TRIM24 links a non-canonical histone signature to breast cancer.

abstract：:Asteroids are primitive Solar System bodies that evolve both collisionally and through disruptions arising from rapid rotation. These processes can lead to the formation of binary asteroids and to the release of dust, both directly and, in some cases, through uncovering frozen volatiles. In a subset of the asteroids c...

journal_title：Nature

authors： Agarwal J,Jewitt D,Mutchler M,Weaver H,Larson S

更新日期：2017-09-20 00:00:00

abstract：:In Drosophila, most individual olfactory receptor neurons (ORNs) project bilaterally to both sides of the brain. Having bilateral rather than unilateral projections may represent a useful redundancy. However, bilateral ORN projections to the brain should also compromise the ability to lateralize odours. Nevertheless, ...

journal_title：Nature

authors： Gaudry Q,Hong EJ,Kain J,de Bivort BL,Wilson RI

更新日期：2013-01-17 00:00:00

abstract：:Haptic (touch) perception normally entails an active exploration of object surfaces over time. This is called active touch. When exploring the shape of an object, we experience both geometrical and force cues. For example, when sliding a finger across a surface with a rigid bump on it, the finger moves over the bump w...

journal_title：Nature

authors： Robles-De-La-Torre G,Hayward V

更新日期：2001-07-26 00:00:00

abstract：:Online hate and extremist narratives have been linked to abhorrent real-world events, including a current surge in hate crimes1-6 and an alarming increase in youth suicides that result from social media vitriol7; inciting mass shootings such as the 2019 attack in Christchurch, stabbings and bombings8-11; recruitment o...

journal_title：Nature

authors： Johnson NF,Leahy R,Restrepo NJ,Velasquez N,Zheng M,Manrique P,Devkota P,Wuchty S

更新日期：2019-09-01 00:00:00

abstract：:The lack of a reliable theory of glass physics has led to the pursuit of correlations between various glass or viscous liquid parameters, one of which is the slope m of the plot of log(viscosity) against Tg/T, extrapolated at the glass-transition temperature, Tg, also termed 'fragility'. Novikov and Sokolov conclude t...

journal_title：Nature

authors： Yannopoulos SN,Johari GP

更新日期：2006-08-03 00:00:00

abstract：:The origin of mutations is central to understanding evolution and of key relevance to health. Variation occurs non-randomly across the genome, and mechanisms for this remain to be defined. Here we report that the 5' ends of Okazaki fragments have significantly increased levels of nucleotide substitution, indicating a ...

journal_title：Nature

authors： Reijns MAM,Kemp H,Ding J,de Procé SM,Jackson AP,Taylor MS

更新日期：2015-02-26 00:00:00

abstract：:Targeted gene disruption in the mouse shows that the Sonic hedgehog (Shh) gene plays a critical role in patterning of vertebrate embryonic tissues, including the brain and spinal cord, the axial skeleton and the limbs. Early defects are observed in the establishment or maintenance of midline structures, such as the no...

journal_title：Nature

authors： Chiang C,Litingtung Y,Lee E,Young KE,Corden JL,Westphal H,Beachy PA

更新日期：1996-10-03 00:00:00

abstract：:The bacterial CRISPR/Cas9 system allows sequence-specific gene editing in many organisms and holds promise as a tool to generate models of human diseases, for example, in human pluripotent stem cells. CRISPR/Cas9 introduces targeted double-stranded breaks (DSBs) with high efficiency, which are typically repaired by no...

journal_title：Nature

authors： Paquet D,Kwart D,Chen A,Sproul A,Jacob S,Teo S,Olsen KM,Gregg A,Noggle S,Tessier-Lavigne M

更新日期：2016-05-05 00:00:00

abstract：:The neocortex of the adult brain consists of neurons and glia that are generated by precursor cells of the embryonic ventricular zone. In general, glia are generated after neurons during development, but radial glia are an exception to this rule. Radial glia are generated before neurogenesis and guide neuronal migrati...

journal_title：Nature

authors： Noctor SC,Flint AC,Weissman TA,Dammerman RS,Kriegstein AR

更新日期：2001-02-08 00:00:00

abstract：:Complexity in male sexual displays is widely appreciated but diversity in female mate choice has received little attention. Males of many species have sexual displays composed of multiple display traits, and females are thought to use these different traits in mate choice. Models of multiple display trait evolution su...

journal_title：Nature

authors： Coleman SW,Patricelli GL,Borgia G

更新日期：2004-04-15 00:00:00

abstract：:The Gram-negative bacterium Yersinia pestis is the causative agent of the systemic invasive infectious disease classically referred to as plague, and has been responsible for three human pandemics: the Justinian plague (sixth to eighth centuries), the Black Death (fourteenth to nineteenth centuries) and modern plague ...

