Abstract：
:Contact inhibition of locomotion was discovered by Abercrombie more than 50 years ago and describes the behaviour of fibroblast cells confronting each other in vitro, where they retract their protrusions and change direction on contact. Its failure was suggested to contribute to malignant invasion. However, the molecular basis of contact inhibition of locomotion and whether it also occurs in vivo are still unknown. Here we show that neural crest cells, a highly migratory and multipotent embryonic cell population, whose behaviour has been likened to malignant invasion, demonstrate contact inhibition of locomotion both in vivo and in vitro, and that this accounts for their directional migration. When two migrating neural crest cells meet, they stop, collapse their protrusions and change direction. In contrast, when a neural crest cell meets another cell type, it fails to display contact inhibition of locomotion; instead, it invades the other tissue, in the same manner as metastatic cancer cells. We show that inhibition of non-canonical Wnt signalling abolishes both contact inhibition of locomotion and the directionality of neural crest migration. Wnt-signalling members localize at the site of cell contact, leading to activation of RhoA in this region. These results provide the first example of contact inhibition of locomotion in vivo, provide an explanation for coherent directional migration of groups of cells and establish a previously unknown role for non-canonical Wnt signalling.
journal_name
Naturejournal_title
Natureauthors
Carmona-Fontaine C,Matthews HK,Kuriyama S,Moreno M,Dunn GA,Parsons M,Stern CD,Mayor Rdoi
10.1038/nature07441subject
Has Abstractpub_date
2008-12-18 00:00:00pages
957-61issue
7224eissn
0028-0836issn
1476-4687pii
nature07441journal_volume
456pub_type
杂志文章相关文献
NATURE文献大全abstract：:Several viral and bacterial live recombinant vaccine vehicles are being developed to produce a new generation of vaccines against a broad spectrum of infectious diseases. The human tuberculosis vaccine Mycobacterium bovis bacillus Calmette-Guerin (BCG) has features that make it a particularly attractive live recombina...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/351479a0
更新日期：1991-06-06 00:00:00
abstract：:De novo engineering of gene circuits inside cells is extremely difficult, and efforts to realize predictable and robust performance must deal with noise in gene expression and variation in phenotypes between cells. Here we demonstrate that by coupling gene expression to cell survival and death using cell-cell communic...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature02491
更新日期：2004-04-22 00:00:00
abstract：:Caenorhabditis elegans senses environmental signals through ciliated sensory neurons located primarily in sensory organs in the head and tail. Cilia function as sensory receptors, and mutants with defective sensory cilia have impaired sensory perception. Cilia are membrane-bound microtubule-based structures and in C. ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/45544
更新日期：1999-12-16 00:00:00
abstract：:The factors driving glacial changes in ocean overturning circulation are not well understood. On the basis of a comparison of 20 climate variables over the past four glacial cycles, the SPECMAP project proposed that summer insolation at high northern latitudes (that is, Milankovitch forcing) drives the same sequence o...
