Abstract:
:Phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II is believed to control the transition from transcription initiation to elongation. The general transcription factor IIH (TFIIH) contains a kinase activity capable of phosphorylating this domain. Factors that promote the association of RNA polymerase II with the preinitiation complex stimulate this activity. The transcription factor IIE, which is required for the stable association of TFIIH with the preinitiation complex, affects the processivity of TFIIH kinase.
journal_name
Naturejournal_title
Natureauthors
Lu H,Zawel L,Fisher L,Egly JM,Reinberg Ddoi
10.1038/358641a0keywords:
subject
Has Abstractpub_date
1992-08-20 00:00:00pages
641-5issue
6388eissn
0028-0836issn
1476-4687journal_volume
358pub_type
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