Total synthesis and isolation of citrinalin and cyclopiamine congeners.

abstract：:Major histocompatibility complex (MHC) class II molecules are highly polymorphic cell-surface glycoproteins that present antigenic peptides to CD4+ T lymphocytes. The normal assembly of class II molecules with cognate peptides for antigen presentation requires an accessory function provided by a gene mapping to the cl...

journal_title：Nature

authors： Fling SP,Arp B,Pious D

更新日期：1994-04-07 00:00:00

abstract：:The gut of healthy human neonates is usually devoid of viruses at birth, but quickly becomes colonized, which-in some cases-leads to gastrointestinal disorders1-4. Here we show that the assembly of the viral community in neonates takes place in distinct steps. Fluorescent staining of virus-like particles purified from...

journal_title：Nature

authors： Liang G,Zhao C,Zhang H,Mattei L,Sherrill-Mix S,Bittinger K,Kessler LR,Wu GD,Baldassano RN,DeRusso P,Ford E,Elovitz MA,Kelly MS,Patel MZ,Mazhani T,Gerber JS,Kelly A,Zemel BS,Bushman FD

更新日期：2020-05-01 00:00:00

abstract：:The hypothesis that certain RNA molecules may be able to catalyse RNA replication is central to current theories of the early evolution of life. In support of this idea, we describe here an RNA that synthesizes RNA using the same reaction as that employed by protein enzymes that catalyse RNA polymerization. In the pre...

journal_title：Nature

authors： Ekland EH,Bartel DP

更新日期：1996-07-25 00:00:00

abstract：:Pathogenic bacteria such as Escherichia coli assemble surface structures termed pili, or fimbriae, to mediate binding to host-cell receptors1. Type 1 pili are assembled via the conserved chaperone-usher pathway2-5. The outer-membrane usher FimD recruits pilus subunits bound by the chaperone FimC via the periplasmic N-...

journal_title：Nature

authors： Du M,Yuan Z,Yu H,Henderson N,Sarowar S,Zhao G,Werneburg GT,Thanassi DG,Li H

更新日期：2018-10-01 00:00:00

abstract：:A significant fraction of patients with advanced prostate cancer treated with androgen deprivation therapy experience relapse with relentless progression to lethal metastatic castration-resistant prostate cancer (mCRPC). Immune checkpoint blockade using antibodies against cytotoxic-T-lymphocyte-associated protein 4 (C...

journal_title：Nature

authors： Lu X,Horner JW,Paul E,Shang X,Troncoso P,Deng P,Jiang S,Chang Q,Spring DJ,Sharma P,Zebala JA,Maeda DY,Wang YA,DePinho RA

更新日期：2017-03-30 00:00:00

abstract：:The regular occurrence of a peak due to an unidentified substance (X) in the gas chromatographic traces obtained from phenolic extracts of urine from human pregnant and non-pregnant females has been reported. The biphasic excretion of X with maxima in the luteal phase of the ovulatory cycle and relatively high levels ...

journal_title：Nature

authors： Stitch SR,Toumba JK,Groen MB,Funke CW,Leemhuis J,Vink J,Woods GF

更新日期：1980-10-23 00:00:00

abstract：:A first step towards somatic hybridization in plants has been achieved. Protoplasts have been isolated and seen to fuse. ...

journal_title：Nature

authors： Power JB,Cummins SE,Cocking EC

更新日期：1970-03-14 00:00:00

abstract：:Therizinosauroids are an enigmatic group of dinosaurs known mostly from the Cretaceous period of Asia, whose derived members are characterized by elongate necks, laterally expanded pelves, small, leaf-shaped teeth, edentulous rostra and mandibular symphyses that probably bore keratinized beaks. Although more than a do...

journal_title：Nature

authors： Kirkland JI,Zanno LE,Sampson SD,Clark JM,DeBlieux DD

更新日期：2005-05-05 00:00:00

abstract：:The detection of horizontal disparities between the right and left retinal images is accepted as an important component in the visual perception of depth. It has occasionally been pointed out that a disparity will also occur in the vertical when a target is nearer to one eye than the other and could be used as a secon...

journal_title：Nature

authors： Westheimer G

更新日期：1984-02-16 00:00:00

abstract：:Endocytosis of the major histocompatibility complex (MHC)-encoded class I and class II molecules has been the subject of recent investigations. Class I molecules, which are key elements in T cell-mediated cytotoxicity, are differentially endocytosed by different cell types. Fibroblasts internalize their class I molecu...

