Abstract:
:The maternal messenger RNA An3 was originally identified localized to the animal hemisphere of Xenopus laevis oocytes, eggs and early embryos. Xenopus embryos depend on mRNA and protein present in the egg before fertilization (maternal molecules) to provide the information needed for early development. Localization of maternal mRNA gives cells derived from different regions of the egg distinctive capacities for protein synthesis. We show here that An3 mRNA encodes a protein with 74% identity to a protein encoded by the testes-specific mRNA PL10 found in mouse, which is proposed to have RNA helicase activity. Because the gene encoding An3 mRNA is reactivated after gastrulation and remains active throughout embryogenesis, we have examined its distribution in embryonic and adult tissues. Unlike PL10 mRNA, which is primarily restricted to the testes, An3 mRNA is broadly distributed in later development.
journal_name
Naturejournal_title
Natureauthors
Gururajan R,Perry-O'Keefe H,Melton DA,Weeks DLdoi
10.1038/349717a0subject
Has Abstractpub_date
1991-02-21 00:00:00pages
717-9issue
6311eissn
0028-0836issn
1476-4687journal_volume
349pub_type
杂志文章相关文献
NATURE文献大全abstract::The skeletal muscles of the limbs develop from myogenic progenitors that originate in the paraxial mesoderm and migrate into the limb-bud mesenchyme. Among the genes known to be important for muscle development in mammalian embryos are those encoding the basic helix-loop-helix (bHLH) myogenic regulatory factors (MRFs;...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/21892
更新日期:1999-07-01 00:00:00
abstract::Transport of fermions, particles with half-integer spin, is central to many fields of physics. Electron transport runs modern technology, defining states of matter such as superconductors and insulators, and electron spin is being explored as a new carrier of information. Neutrino transport energizes supernova explosi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09989
更新日期:2011-04-14 00:00:00
abstract::The DNA synthetic (S) phase of cell division is about twice as long in human basal cell carcinoma (BCC) as the normal epidermis and several non-malignant skin diseases. A similar increase in S phase duration seems to occur in tumours of the human oesophagus, larynx and recto-colon. At the molecular level, the overall ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/285265a0
更新日期:1980-05-22 00:00:00
abstract::The main function of postural nervous mechanisms in different species, from mollusc to man, is to counteract the force of gravity and stabilize body orientation in space. Here we investigate the basic principles of postural control in a simple animal model, the marine mollusc Clione limacina. When swimming, C. limacin...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/30251
更新日期:1998-05-14 00:00:00
abstract::Recent advances in stem-cell technology are now allowing the mechanisms of human disease to be studied in human cells. A new era for regenerative medicine is arising from such disease models, extending beyond early cell-based therapies and towards evaluating genetic variation in humans and identifying the molecular pa...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07037
更新日期:2008-05-15 00:00:00
abstract::The discovery that atrial extracts have potent diuretic and natriuretic properties revealed a possible endocrine function of the heart in the regulation of extracellular fluid volume. Since that first report intense research activity has been directed towards determining the mechanism of action of the active atrial na...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326697a0
更新日期:1987-04-16 00:00:00
abstract::The mechanism by which insulin regulates cellular metabolism remains unknown although indirect evidence suggests that alterations in intracellular calcium are important. More specifically, it has been proposed that insulin triggers an increase in intracellular calcium which is responsible for the subsequent modificati...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/281495a0
更新日期:1979-10-11 00:00:00
abstract::The spectral purity of an oscillator is central to many applications, such as detecting gravity waves, defining the second, ground-state cooling and quantum manipulation of nanomechanical objects, and quantum computation. Recent proposals suggest that laser oscillators which use very narrow optical transitions in atom...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10920
更新日期:2012-04-04 00:00:00
abstract::At most synapses in the brain, short-term plasticity dynamically modulates synaptic strength. Rapid frequency-dependent changes in synaptic strength have key roles in sensory adaptation, gain control and many other neural computations. However, some auditory, vestibular and cerebellar synapses maintain constant streng...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature24474
更新日期:2017-11-23 00:00:00
abstract::The four R-spondin secreted ligands (RSPO1-RSPO4) act via their cognate LGR4, LGR5 and LGR6 receptors to amplify WNT signalling1-3. Here we report an allelic series of recessive RSPO2 mutations in humans that cause tetra-amelia syndrome, which is characterized by lung aplasia and a total absence of the four limbs. Fun...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0118-y
更新日期:2018-05-01 00:00:00
abstract::For more than 140 years, pollen tube guidance in flowering plants has been thought to be mediated by chemoattractants derived from target ovules. However, there has been no convincing evidence of any particular molecule being the true attractant that actually controls the navigation of pollen tubes towards ovules. Eme...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07882
更新日期:2009-03-19 00:00:00
abstract::Major histocompatibility complex (MHC) class I and class II molecules bind immunogenic peptides and present them to lymphocytes bearing the alpha beta T-cell antigen receptor (TCR). An analogous antigen-presenting function also has been proposed for the non-MHC-encoded CD1 molecules, a family of non-polymorphic, beta ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/372691a0
更新日期:1994-12-15 00:00:00
abstract::Gradual accumulation of evidence is thought to be fundamental for decision-making, and its neural correlates have been found in several brain regions. Here we develop a generalizable method to measure tuning curves that specify the relationship between neural responses and mentally accumulated evidence, and apply it t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14066
更新日期:2015-04-09 00:00:00
abstract::Integral membrane proteins are encoded by approximately 25% of all protein-coding genes1. In eukaryotes, the majority of membrane proteins are inserted, modified and folded at the endoplasmic reticulum (ER)2. Research over the past several decades has determined how membrane proteins are targeted to the ER and how ind...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2624-y
