Abstract：
:Synapse assembly requires trans-synaptic signals between the pre- and postsynapse, but our understanding of the essential organizational molecules involved in this process remains incomplete. Teneurin proteins are conserved, epidermal growth factor (EGF)-repeat-containing transmembrane proteins with large extracellular domains. Here we show that two Drosophila Teneurins, Ten-m and Ten-a, are required for neuromuscular synapse organization and target selection. Ten-a is presynaptic whereas Ten-m is mostly postsynaptic; neuronal Ten-a and muscle Ten-m form a complex in vivo. Pre- or postsynaptic Teneurin perturbations cause severe synapse loss and impair many facets of organization trans-synaptically and cell autonomously. These include defects in active zone apposition, release sites, membrane and vesicle organization, and synaptic transmission. Moreover, the presynaptic microtubule and postsynaptic spectrin cytoskeletons are severely disrupted, suggesting a mechanism whereby Teneurins organize the cytoskeleton, which in turn affects other aspects of synapse development. Supporting this, Ten-m physically interacts with α-Spectrin. Genetic analyses of teneurin and neuroligin reveal that they have differential roles that synergize to promote synapse assembly. Finally, at elevated endogenous levels, Ten-m regulates target selection between specific motor neurons and muscles. Our study identifies the Teneurins as a key bi-directional trans-synaptic signal involved in general synapse organization, and demonstrates that proteins such as these can also regulate target selection.
journal_name
Naturejournal_title
Natureauthors
Mosca TJ,Hong W,Dani VS,Favaloro V,Luo Ldoi
10.1038/nature10923subject
Has Abstractpub_date
2012-03-18 00:00:00pages
237-41issue
7393eissn
0028-0836issn
1476-4687pii
nature10923journal_volume
484pub_type
杂志文章相关文献
NATURE文献大全abstract：:The cloning of mammals from differentiated donor cells has refuted the old dogma that development is an irreversible process. It has demonstrated that the oocyte can reprogramme an adult nucleus into an embryonic state that can direct development of a new organism. The prospect of deriving patient-specific embryonic s...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/nature04955
更新日期：2006-06-29 00:00:00
abstract：:Breast cancer patients with the same stage of disease can have markedly different treatment responses and overall outcome. The strongest predictors for metastases (for example, lymph node status and histological grade) fail to classify accurately breast tumours according to their clinical behaviour. Chemotherapy or ho...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/415530a
更新日期：2002-01-31 00:00:00
abstract：:Strong interactions between electrons in a solid material can lead to surprising properties. A prime example is the Mott insulator, in which suppression of conductivity occurs as a result of interactions rather than a filled Bloch band. Proximity to the Mott insulating phase in fermionic systems is the origin of many ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature07244
更新日期：2008-09-11 00:00:00
abstract：:Prostaglandins have wide-ranging effects in the body and are thought to be important mediators of inflammation. Cyclooxygenase (COX) plays a key regulatory role in prostaglandin synthesis, and occurs in both constitutive (COX-1) and inducible (COX-2) isoforms. COX-1 is thought to provide cytoprotective effects, wherea...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/378406a0
更新日期：1995-11-23 00:00:00
abstract：:A connection between thunderstorms and the ionosphere has been hypothesized since the mid-1920s. Several mechanisms have been proposed to explain this connection, and evidence from modelling as well as various types of measurements demonstrate that lightning can interact with the lower ionosphere. It has been proposed...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature03638
更新日期：2005-06-09 00:00:00
abstract：:The GAL4 protein activates transcription of the genes required for galactose utilization in Saccharomyces cerevisiae. The protein, consisting of 881 amino acids, is dimeric when bound to one of the approximately twofold symmetrical DNA sites present in the galactose upstream activating sequence (UASG). Here we use two...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/356450a0
更新日期：1992-04-02 00:00:00
abstract：:Recognition of modified histone species by distinct structural domains within 'reader' proteins plays a critical role in the regulation of gene expression. Readers that simultaneously recognize histones with multiple marks allow transduction of complex chromatin modification patterns into specific biological outcomes....
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09542
更新日期：2010-12-16 00:00:00
abstract：:Oligodendrocytes and astrocytes are macroglial cells of the vertebrate central nervous system. These cells have diverse roles in the maintenance of neurological function. In the embryo, the genetic mechanisms that underlie the specification of macroglial precursors in vivo appear strikingly similar to those that regul...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/nature09611
更新日期：2010-11-11 00:00:00
abstract：:Asteroids are primitive Solar System bodies that evolve both collisionally and through disruptions arising from rapid rotation. These processes can lead to the formation of binary asteroids and to the release of dust, both directly and, in some cases, through uncovering frozen volatiles. In a subset of the asteroids c...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature23892
更新日期：2017-09-20 00:00:00
abstract：:Global patterns of species richness and their structuring forces have fascinated biologists since Darwin and provide critical context for contemporary studies in ecology, evolution and conservation. Anthropogenic impacts and the need for systematic conservation planning have further motivated the analysis of diversity...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09329
更新日期：2010-08-26 00:00:00
abstract：:Growth factors raise intracellular pH (pHi) by stimulating Na+/H+ exchange in the absence of HCO3-. In mutant cells that lack the Na+/H+ exchange activity, this alkalinization does not occur, and the cells do not proliferate without artificial elevation of pHi. It has therefore been widely suggested that an early pHi ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/337648a0
更新日期：1989-02-16 00:00:00
abstract：:A basic requirement for quantum information processing systems is the ability to completely control the state of a single qubit. For qubits based on electron spin, a universal single-qubit gate is realized by a rotation of the spin by any angle about an arbitrary axis. Driven, coherent Rabi oscillations between two sp...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature07530
更新日期：2008-11-13 00:00:00
abstract：:Large-scale systematic sequencing has generally depended on the availability of an ordered library of large-insert bacterial or viral genomic clones for the organism under study. The generation of these large insert libraries, and the location of each clone on a genome map, is a laborious and time-consuming process. I...