journal_title：Nature

authors： Machy P,Truneh A,Gennaro D,Hoffstein S

更新日期：1987-08-20 00:00:00

abstract：:The yeast nuclear protein Yra1p is an essential export factor for mRNA. Yra1p interacts directly with the mRNA transport factor Mex67p/Mtr2p, which is associated with the nuclear pore. Here, we report a genetic interaction between YRA1 and SUB2, the gene for a DEAD box helicase involved in splicing. Mutation of SUB2 a...

journal_title：Nature

authors： Strässer K,Hurt E

更新日期：2001-10-11 00:00:00

abstract：:How to image objects that are hidden from a camera's view is a problem of fundamental importance to many fields of research, with applications in robotic vision, defence, remote sensing, medical imaging and autonomous vehicles. Non-line-of-sight (NLOS) imaging at macroscopic scales has been demonstrated by scanning a ...

journal_title：Nature

authors： O'Toole M,Lindell DB,Wetzstein G

更新日期：2018-03-15 00:00:00

abstract：:Established infections with the human and simian immunodeficiency viruses (HIV and SIV, respectively) are thought to be permanent with even the most effective immune responses and antiretroviral therapies only able to control, but not clear, these infections. Whether the residual virus that maintains these infections ...

journal_title：Nature

authors： Hansen SG,Piatak M Jr,Ventura AB,Hughes CM,Gilbride RM,Ford JC,Oswald K,Shoemaker R,Li Y,Lewis MS,Gilliam AN,Xu G,Whizin N,Burwitz BJ,Planer SL,Turner JM,Legasse AW,Axthelm MK,Nelson JA,Früh K,Sacha JB,Estes JD

更新日期：2013-10-03 00:00:00

abstract：:Ultra-compact dwarf galaxies are among the densest stellar systems in the Universe. These systems have masses of up to 2 × 10(8) solar masses, but half-light radii of just 3-50 parsecs. Dynamical mass estimates show that many such dwarfs are more massive than expected from their luminosity. It remains unclear whether ...

journal_title：Nature

authors： Seth AC,van den Bosch R,Mieske S,Baumgardt H,den Brok M,Strader J,Neumayer N,Chilingarian I,Hilker M,McDermid R,Spitler L,Brodie J,Frank MJ,Walsh JL

更新日期：2014-09-18 00:00:00

abstract：:The DNA polymerase V (pol V) and RecA proteins are essential components of a mutagenic translesion synthesis pathway in Escherichia coli designed to cope with DNA damage. Previously, it has been assumed that RecA binds to the DNA template strand being copied. Here we show, however, that pol-V-catalysed translesion syn...

journal_title：Nature

authors： Schlacher K,Cox MM,Woodgate R,Goodman MF

更新日期：2006-08-24 00:00:00

abstract：: ...

journal_title：Nature

authors： Gewin V

更新日期：2018-12-01 00:00:00

abstract：:Methane is a potent greenhouse gas that is produced in significant quantities by aerobic marine organisms. These bacteria apparently catalyse the formation of methane through the cleavage of the highly unreactive carbon-phosphorus bond in methyl phosphonate (MPn), but the biological or terrestrial source of this compo...

journal_title：Nature

authors： Kamat SS,Williams HJ,Dangott LJ,Chakrabarti M,Raushel FM

更新日期：2013-05-02 00:00:00

abstract：:Replication of multipotential stem cells in long-term murine bone marrow cell culture is known to depend on the development of an adherent stromal cell layer. In these conditions, restricted haematopoietic progenitor cells have also been generated for up to several months1-3. However, maturation is observed only in th...

journal_title：Nature

authors： Wendling F,Shreeve MM,McLeod DL,Axelrad AA

更新日期：1983-10-13 00:00:00

abstract：:Nerve growth factor (NGF) is involved in a variety of processes involving signalling, such as cell differentiation and survival, growth cessation and apoptosis of neurons. These events are mediated by NGF as a result of binding to its two cell-surface receptors, TrkA and p75. TrkA is a receptor with tyrosine kinase ac...

journal_title：Nature

authors： Wiesmann C,Ultsch MH,Bass SH,de Vos AM

更新日期：1999-09-09 00:00:00

abstract：:De novo engineering of gene circuits inside cells is extremely difficult, and efforts to realize predictable and robust performance must deal with noise in gene expression and variation in phenotypes between cells. Here we demonstrate that by coupling gene expression to cell survival and death using cell-cell communic...

