Oceanic forcing of penultimate deglacial and last interglacial sea-level rise.

abstract：:The Ca2+ + Mg2+-activated ATPase of the sarcoplasmic reticulum is responsible for the active Ca2+ transport of this membrane system, the key feature of which is the formation of an energy-rich phosphorylated transport enzyme (EP) and its conversion. To understand the Ca2+-transport mechanism, it is essential to clarif...

journal_title：Nature

authors： Takisawa H,Makinose M

更新日期：1981-03-19 00:00:00

abstract：:The histocompatibility-Y (H-Y) antigen is a minor histocompatibility antigen which has been detected on cell surfaces from the heterogametic sexes of mammalian, bird, amphibian, teleost and invertebrate species. H-Y is thought to be a male-determining substance in mammals because of its almost perfect correlation with...

journal_title：Nature

authors： Shapiro M,Erickson RP

更新日期：1981-04-09 00:00:00

abstract：:Human-mediated translocation of species to areas beyond their natural distribution (which results in 'alien' populations1) is a key signature of the Anthropocene2, and is a primary global driver of biodiversity loss and environmental change3. Stemming the tide of invasions requires understanding why some species fail ...

journal_title：Nature

authors： Redding DW,Pigot AL,Dyer EE,Şekercioğlu ÇH,Kark S,Blackburn TM

更新日期：2019-07-01 00:00:00

abstract：:SEVERAL dioecious marine brown algae have been valuable in studying chemical communication during sexual reproduction. For example, female gametes of Ectocarpus siliculosus, Cutleria multifida and Fucus serratus secrete olefinic hydrocarbons into the seawater to attract male gametes(1-3). A more complex system is foun...

journal_title：Nature

authors： Müller DG,Gassmann G,Lüning K

更新日期：1979-05-31 00:00:00

abstract：:The inner ear is capable of highly selective frequency discrimination. This is achieved not only by the travelling wave of the basilar membrane in the cochlear partition, but also by the active participation of nonlinear and vulnerable elements that enhance frequency selectivity. It has been shown that isolated mammal...

journal_title：Nature

authors： Brundin L,Flock A,Canlon B

更新日期：1989-12-14 00:00:00

abstract：:How the brain selects appropriate sensory inputs and suppresses distractors is unknown. Given the well-established role of the prefrontal cortex (PFC) in executive function, its interactions with sensory cortical areas during attention have been hypothesized to control sensory selection. To test this idea and, more ge...

journal_title：Nature

authors： Wimmer RD,Schmitt LI,Davidson TJ,Nakajima M,Deisseroth K,Halassa MM

更新日期：2015-10-29 00:00:00

abstract：:Phylogenetic analysis of early tetrapod evolution has resulted in a consensus across diverse data sets in which the tetrapod stem group is a relatively homogenous collection of medium- to large-sized animals showing a progressive loss of 'fish' characters as they become increasingly terrestrial, whereas the crown grou...

journal_title：Nature

authors： Pardo JD,Szostakiwskyj M,Ahlberg PE,Anderson JS

更新日期：2017-06-29 00:00:00

abstract：:Comparative mapping, which compares the location of homologous genes in different species, is a powerful tool for studying genome evolution. Comparative maps suggest that rates of chromosomal change in mammals can vary from one to ten rearrangements per million years. On the basis of these rates we would expect 84 to ...

journal_title：Nature

authors： Burt DW,Bruley C,Dunn IC,Jones CT,Ramage A,Law AS,Morrice DR,Paton IR,Smith J,Windsor D,Sazanov A,Fries R,Waddington D

更新日期：1999-11-25 00:00:00

abstract：:It has been speculated that brain activities might directly control adaptive immune responses in lymphoid organs, although there is little evidence for this. Here we show that splenic denervation in mice specifically compromises the formation of plasma cells during a T cell-dependent but not T cell-independent immune ...

journal_title：Nature

authors： Zhang X,Lei B,Yuan Y,Zhang L,Hu L,Jin S,Kang B,Liao X,Sun W,Xu F,Zhong Y,Hu J,Qi H

更新日期：2020-05-01 00:00:00

abstract：:Melanocytes are phenotypically prominent but histologically inconspicuous skin cells. They are responsible for the pigmentation of skin and hair, and thereby contribute to the appearance of skin and provide protection from damage by ultraviolet radiation. Pigmentation mutants in various species are highly informative ...

journal_title：Nature

authors： Lin JY,Fisher DE

更新日期：2007-02-22 00:00:00

abstract：:The fusion pore is the first crucial intermediate formed during exocytosis, yet little is known about the mechanisms that determine the size and kinetic properties of these transient structures. Here, we reduced the number of available SNAREs (proteins that mediate vesicle fusion) in neurons and observed changes in tr...