journal_title：Nature
pub_type： 杂志文章
doi：
更新日期：1997-05-29 00:00:00
abstract：:Observing and controlling macroscopic quantum systems has long been a driving force in quantum physics research. In particular, strong coupling between individual quantum systems and mechanical oscillators is being actively studied1-3. Whereas both read-out of mechanical motion using coherent control of spin systems4-...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2133-z
更新日期：2020-04-01 00:00:00
abstract：:The role of magnetic domains (and the walls between domains) in determining the electrical properties of ferromagnetic materials has been investigated in great detail for many years, not least because control over domains offers a means of manipulating electron spin to control charge transport in 'spintronic' devices....
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature06826
更新日期：2008-04-17 00:00:00
abstract：:Several species related to Drosophila melanogaster have two loci containing sequences which code for the major heat-shock protein of molecular weight 70,000 (hsp70). These sequences are arranged as two pairs of inverted repeats. The structure of the 87C locus in D. melanogaster seems to have arisen through DNA inserti...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/290677a0
更新日期：1981-04-23 00:00:00
abstract：:Variation in ways in which proteins can identify and lock on to genes due for transcription is illuminated by studies of the Arc repressor, which has a beta-sheet, rather than alpha-helical, recognition motif. ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/368082a0
更新日期：1994-03-03 00:00:00
abstract：:Since the discovery of plate tectonics, the relative importance of driving forces of plate motion has been debated. Resolution of this issue has been hindered by uncertainties in estimates of basal traction, which controls the coupling between lithospheric plates and underlying mantle convection. Hotspot tracks preser...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature05675
更新日期：2007-03-22 00:00:00
abstract：:Visible-light absorption and transport of the resultant electronic excitations to a reaction centre through Förster resonance energy transfer1-3 (FRET) are critical to the operation of biological light-harvesting systems4, and are used in various artificial systems made of synthetic dyes5, polymers6 or nanodots7,8. Th...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-03081-y
更新日期：2021-01-01 00:00:00
abstract：:Palaeomagnetic measurements of meteorites suggest that, shortly after the birth of the Solar System, the molten metallic cores of many small planetary bodies convected vigorously and were capable of generating magnetic fields. Convection on these bodies is currently thought to have been thermally driven, implying that...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature14114
更新日期：2015-01-22 00:00:00
abstract：:Auroral substorms, dynamic phenomena that occur in the upper atmosphere at night, are caused by global reconfiguration of the magnetosphere, which releases stored solar wind energy. These storms are characterized by auroral brightening from dusk to midnight, followed by violent motions of distinct auroral arcs that su...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature25505
更新日期：2018-02-14 00:00:00
abstract：:Flash spectra of the total solar eclipse throughout all its phases have been obtained in the extreme ultraviolet for the first time. ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/226249a0
更新日期：1970-04-18 00:00:00
abstract：:The Ndc80 complex is a key site of regulated kinetochore-microtubule attachment (a process required for cell division), but the molecular mechanism underlying its function remains unknown. Here we present a subnanometre-resolution cryo-electron microscopy reconstruction of the human Ndc80 complex bound to microtubules...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09423
更新日期：2010-10-14 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 评论,新闻
doi：10.1038/d41586-018-07008-6
更新日期：2018-11-01 00:00:00
abstract：:Photosystem II is the site of photosynthetic water oxidation and contains 20 subunits with a total molecular mass of 350 kDa. The structure of photosystem II has been reported at resolutions from 3.8 to 2.9 Å. These resolutions have provided much information on the arrangement of protein subunits and cofactors but are...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09913
更新日期：2011-05-05 00:00:00
abstract：:One reason for the failure of chemotherapy in the treatment of advanced cancers may be the outgrowth of multidrug-resistant tumour cells. Multidrug resistance has been modelled in numerous mammalian cell lines in which the phenotype is characterized by a pleiotropic cross-resistance to unrelated drugs. In the study re...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/316820a0
更新日期：1985-08-29 00:00:00
abstract：:Abiraterone blocks androgen synthesis and prolongs survival in patients with castration-resistant prostate cancer, which is otherwise driven by intratumoral androgen synthesis. Abiraterone is metabolized in patients to Δ(4)-abiraterone (D4A), which has even greater anti-tumour activity and is structurally similar to e...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature17954
更新日期：2016-05-26 00:00:00
abstract：:Neurons in the visual cortex typically respond selectively to the orientation, and velocity and direction of movement, of moving-bar stimuli. These responses are generally thought to provide information about the orientation and position of lines and edges in the visual field. Some cells are also endstopped, that is s...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/329438a0
更新日期：1987-10-01 00:00:00
abstract：:The chemical composition of basaltic magma erupted at the Earth's surface is the end product of a complex series of processes, beginning with partial melting and melt extraction from a mantle source and ending with fractional crystallization and crustal assimilation at lower pressures. It has been proposed that studyi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature05759
更新日期：2007-05-17 00:00:00
abstract：:Formation of electron pairs is essential to superconductivity. For conventional superconductors, tunnelling spectroscopy has established that pairing is mediated by bosonic modes (phonons); a peak in the second derivative of tunnel current d2I/dV2 corresponds to each phonon mode. For high-transition-temperature (high-...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature04973
更新日期：2006-08-03 00:00:00