journal_title：Nature
pub_type： 历史文章,杂志文章
doi：10.1038/nature07425
更新日期：2008-11-06 00:00:00
abstract：:The observation that a few species in ecological communities are exceptionally abundant, whereas most are rare, prompted the development of species abundance models. Nevertheless, despite the large literature on the commonness and rarity of species inspired by these pioneering studies, some widespread empirical patter...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature01547
更新日期：2003-04-17 00:00:00
abstract：:T-cell differentiation in the thymus is thought to involve a progression from the CD4-CD8- phenotype through CD4+CD8+ intermediates to mature CD4+ or CD8+ cells. There is evidence that during this process T cells bearing receptors potentially reactive to 'self' are deleted by a process termed 'negative selection' One ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/340559a0
更新日期：1989-08-17 00:00:00
abstract：:During animal development, cells have to respond appropriately to localized secreted signals. Proper responses to Hedgehog, transforming growth factor-beta, epidermal growth factor and fibroblast growth factor/Ras signals require cognate inducible antagonists such as Patched, Dad, Argos and Sprouty. Wnt signals are cr...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35001615
更新日期：2000-02-17 00:00:00
abstract：:In the unactivated Limulus sperm, a 60- micro m-long bundle of actin filaments crosslinked by the protein scruin is bent and twisted into a coil around the base of the nucleus. At fertilization, the bundle uncoils and fully extends in five seconds to support a finger of membrane known as the acrosomal process. This bi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature02881
更新日期：2004-09-02 00:00:00
abstract：:Reactive oxygen species are involved in many cellular metabolic and signalling processes and are thought to have a role in disease, particularly in carcinogenesis and ageing. We have generated mice with targeted inactivation of Prdx1, a member of the peroxiredoxin family of antioxidant enzymes. Here we show that mice ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature01819
更新日期：2003-07-31 00:00:00
abstract：:The import of nuclear proteins proceeds through the nuclear pore complex and requires nuclear localization signals (NLSs), energy and soluble factors, namely importin-alpha (M(r) 60K), importin-beta (90K) and Ran. Importin-alpha is primarily responsible for NLS recognition and is a member of a protein family that incl...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/377246a0
更新日期：1995-09-21 00:00:00
abstract：:The activation of T cells through interaction of their T-cell receptors with antigenic peptide bound to major histocompatibility complex (MHC) on the surface of antigen presenting cells (APCs) is a crucial step in adaptive immunity. Here we use three-dimensional fluorescence microscopy to visualize individual peptide-...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature01076
更新日期：2002-10-24 00:00:00
abstract：:Neurons in the developing rodent cortex are generated from radial glial cells that function as neural stem cells. These epithelial cells line the cerebral ventricles and generate intermediate progenitor cells that migrate into the subventricular zone (SVZ) and proliferate to increase neuronal number. The developing hu...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature08845
更新日期：2010-03-25 00:00:00
abstract：:To understand the molecular basis of microtubule-associated motility during mitosis, the mechanochemical factors that generate the relevant motile force must be identified. Myosin, the ATPase that interacts with actin to produce the force for muscle contraction and other forms of cell motility, is believed to be invol...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/318483a0
更新日期：1985-12-05 00:00:00
abstract：:A brief account is provided of a meeting between federal officials and representatives of the Industrial Biotechnology Association (IBA), a consortium of companies concerned about the regulatory outlook for their industry. Current regulatory interest is focused on the Environmental Protection Agency, which has declar...
journal_title：Nature
pub_type： 新闻
doi：10.1038/305755a0
更新日期：1983-10-27 00:00:00
abstract：:T cells recognize foreign proteins as peptides bound to self molecules encoded by the major histocompatibility complex (MHC). The kinetics of interaction between purified class II MHC molecules and peptides is unusual, in that the rate of association is very slow, but once formed, the complexes are extremely stable. T...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/342800a0
更新日期：1989-12-14 00:00:00
abstract：:The neural crest, a source of many different cell types in vertebrate embryos, has not been identified in other chordates. Current opinion therefore holds that neural crest cells were a vertebrate innovation. Here we describe a migratory cell population resembling neural crest cells in the ascidian urochordate Ecteina...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature02975
更新日期：2004-10-07 00:00:00
abstract：:Endothelial cells adopt tissue-specific characteristics to instruct organ development and regeneration1,2. This adaptability is lost in cultured adult endothelial cells, which do not vascularize tissues in an organotypic manner. Here, we show that transient reactivation of the embryonic-restricted ETS variant transcri...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2712-z
