相关文献
NATURE文献大全abstract::With the discovery1 of superconductivity at 203 kelvin in H3S, attention returned to conventional superconductors with properties that can be described by the Bardeen-Cooper-Schrieffer and the Migdal-Eliashberg theories. Although these theories predict the possibility of room-temperature superconductivity in metals th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1201-8
更新日期:2019-05-01 00:00:00
abstract::Specific chromosomal deletions sometimes associated with tumours such as retinoblastoma (chromosome 13q14) and Wilm's tumour (chromosome 11p13) have led to the hypothesis that recessive genes may be involved in tumorigenesis. This hypothesis is supported by demonstration of allele loss specific for these regions using...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/329451a0
更新日期:1987-10-01 00:00:00
abstract::Cancer genomics has revealed many genes and core molecular processes that contribute to human malignancies, but the genetic and molecular bases of many rare cancers remains unclear. Genetic predisposition accounts for 5 to 10% of cancer diagnoses in children1,2, and genetic events that cooperate with known somatic dri...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2164-5
更新日期:2020-04-01 00:00:00
abstract::Continental rifts are important sources of mantle carbon dioxide (CO2) emission into Earth's atmosphere1-3. Because deep carbon is stored for long periods in the lithospheric mantle4-6, rift CO2 flux depends on lithospheric processes that control melt and volatile transport1,3,7. The influence of compositional and thi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2328-3
更新日期:2020-06-01 00:00:00
abstract::Deep chlorophyll maxima (DCMs) are widespread in large parts of the world's oceans. These deep layers of high chlorophyll concentration reflect a compromise of phytoplankton growth exposed to two opposing resource gradients: light supplied from above and nutrients supplied from below. It is often argued that DCMs are ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04245
更新日期:2006-01-19 00:00:00
abstract::Immunoprecipitation and tryptic peptide analysis of newly synthesized proteins from rat islets have identified an 18,000 molecular weight (MW) protein as proglucagon. Conversion of this precursor was kinetically similar to the conversion of proinsulin and resulted in the formation of both pancreatic glucagon and a 10,...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/282260a0
更新日期:1979-11-15 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) remains recalcitrant to all forms of cancer treatment and carries a five-year survival rate of only 8%1. Inhibition of oncogenic KRAS (hereafter KRAS*), the earliest lesion in disease development that is present in more than 90% of PDACs, and its signalling surrogates has yielde...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1062-1
更新日期:2019-04-01 00:00:00
abstract::The clinical development of an inhibitor of cellular proteasome function suggests that compounds targeting other components of the ubiquitin-proteasome system might prove useful for the treatment of human malignancies. NEDD8-activating enzyme (NAE) is an essential component of the NEDD8 conjugation pathway that contro...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07884
更新日期:2009-04-09 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 评论,新闻
doi:10.1038/d41586-019-00761-2
更新日期:2019-03-01 00:00:00
abstract::The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial com...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01262
更新日期:2002-12-05 00:00:00
abstract::The evolutionary biologist "studies the steps by which the miraculous adaptations so characteristic of every aspect of the organic world have evolved". But the general nature of such adaptive steps is still unclear. Evolution is often thought to be random and dependent on unpredictable events. In this light, one might...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35095046
更新日期:2001-09-20 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-019-00292-w
更新日期:2019-02-01 00:00:00
abstract::beta Pictoris (beta Pic) is a main-sequence star with an edge-on dust disk that might represent a state of the early Solar System. The dust does not seem to be a remnant from the original protoplanetary disk, but rather is thought to have been generated from large bodies like planetesimals and/or comets. The history a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02948
更新日期:2004-10-07 00:00:00
abstract::MyoD1 and myogenin are muscle-specific proteins which can convert non-myogenic cells in culture to differentiated muscle fibres, implicating them in myogenic determination. The pattern of expression of MyoD1 and myogenin during the early stages of muscle formation in the mouse embryo in vivo and in limb-bud explants c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/341303a0
更新日期:1989-09-28 00:00:00
abstract::Type II DNA topoisomerases are ubiquitous ATP-dependent enzymes capable of transporting a DNA through a transient double-strand break in a second DNA segment. This enables them to untangle DNA and relax the interwound supercoils (plectonemes) that arise in twisted DNA. In vivo, they are responsible for untangling repl...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35009144
更新日期:2000-04-20 00:00:00
abstract::Outbreaks of haemorrhagic fever caused by the Ebola virus are associated with high mortality rates that are a distinguishing feature of this human pathogen. The highest lethality is associated with the Zaire subtype, one of four strains identified to date. Its rapid progression allows little opportunity to develop nat...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35046108
