Abstract：
:During animal development, cells have to respond appropriately to localized secreted signals. Proper responses to Hedgehog, transforming growth factor-beta, epidermal growth factor and fibroblast growth factor/Ras signals require cognate inducible antagonists such as Patched, Dad, Argos and Sprouty. Wnt signals are crucial in development and neoplasia. Here we show that naked cuticle (nkd), a Drosophila segment-polarity gene, encodes an inducible antagonist for the Wnt signal Wingless (Wg). In fly embryos and imaginal discs nkd transcription is induced by Wg. In embryos, decreased nkd function has an effect similar to excess Wg; at later stages such a decrease appears to have no effect. Conversely, overproduction of Nkd in Drosophila and misexpression of Nkd in the vertebrate Xenopus laevis result in phenotypes resembling those of loss of Wg/Wnt function. nkd encodes a protein with a single EF hand (a calcium-binding motif) that is most similar to the recoverin family of myristoyl switch proteins. Nkd may therefore link ion fluxes to the regulation of the potency, duration or distribution of Wnt signals. Signal-inducible feedback antagonists such as nkd may limit the effects of Wnt proteins in development and disease.
journal_name
Naturejournal_title
Natureauthors
Zeng W,Wharton KA Jr,Mack JA,Wang K,Gadbaw M,Suyama K,Klein PS,Scott MPdoi
10.1038/35001615keywords:
subject
Has Abstractpub_date
2000-02-17 00:00:00pages
789-95issue
6771eissn
0028-0836issn
1476-4687journal_volume
403pub_type
杂志文章相关文献
NATURE文献大全abstract：:The superposition principle is a fundamental tenet of quantum mechanics. It allows a quantum system to be 'in two places at the same time', because the quantum state of a physical system can simultaneously include measurably different physical states. The preparation and use of such superposed states forms the basis o...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature08005
更新日期：2009-05-28 00:00:00
abstract：:IN 1969, Murozumi et al.1 demonstrated that the concentration of lead in Greenland snow had increased by a factor of 200 since ancient times, and concluded that most of this increase was a result of the use of alkyl-leaded petrol. Partly because of these findings, the United States and other western countries limited ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/362333a0
更新日期：1993-03-25 00:00:00
abstract：:Among the ten subtypes of mammalian voltage-gated calcium (Cav) channels, Cav3.1-Cav3.3 constitute the T-type, or the low-voltage-activated, subfamily, the abnormal activities of which are associated with epilepsy, psychiatric disorders and pain1-5. Here we report the cryo-electron microscopy structures of human Cav3....
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-019-1801-3
更新日期：2019-12-01 00:00:00
abstract：:The efficiency of generating electricity from heat using concentrated solar power plants (which use mirrors or lenses to concentrate sunlight in order to drive heat engines, usually involving turbines) may be appreciably increased by operating with higher turbine inlet temperatures, but this would require improved hea...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-018-0593-1
更新日期：2018-10-01 00:00:00
abstract：:Mitochondrial cytochrome oxidase is a functionally complex, membrane-bound respiratory enzyme which catalyses both the reduction of O2 to water and proton-pumping. During respiration, an exogenous donor, cytochrome c, donates four electrons to O2 bound at the bimetallic haem alpha 3 Fe-Cu centre within the enzyme. The...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/338776a0
更新日期：1989-04-27 00:00:00
abstract：:Ongoing efforts within synthetic and systems biology have been directed towards the building of artificial computational devices using engineered biological units as basic building blocks. Such efforts, inspired in the standard design of electronic circuits, are limited by the difficulties arising from wiring the basi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09679
更新日期：2011-01-13 00:00:00
abstract：:N-glycosylation of proteins in the endoplasmic reticulum (ER) has a central role in protein quality control. Here we report that N-glycan serves as a signal for degradation by the Skp1-Cullin1-Fbx2-Roc1 (SCF(Fbx2)) ubiquitin ligase complex. The F-box protein Fbx2 (ref. 4) binds specifically to proteins attached to N-l...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature00890
更新日期：2002-07-25 00:00:00
abstract：:This corrects the article DOI: 10.1038/nature24295. ...