更新日期:2020-08-01 00:00:00
abstract::In photoreceptors, a latency of many milliseconds elapses between the absorption of a light quantum and the occurrence of the late receptor potential, even for strong light stimuli. Surprisingly, this is much longer than the time necessary for conductance changes such as occur in membranes of neurones or muscles, medi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/283859a0
更新日期:1980-02-28 00:00:00
abstract::G-protein-coupled receptors comprise the largest family of mammalian transmembrane receptors. They mediate numerous cellular pathways by coupling with downstream signalling transducers, including the hetrotrimeric G proteins Gs (stimulatory) and Gi (inhibitory) and several arrestin proteins. The structural mechanisms ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0215-y
更新日期:2018-06-01 00:00:00
abstract::Neurotransmitter/sodium symporters (NSSs) couple the uptake of neurotransmitter with one or more sodium ions, removing neurotransmitter from the synaptic cleft. NSSs are essential to the function of chemical synapses, are associated with multiple neurological diseases and disorders, and are the targets of therapeutic ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09581
更新日期:2010-12-23 00:00:00
abstract::Thermoelectric energy harvesting-the transformation of waste heat into useful electricity-is of great interest for energy sustainability. The main obstacle is the low thermoelectric efficiency of materials for converting heat to electricity, quantified by the thermoelectric figure of merit, ZT. The best available n-ty...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08088
更新日期:2009-06-18 00:00:00
abstract::The evolution of snakes involved major changes in vertebrate body plan organization, but the developmental basis of those changes is unknown. The python axial skeleton consists of hundreds of similar vertebrae, forelimbs are absent and hindlimbs are severely reduced. Combined limb loss and trunk elongation is found in...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/20944
更新日期:1999-06-03 00:00:00
abstract::Multiple endocrine neoplasia type 1 (MEN-1) is a predisposition to hyperplasia of the parathyroid glands, and to hyperplasia or tumours of the anterior pituitary and the endocrine pancreas, and is inherited as an autosomal dominant trait. Here we map the MEN-1 locus to chromosome 11 by family studies, and demonstrate ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/332085a0
更新日期:1988-03-03 00:00:00
abstract::High-temperature superconductivity is achieved by doping copper oxide insulators with charge carriers. The density of carriers in conducting materials can be determined from measurements of the Hall voltage--the voltage transverse to the flow of the electrical current that is proportional to an applied magnetic field....
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01890
更新日期:2003-08-21 00:00:00
abstract::The erosion of mountain belts controls their topographic and structural evolution and is the main source of sediment delivered to the oceans. Mountain erosion rates have been estimated from current relief and precipitation, but a more complete evaluation of the controls on erosion rates requires detailed measurements ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02150
更新日期:2003-12-11 00:00:00
abstract::Studies of the actin-based motility of the intracellular pathogens Listeria monocytogenes and Shigella flexneri have provided important insight into the events occurring at the leading edges of motile cells. Like the bacteria Listeria and Shigella, vaccinia virus, a relative of the causative agent of smallpox, uses ac...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/44860
更新日期:1999-10-28 00:00:00
abstract::Acetylcholine and dopamine are key neurotransmitters in the extrapyramidal motor system, where they are thought to lie in a 'functional balance' brought about by interactions between the terminals of the dopamine-containing nigrostriatal tract and the cholinergic interneurones of the striatum. The precise nature of th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/323625a0
更新日期:1986-10-16 00:00:00
abstract::The 18-base-pair sequence element AGGTCGACCAGTACTCCG (the Sal box) signals termination of mouse ribosomal gene transcription. This sequence is recognized by a sequence-specific DNA-binding protein, TTF I, which mediates the termination of transcription by RNA polymerase I (pol I). Subsequently, the ends of the primary...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/344559a0
更新日期:1990-04-05 00:00:00
abstract::Species that depend on membership in social groups for survival exhibit changes in neuronal gene expression and behaviour when they face restricted social interactions or isolation1-3. Here we show that, across the lifespan of zebrafish (Danio rerio), social isolation specifically decreased the level of transcription ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2988-z
更新日期:2020-12-01 00:00:00
abstract::Two approaches to the antibody-directed targeting of toxic or cytolytic activity and augmentation of cellular immune responses have been explored for tumour immunotherapy, but so far success has been limited. Obstacles facing immunotherapy are the limited accessibility of antibodies or antibody conjugates to solid tum...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/385078a0
更新日期:1997-01-02 00:00:00
abstract::oop RNA, which is initiated at the po promoter and is 81 nucleotides long, can function as a leader sequence for the lambda immunity establishment transcription, previously believed to originate at a special promoter pre located in the y region. Thus, oop RNA seems to have a dual role, either favouring the lytic cycle...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/262112a0
更新日期:1976-07-08 00:00:00
abstract::There is compelling evidence that sleep contributes to the long-term consolidation of new memories. This function of sleep has been linked to slow (<1 Hz) potential oscillations, which predominantly arise from the prefrontal neocortex and characterize slow wave sleep. However, oscillations in brain potentials are comm...
journal_title:Nature
pub_type: 临床试验,杂志文章
doi:10.1038/nature05278
更新日期:2006-11-30 00:00:00
abstract::The three-dimensional structure of the 66-amino acid cro repressor protein of bacteriophage lambda suggests how it binds to its operator DNA. We propose that a dimer of cro protein is bound to the B-form of DNA with the 2-fold axis of the dimer coincident with the 2-fold axis of DNA. A pair of 2-fold-related alpha-hel...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/290754a0
更新日期:1981-04-30 00:00:00