Abstract:
:It has been speculated that brain activities might directly control adaptive immune responses in lymphoid organs, although there is little evidence for this. Here we show that splenic denervation in mice specifically compromises the formation of plasma cells during a T cell-dependent but not T cell-independent immune response. Splenic nerve activity enhances plasma cell production in a manner that requires B-cell responsiveness to acetylcholine mediated by the α9 nicotinic receptor, and T cells that express choline acetyl transferase1,2 probably act as a relay between the noradrenergic nerve and acetylcholine-responding B cells. We show that neurons in the central nucleus of the amygdala (CeA) and the paraventricular nucleus (PVN) that express corticotropin-releasing hormone (CRH) are connected to the splenic nerve; ablation or pharmacogenetic inhibition of these neurons reduces plasma cell formation, whereas pharmacogenetic activation of these neurons increases plasma cell abundance after immunization. In a newly developed behaviour regimen, mice are made to stand on an elevated platform, leading to activation of CeA and PVN CRH neurons and increased plasma cell formation. In immunized mice, the elevated platform regimen induces an increase in antigen-specific IgG antibodies in a manner that depends on CRH neurons in the CeA and PVN, an intact splenic nerve, and B cell expression of the α9 acetylcholine receptor. By identifying a specific brain-spleen neural connection that autonomically enhances humoral responses and demonstrating immune stimulation by a bodily behaviour, our study reveals brain control of adaptive immunity and suggests the possibility to enhance immunocompetency by behavioural intervention.
journal_name
Naturejournal_title
Natureauthors
Zhang X,Lei B,Yuan Y,Zhang L,Hu L,Jin S,Kang B,Liao X,Sun W,Xu F,Zhong Y,Hu J,Qi Hdoi
10.1038/s41586-020-2235-7subject
Has Abstractpub_date
2020-05-01 00:00:00pages
204-208issue
7807eissn
0028-0836issn
1476-4687pii
10.1038/s41586-020-2235-7journal_volume
581pub_type
杂志文章相关文献
NATURE文献大全abstract::Tumour necrosis factor is a trimeric molecule, each subunit of which consists of an antiparallel beta-sandwich. Individual subunits from the trimer by a novel edge-to-face packing of beta-sheets. A comparison of the subunit fold with that of other proteins reveals a remarkable similarity to the 'jelly-roll' structural...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/338225a0
更新日期:1989-03-16 00:00:00
abstract::The observations that atherosclerosis often occurs in non-smokers without elevated levels of low-density lipoprotein cholesterol, and that most atherosclerosis loci so far identified in mice do not affect systemic risk factors associated with atherosclerosis, suggest that as-yet-unidentified mechanisms must contribute...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03527
更新日期:2005-05-26 00:00:00
abstract::Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by environmental influences, and functionally implicated in behavioural responses to stress and antidepressants1-4. However, how adult-born neurons regulate dentate gyrus information processing to protect from stress-induced anxiety-like be...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0262-4
更新日期:2018-07-01 00:00:00
abstract::Gene targeting in mouse embryo-derived stem cells has been used to disrupt the homeobox gene hox-1.5. Mice heterozygous at the hox-1.5 locus appear normal, whereas hox-1.5-/hox-1.5- mice die at or shortly after birth. These homozygotes are athymic, aparathyroid, have reduced thyroid and submaxillary tissue and exhibit...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/350473a0
更新日期:1991-04-11 00:00:00
abstract::Highly correlated electronic systems--such as transition-metal oxides that are doped Mott insulators--are complex systems which exhibit puzzling phenomena, including high-temperature superconductivity and colossal magnetoresistivity. Recent studies suggest that in such systems collective electronic phenomena are impor...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35021018
更新日期:2000-08-17 00:00:00
abstract::Microbialites, including biogenic stromatolites, thrombolites and dendrolites, were formed by various microbial mats that trapped and bound sediments or formed the locus of mineral precipitation. Microbialites were common and diverse during the Proterozoic, but declined in abundance and morphological diversity when mu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02654
更新日期:2004-07-01 00:00:00
abstract::Laboratory measurements of sound velocities of high-pressure minerals provide crucial information on the composition and constitution of the deep mantle via comparisons with observed seismic velocities. Calcium silicate (CaSiO3) perovskite (CaPv) is a high-pressure phase that occurs at depths greater than about 560 ki...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0816-5
更新日期:2019-01-01 00:00:00
abstract::Bax (Bcl2-associated X protein) is an apoptosis-inducing protein that participates in cell death during normal development and in various diseases. Bax resides in an inactive state in the cytosol of many cells. In response to death stimuli, Bax protein undergoes conformational changes that expose membrane-targeting do...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01627
更新日期:2003-05-22 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/d41586-018-07209-z
更新日期:2018-11-01 00:00:00
abstract::How to image objects that are hidden from a camera's view is a problem of fundamental importance to many fields of research, with applications in robotic vision, defence, remote sensing, medical imaging and autonomous vehicles. Non-line-of-sight (NLOS) imaging at macroscopic scales has been demonstrated by scanning a ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature25489
更新日期:2018-03-15 00:00:00
abstract::The evolutionary history of extant hominoids (humans and apes) remains poorly understood. The African fossil record during the crucial time period, the Miocene epoch, largely comprises isolated jaws and teeth, and little is known about ape cranial evolution. Here we report on the, to our knowledge, most complete fossi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature23456
更新日期:2017-08-09 00:00:00
abstract::Nuclear-architecture defects have been shown to correlate with the manifestation of a number of human diseases as well as ageing. It is therefore plausible that diseases whose manifestations correlate with ageing might be connected to the appearance of nuclear aberrations over time. We decided to evaluate nuclear orga...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11557
更新日期:2012-11-22 00:00:00
abstract::The preparation of synthetic molecules showing the remarkable efficiencies characteristic of natural biopolymer catalysts remains a formidable challenge for chemical biology. Although significant advances have been made in the understanding of protein structure and function, the de novo construction of such systems re...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/39556