journal_title：Nature
pub_type： 杂志文章,已发布勘误
doi：10.1038/nature25017
更新日期：2018-01-25 00:00:00
abstract：:Silbo Gomero is a whistled language that is a rare and endangered surrogate of Spanish, used by shepherds on the island of La Gomera in the Canary Islands for communication over long distances on difficult terrain. Here we show that areas of the brain normally associated with spoken-language function are also activate...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/433031a
更新日期：2005-01-06 00:00:00
abstract：:Methyl chloride is the largest natural source of ozone-depleting chlorine compounds, and accounts for about 15 per cent of the present atmospheric chlorine content. This contribution was likely to have been relatively greater in pre-industrial times, when additional anthropogenic sources-such as chlorofluorocarbons-we...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/416163a
更新日期：2002-03-14 00:00:00
abstract：:Defects in the architecture or integrity of the nuclear envelope are associated with a variety of human diseases1. Micronuclei, one common nuclear aberration, are an origin for chromothripsis2, a catastrophic mutational process that is commonly observed in cancer3-5. Chromothripsis occurs after micronuclei spontaneous...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-018-0534-z
更新日期：2018-09-01 00:00:00
abstract：:The discovery of the structure of DNA transformed biology profoundly, catalysing the sequencing of the human genome and engendering a new view of biology as an information science. Two features of DNA structure account for much of its remarkable impact on science: its digital nature and its complementarity, whereby on...
journal_title：Nature
pub_type： 评论,杂志文章,评审
doi：10.1038/nature01410
更新日期：2003-01-23 00:00:00
abstract：:Non-small-cell lung cancer is the leading cause of cancer-related death worldwide. Chemotherapies such as the topoisomerase II (TopoII) inhibitor etoposide effectively reduce disease in a minority of patients with this cancer; therefore, alternative drug targets, including epigenetic enzymes, are under consideration f...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature14122
更新日期：2015-04-09 00:00:00
abstract：:The cranial morphology of the earliest known hominins in the genus Australopithecus remains unclear. The oldest species in this genus (Australopithecus anamensis, specimens of which have been dated to 4.2-3.9 million years ago) is known primarily from jaws and teeth, whereas younger species (dated to 3.5-2.0 million y...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-019-1513-8
更新日期：2019-09-01 00:00:00
abstract：:Mutations or amplification of the MET proto-oncogene are involved in the pathogenesis of several tumours, which rely on the constitutive engagement of this pathway for their growth and survival. However, MET is expressed not only by cancer cells but also by tumour-associated stromal cells, although its precise role in...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature14407
更新日期：2015-06-18 00:00:00
abstract：:The type 1 human immunodeficiency virus (HIV-1) contains a conical capsid comprising approximately 1,500 CA protein subunits, which organizes the viral RNA genome for uncoating and replication in a new host cell. In vitro, CA spontaneously assembles into helical tubes and cones that resemble authentic viral capsids. H...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35030177
更新日期：2000-09-21 00:00:00
abstract：:The death of massive stars produces a variety of supernovae, which are linked to the structure of the exploding stars. The detection of several precursor stars of type II supernovae has been reported (see, for example, ref. 3), but we do not yet have direct information on the progenitors of the hydrogen-deficient type...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature05825
更新日期：2007-06-14 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 新闻
doi：10.1038/d41586-018-07413-x
更新日期：2018-11-01 00:00:00
abstract：:Neuroectoderm cells in the cortical ventricular zone generate many diverse cell types, maintain the ventricular zone during embryonic life and create another germinal layer, the subventricular zone, which persists into adulthood. In other vertebrate tissues, including skin, intestine, blood and neural crest, stem cell...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/372263a0
更新日期：1994-11-17 00:00:00
