Developmental regulation of NMDA receptor-mediated synaptic currents at a central synapse.

Abstract:

:The central nervous system has extraordinary plasticity in early life. This is thought to involve N-methyl-D-aspartate (NMDA) receptors which, along with the non-NMDA receptors, mediate fast excitatory synaptic transmission. Although NMDA receptors may be transiently enhanced early in life, it has not been possible to demonstrate directly a functional change in the NMDA receptor-mediated synaptic response because of the voltage-dependence of the NMDA conductance and the overlapping inhibitory synaptic conductances. Here I report that the duration of evoked NMDA-receptor-mediated excitatory postsynaptic currents (e.p.s.cs) in the superior colliculus is several times longer at early developmental stages compared to that measured in older animals. In contrast, the amplitude of NMDA-receptor-mediated miniature e.p.s.cs does not change during development. The kinetic response of excised membrane patches to a brief activation of NMDA receptors is similar to that of the NMDA e.p.s.c, which suggests that the time course of the NMDA e.p.s.c. in the superior colliculus reflects slow NMDA channel properties as in the hippocampus. Therefore, these data indicate that the molecular properties of NMDA receptors are developmentally regulated and thus may be controlling the ability of synapses to change in early life.

journal_name

Nature

journal_title

Nature

authors

Hestrin S

doi

10.1038/357686a0

keywords:

subject

Has Abstract

pub_date

1992-06-25 00:00:00

pages

686-9

issue

6380

eissn

0028-0836

issn

1476-4687

journal_volume

357

pub_type

杂志文章

相关文献

NATURE文献大全
  • A natural variant and engineered mutation in a GPCR promote DEET resistance in C. elegans.

    abstract::DEET (N,N-diethyl-meta-toluamide) is a synthetic chemical identified by the US Department of Agriculture in 1946 in a screen for repellents to protect soldiers from mosquito-borne diseases1,2. Since its discovery, DEET has become the world's most widely used arthropod repellent and is effective against invertebrates s...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-018-0546-8

    authors: Dennis EJ,Dobosiewicz M,Jin X,Duvall LB,Hartman PS,Bargmann CI,Vosshall LB

    更新日期:2018-10-01 00:00:00

  • Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11.

    abstract::In mammals, one of the most pronounced consequences of viral infection is the induction of type I interferons, cytokines with potent antiviral activity. Schlafen (Slfn) genes are a subset of interferon-stimulated early response genes (ISGs) that are also induced directly by pathogens via the interferon regulatory fact...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature11433

    authors: Li M,Kao E,Gao X,Sandig H,Limmer K,Pavon-Eternod M,Jones TE,Landry S,Pan T,Weitzman MD,David M

    更新日期:2012-11-01 00:00:00

  • Polymorphism control of superconductivity and magnetism in Cs(3)C(60) close to the Mott transition.

    abstract::The crystal structure of a solid controls the interactions between the electronically active units and thus its electronic properties. In the high-temperature superconducting copper oxides, only one spatial arrangement of the electronically active Cu(2+) units-a two-dimensional square lattice-is available to study the...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature09120

    authors: Ganin AY,Takabayashi Y,Jeglic P,Arcon D,Potocnik A,Baker PJ,Ohishi Y,McDonald MT,Tzirakis MD,McLennan A,Darling GR,Takata M,Rosseinsky MJ,Prassides K

    更新日期:2010-07-08 00:00:00

  • Ceramic-metal composites for heat exchangers in concentrated solar power plants.

    abstract::The efficiency of generating electricity from heat using concentrated solar power plants (which use mirrors or lenses to concentrate sunlight in order to drive heat engines, usually involving turbines) may be appreciably increased by operating with higher turbine inlet temperatures, but this would require improved hea...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-018-0593-1

    authors: Caccia M,Tabandeh-Khorshid M,Itskos G,Strayer AR,Caldwell AS,Pidaparti S,Singnisai S,Rohskopf AD,Schroeder AM,Jarrahbashi D,Kang T,Sahoo S,Kadasala NR,Marquez-Rossy A,Anderson MH,Lara-Curzio E,Ranjan D,Henry A,Sandhag

    更新日期:2018-10-01 00:00:00

  • Calcium-dependent interaction of N-type calcium channels with the synaptic core complex.