journal_title：Nature

authors： Bao H,Das D,Courtney NA,Jiang Y,Briguglio JS,Lou X,Roston D,Cui Q,Chanda B,Chapman ER

更新日期：2018-02-08 00:00:00

abstract：:In the HTML version of this Letter, the affiliations for authors Andrew S. Azman, Dhirendra Kumar and Thandavarayan Ramamurthy were inverted (the PDF and print versions of the Letter were correct); the affiliations have been corrected online. ...

journal_title：Nature

authors： Weill FX,Domman D,Njamkepo E,Almesbahi AA,Naji M,Nasher SS,Rakesh A,Assiri AM,Sharma NC,Kariuki S,Pourshafie MR,Rauzier J,Abubakar A,Carter JY,Wamala JF,Seguin C,Bouchier C,Malliavin T,Bakhshi B,Abulmaali HHN,Kuma

更新日期：2019-02-01 00:00:00

abstract：:The spread of antibiotic resistance in Gram-negative bacteria has sustained a continuing search for new agents with antibacterial activity against this important class of bacterial pathogen. Because the biosynthesis of lipopolysaccharide (LPS) is unique to Gram-negative bacteria and required by them for growth and vir...

journal_title：Nature

authors： Goldman R,Kohlbrenner W,Lartey P,Pernet A

更新日期：1987-09-10 00:00:00

abstract：:Analytical tools that have spatial resolution at the nanometre scale are indispensable for the life and physical sciences. It is desirable that these tools also permit elemental and chemical identification on a scale of 10 nm or less, with large penetration depths. A variety of techniques in X-ray imaging are currentl...

journal_title：Nature

authors： Chao W,Harteneck BD,Liddle JA,Anderson EH,Attwood DT

更新日期：2005-06-30 00:00:00

abstract：:Kinetoplastid RNA editing alters mitochondrial RNA transcripts by addition and deletion of uridine residues, producing open reading frames that may be twice as long as the original RNA. Although the COIII gene encoding cytochrome c oxidase subunit III in Trypanosoma brucei is edited along its entire length, the presum...

journal_title：Nature

authors： Landweber LF,Gilbert W

更新日期：1993-05-13 00:00:00

abstract：:Lung epithelial cells can influence immune responses to airway allergens. Airway epithelial cells also undergo apoptosis after encountering environmental allergens; yet, relatively little is known about how these are cleared, and their effect on airway inflammation. Here we show that airway epithelial cells efficientl...

journal_title：Nature

authors： Juncadella IJ,Kadl A,Sharma AK,Shim YM,Hochreiter-Hufford A,Borish L,Ravichandran KS

更新日期：2013-01-24 00:00:00

abstract：:The import of nuclear proteins proceeds through the nuclear pore complex and requires nuclear localization signals (NLSs), energy and soluble factors, namely importin-alpha (M(r) 60K), importin-beta (90K) and Ran. Importin-alpha is primarily responsible for NLS recognition and is a member of a protein family that incl...

journal_title：Nature

authors： Görlich D,Vogel F,Mills AD,Hartmann E,Laskey RA

更新日期：1995-09-21 00:00:00

abstract：:The murine cardioviruses, such as the Mengo and encephalomyocarditis viruses, and the bovine aphthoviruses, such as foot-and-mouth disease virus, are distinguished among positive-strand RNA viruses by the presence of long homopolymeric poly(C) tracts within their 5' noncoding sequences. Although the specific lengths (...

journal_title：Nature

authors： Duke GM,Osorio JE,Palmenberg AC

更新日期：1990-02-01 00:00:00

abstract：:The maternal messenger RNA An3 was originally identified localized to the animal hemisphere of Xenopus laevis oocytes, eggs and early embryos. Xenopus embryos depend on mRNA and protein present in the egg before fertilization (maternal molecules) to provide the information needed for early development. Localization of...

journal_title：Nature

authors： Gururajan R,Perry-O'Keefe H,Melton DA,Weeks DL

更新日期：1991-02-21 00:00:00

abstract：:DNA sequences containing the 5'-flanking regions of the insulin and chymotrypsin genes were linked to the coding sequence of the chloramphenicol acetyltransferase (CAT) gene. The insulin gene recombinant elicits preferential expression of CAT activity when introduced into cells producing insulin; similarly, the chymot...

journal_title：Nature

authors： Walker MD,Edlund T,Boulet AM,Rutter WJ

更新日期：1983-12-08 00:00:00

abstract：:Phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II is believed to control the transition from transcription initiation to elongation. The general transcription factor IIH (TFIIH) contains a kinase activity capable of phosphorylating this domain. Factors that promote the associat...

