Abstract:
:DNA sequences containing the 5'-flanking regions of the insulin and chymotrypsin genes were linked to the coding sequence of the chloramphenicol acetyltransferase (CAT) gene. The insulin gene recombinant elicits preferential expression of CAT activity when introduced into cells producing insulin; similarly, the chymotrypsin gene recombinant elicits preferential expression in chymotrypsin-producing cells. Sequences located upstream of previously defined transcriptional control elements are essential for efficient expression in both cases.
journal_name
Naturejournal_title
Natureauthors
Walker MD,Edlund T,Boulet AM,Rutter WJdoi
10.1038/306557a0subject
Has Abstractpub_date
1983-12-08 00:00:00pages
557-61issue
5943eissn
0028-0836issn
1476-4687journal_volume
306pub_type
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