当前位置： SCI文献检索 > NATURE期刊下所有文献 > Thalamic control of sensory selection in divided attention.

Thalamic control of sensory selection in divided attention.

Abstract：

:How the brain selects appropriate sensory inputs and suppresses distractors is unknown. Given the well-established role of the prefrontal cortex (PFC) in executive function, its interactions with sensory cortical areas during attention have been hypothesized to control sensory selection. To test this idea and, more generally, dissect the circuits underlying sensory selection, we developed a cross-modal divided-attention task in mice that allowed genetic access to this cognitive process. By optogenetically perturbing PFC function in a temporally precise window, the ability of mice to select appropriately between conflicting visual and auditory stimuli was diminished. Equivalent sensory thalamocortical manipulations showed that behaviour was causally dependent on PFC interactions with the sensory thalamus, not sensory cortex. Consistent with this notion, we found neurons of the visual thalamic reticular nucleus (visTRN) to exhibit PFC-dependent changes in firing rate predictive of the modality selected. visTRN activity was causal to performance as confirmed by bidirectional optogenetic manipulations of this subnetwork. Using a combination of electrophysiology and intracellular chloride photometry, we demonstrated that visTRN dynamically controls visual thalamic gain through feedforward inhibition. Our experiments introduce a new subcortical model of sensory selection, in which the PFC biases thalamic reticular subnetworks to control thalamic sensory gain, selecting appropriate inputs for further processing.

journal_name

Nature

journal_title

Nature

authors

Wimmer RD,Schmitt LI,Davidson TJ,Nakajima M,Deisseroth K,Halassa MM

doi

10.1038/nature15398

subject

Has Abstract

pub_date

2015-10-29 00:00:00

pages

705-9

issue

7575

eissn

0028-0836

issn

1476-4687

pii

nature15398

journal_volume

526

pub_type

杂志文章

相关文献

NATURE文献大全
  • Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

    abstract：:Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. Studies in aP2-deficient mice have shown that this lipid chaperone has a significant role in several aspects of metabolic syndrome, including type 2 diabetes and atheroscle...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature05844

    authors： Furuhashi M,Tuncman G,Görgün CZ,Makowski L,Atsumi G,Vaillancourt E,Kono K,Babaev VR,Fazio S,Linton MF,Sulsky R,Robl JA,Parker RA,Hotamisligil GS

    更新日期：2007-06-21 00:00:00

  • Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form.

    abstract：:Troponin is essential in Ca(2+) regulation of skeletal and cardiac muscle contraction. It consists of three subunits (TnT, TnC and TnI) and, together with tropomyosin, is located on the actin filament. Here we present crystal structures of the core domains (relative molecular mass of 46,000 and 52,000) of human cardia...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature01780

    authors： Takeda S,Yamashita A,Maeda K,Maéda Y

    更新日期：2003-07-03 00:00:00

  • Why do we age?

    abstract：:The evolutionary theory of ageing explains why ageing occurs, giving valuable insight into the mechanisms underlying the complex cellular and molecular changes that contribute to senescence. Such understanding also helps to clarify how the genome shapes the ageing process, thereby aiding the study of the genetic facto...

    journal_title：Nature

    pub_type： 杂志文章,评审

    doi：10.1038/35041682

    authors： Kirkwood TB,Austad SN

    更新日期：2000-11-09 00:00:00

  • Defining brain wiring patterns and mechanisms through gene trapping in mice.

    abstract：:The search to understand the mechanisms regulating brain wiring has relied on biochemical purification approaches in vertebrates and genetic approaches in invertebrates to identify molecular cues and receptors for axon guidance. Here we describe a phenotype-based gene-trap screen in mice designed for the large-scale i...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/35065539

    authors： Leighton PA,Mitchell KJ,Goodrich LV,Lu X,Pinson K,Scherz P,Skarnes WC,Tessier-Lavigne M

    更新日期：2001-03-08 00:00:00

  • Postsynaptic hyperpolarization during conditioning reversibly blocks induction of long-term potentiation.

    abstract：:Activity-induced changes in the efficacy of synaptic transmission between neurones are central to several prominent theories of learning. In both in vivo and in vitro preparations of the hippocampus, a conditioning high-frequency stimulus delivered to afferent fibres results in a long-term potentiation of synaptic tra...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/320529a0

    authors： Malinow R,Miller JP

    更新日期：1986-04-10 00:00:00

  • Binding of an SV40 T antigen-related protein to the DNA of SV40 regulatory mutants.