journal_title：Nature

authors： Parkhill J,Wren BW,Thomson NR,Titball RW,Holden MT,Prentice MB,Sebaihia M,James KD,Churcher C,Mungall KL,Baker S,Basham D,Bentley SD,Brooks K,Cerdeño-Tárraga AM,Chillingworth T,Cronin A,Davies RM,Davis P,Dougan G,

更新日期：2001-10-04 00:00:00

abstract：:The thymus is the major, if not the sole site of maturation of T lymphocytes from their haematopoietic precursors. During embryonic life (at a few well-defined intervals, at least in birds) the thymus receives thymus-homing haematopoietic precursors that give rise to antigen-specific functional T lymphocytes. Although...

journal_title：Nature

authors： Ezine S,Weissman IL,Rouse RV

更新日期：1984-06-14 00:00:00

abstract：:The first zygotic genes to be expressed during early Drosophila development are the gap genes. Their role is to read and interpret coarse positional information deposited in the egg by the mother and to refine it by cross-regulatory interactions and by controlling a class of pair-rule genes. Little is known about the ...

journal_title：Nature

authors： Treisman J,Desplan C

更新日期：1989-09-28 00:00:00

abstract：:The complexity of ecosystems can cause subtle and chaotic responses to changes in external forcing. Although ecosystems may not normally behave chaotically, sensitivity to external influences associated with nonlinearity can lead to amplification of climatic signals. Strong correlations between an El Niño index and ra...

journal_title：Nature

authors： Taylor AH,Allen JI,Clark PA

更新日期：2002-04-11 00:00:00

abstract：:Null mutations of glass specifically remove photoreceptor cells, leaving other cell types intact. We have isolated the glass gene and have shown that its transcript encodes a putative protein of 604 amino acids with five zinc-fingers. The glass product may be a transcription factor required for the development of a si...

journal_title：Nature

authors： Moses K,Ellis MC,Rubin GM

更新日期：1989-08-17 00:00:00

abstract：:Dopamine D2 receptors (D2Rs) are densely expressed in the striatum and have been linked to neuropsychiatric disorders such as schizophrenia1,2. High-affinity binding of dopamine suggests that D2Rs detect transient reductions in dopamine concentration (the dopamine dip) during punishment learning3-5. However, the natur...

journal_title：Nature

authors： Iino Y,Sawada T,Yamaguchi K,Tajiri M,Ishii S,Kasai H,Yagishita S

更新日期：2020-03-01 00:00:00

abstract：:The genes for the T-cell receptor, like the immunoglobulin genes, are rearranged as DNA. The mechanism of this rearrangement is not clear; unequal crossover between chromosomes and the looping-out and excision of the excess DNA have both been suggested. We isolated small polydisperse circular (spc) DNAs from mouse thy...

journal_title：Nature

authors： Fujimoto S,Yamagishi H

更新日期：1987-05-21 00:00:00

abstract：:Electrons in a single sheet of graphene behave quite differently from those in traditional two-dimensional electron systems. Like massless relativistic particles, they have linear dispersion and chiral eigenstates. Furthermore, two sets of electrons centred at different points in reciprocal space ('valleys') have this...

journal_title：Nature

authors： Song YJ,Otte AF,Kuk Y,Hu Y,Torrance DB,First PN,de Heer WA,Min H,Adam S,Stiles MD,MacDonald AH,Stroscio JA

更新日期：2010-09-09 00:00:00

abstract：:The human alpha-interferon (IFN-alpha) gene family consists of at least 14 potentially functional non-allelic members; the amino acid sequences they encode differ from each other by up to approximately 20% of their residues. Human IFN-beta, which is encoded by a single gene, is distantly related to the IFN-alpha famil...

journal_title：Nature

authors： Valenzuela D,Weber H,Weissmann C

更新日期：1985-02-21 00:00:00

abstract：:Fluctuations in the counting rate of photons originating from uncorrelated point sources become, within the coherently illuminated area, slightly enhanced compared to a random sequence of classical particles. This phenomenon, known in astronomy as the Hanbury Brown-Twiss effect, is a consequence of quantum interferenc...

journal_title：Nature

authors： Kiesel H,Renz A,Hasselbach F

更新日期：2002-07-25 00:00:00

abstract：:Thrombin is a coagulation protease that activates platelets, leukocytes, endothelial and mesenchymal cells at sites of vascular injury, acting partly through an unusual proteolytically activated G-protein-coupled receptor. Knockout of the gene encoding this receptor provided definitive evidence for a second thrombin r...