journal_title：Nature

authors： You L,Cox RS 3rd,Weiss R,Arnold FH

更新日期：2004-04-22 00:00:00

abstract：:N-methyl-d-aspartate (NMDA) receptors (NMDARs) are a major class of excitatory neurotransmitter receptors in the central nervous system. They form glutamate-gated ion channels that are highly permeable to calcium and mediate activity-dependent synaptic plasticity. NMDAR dysfunction is implicated in multiple brain diso...

journal_title：Nature

authors： Gielen M,Siegler Retchless B,Mony L,Johnson JW,Paoletti P

更新日期：2009-06-04 00:00:00

abstract：:In sexually reproducing animals, a crucial step in zygote formation is the decondensation of the fertilizing sperm nucleus into a DNA replication-competent male pronucleus. Genome-wide nucleosome assembly on paternal DNA implies the replacement of sperm chromosomal proteins, such as protamines, by maternally provided ...

journal_title：Nature

authors： Loppin B,Bonnefoy E,Anselme C,Laurençon A,Karr TL,Couble P

更新日期：2005-10-27 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:The discovery of a plume of water vapour and ice particles emerging from warm fractures ('tiger stripes') in Saturn's small, icy moon Enceladus raised the question of whether the plume emerges from a subsurface liquid source or from the decomposition of ice. Previous compositional analyses of particles injected by the...

journal_title：Nature

authors： Postberg F,Schmidt J,Hillier J,Kempf S,Srama R

更新日期：2011-06-22 00:00:00

abstract：:The Colorado plateau is a large, tectonically intact, physiographic province in the southwestern North American Cordillera that stands at ∼1,800-2,000 m elevation and has long been thought to be in isostatic equilibrium. The origin of these high elevations is unclear because unlike the surrounding provinces, which hav...

journal_title：Nature

authors： Levander A,Schmandt B,Miller MS,Liu K,Karlstrom KE,Crow RS,Lee CT,Humphreys ED

更新日期：2011-04-28 00:00:00

abstract：:The nucleus of mammalian cells displays a distinct spatial segregation of active euchromatic and inactive heterochromatic regions of the genome1,2. In conventional nuclei, microscopy shows that euchromatin is localized in the nuclear interior and heterochromatin at the nuclear periphery1,2. Genome-wide chromosome conf...

journal_title：Nature

authors： Falk M,Feodorova Y,Naumova N,Imakaev M,Lajoie BR,Leonhardt H,Joffe B,Dekker J,Fudenberg G,Solovei I,Mirny LA

更新日期：2019-06-01 00:00:00

abstract：:Although phytoalexins have long been inferred to be important in the defence of plants against fungal infection, there are few reports showing that they provide resistance to infection. Several plants, including grapevine, synthesize the stilbene-type phytoalexin resveratrol when attacked by pathogens. Stilbenes with ...

journal_title：Nature

authors： Hain R,Reif HJ,Krause E,Langebartels R,Kindl H,Vornam B,Wiese W,Schmelzer E,Schreier PH,Stöcker RH

更新日期：1993-01-14 00:00:00

abstract：:To understand the processes that regulate the abundance and persistence of wild populations is a fundamental goal of ecology and a prerequisite for the management of living resources. Variable abundance data, however, make the demonstration of regulation processes challenging. A previously overlooked aspect in underst...

journal_title：Nature

authors： Minto C,Myers RA,Blanchard W

更新日期：2008-03-20 00:00:00

abstract：:NADH oxidation in the respiratory chain is coupled to ion translocation across the membrane to build up an electrochemical gradient. The sodium-translocating NADH:quinone oxidoreductase (Na(+)-NQR), a membrane protein complex widespread among pathogenic bacteria, consists of six subunits, NqrA, B, C, D, E and F. To ou...

journal_title：Nature

authors： Steuber J,Vohl G,Casutt MS,Vorburger T,Diederichs K,Fritz G

更新日期：2014-12-04 00:00:00

abstract：:Introduced in its contemporary form in 1946 (ref. 1), but with roots that go back to the eighteenth century, the gravity law is the prevailing framework with which to predict population movement, cargo shipping volume and inter-city phone calls, as well as bilateral trade flows between nations. Despite its widespread ...

journal_title：Nature

authors： Simini F,González MC,Maritan A,Barabási AL

更新日期：2012-02-26 00:00:00