更新日期：2020-09-01 00:00:00
abstract：:Translation initiation determines both the quantity and identity of the protein that is encoded in an mRNA by establishing the reading frame for protein synthesis. In eukaryotic cells, numerous translation initiation factors prepare ribosomes for polypeptide synthesis; however, the underlying dynamics of this process ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-019-1561-0
更新日期：2019-09-01 00:00:00
abstract：:A decision is a commitment to a proposition or plan of action based on evidence and the expected costs and benefits associated with the outcome. Progress in a variety of fields has led to a quantitative understanding of the mechanisms that evaluate evidence and reach a decision. Several formalisms propose that a repre...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature08275
更新日期：2009-09-10 00:00:00
abstract：:The origin of tetrapods from their fish antecedents, approximately 400 million years ago, was coupled with the origin of terrestrial locomotion and the evolution of supporting limbs. Polypterus is a member of the basal-most group of ray-finned fish (actinopterygians) and has many plesiomorphic morphologies that are co...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature13708
更新日期：2014-09-04 00:00:00
abstract：:Necroptosis has emerged as an important pathway of programmed cell death in embryonic development, tissue homeostasis, immunity and inflammation. RIPK1 is implicated in inflammatory and cell death signalling and its kinase activity is believed to drive RIPK3-mediated necroptosis. Here we show that kinase-independent s...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature13608
更新日期：2014-09-04 00:00:00
abstract：:The human T cell erythrocyte receptor (CD2 antigen) allows thymocytes and mature T cells to adhere to thymic epithelium and target cells through a cell surface protein, LFA-3 (refs 1-6). Monoclonal antibodies recognizing CD2 can either block adhesion or, in certain combinations, induce an antigen-independent T cell ac...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/329842a0
更新日期：1987-10-29 00:00:00
abstract：:IN 1969, Murozumi et al.1 demonstrated that the concentration of lead in Greenland snow had increased by a factor of 200 since ancient times, and concluded that most of this increase was a result of the use of alkyl-leaded petrol. Partly because of these findings, the United States and other western countries limited ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/362333a0
更新日期：1993-03-25 00:00:00
abstract：:Planet formation theories predict that some planets may be ejected from their parent systems as result of dynamical interactions and other processes. Unbound planets can also be formed through gravitational collapse, in a way similar to that in which stars form. A handful of free-floating planetary-mass objects have b...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature23276
更新日期：2017-08-10 00:00:00
abstract：:The recruitment model for gene activation stipulates that an activator works by bringing the transcriptional machinery to the DNA. Recent experiments in bacteria and yeast indicate that many genes can be activated by this mechanism. These findings have implications for our understanding of the nature of activating reg...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/386569a0
更新日期：1997-04-10 00:00:00
abstract：:Contamination of ground waters with water-soluble aromatic hydrocarbons, common components of petroleum pollution, often produces anoxic conditions under which microbial degradation of the aromatics is slow. Oxygen is often added to contaminated ground water to stimulate biodegradation, but this can be technically dif...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/370128a0
更新日期：1994-07-14 00:00:00
abstract：:In infected cells, the RNA genomes of RNA tumour viruses are copied into DNA by a virus-encoded reverse transcriptase enzyme. This transfer of information from RNA into DNA was thought to be a unique feature of RNA tumour viruses, but recent results suggest it may be a more general strategy. Hepatitis B virus (HBV) ha...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/305827a0
更新日期：1983-10-27 00:00:00
abstract：:The shape of the human erythrocyte depends on intracellular ATP content and echinocytic erythrocyte ghosts obtained in the presence of Mg-ATP acquire a diskocytic shape after incubation at 37 degrees C; however, agreement is lacking about the molecular basis of the shape changes. The suggestion that phosphorylation of...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/307376a0
更新日期：1984-01-26 00:00:00
abstract：:Observing and controlling macroscopic quantum systems has long been a driving force in quantum physics research. In particular, strong coupling between individual quantum systems and mechanical oscillators is being actively studied1-3. Whereas both read-out of mechanical motion using coherent control of spin systems4-...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2133-z
更新日期：2020-04-01 00:00:00
abstract：:Control of protein synthesis is associated with changes in the ratio of intracellular Na+ to K+ in the cultured embryonic chick lens. Correlations of intracellular Na+/K+ ratios with crystallin synthesis and cataract formation in vitro suggest that the Na+/K+ ratio may have an important role in the regulation of prote...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/270406a0
更新日期：1977-12-01 00:00:00