journal_title：Nature

authors： Ishihara H,Connolly AJ,Zeng D,Kahn ML,Zheng YW,Timmons C,Tram T,Coughlin SR

更新日期：1997-04-03 00:00:00

abstract：:Retinoic-acid-inducible gene-I (RIG-I; also called DDX58) is a cytosolic viral RNA receptor that interacts with MAVS (also called VISA, IPS-1 or Cardif) to induce type I interferon-mediated host protective innate immunity against viral infection. Furthermore, members of the tripartite motif (TRIM) protein family, whic...

journal_title：Nature

authors： Gack MU,Shin YC,Joo CH,Urano T,Liang C,Sun L,Takeuchi O,Akira S,Chen Z,Inoue S,Jung JU

更新日期：2007-04-19 00:00:00

abstract：:The extent of allelic variation has been estimated at 46 structural gene loci within three major colonies of Swiss mice and between inbred derivative strains. The colonies have retained nearly the same amount and type of variation found in natural murine or human populations despite laboratory propagation for more tha...

journal_title：Nature

authors： Rice MC,O'Brien SJ

更新日期：1980-01-10 00:00:00

abstract：:A review of fossil mammalian faunas from the Middle Awash indicates they span most of the later Neogene and document evolutionary change in several mammalian groups, especially Primates, Proboscidea and Artiodactyla. Oldowan artefacts first appear in the late Pliocene, while Acheulian and later industries and apparent...

journal_title：Nature

authors： Kalb JE,Jolly CJ,Mebrate A,Tebedge S,Smart C,Oswald EB,Cramer D,Whitehead P,Wood CB,Conroy GC,Adefris T,Sperling L,Kana B

更新日期：1982-07-01 00:00:00

abstract：:Groundwater drawn daily from shallow alluvial sands by millions of wells over large areas of south and southeast Asia exposes an estimated population of over a hundred million people to toxic levels of arsenic. Holocene aquifers are the source of widespread arsenic poisoning across the region. In contrast, Pleistocene...

journal_title：Nature

authors： van Geen A,Bostick BC,Pham TK,Vi ML,Nguyen-Ngoc M,Phu DM,Pham HV,Radloff K,Aziz Z,Mey JL,Stahl MO,Harvey CF,Oates P,Weinman B,Stengel C,Frei F,Kipfer R,Berg M

更新日期：2013-09-12 00:00:00

abstract：:Extracellular signalling by the purine nucleotide ATP has long been associated with sensory function. In the periphery, ATP mediates nociception, mechanosensitivity, thermal sensitivity and O2 chemosensitivity. These processes share a common mechanism that involves the release of ATP to excite afferent fibres via acti...

journal_title：Nature

authors： Gourine AV,Llaudet E,Dale N,Spyer KM

更新日期：2005-07-07 00:00:00

abstract：:Diatremes are carrot-shaped bodies forming the upper parts of very deep magmatic intrusions of kimberlite rock. These unusual, enigmatic and complex features are famous as the source of diamonds. Here we present a new model of kimberlite ascent and eruption, emphasizing the extremely unsteady nature of this process to...

journal_title：Nature

authors： Wilson L,Head Iii JW 3rd

更新日期：2007-05-03 00:00:00

abstract：:Nuclear magic numbers correspond to fully occupied energy shells of protons or neutrons inside atomic nuclei. Doubly magic nuclei, with magic numbers for both protons and neutrons, are spherical and extremely rare across the nuclear landscape. Although the sequence of magic numbers is well established for stable nucle...

journal_title：Nature

authors： Taniuchi R,Santamaria C,Doornenbal P,Obertelli A,Yoneda K,Authelet G,Baba H,Calvet D,Château F,Corsi A,Delbart A,Gheller JM,Gillibert A,Holt JD,Isobe T,Lapoux V,Matsushita M,Menéndez J,Momiyama S,Motobayashi T,Nii

更新日期：2019-05-01 00:00:00

abstract：:Sea-level histories during the two most recent deglacial-interglacial intervals show substantial differences1-3 despite both periods undergoing similar changes in global mean temperature4,5 and forcing from greenhouse gases6. Although the last interglaciation (LIG) experienced stronger boreal summer insolation forcing...

journal_title：Nature

authors： Clark PU,He F,Golledge NR,Mitrovica JX,Dutton A,Hoffman JS,Dendy S

更新日期：2020-01-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class II molecules are highly polymorphic cell-surface glycoproteins that present antigenic peptides to CD4+ T lymphocytes. The normal assembly of class II molecules with cognate peptides for antigen presentation requires an accessory function provided by a gene mapping to the cl...

journal_title：Nature

authors： Fling SP,Arp B,Pious D

更新日期：1994-04-07 00:00:00