journal_title：Nature

authors： Lu H,Zawel L,Fisher L,Egly JM,Reinberg D

更新日期：1992-08-20 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) neurotransmission is widespread in vertebrate and invertebrate nervous systems. Here we use a genetic approach to identify molecules specific to GABA function. On the basis of the known in vivo roles of GABAergic neurons in controlling behaviour of the nematode Caenorhabditis elegans, we...

journal_title：Nature

authors： McIntire SL,Jorgensen E,Horvitz HR

更新日期：1993-07-22 00:00:00

abstract：:Hydrothermal vents are ephemeral because of frequent volcanic and tectonic activities associated with crust formation. Although the larvae of hydrothermal vent fauna can rapidly colonize new vent sites separated by tens to hundreds of kilometres, the mechanisms by which these larvae disperse and recruit are not unders...

journal_title：Nature

authors： Marsh AG,Mullineaux LS,Young CM,Manahan DT

更新日期：2001-05-03 00:00:00

abstract：:Cornelia de Lange syndrome (CdLS) is a dominantly inherited congenital malformation disorder, caused by mutations in the cohesin-loading protein NIPBL for nearly 60% of individuals with classical CdLS, and by mutations in the core cohesin components SMC1A (~5%) and SMC3 (<1%) for a smaller fraction of probands. In hum...

journal_title：Nature

authors： Deardorff MA,Bando M,Nakato R,Watrin E,Itoh T,Minamino M,Saitoh K,Komata M,Katou Y,Clark D,Cole KE,De Baere E,Decroos C,Di Donato N,Ernst S,Francey LJ,Gyftodimou Y,Hirashima K,Hullings M,Ishikawa Y,Jaulin C,Kaur

更新日期：2012-09-13 00:00:00

abstract：:CD4(+) T helper 2 (T(H)2) cells secrete interleukin (IL)4, IL5 and IL13, and are required for immunity to gastrointestinal helminth infections. However, T(H)2 cells also promote chronic inflammation associated with asthma and allergic disorders. The non-haematopoietic-cell-derived cytokines thymic stromal lymphopoieti...

journal_title：Nature

authors： Saenz SA,Siracusa MC,Perrigoue JG,Spencer SP,Urban JF Jr,Tocker JE,Budelsky AL,Kleinschek MA,Kastelein RA,Kambayashi T,Bhandoola A,Artis D

更新日期：2010-04-29 00:00:00

abstract：:PIWI-interacting RNAs (piRNAs) silence transposons to maintain genome integrity in animal germ lines. piRNAs are classified as primary and secondary piRNAs, depending on their biogenesis machinery. Primary piRNAs are processed from long non-coding RNA precursors transcribed from piRNA clusters in the genome through th...

journal_title：Nature

authors： Nishimasu H,Ishizu H,Saito K,Fukuhara S,Kamatani MK,Bonnefond L,Matsumoto N,Nishizawa T,Nakanaga K,Aoki J,Ishitani R,Siomi H,Siomi MC,Nureki O

更新日期：2012-11-08 00:00:00

abstract：:Recurrent chromosomal translocations involving the mixed lineage leukaemia (MLL) gene initiate aggressive forms of leukaemia, which are often refractory to conventional therapies. Many MLL-fusion partners are members of the super elongation complex (SEC), a critical regulator of transcriptional elongation, suggesting ...

journal_title：Nature

authors： Dawson MA,Prinjha RK,Dittmann A,Giotopoulos G,Bantscheff M,Chan WI,Robson SC,Chung CW,Hopf C,Savitski MM,Huthmacher C,Gudgin E,Lugo D,Beinke S,Chapman TD,Roberts EJ,Soden PE,Auger KR,Mirguet O,Doehner K,Delwel R,

更新日期：2011-10-02 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:Animal microRNAs (miRNAs) regulate gene expression by inhibiting translation and/or by inducing degradation of target messenger RNAs. It is unknown how much translational control is exerted by miRNAs on a genome-wide scale. We used a new proteomic approach to measure changes in synthesis of several thousand proteins i...

journal_title：Nature

authors： Selbach M,Schwanhäusser B,Thierfelder N,Fang Z,Khanin R,Rajewsky N

更新日期：2008-09-04 00:00:00

abstract：:T-cell clones that grow continuously in tissue culture have become a major tool for studying the properties of T lymphocytes. It is therefore important to know to what extent such clones resemble their normal counterparts. Several reports have appeared recently which demonstrate that long-term T-cell lines may lose th...

journal_title：Nature

authors： Simon MM,Weltzien HU,Bühring HJ,Eichmann K

更新日期：1984-03-22 00:00:00