Abstract:
:Measures to prevent sexual mucosal transmission of human immunodeficiency virus (HIV)-1 are urgently needed to curb the growth of the acquired immunodeficiency syndrome (AIDS) pandemic and ultimately bring it to an end. Studies in animal models and acute HIV-1 infection reviewed here reveal potential viral vulnerabilities at the mucosal portal of entry in the earliest stages of infection that might be most effectively targeted by vaccines and microbicides, thereby preventing acquisition and averting systemic infection, CD4 T-cell depletion and pathologies that otherwise rapidly ensue.
journal_name
Naturejournal_title
Natureauthors
Haase ATdoi
10.1038/nature08757subject
Has Abstractpub_date
2010-03-11 00:00:00pages
217-23issue
7286eissn
0028-0836issn
1476-4687pii
nature08757journal_volume
464pub_type
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