    abstract::Neurotransmitter release is initiated by influx of Ca2+ through voltage-gated Ca2+ channels, within 200 microseconds of the action potential arriving at the synaptic terminal, as the Ca2+ concentration increases from 100 nM to > 200 microM. Exocytosis requires high Ca2+ concentration, with a threshold of 20-50 microM ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/379451a0

    authors: Sheng ZH,Rettig J,Cook T,Catterall WA

    更新日期:1996-02-01 00:00:00

  • CD95's deadly mission in the immune system.

    abstract::Apoptosis in the immune system is a fundamental process regulating lymphocyte maturation, receptor repertoire selection and homeostasis. Thus, death by apoptosis is as essential for the function of lymphocytes as growth and differentiation. This article focuses on death receptor-associated apoptosis and the role of CD...

    journal_title:Nature

    pub_type: 杂志文章,评审

    doi:10.1038/35037728

    authors: Krammer PH

    更新日期:2000-10-12 00:00:00

  • Co-localization of corticotropin-releasing factor and vasopressin in median eminence neurosecretory vesicles.

    abstract::Vasopressin (VP) potentiates the effect of corticotropin-releasing factor (CRF) on the secretion of adrenocorticotropic hormone (ACTH) from anterior pituitary cells in vitro, and both CRF and VP have been found in portal blood. These data support the hypothesis that VP acts synergistically with CRF to cause the secret...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/317248a0

    authors: Whitnall MH,Mezey E,Gainer H

    更新日期:1985-09-19 00:00:00

  • Glass behaviour: Poisson's ratio and liquid's fragility.

    abstract::The lack of a reliable theory of glass physics has led to the pursuit of correlations between various glass or viscous liquid parameters, one of which is the slope m of the plot of log(viscosity) against Tg/T, extrapolated at the glass-transition temperature, Tg, also termed 'fragility'. Novikov and Sokolov conclude t...

    journal_title:Nature

    pub_type: 评论,杂志文章

    doi:10.1038/nature04967

    authors: Yannopoulos SN,Johari GP

    更新日期:2006-08-03 00:00:00

  • Are U4 small nuclear ribonucleoproteins involved in polyadenylation?

    abstract::The mechanism whereby eukaryotic pre-messenger RNAs are polyadenylated is unknown. Most models for polyadenylation invoke cleavage of precursor transcripts at the site of poly(A) addition followed by polymerization of A residues by poly(A) polymerase. Analysis of the sequences surrounding poly(A) addition sites has id...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/309179a0

    authors: Berget SM

    更新日期:1984-05-10 00:00:00

  • High-frequency acoustic waves are not sufficient to heat the solar chromosphere.

    abstract::One of the main unanswered questions in solar physics is why the Sun's outer atmosphere is hotter than its surface. Theory predicts abundant production of high-frequency (10-50 mHz) acoustic waves in subsurface layers of the Sun, and such waves are believed by many to constitute the dominant heating mechanism of the c...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature03695

    authors: Fossum A,Carlsson M

    更新日期:2005-06-16 00:00:00

  • Induction of apoptosis in mature T cells by tumour necrosis factor.

    abstract::T-cell receptor-induced apoptosis regulates immune responses and can result from interactions between Fas (Apo1/CD95) and Fas ligand (FasL). Mutations in the genes for Fas and FasL cause disorders resembling human autoimmune diseases in lpr and gld mice, respectively. However, peripheral T-cell deletion takes place in...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/377348a0

    authors: Zheng L,Fisher G,Miller RE,Peschon J,Lynch DH,Lenardo MJ

    更新日期:1995-09-28 00:00:00

  • Neolithic trade routes re-aligned by oxygen isotope analyses.

    abstract::Oxygen isotope analyses of Spondylus shells from neolithic sites suggest that the source for the shells used as ornaments in the Balkans and central Europe during the fourth millennium BC was the Aegean and not the Black Sea. The trade in Spondylus may have taken the form of an exchange of gifts. ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/2281062a0

    authors: Shackleton N,Renfrew C

    更新日期:1970-12-12 00:00:00

  • Palladium-catalysed C-H activation of aliphatic amines to give strained nitrogen heterocycles.