    abstract：:When simian virus 40 (SV40) infects host cells, the viral genes are expressed in two phases. Early in infection, the virus genome is transcribed and translated to yield two related proteins, 'large T' and 'small t' antigens. Later the rate of synthesis of the early messenger RNA falls and the viral genes coding for th...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/289810a0

    authors： McKay R,DiMaio D

    更新日期：1981-02-26 00:00:00

  • Temporally distinct pre- and post-synaptic mechanisms maintain long-term potentiation.

    abstract：:Long-term potentiation (LTP) in the hippocampus is widely studied as the mechanisms involved in its induction and maintenance are believed to underlie fundamental properties of learning and memory in vertebrates. Most synapses that exhibit LTP use an excitatory amino-acid neurotransmitter that acts on two types of rec...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/338500a0

    authors： Davies SN,Lester RA,Reymann KG,Collingridge GL

    更新日期：1989-04-06 00:00:00

  • Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice.

    abstract：:Expression of Ets2, a proto-oncogene and transcription factor, occurs in a variety of cell types. During murine development it is highly expressed in newly forming cartilage, including in the skull precursor cells and vertebral primordia. Ets2 is located on human chromosome 21 (ref. 8) and is overexpressed in Down's s...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/379534a0

    authors： Sumarsono SH,Wilson TJ,Tymms MJ,Venter DJ,Corrick CM,Kola R,Lahoud MH,Papas TS,Seth A,Kola I

    更新日期：1996-02-08 00:00:00

  • Sterically controlled mechanochemistry under hydrostatic pressure.

    abstract：:Mechanical stimuli can modify the energy landscape of chemical reactions and enable reaction pathways, offering a synthetic strategy that complements conventional chemistry. These mechanochemical mechanisms have been studied extensively in one-dimensional polymers under tensile stress using ring-opening and reorganiza...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature25765

    authors： Yan H,Yang F,Pan D,Lin Y,Hohman JN,Solis-Ibarra D,Li FH,Dahl JEP,Carlson RMK,Tkachenko BA,Fokin AA,Schreiner PR,Galli G,Mao WL,Shen ZX,Melosh NA

    更新日期：2018-02-21 00:00:00

  • Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase.

    abstract：:The structural components involved in transduction of extracellular signals as diverse as a photon of light impinging on the retina or a hormone molecule impinging on a cell have been highly conserved. These components include a recognition unit or receptor (for example, the beta-adrenergic receptor (beta AR) for cate...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/321869a0

    authors： Benovic JL,Mayor F Jr,Somers RL,Caron MG,Lefkowitz RJ

    更新日期：1986-06-26 00:00:00

  • Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.

    abstract：:Recurrent chromosomal translocations involving the mixed lineage leukaemia (MLL) gene initiate aggressive forms of leukaemia, which are often refractory to conventional therapies. Many MLL-fusion partners are members of the super elongation complex (SEC), a critical regulator of transcriptional elongation, suggesting ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature10509

    authors： Dawson MA,Prinjha RK,Dittmann A,Giotopoulos G,Bantscheff M,Chan WI,Robson SC,Chung CW,Hopf C,Savitski MM,Huthmacher C,Gudgin E,Lugo D,Beinke S,Chapman TD,Roberts EJ,Soden PE,Auger KR,Mirguet O,Doehner K,Delwel R,

    更新日期：2011-10-02 00:00:00

  • Can the lumpy distribution of galaxies be detected by X-ray observations?

    abstract：:Published data from X-ray telescopes are not adequate to reveal the fluctuations in the surface brightness of the background radiation caused by clustering or superclustering of the sources giving rise to the background. ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/238020a0

    authors： Webster AS

    更新日期：1972-07-07 00:00:00

  • Cultured epithelial cells of cornea, conjunctiva and skin: absence of marked intrinsic divergence of their differentiated states.

    abstract：:Keratinocytes of three different epithelia grown in cell culture express a large number of differentiation markers with either no differences or relatively small differences, depending on the species. Much of the distinctive phenotype of these epithelia in vivo must be due to external modulation and relatively little,...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/269489a0

    authors： Sun TT,Green H

    更新日期：1977-10-06 00:00:00

  • Evolution of distinct developmental functions of three Drosophila genes by acquisition of different cis-regulatory regions.

