Abstract:
:B LYMPHOCYTES are key participants in the immune response because of their specificity, their ability to take up and present antigens to T cells, and their capacity to differentiate into antibody-secreting cells. To limit reactivity to self antigens, autospecific B cells can be functionally inactivated or deleted. Developing B cells that react with membrane antigens expressed in the bone marrow are deleted from the peripheral lymphocyte pool. It is important to ascertain the fate of B cells that recognize membrane autoantigens expressed exclusively on peripheral tissues because B cells in the peripheral lymphoid organs are phenotypically and functionally distinct from bone-marrow B cells. Here we show that in immunoglobulin-transgenic mice, B cells specific for major histocompatibility complex class I antigen can be deleted if they encounter membrane-bound antigen at a post-bone-marrow stage of development. This deletion may be necessary to prevent organ-specific autoimmunity.
journal_name
Naturejournal_title
Natureauthors
Russell DM,Dembić Z,Morahan G,Miller JF,Bürki K,Nemazee Ddoi
10.1038/354308a0subject
Has Abstractpub_date
1991-11-28 00:00:00pages
308-11issue
6351eissn
0028-0836issn
1476-4687journal_volume
354pub_type
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