiation and survival, growth cessation and apoptosis of neurons. These events are mediated by NGF as a result of binding to its two cell-surface receptors, TrkA and p75. TrkA is a receptor with tyrosine kinase ac...

journal_title：Nature

authors： Wiesmann C,Ultsch MH,Bass SH,de Vos AM

更新日期：1999-09-09 00:00:00

abstract：:Protein ubiquitination is a common form of post-translational modification that regulates a broad spectrum of protein substrates in diverse cellular pathways. Through a three-enzyme (E1-E2-E3) cascade, the attachment of ubiquitin to proteins is catalysed by the E3 ubiquitin ligase, which is best represented by the sup...

journal_title：Nature

authors： Angers S,Li T,Yi X,MacCoss MJ,Moon RT,Zheng N

更新日期：2006-10-05 00:00:00

abstract：:Ageing is a result of gradual and overall functional deteriorations across the body; however, it is unknown whether an individual tissue primarily works to mediate the ageing progress and control lifespan. Here we show that the hypothalamus is important for the development of whole-body ageing in mice, and that the un...

journal_title：Nature

authors： Zhang G,Li J,Purkayastha S,Tang Y,Zhang H,Yin Y,Li B,Liu G,Cai D

更新日期：2013-05-09 00:00:00

abstract：:The adult mammalian heart is incapable of regeneration following cardiomyocyte loss, which underpins the lasting and severe effects of cardiomyopathy. Recently, it has become clear that the mammalian heart is not a post-mitotic organ. For example, the neonatal heart is capable of regenerating lost myocardium, and the ...

journal_title：Nature

authors： Nakada Y,Canseco DC,Thet S,Abdisalaam S,Asaithamby A,Santos CX,Shah AM,Zhang H,Faber JE,Kinter MT,Szweda LI,Xing C,Hu Z,Deberardinis RJ,Schiattarella G,Hill JA,Oz O,Lu Z,Zhang CC,Kimura W,Sadek HA

更新日期：2017-01-12 00:00:00

abstract：:Cleavage of the gasdermin proteins to produce pore-forming amino-terminal fragments causes inflammatory cell death (pyroptosis)1. Gasdermin E (GSDME, also known as DFNA5)-mutated in familial ageing-related hearing loss2-can be cleaved by caspase 3, thereby converting noninflammatory apoptosis to pyroptosis in GSDME-ex...

journal_title：Nature

authors： Zhang Z,Zhang Y,Xia S,Kong Q,Li S,Liu X,Junqueira C,Meza-Sosa KF,Mok TMY,Ansara J,Sengupta S,Yao Y,Wu H,Lieberman J

更新日期：2020-03-01 00:00:00

abstract：:Synaptic transmission of most vertebrate synapses is thought to be terminated by rapid transport of the neurotransmitter into presynaptic nerve terminals or neuroglia. L-Glutamate is the major excitatory transmitter in brain and its transport represents the mechanism by which it is removed from the synaptic cleft and ...

journal_title：Nature

authors： Pines G,Danbolt NC,Bjørås M,Zhang Y,Bendahan A,Eide L,Koepsell H,Storm-Mathisen J,Seeberg E,Kanner BI

更新日期：1992-12-03 00:00:00

abstract：:Hunter-Schreger bands (HSB) are seen in teeth that are composed of crossed sets of enamel prisms. They are present in the teeth of man and many other mammals, but absent in most insectivores and multituberculates. It has been suggested that the presence of HSB makes the tooth enamel less likely to split and is associa...

journal_title：Nature

authors： von Koenigswald W,Rensberger JM,Pretzschner HU

更新日期：1987-07-09 00:00:00

abstract：:A key step in the elimination of pathogens from the body is the covalent binding of complement proteins C3 and C4 to their surfaces. Proteolytic activation of these proteins results in a conformational change, and an internal thioester is exposed which reacts with amino or hydroxyl groups on the target surface to form...

journal_title：Nature

authors： Dodds AW,Ren XD,Willis AC,Law SK

更新日期：1996-01-11 00:00:00

abstract：:In BRAF(V600)-mutant tumours, most mechanisms of resistance to drugs that target the BRAF and/or MEK kinases rely on reactivation of the RAS-RAF-MEK-ERK mitogen-activated protein kinase (MAPK) signal transduction pathway, on activation of the alternative, PI(3)K-AKT-mTOR, pathway (which is ERK independent) or on modul...

journal_title：Nature

authors： Boussemart L,Malka-Mahieu H,Girault I,Allard D,Hemmingsson O,Tomasic G,Thomas M,Basmadjian C,Ribeiro N,Thuaud F,Mateus C,Routier E,Kamsu-Kom N,Agoussi S,Eggermont AM,Désaubry L,Robert C,Vagner S

更新日期：2014-09-04 00:00:00