    abstract：:It is generally accepted that the specific function of a gene depends on its coding sequence. The three paired-box and homeobox genes paired (prd), gooseberry (gsb) and gooseberry neuro (gsbn) have distinct developmental functions in Drosophila embryogenesis. During the syncytial blastoderm stage, the pair-rule gene p...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/367083a0

    authors： Li X,Noll M

    更新日期：1994-01-06 00:00:00

  • Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1.

    abstract：:Activated T lymphocytes differentiate into effector cells tailored to meet disparate challenges to host integrity. For example, type 1 and type 2 helper (T(H)1 and T(H)2) cells secrete cytokines that enhance cell-mediated and humoral immunity, respectively. The chemokine monocyte chemoattractant protein-1 (MCP-1) can ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/35006097

    authors： Gu L,Tseng S,Horner RM,Tam C,Loda M,Rollins BJ

    更新日期：2000-03-23 00:00:00

  • Author Correction: The selective tRNA aminoacylation mechanism based on a single G•U pair.

    abstract：:In Fig. 1b of this Article, a U was inadvertently inserted after G15 in the D loop. The original Article has not been corrected. ...

    journal_title：Nature

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41586-018-0760-4

    authors： Naganuma M,Sekine SI,Chong YE,Guo M,Yang XL,Gamper H,Hou YM,Schimmel P,Yokoyama S

    更新日期：2018-12-01 00:00:00

  • Inhibition contributes to orientation selectivity in visual cortex of cat.

    abstract：:Neurons in the visual cortex are selectively responsive to light or dark bars presented at particular orientations. On the basis of physiological data, this orientation selectivity is hypothesized as being due at least partially to intracortical inhibitory mechanisms. But this hypothesis has been challenged by intrace...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/335815a0

    authors： Hata Y,Tsumoto T,Sato H,Hagihara K,Tamura H

    更新日期：1988-10-27 00:00:00

  • Author Correction: El Niño-Southern Oscillation complexity.

    abstract：:In this Review, the middle initial of author Kim M. Cobb was omitted. The original Review has been corrected online. ...

    journal_title：Nature

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41586-019-0994-9

    authors： Timmermann A,An SI,Kug JS,Jin FF,Cai W,Capotondi A,Cobb KM,Lengaigne M,McPhaden MJ,Stuecker MF,Stein K,Wittenberg AT,Yun KS,Bayr T,Chen HC,Chikamoto Y,Dewitte B,Dommenget D,Grothe P,Guilyardi E,Ham YG,Hayashi M

    更新日期：2019-03-01 00:00:00

  • Specific recognition of staphylococcal enterotoxin A by human T cells bearing receptors with the V gamma 9 region.

    abstract：:T cells bearing the alpha beta receptor can specifically react with target cells coated with staphylococcal enterotoxin and expressing major histocompatibility complex class II molecules; these responses depend on which variable region (V) of the receptor's beta-subunit is used. We have now examined whether a similar ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/346572a0

    authors： Rust CJ,Verreck F,Vietor H,Koning F

    更新日期：1990-08-09 00:00:00

  • Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade.

    abstract：:Most patients with cancer either do not respond to immune checkpoint blockade or develop resistance to it, often because of acquired mutations that impair antigen presentation. Here we show that loss of function of the RNA-editing enzyme ADAR1 in tumour cells profoundly sensitizes tumours to immunotherapy and overcome...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/s41586-018-0768-9

    authors： Ishizuka JJ,Manguso RT,Cheruiyot CK,Bi K,Panda A,Iracheta-Vellve A,Miller BC,Du PP,Yates KB,Dubrot J,Buchumenski I,Comstock DE,Brown FD,Ayer A,Kohnle IC,Pope HW,Zimmer MD,Sen DR,Lane-Reticker SK,Robitschek EJ,Grif

    更新日期：2019-01-01 00:00:00

  • Photonic structures in biology.

    abstract：:Millions of years before we began to manipulate the flow of light using synthetic structures, biological systems were using nanometre-scale architectures to produce striking optical effects. An astonishing variety of natural photonic structures exists: a species of Brittlestar uses photonic elements composed of calcit...

    journal_title：Nature

    pub_type： 杂志文章,评审

    doi：10.1038/nature01941

    authors： Vukusic P,Sambles JR

    更新日期：2003-08-14 00:00:00

  • A network-based analysis of systemic inflammation in humans.

    abstract：:Oligonucleotide and complementary DNA microarrays are being used to subclassify histologically similar tumours, monitor disease progress, and individualize treatment regimens. However, extracting new biological insight from high-throughput genomic studies of human diseases is a challenge, limited by difficulties in re...