    abstract::The development of new chemical transformations based on catalytic functionalization of unactivated C-H bonds has the potential to simplify the synthesis of complex molecules dramatically. Transition metal catalysis has emerged as a powerful tool with which to convert these unreactive bonds into carbon-carbon and carb...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature13389

    authors: McNally A,Haffemayer B,Collins BS,Gaunt MJ

    更新日期:2014-06-05 00:00:00

  • Distributed biological computation with multicellular engineered networks.

    abstract::Ongoing efforts within synthetic and systems biology have been directed towards the building of artificial computational devices using engineered biological units as basic building blocks. Such efforts, inspired in the standard design of electronic circuits, are limited by the difficulties arising from wiring the basi...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature09679

    authors: Regot S,Macia J,Conde N,Furukawa K,Kjellén J,Peeters T,Hohmann S,de Nadal E,Posas F,Solé R

    更新日期:2011-01-13 00:00:00

  • CD95 promotes tumour growth.

    abstract::CD95 (also called Fas and APO-1) is a prototypical death receptor that regulates tissue homeostasis mainly in the immune system through the induction of apoptosis. During cancer progression CD95 is frequently downregulated or cells are rendered apoptosis resistant, raising the possibility that loss of CD95 is part of ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature09075

    authors: Chen L,Park SM,Tumanov AV,Hau A,Sawada K,Feig C,Turner JR,Fu YX,Romero IL,Lengyel E,Peter ME

    更新日期:2010-05-27 00:00:00

  • Expression of Hox-7.1 in myoblasts inhibits terminal differentiation and induces cell transformation.

    abstract::The terminal differentiation of myogenic cells initiates in the proximal portion of the limb bud whereas the distal region remains undifferentiated and proliferative. The apical ectodermal ridge maintains the progress zone in an undifferentiated state and induces proliferation of limb mesenchymal cells. Hox-7.1, a hom...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/360477a0

    authors: Song K,Wang Y,Sassoon D

    更新日期:1992-12-03 00:00:00

  • A giant stream of metal-rich stars in the halo of the galaxy M31.

    abstract::Recent observations have revealed streams of gas and stars in the halo of the Milky Way that are the debris from interactions between our Galaxy and some of its dwarf companion galaxies; the Sagittarius dwarf galaxy and the Magellanic clouds. Analysis of the material has shown that much of the halo is made up of canni...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35083506

    authors: Ibata R,Irwin M,Lewis G,Ferguson AM,Tanvir N

    更新日期:2001-07-05 00:00:00

  • Non-volcanic tremor driven by large transient shear stresses.

    abstract::Non-impulsive seismic radiation or 'tremor' has long been observed at volcanoes and more recently around subduction zones. Although the number of observations of non-volcanic tremor is steadily increasing, the causative mechanism remains unclear. Some have attributed non-volcanic tremor to the movement of fluids, whil...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature06017

    authors: Rubinstein JL,Vidale JE,Gomberg J,Bodin P,Creager KC,Malone SD

    更新日期:2007-08-02 00:00:00

  • Feedback regulation of steady-state epithelial turnover and organ size.

    abstract::Epithelial organs undergo steady-state turnover throughout adult life, with old cells being continually replaced by the progeny of stem cell divisions. To avoid hyperplasia or atrophy, organ turnover demands strict equilibration of cell production and loss. However, the mechanistic basis of this equilibrium is unknown...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature23678

    authors: Liang J,Balachandra S,Ngo S,O'Brien LE

    更新日期:2017-08-31 00:00:00

  • Whales originated from aquatic artiodactyls in the Eocene epoch of India.

    abstract::Although the first ten million years of whale evolution are documented by a remarkable series of fossil skeletons, the link to the ancestor of cetaceans has been missing. It was known that whales are related to even-toed ungulates (artiodactyls), but until now no artiodactyls were morphologically close to early whales...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature06343

    authors: Thewissen JG,Cooper LN,Clementz MT,Bajpai S,Tiwari BN

    更新日期:2007-12-20 00:00:00

  • A network that learns to recognize three-dimensional objects.

    abstract::The visual recognition of three-dimensional (3-D) objects on the basis of their shape poses at least two difficult problems. First, there is the problem of variable illumination, which can be addressed by working with relatively stable features such as intensity edges rather than the raw intensity images. Second, ther...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/343263a0

    authors: Poggio T,Edelman S

    更新日期:1990-01-18 00:00:00

  • Role of spectral detail in sound-source localization.