abstract：:Since its discovery in 1989, efforts to grow clinical isolates of the hepatitis C virus (HCV) in cell culture have met with limited success. Only the JFH-1 isolate has the capacity to replicate efficiently in cultured hepatoma cells without cell culture-adaptive mutations. We hypothesized that cultured cells lack one ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature14899
更新日期：2015-08-27 00:00:00
abstract：:A nuclear protein, CREB, has been isolated from rat brain and shown to stimulate transcription of the cyclic AMP-responsive gene somatostatin as a dimer. Biochemical analysis suggests that dimerization and transcriptional efficacy of CREB protein in vitro are regulated by phosphorylation. These findings demonstrate th...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/334494a0
更新日期：1988-08-11 00:00:00
abstract：:In neuronal cells, opioid peptides and opiates inhibit neurotransmitter release, which is a calcium-dependent process. They also inhibit adenylyl cyclase, presumably via the membrane signal-transducing component, Gi, a guanine nucleotide-binding protein (G-protein). No causal relationship between these two events has ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/325445a0
更新日期：1987-01-29 00:00:00
abstract：:Wild-type p53 protein has many properties consistent with its being the product of a tumour suppressor gene. Although the normal roles of tumour suppressor genes are still largely unknown, it seems that they could be involved in promoting cell differentiation as well as in mediating growth arrest by growth-inhibitory ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/352345a0
更新日期：1991-07-25 00:00:00
abstract：:Contact inhibition of locomotion was discovered by Abercrombie more than 50 years ago and describes the behaviour of fibroblast cells confronting each other in vitro, where they retract their protrusions and change direction on contact. Its failure was suggested to contribute to malignant invasion. However, the molecu...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature07441
更新日期：2008-12-18 00:00:00
abstract：:Signal sequences target proteins for secretion from cells or for integration into cell membranes. As nascent proteins emerge from the ribosome, signal sequences are recognized by the signal recognition particle (SRP), which subsequently associates with its receptor (SR). In this complex, the SRP and SR stimulate each ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature02250
更新日期：2004-01-15 00:00:00
abstract：:Calcium (Ca(2+))-activated chloride channels are fundamental mediators in numerous physiological processes including transepithelial secretion, cardiac and neuronal excitation, sensory transduction, smooth muscle contraction and fertilization. Despite their physiological importance, their molecular identity has remain...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature07313
更新日期：2008-10-30 00:00:00
abstract：:MicroRNAs (miRNAs) are endogenous approximately 22-nucleotide RNAs that mediate important gene-regulatory events by pairing to the mRNAs of protein-coding genes to direct their repression. Repression of these regulatory targets leads to decreased translational efficiency and/or decreased mRNA levels, but the relative ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09267
更新日期：2010-08-12 00:00:00
abstract：:Millions of years before we began to manipulate the flow of light using synthetic structures, biological systems were using nanometre-scale architectures to produce striking optical effects. An astonishing variety of natural photonic structures exists: a species of Brittlestar uses photonic elements composed of calcit...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/nature01941
更新日期：2003-08-14 00:00:00
abstract：:Introns are removed from nuclear messenger RNA precursors through two sequential phospho-transesterification reactions in a dynamic RNA-protein complex called the spliceosome. But whether splicing is catalysed by small nuclear RNAs in the spliceosome is unresolved. As the spliceosome is a metalloenzyme, it is importan...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35048617
更新日期：2000-12-14 00:00:00
abstract：:Nitrogen is an essential nutrient for all organisms that must have been available since the origin of life. Abiotic processes including hydrothermal reduction, photochemical reactions, or lightning discharge could have converted atmospheric N2 into assimilable NH4(+), HCN, or NOx species, collectively termed fixed nit...
journal_title：Nature
pub_type： 历史文章,杂志文章
doi：10.1038/nature14180
更新日期：2015-04-30 00:00:00