    journal_title：Nature

    pub_type： 临床试验,杂志文章

    doi：10.1038/nature03985

    authors： Calvano SE,Xiao W,Richards DR,Felciano RM,Baker HV,Cho RJ,Chen RO,Brownstein BH,Cobb JP,Tschoeke SK,Miller-Graziano C,Moldawer LL,Mindrinos MN,Davis RW,Tompkins RG,Lowry SF,Inflamm and Host Response to Injury Large Scale

    更新日期：2005-10-13 00:00:00

  • Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells.

    abstract：:The neurotrophin receptor TrkB is essential for normal function of the mammalian brain. It is expressed in three splice variants. Full-length receptors (TrkB(FL)) possess an intracellular tyrosine kinase domain and are considered as those TrkB receptors that mediate the crucial effects of brain-derived neurotrophic fa...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature01983

    authors： Rose CR,Blum R,Pichler B,Lepier A,Kafitz KW,Konnerth A

    更新日期：2003-11-06 00:00:00

  • Retinoic acid regulates growth hormone gene expression.

    abstract：:Vitamin A is required for normal growth and development, and retinoic acid (RA) may be the active metabolite in this process. Recent evidence indicates that RA acts through binding to a nuclear receptor which belongs to the steroid/thyroid hormone receptor superfamily. The receptors seem to associate with hormone-resp...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/339231a0

    authors： Bedo G,Santisteban P,Aranda A

    更新日期：1989-05-18 00:00:00

  • Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance.

    abstract：:Recognition of self-antigen-derived epitopes presented by major histocompatibility complex class II (MHC II) molecules on thymic epithelial cells (TECs) is critical for the generation of a functional and self-tolerant CD4 T-cell repertoire. Whereas haematopoietic antigen-presenting cells generate MHC-II-peptide comple...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature07208

    authors： Nedjic J,Aichinger M,Emmerich J,Mizushima N,Klein L

    更新日期：2008-09-18 00:00:00

  • Quantum tomography of an electron.

    abstract：:The complete knowledge of a quantum state allows the prediction of the probability of all possible measurement outcomes, a crucial step in quantum mechanics. It can be provided by tomographic methods which have been applied to atomic, molecular, spin and photonic states. For optical or microwave photons, standard tomo...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature13821

    authors： Jullien T,Roulleau P,Roche B,Cavanna A,Jin Y,Glattli DC

    更新日期：2014-10-30 00:00:00

  • Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking.

    abstract：:The basolateral amygdala (BLA) has a crucial role in emotional learning irrespective of valence. The BLA projection to the nucleus accumbens (NAc) is thought to modulate cue-triggered motivated behaviours, but our understanding of the interaction between these two brain regions has been limited by the inability to man...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature10194

    authors： Stuber GD,Sparta DR,Stamatakis AM,van Leeuwen WA,Hardjoprajitno JE,Cho S,Tye KM,Kempadoo KA,Zhang F,Deisseroth K,Bonci A

    更新日期：2011-06-29 00:00:00

  • The emergence of transcriptional identity in somatosensory neurons.

    abstract：:More than twelve morphologically and physiologically distinct subtypes of primary somatosensory neuron report salient features of our internal and external environments1-4. It is unclear how specialized gene expression programs emerge during development to endow these subtypes with their unique properties. To assess t...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/s41586-019-1900-1

    authors： Sharma N,Flaherty K,Lezgiyeva K,Wagner DE,Klein AM,Ginty DD

    更新日期：2020-01-01 00:00:00

  • The projected timing of climate departure from recent variability.

    abstract：:Ecological and societal disruptions by modern climate change are critically determined by the time frame over which climates shift beyond historical analogues. Here we present a new index of the year when the projected mean climate of a given location moves to a state continuously outside the bounds of historical vari...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature12540

    authors： Mora C,Frazier AG,Longman RJ,Dacks RS,Walton MM,Tong EJ,Sanchez JJ,Kaiser LR,Stender YO,Anderson JM,Ambrosino CM,Fernandez-Silva I,Giuseffi LM,Giambelluca TW

    更新日期：2013-10-10 00:00:00

  • How snuggling close affects bats' microbiome.

    abstract：: ...

    journal_title：Nature

    pub_type： 新闻

    doi：10.1038/d41586-018-07706-1

    authors：

    更新日期：2018-12-01 00:00:00