    abstract::Sounds heard over headphones are typically perceived inside the head (internalized), unlike real sound sources which are perceived outside the head (externalized). If the acoustical waveforms from a real sound source are reproduced precisely using headphones, auditory images are appropriately externalized and localize...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/25526

    authors: Kulkarni A,Colburn HS

    更新日期:1998-12-24 00:00:00

  • Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance.

    abstract::Acquired drug resistance is a major problem in the treatment of cancer. Of the more than 500,000 annual deaths from cancer in the United States, many follow the development of resistance to chemotherapy. The emergence of resistance depends in part on the genetic instability, heterogeneity and high mutational rate of t...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/37126

    authors: Boehm T,Folkman J,Browder T,O'Reilly MS

    更新日期:1997-11-27 00:00:00

  • Are baclofen-sensitive GABAB receptors present on primary afferent terminals of the spinal cord?

    abstract::The site of action of the antispastic drug baclofen has long been considered to reside in the spinal cord although supraspinal effects have also been reported. This beta-chlorophenyl derivative of the neurotransmitter gamma-aminobutyric acid (GABA) depresses both monosynaptic and polysynaptic transmission in the cord ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/307071a0

    authors: Price GW,Wilkin GP,Turnbull MJ,Bowery NG

    更新日期:1984-01-05 00:00:00

  • Extraction of a weak climatic signal by an ecosystem.

    abstract::The complexity of ecosystems can cause subtle and chaotic responses to changes in external forcing. Although ecosystems may not normally behave chaotically, sensitivity to external influences associated with nonlinearity can lead to amplification of climatic signals. Strong correlations between an El Niño index and ra...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/416629a

    authors: Taylor AH,Allen JI,Clark PA

    更新日期:2002-04-11 00:00:00

  • Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes.

    abstract::The mechanism of self-tolerance is studied in T-cell-receptor transgenic mice expressing a receptor in many of their T cells for the male (H-Y) antigen in the context of class I H-2Db MHC antigens. Autospecific T cells are deleted in male mice. The deletion affects only transgene-expressing cells with a relatively hig...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/333742a0

    authors: Kisielow P,Blüthmann H,Staerz UD,Steinmetz M,von Boehmer H

    更新日期:1988-06-23 00:00:00

  • Isolation of rare circulating tumour cells in cancer patients by microchip technology.

    abstract::Viable tumour-derived epithelial cells (circulating tumour cells or CTCs) have been identified in peripheral blood from cancer patients and are probably the origin of intractable metastatic disease. Although extremely rare, CTCs represent a potential alternative to invasive biopsies as a source of tumour tissue for th...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature06385

    authors: Nagrath S,Sequist LV,Maheswaran S,Bell DW,Irimia D,Ulkus L,Smith MR,Kwak EL,Digumarthy S,Muzikansky A,Ryan P,Balis UJ,Tompkins RG,Haber DA,Toner M

    更新日期:2007-12-20 00:00:00

  • Structure of the parainfluenza virus 5 F protein in its metastable, prefusion conformation.

    abstract::Enveloped viruses have evolved complex glycoprotein machinery that drives the fusion of viral and cellular membranes, permitting entry of the viral genome into the cell. For the paramyxoviruses, the fusion (F) protein catalyses this membrane merger and entry step, and it has been postulated that the F protein undergoe...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature04322

    authors: Yin HS,Wen X,Paterson RG,Lamb RA,Jardetzky TS

    更新日期:2006-01-05 00:00:00

  • Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy.

    abstract::X-linked spinal and bulbar muscular atrophy (Kennedy's disease) is an adult-onset form of motorneuron disease which may be associated with signs of androgen insensitivity. We have now investigated whether the androgen receptor gene on the proximal long arm of the X chromosome is a candidate gene for this disease. In p...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/352077a0

    authors: La Spada AR,Wilson EM,Lubahn DB,Harding AE,Fischbeck KH

    更新日期:1991-07-04 00:00:00

  • Photoelectrochemical cells.

    abstract::Until now, photovoltaics--the conversion of sunlight to electrical power--has been dominated by solid-state junction devices, often made of silicon. But this dominance is now being challenged by the emergence of a new generation of photovoltaic cells, based, for example, on nanocrystalline materials and conducting pol...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35104607

    authors: Grätzel M

    更新日期:2001-11-15 00:00:00