更新日期:2000-11-30 00:00:00
abstract::Some Pacific island societies, such as those of Easter Island and Mangareva, inadvertently contributed to their own collapse by causing massive deforestation. Others retained forest cover and survived. How can those fateful differences be explained? Although the answers undoubtedly involve both different cultural resp...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02801
更新日期:2004-09-23 00:00:00
abstract::Remodelling its shape, or morphogenesis, is a fundamental property of living tissue. It underlies much of embryonic development and numerous pathologies. Convergent extension (CE) of the axial mesoderm of vertebrates is an intensively studied model for morphogenetic processes that rely on cell rearrangement. It involv...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02620
更新日期:2004-07-15 00:00:00
abstract::The Ndc80 complex is a key site of regulated kinetochore-microtubule attachment (a process required for cell division), but the molecular mechanism underlying its function remains unknown. Here we present a subnanometre-resolution cryo-electron microscopy reconstruction of the human Ndc80 complex bound to microtubules...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09423
更新日期:2010-10-14 00:00:00
abstract::On the basis of fossil and archaeological data it has been hypothesized that the exodus of Homo sapiens out of Africa and into Eurasia between ~50-120 thousand years ago occurred in several orbitally paced migration episodes. Crossing vegetated pluvial corridors from northeastern Africa into the Arabian Peninsula and ...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature19365
更新日期:2016-10-06 00:00:00
abstract::The key behavioural, physiological and anatomical components of a magnetite-based magnetic sense have been demonstrated in rainbow trout (Oncorhynchus mykiss). Candidate receptor cells located within a discrete sub-layer of the olfactory lamellae contained iron-rich crystals that were similar in size and shape to magn...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35018561
更新日期:2000-07-20 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-07324-x
更新日期:2018-11-01 00:00:00
abstract::The CD4 glycoprotein is expressed on T-helper and cytotoxic lymphocytes which are restricted to class II major histocompatibility complex (MHC) antigens on target cells. Antibody inhibition studies imply that CD4 acts to increase the avidity of effector-target cell interactions. These observations have led to the spec...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/330256a0
更新日期:1987-11-19 00:00:00
abstract::The unusual helium-rich (type Ib) supernova SN 2005E is distinguished from all supernovae hitherto observed by its faint and rapidly fading light curve, prominent calcium lines in late-phase spectra and lack of any mark of recent star formation near the supernova location. These properties are claimed to be explained ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09055
更新日期:2010-05-20 00:00:00
abstract::Genotypic variation among independent isolates of human immunodeficiency virus type-1 (HIV-1) is well known, but its molecular basis and biological consequences are poorly understood. We examined the genesis of molecular variation in HIV-1 by sequential virus isolations from two chronically infected individuals and an...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/334440a0
更新日期:1988-08-04 00:00:00
abstract::Quasicrystals are unique structures with long-range order but no periodicity. Their properties have intrigued scientists ever since their discovery and initial theoretical analysis. The lack of periodicity excludes the possibility of describing quasicrystal structures with well-established analytical tools, including ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04722
更新日期:2006-04-27 00:00:00
abstract::After observation of detailed structural evidence for the origin of birds from dinosaurs, and in light of evidence that dinosaur bone tissue resembles the histology in mammals, the histology of bone has become one of the focal points in discussions of the physiology of dinosaurs and Mesozoic birds. Most of this micros...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35020550
更新日期:2000-08-10 00:00:00
abstract::There have been many reports that eukaryotic cells contain ring-shaped 19S or 20S particles which are composed of numerous polypeptide subunits ranging in size between 25 and 35 kilodaltons. Because these particles seemed to copurify with inactive mRNA, they were assumed to function in regulating mRNA translation and ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/331192a0
更新日期:1988-01-14 00:00:00
abstract::Synapse assembly requires trans-synaptic signals between the pre- and postsynapse, but our understanding of the essential organizational molecules involved in this process remains incomplete. Teneurin proteins are conserved, epidermal growth factor (EGF)-repeat-containing transmembrane proteins with large extracellula...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10923
更新日期:2012-03-18 00:00:00
abstract::Retinal nerve fibres form an orderly map of visual space in several centres in the vertebrate brain. Such topographic maps are a common feature of central nervous system organization, yet the way in which they develop is poorly understood. Early nerve projections in the fetal and neonatal mammalian brain have been fou...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/301150a0
更新日期:1983-01-13 00:00:00