更新日期:1997-10-16 00:00:00
abstract::GTPase-activating proteins (GAPs) increase the rate of GTP hydrolysis on guanine nucleotide-binding proteins by many orders of magnitude. Studies with Ras and Rho have elucidated the mechanism of GAP action by showing that their catalytic machinery is both stabilized by GAP binding and complemented by the insertion of...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/415662a
更新日期:2002-02-07 00:00:00
abstract::Sex differences in behaviour extend to cognitive-like processes such as learning, but the underlying dimorphisms in neural circuit development and organization that generate these behavioural differences are largely unknown. Here we define at the single-cell level-from development, through neural circuit connectivity,...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature15700
更新日期:2015-10-15 00:00:00
abstract::Magnetic interactions and magnetic impurities are destructive to superconductivity in conventional superconductors. By contrast, in some unconventional macroscopic quantum systems (such as superfluid 3He and superconducting UGe2), the superconductivity (or superfluidity) is actually mediated by magnetic interactions. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35082019
更新日期:2001-06-21 00:00:00
abstract::The gut of healthy human neonates is usually devoid of viruses at birth, but quickly becomes colonized, which-in some cases-leads to gastrointestinal disorders1-4. Here we show that the assembly of the viral community in neonates takes place in distinct steps. Fluorescent staining of virus-like particles purified from...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2192-1
更新日期:2020-05-01 00:00:00
abstract::Understanding crystal growth is essential for controlling the crystallization used in industrial separation and purification processes. Because solids interact through their surfaces, crystal shape can influence both chemical and physical properties. The thermodynamic morphology can readily be predicted, but most part...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04173
更新日期:2005-11-03 00:00:00
abstract::T200, a major cell-surface glycoprotein on lymphoid cells, exists in several forms with different electrophoretic mobilities. These forms have been correlated with different classes of lymphoid cell. The smaller forms, with molecular weights (MWs) of congruent to 170,000 and 180,000 are found predominantly on T cells ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/289681a0
更新日期:1981-02-19 00:00:00
abstract::Triton is Neptune's principal satellite and is by far the largest retrograde satellite in the Solar System (its mass is approximately 40 per cent greater than that of Pluto). Its inclined and circular orbit lies between a group of small inner prograde satellites and a number of exterior irregular satellites with both ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04792
更新日期:2006-05-11 00:00:00
abstract::By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs. Some of these genes serve dual functions, providing growth advantages both in the primary tumour and in the lung microe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03799
更新日期:2005-07-28 00:00:00
abstract::Increasing population and consumption are placing unprecedented demands on agriculture and natural resources. Today, approximately a billion people are chronically malnourished while our agricultural systems are concurrently degrading land, water, biodiversity and climate on a global scale. To meet the world's future ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10452
更新日期:2011-10-12 00:00:00
abstract::Perfusion chromatography is a technique based on fluid dynamics for reducing stagnant mobile phase mass transfer in liquid chromatography. This is achieved by using supports with large pores that allow mobile phase to flow through particles. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/350634a0
更新日期:1991-04-18 00:00:00
abstract::Much of our knowledge of galaxies comes from analysing the radiation emitted by their stars, which depends on the present number of each type of star in the galaxy. The present number depends on the stellar initial mass function (IMF), which describes the distribution of stellar masses when the population formed, and ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10972
更新日期:2012-04-25 00:00:00
abstract::The Axl receptor tyrosine kinase was identified as a protein encoded by a transforming gene from primary human myeloid leukaemia cells by DNA-mediated transformation of NIH 3T3 cells. Axl is the founding member of a family of related receptors that includes Eyk, encoded by a chicken proto-oncogene originally described...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/373623a0
更新日期:1995-02-16 00:00:00
abstract::The methylation of vertebrate DNA at the 5-position of approximately 3-10% of its cytosine residues occurs in a sequence-specific and tissue-specific manner and has been implicated in the control of transcription. How these differences are established and how they mediate the initiation or maintenance of transcription...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/308293a0
更新日期:1984-03-15 00:00:00
abstract::The shape of the human erythrocyte depends on intracellular ATP content and echinocytic erythrocyte ghosts obtained in the presence of Mg-ATP acquire a diskocytic shape after incubation at 37 degrees C; however, agreement is lacking about the molecular basis of the shape changes. The suggestion that phosphorylation of...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/307376a0
更新日期:1984-01-26 00:00:00
abstract::The murine cardioviruses, such as the Mengo and encephalomyocarditis viruses, and the bovine aphthoviruses, such as foot-and-mouth disease virus, are distinguished among positive-strand RNA viruses by the presence of long homopolymeric poly(C) tracts within their 5' noncoding sequences. Although the specific lengths (...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/343474a0
更新日期:1990-02-01 00:00:00
abstract::Nutrients, such as amino acids and glucose, signal through the Rag GTPases to activate mTORC1. The GATOR1 protein complex-comprising DEPDC5, NPRL2 and NPRL3-regulates the Rag GTPases as a GTPase-activating protein (GAP) for RAGA; loss of GATOR1 desensitizes mTORC1 signalling to nutrient starvation. GATOR1 components h...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature26158
更新日期:2018-04-05 00:00:00
abstract::Globular star clusters are compact and massive stellar systems old enough to have witnessed the entire history of our Galaxy, the Milky Way. Although recent results suggest that their formation may have been more complex than previously thought, they still are the best approximation to a stellar population formed over...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08581
更新日期:2009-11-26 00:00:00